Metabolomics of Mice with Type 2 Diabetes and Nonalcoholic Fatty Liver Treated by Acupuncture
CONCLUSION: Our study shows that acupuncture can regulate the liver metabolism mode of T2DM in NAFLD mice. It can reduce blood glucose and lipid accumulation in the liver, and these findings provide a new idea and theoretical basis for acupuncture in the treatment of diseases related to glucose and lipid metabolism.PMID:38633528 | PMC:PMC11023731 | DOI:10.1155/2024/5568337 (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - April 18, 2024 Category: Endocrinology Authors: Yihui Guo Liying Zhang Mengyuan Li Linan Lin Fuyu Xue Wanning Gao Xiaoru Xu Haipeng Huang Source Type: research
Dapagliflozin and Empagliflozin in Paediatric Indications: A Systematic Review
CONCLUSION: Early evidence suggests that dapagliflozin and empagliflozin are well tolerated in children. A clinical pharmacology rationale currently exists only for adolescents with diabetes mellitus.PROSPERO REGISTRATION NUMBER: CRD42023438162.PMID:38635113 | DOI:10.1007/s40272-024-00623-z (Source: Paediatric Drugs)
Source: Paediatric Drugs - April 18, 2024 Category: Pediatrics Authors: Sebastiano A G Lava Craig Laurence Alessandro Di Deo Nicole Sekarski Michael Burch Oscar Della Pasqua Source Type: research
Correlation Analysis of NAMPT rs61330082 Polymorphism in Type 2 Diabetes Mellitus Combined with Hypertension
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - April 18, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research
Correlation between fat-to-muscle mass ratio and cognitive impairment in elderly patients with type 2 diabetes mellitus: a cross-sectional study
Fat to muscle mass ratio (FMR), a novel index integrating fat and muscle composition, has garnered attention in age-related conditions such as type 2 diabetes mellitus (T2DM) and neurodegenerative diseases. De... (Source: BMC Geriatrics)
Source: BMC Geriatrics - April 18, 2024 Category: Geriatrics Authors: Fan Wu, Yanlan Liu, Chenying Lin, Nahal Haghbin, Longfei Xia, Yaoshuang Li, Tong Chen, Huina Qiu, Weiran Jiang, Jingbo Li and Jingna Lin Tags: Research Source Type: research
IJERPH, Vol. 21, Pages 500: Cognitive Profile and Cardiovascular Risk Factors in Older Adults with Mild Cognitive Impairment
The DIALCAT Consortium
The prevalence of cardiovascular risk factors (CVRFs) in the older adults population and their specific impact on their cognitive profiles still requires further research. For this purpose, a cross-sectional study was carried out to describe the presence of CVRFs and their association with cognitive performance in a sample of older adults (65–85 years old) with Mild Cognitive Impairment (MCI). Participants (n = 185) were divided into three groups concerning their cardiovascular risk level determined by the presence of different CVRFs, including Type 2 Diabetes (T2D), dyslipidemia,...
Source: International Journal of Environmental Research and Public Health - April 18, 2024 Category: Environmental Health Authors: Sebasti án Ortiz-Zu ñiga Ciudin Ars Inzitari Sim ó Hern ández Ari ño-Blasco Barahona Franco Giron ès Crespo-Maraver Rovira Castellano-Tejedor The DIALCAT Consortium Tags: Article Source Type: research
Unexplained Residual Risk In Type 2 Diabetes: How Big Is The Problem?
AbstractPurpose of ReviewWhat is new? Cardiovascular disease (CVD) is the leading cause of mortality in type 2 diabetes (T2D) individuals. Of the major risk factors for CVD, less than 10% of T2D people meet the American Diabetes Association/American Heart Association recommended goals of therapy. The present review examines how much of the absolute cardiovascular (CV) risk in type 2 diabetes patients can be explained by major CV intervention trials.Recent FindingsMultiple long-term cardiovascular (CV) intervention trials have examined the effect of specific target-directed therapies on the MACE endpoint. Only oneprospectiv...
