Effect of Luseogliflozin on Myocardial Flow Reserve in Patients with Type 2 Diabetes Mellitus (LUCENT-J Study)
AbstractIntroductionIn patients with type 2 diabetes (T2D), treatment with sodium –glucose cotransporter-2 (SGLT2) inhibitors has been shown to reduce hospital admission rates for heart failure (HF). However, the multiple mechanisms hypothesized and investigated to explain the cardioprotection of SGLT2 inhibitors are not fully understood.ObjectivesThe effect of luseogliflozin on myocardial flow reserve (MFR) in patients with T2D (LUCENT-J) study aims to examine the effects of SGLT2 inhibitors on myocardial perfusion.MethodsThe LUCENT-J study is a prospective, single-center, randomized, two-arm, parallel-group, open-label...
Source: Diabetes Therapy - April 4, 2024 Category: Endocrinology Source Type: research
Dual and Triple Incretin-Based Co-agonists: Novel Therapeutics for Obesity and Diabetes
AbstractThe discovery of long-acting incretin receptor agonists represents a major stride forward in tackling the dual epidemic of obesity and diabetes. Here we outline the evolution of incretin-based pharmacotherapy, from exendin-4 to the discovery of the multi-incretin hormone receptor agonists that look set to be our next step toward curing diabetes and obesity. We discuss the multiagonists currently in clinical trials and the improvement in efficacy each new generation of these drugs bring. The success of these agents in preclinical models and clinical trials suggests a promising future for multiagonists in the treatme...
Source: Diabetes Therapy - April 4, 2024 Category: Endocrinology Source Type: research
An Obesity-Centric Approach with and Without Anti-Obesity Medications Compared to the Usual-Care Approach to Management of Patients with Obesity and Type 2 Diabetes in an Employer Setting: A Pragmatic Randomized Controlled Trial (EMPOWER-T2D)
ConclusionsIncluding anti-obesity medication was associated with superior weight loss with noninferior HbA1c reductions, warranting further evaluation in larger study populations of obesity-focused approaches to type 2 diabetes management.Graphical abstract available for this article.Trial RegistrationClinicalTrials.gov NCT03799198.Graphical Abstract (Source: Diabetes Therapy)
Source: Diabetes Therapy - April 4, 2024 Category: Endocrinology Source Type: research
Effectiveness of a Lifestyle Improvement Support App in Combination with a Wearable Device in Japanese People with Type 2 Diabetes Mellitus: STEP-DM Study
ConclusionsThe unique features of TOMOCO ™ in combination with Fitbit, together with conventional therapy, may promote a healthy lifestyle and thus contribute to improving HbA1c in people with T2DM.Clinical Trial RegistrationjRCT1070220007. (Source: Diabetes Therapy)
Source: Diabetes Therapy - March 30, 2024 Category: Endocrinology Source Type: research
Association of Premorbid GLP-1RA and SGLT-2i Prescription Alone and in Combination with COVID-19 Severity
ConclusionAmong adults who tested positive for SARS-CoV-2, premorbid use of either GLP-1RA or SGLT-2i is associated with lower odds of mortality compared to DPP-4i. Furthermore, concomitant use of GLP-1RA and SGLT-2i is linked to lower odds of other severe COVID-19 outcomes, including ER visits, hospitalizations, and mechanical ventilation, compared to SGLT-2i use alone.Graphical abstract available for this article.Graphical Abstract (Source: Diabetes Therapy)
Source: Diabetes Therapy - March 27, 2024 Category: Endocrinology Source Type: research
Adherence and Persistence to Basal Insulin Among People with Type 2 Diabetes in Europe: A Systematic Literature Review and Meta-analysis
ConclusionThe results highlight that almost half of patients with T2D in Western Europe have poor adherence to insulin therapy and, at 18 months, one in three patients do not persist on treatment. These findings call for new basal insulin therapies and diabetes management strategies that can improve treatment persistence and adherence among people with T2D. (Source: Diabetes Therapy)
Source: Diabetes Therapy - March 23, 2024 Category: Endocrinology Source Type: research
Validity of Montreal Cognitive Assessment to Detect Cognitive Impairment in Individuals with Type 2 Diabetes
ConclusionsThe recommended screening cut-off point on MoCA of < 26 has a suboptimal specificity and may increase the referral burden in memory clinics. A lower cut-off of < 21 on MoCA maximizes the diagnostic accuracy.Interactive Visual Abstract available for this article. (Source: Diabetes Therapy)
Source: Diabetes Therapy - March 23, 2024 Category: Endocrinology Source Type: research
The Why, What and Where Podcast on the Updated 2023 IWGDF Guideline on Offloading Treatments for Diabetes-Related Foot Ulcers
AbstractIn this podcast the lead authors of the 2023 International Working Group on the Diabetic Foot (IWGDF) guideline on offloading treatments for diabetes-related foot ulcers briefly discuss why we need offloading treatments for people with diabetes-related foot ulcers, what the new international offloading guideline recommends, and where offloading treatment might go into the future.A podcast audio is available with this article. (Source: Diabetes Therapy)
Source: Diabetes Therapy - March 23, 2024 Category: Endocrinology Source Type: research
Adherence and Persistence to Basal Insulin Among People with Type 2 Diabetes in Europe: A Systematic Literature Review and Meta-analysis
ConclusionThe results highlight that almost half of patients with T2D in Western Europe have poor adherence to insulin therapy and, at 18 months, one in three patients do not persist on treatment. These findings call for new basal insulin therapies and diabetes management strategies that can improve treatment persistence and adherence among people with T2D. (Source: Diabetes Therapy)
Source: Diabetes Therapy - March 23, 2024 Category: Endocrinology Source Type: research
Validity of Montreal Cognitive Assessment to Detect Cognitive Impairment in Individuals with Type 2 Diabetes
ConclusionsThe recommended screening cut-off point on MoCA of < 26 has a suboptimal specificity and may increase the referral burden in memory clinics. A lower cut-off of < 21 on MoCA maximizes the diagnostic accuracy.Interactive Visual Abstract available for this article. (Source: Diabetes Therapy)
Source: Diabetes Therapy - March 23, 2024 Category: Endocrinology Source Type: research
The Why, What and Where Podcast on the Updated 2023 IWGDF Guideline on Offloading Treatments for Diabetes-Related Foot Ulcers
AbstractIn this podcast the lead authors of the 2023 International Working Group on the Diabetic Foot (IWGDF) guideline on offloading treatments for diabetes-related foot ulcers briefly discuss why we need offloading treatments for people with diabetes-related foot ulcers, what the new international offloading guideline recommends, and where offloading treatment might go into the future.A podcast audio is available with this article. (Source: Diabetes Therapy)
Source: Diabetes Therapy - March 23, 2024 Category: Endocrinology Source Type: research
Podcast on How to Classify Foot Ulcers in People with Diabetes (2023 Update of the IWGDF Guidelines on Classification)
ConclusionAlthough there is no classification that fits all purposes, it is crucial that healthcare professionals standardize the way they characterise diabetes-related foot ulcers and guide their decision-making process by using validated classification systems. (Source: Diabetes Therapy)
Source: Diabetes Therapy - March 21, 2024 Category: Endocrinology Source Type: research
