Simplification of Complex Insulin Regimens with IdegLira in People with Type 2 Diabetes: Literature Review and Clinical Recommendations
ConclusionsOn the basis of the findings of these studies, we made some recommendations for clinical practice to simplify treatment. The results of these studies support an algorithm that simplifies the treatment of complex insulin regimens. (Source: Diabetes Therapy)
Source: Diabetes Therapy - September 22, 2023 Category: Endocrinology Source Type: research
Insulin Therapy for the Management of Diabetes Mellitus: A Narrative Review of Innovative Treatment Strategies
AbstractThe discovery of insulin was presented to the international medical community on May 3, 1922. Since then, insulin has become one of the most effective pharmacological agents used to treat type 1 and type 2 diabetes mellitus. However, the initiation and intensification of insulin therapy is often delayed in people living with type 2 diabetes due to numerous challenges associated with daily subcutaneous administration. Reducing the frequency of injections, using insulin pens instead of syringes and vials, simplifying treatment regimens, or administering insulin through alternative routes may help improve adherence to...
Source: Diabetes Therapy - September 22, 2023 Category: Endocrinology Source Type: research
Correction to: Prevalence of Diabetic Kidney Disease with Different Subtypes in Hospitalized Patients with Diabetes and Correlation Between eGFR and LncRNA XIST Expression in PBMCs
(Source: Diabetes Therapy)
Source: Diabetes Therapy - September 20, 2023 Category: Endocrinology Source Type: research
Optimising Insulin Injection Techniques to Improve Diabetes Outcomes
AbstractThe effectiveness of therapy in patients with diabetes depends on the correct use of the insulin injection technique. However, despite many established recommendations and evidence that an effective insulin injection technique is essential to improve glycaemic control and minimise the risk associated with diabetes, there is still a need to identify impediments to the insulin injection technique among patients and create awareness among patients and healthcare professionals about the importance of the optimisation of insulin injection techniques. This review focuses on the recent advancements in delivery devices, in...
Source: Diabetes Therapy - September 16, 2023 Category: Endocrinology Source Type: research
Glycaemic Control and Weight Reduction: A Narrative Review of New Therapies for Type 2 Diabetes
AbstractEarly and intensive treatment of type 2 diabetes (T2D) has been associated with lower risk of diabetes-related complications. Control of overweight and obesity, which are strongly associated with T2D and many of its complications, is also key in the management of the disease. New therapies allow for individualised glycaemic control targets with greater safety. Thus, in patients with a higher cardiovascular and renal risk profile, current guidelines encourage early treatment with metformin together with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium-glucose co-transporter-2 inhibitors with proven c...
Source: Diabetes Therapy - September 15, 2023 Category: Endocrinology Source Type: research
Probiotic for Pancreatic β-Cell Function in Type 2 Diabetes: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial
ConclusionsProbiotic therapies modestly improved β-cell function in patients with T2D. Modulating the gut microbiota represents a new diabetes treatment and should be tested in more extensive studies.Trial RegistrationNCT05765292. (Source: Diabetes Therapy)
Source: Diabetes Therapy - September 15, 2023 Category: Endocrinology Source Type: research
Glycaemic Control and Weight Reduction: A Narrative Review of New Therapies for Type 2 Diabetes
AbstractEarly and intensive treatment of type 2 diabetes (T2D) has been associated with lower risk of diabetes-related complications. Control of overweight and obesity, which are strongly associated with T2D and many of its complications, is also key in the management of the disease. New therapies allow for individualised glycaemic control targets with greater safety. Thus, in patients with a higher cardiovascular and renal risk profile, current guidelines encourage early treatment with metformin together with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium-glucose co-transporter-2 inhibitors with proven c...
Source: Diabetes Therapy - September 15, 2023 Category: Endocrinology Source Type: research
Probiotic for Pancreatic β-Cell Function in Type 2 Diabetes: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial
ConclusionsProbiotic therapies modestly improved β-cell function in patients with T2D. Modulating the gut microbiota represents a new diabetes treatment and should be tested in more extensive studies.Trial RegistrationNCT05765292. (Source: Diabetes Therapy)
Source: Diabetes Therapy - September 15, 2023 Category: Endocrinology Source Type: research
Safety and Clinical Outcomes of Insulin Degludec in Korean Patients with Diabetes in Real-World Practices: A Prospective, Observational Study
ConclusionIn real-world clinical practice, 26 weeks of IDeg treatment resulted in significant reductions in glycemic parameters with a low incidence of AEs in Korean patients with diabetes. No new safety signals were observed.Clinical Trials Registry and Registration NumberThis trial is registered under ClinicalTrials.gov (NCT02779413) and the universal trial number is [U1111-1176-2287]. (Source: Diabetes Therapy)
Source: Diabetes Therapy - September 14, 2023 Category: Endocrinology Source Type: research
Living with Type 1 Diabetes as Experienced by Adults with Prolonged Elevated HbA1c: A Qualitative Study
ConclusionsThe findings revealed the diverse experiences of adults with prolonged elevated HbA1c. Living with T1D, a lifelong non-chosen follower, could be perceived as constraining but manageable in different degrees. A person-centered care approach addressing both dimensions may be beneficial. Experiences of living with and managing diabetes are multifaceted and intertwined with life context and medical prerequisites. (Source: Diabetes Therapy)
Source: Diabetes Therapy - September 14, 2023 Category: Endocrinology Source Type: research
Effect of a Disease Management Program on the Adherence to Guideline-Recommended HbA1c Monitoring in Patients with Diabetes in Slovakia
ConclusionsPhysician participation in a DMP was found to significantly increase the number of HbA1c tests ordered by physicians, potentially leading to improved glycemic control. (Source: Diabetes Therapy)
Source: Diabetes Therapy - September 14, 2023 Category: Endocrinology Source Type: research
Treatment Burden on Once-Weekly Omarigliptin Versus Daily Dipeptidyl Peptidase-4 Inhibitors in Patients with Type 2 Diabetes: Randomized Controlled Trial (ONWARD-DPP4 Study)
ConclusionAlthough this study failed to demonstrate the improvement of DTBQ total score by switching from daily DPP4is to omarigliptin compared with continuing the daily DPP4is, the DTBQ subscale score implementation and flexibility burden score were significantly improved only in the group that switched to omarigliptin, suggesting the possibility of switching from daily DPP4is to omarigliptin to decrease the patients ’ medication burden.Trial RegistrationjRCTs031200437. (Source: Diabetes Therapy)
Source: Diabetes Therapy - September 14, 2023 Category: Endocrinology Source Type: research
Should Prediabetes be Treated Pharmacologically?
ConclusionsPharmacological treatment of the dysglycemia of prediabetes is not warranted. On the other hand, the ability of high doses of glucagon-like peptide (GLP)-1 receptor agonists and the combination of a GLP-1 receptor agonist and the glucose-dependent insulinotropic polypeptide (GIP) to lower weight by 15% and 20%, respectively, deserves consideration for the treatment of prediabetes. This amount of weight loss should decrease insulin resistance, allowing endogenous insulin secretion to be more effective and lower the risk for developing diabetes. (Source: Diabetes Therapy)
Source: Diabetes Therapy - September 14, 2023 Category: Endocrinology Source Type: research