Source: Current Cardiology Reports - April 18, 2024 Category: Cardiology Source Type: research
Molecular Genealogy of Metabolic-associated Hepatocellular Carcinoma
In conclusion, deciphering the intricate interactions among metabolic processes, genetic predispositions, inflammatory responses, immune regulation, and microbial ecology is imperative for the development of novel therapeutic and preventative measures against metabolic-associated HCC. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Seminars in Liver Disease)
Source: Seminars in Liver Disease - April 18, 2024 Category: Gastroenterology Authors: Kodama, Takahiro Takehara, Tetsuo Tags: Review Article Source Type: research
Health and economic impact of dapagliflozin for type 2 diabetes patients who had or were at risk for atherosclerotic cardiovascular disease in the Italian general practitioners setting: a budget impact analysis
ConclusionsThe use of dapagliflozin in GPs setting reduce the number of CVD events, kidney disease progression and healthcare costs in Italy. These data should be considered to optimize the value produced for the T2D patients who had or were at risk for atherosclerotic cardiovascular disease. (Source: Acta Diabetologica)
Source: Acta Diabetologica - April 18, 2024 Category: Endocrinology Source Type: research
Dapagliflozin and Empagliflozin in Paediatric Indications: A Systematic Review
ConclusionEarly evidence suggests that dapagliflozin and empagliflozin are well tolerated in children. A clinical pharmacology rationale currently exists only for adolescents with diabetes mellitus.Prospero Registration NumberCRD42023438162. (Source: Pediatric Drugs)
Source: Pediatric Drugs - April 18, 2024 Category: Pediatrics Source Type: research
Correction: Cardiac angiogenesis enhances by activating Mir-126 and related target proteins in type 2 diabetic rats: rescue combination effect of sodium butyrate and voluntary exercise therapy
(Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 18, 2024 Category: Endocrinology Source Type: research
Leptin and ghrelin dynamics: unraveling their influence on food intake, energy balance, and the pathophysiology of type 2 diabetes mellitus
ConclusionGhrelin, known for its appetite-stimulating effects, and leptin, a hormone involved in the regulation of energy balance, have been implicated in insulin resistance and glucose metabolism. Understanding the complexities of ghrelin and leptin interactions in the context of T2DM may offer insights into novel therapeutic strategies for this prevalent metabolic disorder. Further research is warranted to elucidate the molecular mechanisms underlying these hormone actions and to explore their clinical implications for T2DM prevention and management. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 18, 2024 Category: Endocrinology Source Type: research
MiR-9-3 hypermethylation is associated with stages of diabetic retinopathy
ConclusionThe methylation profile of the miR-9-3 promoter increases the risk of developing PDR. Higher levels of VEGF-A are associated with miR-9-3 hypermethylated profile in patients in the DR and NPDR stages. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 18, 2024 Category: Endocrinology Source Type: research
The value of lipid accumulation products in predicting type 2 diabetes mellitus: a cross-sectional study on elderlies over 65 in Shanghai
ConclusionLAP is more significantly associated with the risk of T2DM in elderlies than FPG, UN or NC, and it serves as a strong predictor of T2DM. However, this is impacted by FPG and neck circumference to a certain extent. Future large-scale studies are needed to confirm its efficacy in predicting diabetes. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 18, 2024 Category: Endocrinology Source Type: research
Association of common single-nucleotide polymorphism of HHEX with type 2 diabetes mellitus
ConclusionOur study revealed that polymorphisms rs7923837 ofHHEX were not associated with T2DM. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 18, 2024 Category: Endocrinology Source Type: research
Inflammation and immunological disarrays are associated with acute exercise in type 2 diabetes
ConclusionFinally; JUN, IL6, IL1B, PTGS2, FOS, ATF3, CXCL8, EGR1, and EGR2 were introduced as the critical targeted genes by exercise. Since the critical genes after exercise are upregulated and mostly are known as the risk factors of T2D, it can be concluded that unsuitable exercise can develop diabetic conditions in patients. Acute exercise-induced inflammation and immune disturbances seem to be associated with the development of T2D in patients. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 18, 2024 Category: Endocrinology Source Type: research
