Exosomes biogenesis was increased in metformin-treated human ovary cancer cells; possibly to mediate resistance
Exosomes derived from tumor cells contribute to the pathogenesis of cancers. Metformin, the most usually used drug for type 2 diabetes, has been frequently investigated for anticancer effects. Here, we examine... (Source: Cancer Cell International)
Source: Cancer Cell International - April 16, 2024 Category: Cancer & Oncology Authors: Reza Abbasi, Vahid Nejati and Jafar Rezaie Tags: Research Source Type: research
Body Mass Index Distribution Among Patients with Heart Failure and Reduced Ejection Fraction: Implication for Future Trials
Obesity related heart failure with preserved ejection fraction (HFpEF) has been well described as a distinct phenotype associated with cardiac structural and functional alterations as well as a systemic proinflammatory milieu. Semaglutide, a long-acting glucagon like peptide (GLP)-1 receptor agonist, was recently assessed in patients with HF and an LVEF of ≥45% and obesity (without type 2 diabetes) in the STEP-HFpEF (Semaglutide Treatment Effect in People with Obesity and Heart Failure with preserved Ejection Fraction) trial and was shown to improve symptoms, and exercise capacity, compared with placebo. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - April 16, 2024 Category: Cardiology Authors: Javed Butler, Ambica Nair, Muhammad Shahzeb Khan Tags: Research Letter Source Type: research
Mediterranean diet in the targeted prevention and personalized treatment of chronic diseases: evidence, potential mechanisms, and prospects
AbstractThe prevalence of chronic diseases is currently a major public health issue worldwide and is exploding with the population growth and aging. Dietary patterns are well known to play a important role in our overall health and well-being, and therefore, poor diet and malnutrition are among the most critical risk factors for chronic disease. Thus, dietary recommendation and nutritional supplementation have significant clinical implications for the targeted treatment of some of these diseases. Multiple dietary patterns have been proposed to prevent chronic disease incidence, like Dietary Approaches to Stop Hypertension ...
Source: EPMA Journal - April 16, 2024 Category: International Medicine & Public Health Source Type: research
Correction to: High remnant cholesterol as a risk factor for developing chronic kidney disease in patients with prediabetes and type 2 diabetes: a cross-sectional study of a US population
(Source: Acta Diabetologica)
Source: Acta Diabetologica - April 16, 2024 Category: Endocrinology Source Type: research
Uric acid is associated with type 2 diabetes: data mining approaches
ConclusionThere was a significant association between hypertension and dyslipidemia history, TG, Uric acid, and hs-CRP with T2D development, along with age, WC, and blood pressure through the LR and DT methods.Graphical abstract (Source: Diabetology International)
Source: Diabetology International - April 16, 2024 Category: Endocrinology Source Type: research
An 8-Week study on the effects of high and Moderate-Intensity interval exercises on mitochondrial MOTS-C changes and their relation to metabolic markers in male diabetic sand rats
This study explored the impact of high and moderate-intensity interval exercises on mitochondrial MOTS-C alterations and their correlation with metabolic markers in male diabetic sand rats. Thirty male sand rats were divided into six groups: control, MIIT, DM + HIIT, DM + MIIT, DM, and HIIT (5 rats each). Diabetes was induced using a high-fat diet (HFD) combined with streptozotocin (STZ). (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 16, 2024 Category: Endocrinology Authors: Sahar Parseh, Saeid Shakerian, Mohammad Reza Tabandeh, Abdolhamid Habibi Source Type: research
Enhancing insulin sensitivity in type 2 diabetes mellitus using apelin-loaded small extracellular vesicles from Wharton ’s jelly-derived mesenchymal stem cells: a novel therapeutic approach
