Methods to predict heart failure in diabetes patients
Expert Rev Endocrinol Metab. 2024 Apr 15:1-16. doi: 10.1080/17446651.2024.2342812. Online ahead of print.ABSTRACTINTRODUCTION: Type 2 diabetes mellitus (T2DM) is one of the leading causes of cardiovascular disease and powerful predictor for new-onset heart failure (HF).AREAS COVERED: We focus on the relevant literature covering evidence of risk stratification based on imaging predictors and circulating biomarkers to optimize approaches to preventing HF in DM patients.EXPERT OPINION: Multiple diagnostic algorithms based on echocardiographic parameters of cardiac remodeling including global longitudinal strain/strain rate ar...
Source: Expert Review of Endocrinology and Metabolism - April 16, 2024 Category: Endocrinology Authors: Alexander E Berezin Tetiana A Berezina Uta C Hoppe Michael Lichtenauer Alexander A Berezin Source Type: research
The effect of EGCG/tyrosol-loaded chitosan/lecithin nanoparticles on hyperglycemia and hepatic function in streptozotocin-induced diabetic mice
In conclusion, the EGCG/tyrosol-loaded C/L NPs reduced hyperglycemia, oxidative stress, and inflammation in diabetic mice. These findings suggest that EGCG/tyrosol-loaded C/L NPs could be a promising therapeutic option for type 2 diabetes management.PMID:38626839 | DOI:10.1016/j.ijbiomac.2024.131496 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 16, 2024 Category: Biochemistry Authors: Ali Es-Haghi Mozhgan Soltani Masoud Homayouni Tabrizi Maryam Karimi Noghondar Nilofar Khatamian Niloofar Barati Naeeni Matin Kharaghani Source Type: research
Role of Synbiotics (Prebiotics and Probiotics) as Dietary Supplements in Type 2 Diabetes Mellitus Induced Health Complications
J Diet Suppl. 2024 Apr 15:1-32. doi: 10.1080/19390211.2024.2340509. Online ahead of print.ABSTRACTDiabetes is a metabolic disorder whose prevalence has become a worrying condition in recent decades. Chronic diabetes can result in serious health conditions such as impaired kidney function, stroke, blindness, and myocardial infarction. Despite a variety of currently available treatments, cases of diabetes and its complications are on the rise. This review article provides a comprehensive account of the ameliorative effect of prebiotics and probiotics individually or in combination i.e. synbiotics on health complications indu...
Source: Journal of Dietary Supplements - April 16, 2024 Category: Nutrition Authors: Kalpana Baghel Aamir Khan Naveen Kango Source Type: research
Plasma proteomics of diabetic kidney disease among Asians with younger-onset type 2 diabetes
CONCLUSION: Large-scale proteomic analysis identified novel proteomic biomarkers for DKD progression in YT2D. Genetic evidence suggest a causal role of plasma angiogenin in DKD progression.PMID:38626182 | DOI:10.1210/clinem/dgae266 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 16, 2024 Category: Endocrinology Authors: Resham Lal Gurung Huili Zheng Hiromi Wai Ling Koh M Yiamunaa Jian-Jun Liu Sylvia Liu Clara Chan Keven Ang Clara Si Hua Tan Radoslaw Mikolaj Sobota Tavintharan Subramaniam Chee Fang Sum Su Chi Lim Source Type: research
IRE1 α regulates macrophage polarization in type 2 diabetic periodontitis through promoting endoplasmic reticulum stress
CONCLUSIONS: These findings suggest that inhibiting IRE1α can modulate macrophage polarization and alleviate ligature-induced diabetic periodontitis via the MAPK signaling pathway. This unveils a novel mechanism, offering a scientific foundation for the treatment of experimental diabetic periodontitis.PMID:38626546 | DOI:10.1016/j.intimp.2024.112056 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 16, 2024 Category: Allergy & Immunology Authors: Yang Zhang Yanan Zhang Miao Lu Xulei Yuan Guangyue Li Ling Xu Tingwei Zhang Jinlin Song Source Type: research
Therapy combining glucagon-like peptide-1 receptor agonist with sodium-glucose cotransporter 2 inhibitor suppresses atherosclerosis in diabetic ApoE-deficient mice
Conclusions Our data suggest that combination therapy with liraglutide and ipragliflozin may be an efficient regimen for preventing the development of atherosclerosis in diabetic ApoE-deficient mice.PMID:38626913 | DOI:10.1055/a-2307-8036 (Source: Atherosclerosis)
Source: Atherosclerosis - April 16, 2024 Category: Cardiology Authors: Masahiro Takubo Kentaro Watanabe Hitoki Saito Genta Kohno Hisamitsu Ishihara Source Type: research
Comprehensive safety profile of dipeptidyl peptidase-4 inhibitors: a post-marketing study based on FAERS database using signal detection algorithms
CONCLUSION: Several significant disproportionality signals were observed with DPP-4 inhibitors. However, clinicians have to consider the comorbidities and concomitant drugs while prescribing these drugs.PMID:38626310 | DOI:10.1080/14740338.2024.2343015 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - April 16, 2024 Category: Drugs & Pharmacology Authors: Dipika Bansal Beema T Yoosuf Muhammed Favas Kt Pinaki Dutta Source Type: research
Role of Synbiotics (Prebiotics and Probiotics) as Dietary Supplements in Type 2 Diabetes Mellitus Induced Health Complications
J Diet Suppl. 2024 Apr 15:1-32. doi: 10.1080/19390211.2024.2340509. Online ahead of print.ABSTRACTDiabetes is a metabolic disorder whose prevalence has become a worrying condition in recent decades. Chronic diabetes can result in serious health conditions such as impaired kidney function, stroke, blindness, and myocardial infarction. Despite a variety of currently available treatments, cases of diabetes and its complications are on the rise. This review article provides a comprehensive account of the ameliorative effect of prebiotics and probiotics individually or in combination i.e. synbiotics on health complications indu...
