Midnight Cortisol is Associated with Changes in Systolic Blood Pressure and Diabetic Neuropathy in Subjects with Type 1 Diabetes Undergoing Simultaneous Kidney-Pancreas Transplantation
ConclusionsIn this exploratory study, lower MC was associated with a lower baseline SBP, an improvement of antihypertensive treatment 1 year after transplant, and a higher diabetic neuropathy prevalence in SPKT recipients. (Source: Diabetes Therapy)
Source: Diabetes Therapy - November 2, 2023 Category: Endocrinology Source Type: research
Optimizing Collaborative Care of Patients with Chronic Kidney Disease Associated with Type 2 Diabetes: An Example Practice Model at a Health Care Practice in Kentucky, United States
We describe an example practice model of a clinical practice called Baptist Health Deaconess, based in Madisonville, Kentucky, USA, where a small multidisciplinary team consisting of an endocrinologist, nurse practitioner, and pharmacist (authors of this article) work c ollaboratively in an ambulatory care setting to provide health care to the patients they serve. Many of the patients who receive care at Baptist Health Deaconess are on a low income, have poor health literacy, and do not have a primary care physician. The presence of a pharmacist in the team allows for insurance/access investigations to assess drug choice a...
Source: Diabetes Therapy - November 2, 2023 Category: Endocrinology Source Type: research
The Hybrid Closed-Loop System Tandem t:slim X2 ™ with Control-IQ Technology: Expert Recommendations for Better Management and Optimization
AbstractTechnological advances in the management of diabetes, especially type 1 diabetes (T1D), have played a main role in significantly improving glycemic control of these patients in recent years. Undoubtedly, the most important advance has been the commercialization of hybrid closed-loop systems (HCL). Their effectiveness places them in the different guidelines from scientific societies as the gold standard for the treatment of people with T1D. However, obtaining the maximum performance from these systems requires a degree of expertise from the professionals who care for these patients. Specifically, the Tandem X2:slim ...
Source: Diabetes Therapy - October 20, 2023 Category: Endocrinology Source Type: research
Prevalence of Metabolic Syndrome in Patients with Type 2 Diabetes in Japan: A Retrospective Cross-Sectional Study
ConclusionThe prevalence of metabolic syndrome in Japanese patients with T2D was 43.0% and increased with higher BMI. In patients with T2D and metabolic syndrome, cardiovascular drug usage and comorbidities increased in patients with a higher BMI. These data highlight the importance of managing metabolic parameters in addition to glycemic control in Japanese patients with T2D, particularly in patients with metabolic syndrome and BMI ≥ 25 kg/m2. (Source: Diabetes Therapy)
Source: Diabetes Therapy - October 19, 2023 Category: Endocrinology Source Type: research
Clinical Features, Cardiovascular Risk Profile, and Therapeutic Trajectories of Patients with Type 2 Diabetes Candidate for Oral Semaglutide Therapy in the Italian Specialist Care
ConclusionThe study supports the potential of early implementation of oral semaglutide as a strategy to overcome therapeutic inertia and enhance T2D management. (Source: Diabetes Therapy)
Source: Diabetes Therapy - October 18, 2023 Category: Endocrinology Source Type: research
A Simplified Screening Model to Predict the Risk of Gestational Diabetes Mellitus in Pregnant Chinese Women
ConclusionWe developed a simplified clinical screening model for predicting the risk of GDM in pregnant Chinese women. The model provides a feasible and convenient protocol to identify women at high risk of GDM in early pregnancy. Further validations are needed to evaluate the performance of the model in other populations.Trial RegistrationClinicalTrials.gov identifier: NCT03246295. (Source: Diabetes Therapy)
Source: Diabetes Therapy - October 16, 2023 Category: Endocrinology Source Type: research
Treatment Satisfaction and Quality of Life with Tirzepatide Versus Dulaglutide Among Japanese Patients with Type 2 Diabetes: Exploratory Evaluation of the SURPASS J-mono Trial
ConclusionPatients with T2D reported higher treatment satisfaction with once-weekly tirzepatide (5, 10, and 15 mg) compared with dulaglutide 0.75 mg after 52 weeks of treatment.Trial RegistrationClinicalTrials.gov, NCT03861052. (Source: Diabetes Therapy)
Source: Diabetes Therapy - October 16, 2023 Category: Endocrinology Source Type: research
A Simplified Screening Model to Predict the Risk of Gestational Diabetes Mellitus in Pregnant Chinese Women
ConclusionWe developed a simplified clinical screening model for predicting the risk of GDM in pregnant Chinese women. The model provides a feasible and convenient protocol to identify women at high risk of GDM in early pregnancy. Further validations are needed to evaluate the performance of the model in other populations.Trial RegistrationClinicalTrials.gov identifier: NCT03246295. (Source: Diabetes Therapy)
Source: Diabetes Therapy - October 16, 2023 Category: Endocrinology Source Type: research
Treatment Satisfaction and Quality of Life with Tirzepatide Versus Dulaglutide Among Japanese Patients with Type 2 Diabetes: Exploratory Evaluation of the SURPASS J-mono Trial
ConclusionPatients with T2D reported higher treatment satisfaction with once-weekly tirzepatide (5, 10, and 15 mg) compared with dulaglutide 0.75 mg after 52 weeks of treatment.Trial RegistrationClinicalTrials.gov, NCT03861052. (Source: Diabetes Therapy)
Source: Diabetes Therapy - October 16, 2023 Category: Endocrinology Source Type: research
The Effects of Sodium –Glucose Cotransporter 2 Inhibitors on Body Composition in Type 2 Diabetes Mellitus: A Narrative Review
AbstractBody composition is related to cardiometabolic disorders and is a major driver of the growing incidence of type 2 diabetes mellitus (T2DM). Altered fat distribution and decreased muscle mass are related to dysglycemia and impose adverse health-related outcomes in people with T2DM. Hence, improving body composition and maintaining muscle mass is crucial in T2DM. Sodium-glucose cotransporter 2 (SGLT2) inhibi tors are novel glucose-lowering medications gaining popularity because of their cardiorenal-protective effects and weight-lowering characteristics. However, reports on myopathy secondary to SGLT2 inhibitor tre...
Source: Diabetes Therapy - October 14, 2023 Category: Endocrinology Source Type: research
Efficacy and Safety of a Biosimilar Liraglutide (Melitide ®) Versus the Reference Liraglutide (Victoza®) in People with Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Noninferiority Clinical Trial
ConclusionThe biosimilar liraglutide (Melitide®) was noninferior in efficacy and comparable in safety when compared with the reference liraglutide.Trial RegistrationNCT03421119. (Source: Diabetes Therapy)
Source: Diabetes Therapy - October 12, 2023 Category: Endocrinology Source Type: research
Systematic Literature Review and Indirect Treatment Comparison of Three Ready-to-Use Glucagon Treatments for Severe Hypoglycemia
ConclusionBaqsimi, Gvoke and Zegalogue had comparable high proportions of treatment success in reversing insulin-induced hypoglycemia. Baqsimi achieved a lower mean maximum blood glucose value, which may have implications for the re-establishment of euglycemia. These findings may help support patients, caregivers and health care providers in their decision-making process when discussing various ready-to-use glucagon treatment options. (Source: Diabetes Therapy)
Source: Diabetes Therapy - October 12, 2023 Category: Endocrinology Source Type: research