Source: Journal of Dietary Supplements - April 16, 2024 Category: Nutrition Authors: Kalpana Baghel Aamir Khan Naveen Kango Source Type: research
The effect of EGCG/tyrosol-loaded chitosan/lecithin nanoparticles on hyperglycemia and hepatic function in streptozotocin-induced diabetic mice
In conclusion, the EGCG/tyrosol-loaded C/L NPs reduced hyperglycemia, oxidative stress, and inflammation in diabetic mice. These findings suggest that EGCG/tyrosol-loaded C/L NPs could be a promising therapeutic option for type 2 diabetes management.PMID:38626839 | DOI:10.1016/j.ijbiomac.2024.131496 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 16, 2024 Category: Biochemistry Authors: Ali Es-Haghi Mozhgan Soltani Masoud Homayouni Tabrizi Maryam Karimi Noghondar Nilofar Khatamian Niloofar Barati Naeeni Matin Kharaghani Source Type: research
Methods to predict heart failure in diabetes patients
Expert Rev Endocrinol Metab. 2024 Apr 15:1-16. doi: 10.1080/17446651.2024.2342812. Online ahead of print.ABSTRACTINTRODUCTION: Type 2 diabetes mellitus (T2DM) is one of the leading causes of cardiovascular disease and powerful predictor for new-onset heart failure (HF).AREAS COVERED: We focus on the relevant literature covering evidence of risk stratification based on imaging predictors and circulating biomarkers to optimize approaches to preventing HF in DM patients.EXPERT OPINION: Multiple diagnostic algorithms based on echocardiographic parameters of cardiac remodeling including global longitudinal strain/strain rate ar...
Source: Expert Review of Endocrinology and Metabolism - April 16, 2024 Category: Endocrinology Authors: Alexander E Berezin Tetiana A Berezina Uta C Hoppe Michael Lichtenauer Alexander A Berezin Source Type: research
Plasma proteomics of diabetic kidney disease among Asians with younger-onset type 2 diabetes
CONCLUSION: Large-scale proteomic analysis identified novel proteomic biomarkers for DKD progression in YT2D. Genetic evidence suggest a causal role of plasma angiogenin in DKD progression.PMID:38626182 | DOI:10.1210/clinem/dgae266 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 16, 2024 Category: Endocrinology Authors: Resham Lal Gurung Huili Zheng Hiromi Wai Ling Koh M Yiamunaa Jian-Jun Liu Sylvia Liu Clara Chan Keven Ang Clara Si Hua Tan Radoslaw Mikolaj Sobota Tavintharan Subramaniam Chee Fang Sum Su Chi Lim Source Type: research
Latent Profile Analysis of Medication Beliefs in Patients with Type 2 Diabetes in the Hospital-Home Transition and Comparison with Medication Adherence
(Source: Patient Preference and Adherence)
Source: Patient Preference and Adherence - April 16, 2024 Category: International Medicine & Public Health Tags: Patient Preference and Adherence Source Type: research
GSE263852 Linc-ADAIN, A Human Adipose LincRNA Regulates Adipogenesis by Modulating KLF5 and IL-8 mRNA stability
Contributors : Marcella E O'Reilly ; Chenyi Xue ; Eunyoung KimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAdipose tissue remodeling and dysfunction, characterized by increased inflammation and insulin resistance, play a central role in obesity-related development of type 2 diabetes (T2DM) and cardiovascular diseases. Long intergenic non-coding RNAs (lincRNAs) are important regulators of cellular functions. Here we describe the functions of linc-ADAIN (ADipose Anti-INflammatory), an adipose lincRNA that is downregulated in white adipose tissue of obese humans. We demonstrate that...
Source: GEO: Gene Expression Omnibus - April 16, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Modification of lipoprotein metabolism and function driving atherogenesis in diabetes
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease, characterized by raised blood glucose levels and impaired lipid metabolism resulting from insulin resistance and relative insulin deficiency. In diabetes, the peculiar plasma lipoprotein phenotype, consisting in higher levels of apolipoprotein B-containing lipoproteins, hypertriglyceridemia, low levels of HDL cholesterol, elevated number of small, dense LDL, and increased non-HDL cholesterol, results from an increased synthesis and impaired clearance of triglyceride rich lipoproteins. (Source: Atherosclerosis)
Source: Atherosclerosis - April 16, 2024 Category: Cardiology Authors: Lorenzo Luciani, Matteo Pedrelli, Paolo Parini Source Type: research