Type 2 diabetes mellitus (T2DM), characterized by β-cell dysfunction and insulin resistance (IR), presents considerable treatment challenges. Apelin is an adipocyte-derived factor that shows promise in improvi... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - April 16, 2024 Category: Endocrinology Authors: Jing Cui, Mingkun Wang, Wenhong Zhang, Jiachen Sun, Yan Zhang, Li Zhao, Zhibo Hong, Dongtao Li, Yi Xiong Huang, Ningkun Zhang and Yu Chen Tags: Research Source Type: research
Impact of SGLT-2 inhibitors on modifiable cardiovascular risk factors in Romanian patients with type 2 diabetes mellitus
Modifiable cardiovascular risk factors are high blood pressure, smoking, diabetes, sedentary lifestyle, obesity, and hypercholesterolemia. (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - April 16, 2024 Category: Endocrinology Authors: Adriana Gherbon, Mirela Frandes, Darius D îrpeş, Romulus Timar and Bogdan Timar Tags: Research Source Type: research
Targeting microbiota –immune–synaptic plasticity to explore the effect of tea polyphenols on improving memory in the aged type 2 diabetic rat model
. (Source: Nutritional Neuroscience)
Source: Nutritional Neuroscience - April 16, 2024 Category: Nutrition Authors: Chenhui LvLe ChengWenjuan FengHaoran XieJie KouLili WangMengqian ShiXin SongXi WangShuangzhi ChenLushan XueCheng ZhangXuemin LiHaifeng Zhaoa Department of Nutrition and Food Hygiene, Shanxi Medical University, Taiyuan, People ’s Republic of Chinab Cente Source Type: research
Incretin-based investigational therapies for the treatment of MASLD/MASH
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is the most common form of chronic liver disease. It exists as either simple steatosis or its more progressive form, metabolic dysfunction-associated steatohepatitis (MASH), formerly, non-alcoholic steatohepatitis (NASH). The global prevalence of MASLD is estimated to be 32% among adults and is projected to continue to rise with increasing rates of obesity, type 2 diabetes, and metabolic syndrome. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - April 16, 2024 Category: Endocrinology Authors: Bram Brouwers, Girish Rao, Yuanyuan Tang, Ángel Rodríguez, Leonard C Glass, Mark L Hartman Source Type: research
Association between DASH and novel atherogenic risk factors, anthropometric indices and foot ulcer indicators in type 2 diabetic patients with foot ulcer: a cross-sectional study
ConclusionDASH adherence did not change neuropathy score and cholindex and cardiovascular risk factors significantly and has no significant effect on foot ulcer size. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 16, 2024 Category: Endocrinology Source Type: research
People with complicated pregnancies may suffer health problems, die early
Preterm births are a well-known hazard for babies—who can require months and sometimes years of extra care—but far less attention is paid to the people who deliver them. Now, a new analysis of more than 2 million pregnancies over 4 decades finds those parents need consideration, too: Even years later, people who experienced some common pregnancy complications had a higher risk of death.
“We are starting to understand that pregnancy complications … are windows into longer term complications,” says Cynthia Gyamfi-Bannerman, a maternal fetal medicine specialist at the University of California San Diego who was...
Source: Science of Aging Knowledge Environment - April 15, 2024 Category: Geriatrics Source Type: research
Weight Management with Orlistat in Type 2 Diabetes - An Electronic Healthcare Records Study
CONCLUSIONS: Orlistat was significantly associated with weight loss in T2DM/prediabetes when taken for at least 12 weeks. However, orlistat is infrequently prescribed and often taken for <12 weeks. Orlistat may be a useful adjunct to lifestyle modifications in T2DM/prediabetes however barriers to continuing orlistat means it may not be effective for everyone in managing weight loss.PMID:38621802 | DOI:10.3399/BJGP.2023.0684 (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - April 15, 2024 Category: Primary Care Authors: Shraboni Ghosal Neil Heron Kayleigh Mason James Bailey Kelvin Jordan Source Type: research
Weight Management with Orlistat in Type 2 Diabetes - An Electronic Healthcare Records Study
CONCLUSIONS: Orlistat was significantly associated with weight loss in T2DM/prediabetes when taken for at least 12 weeks. However, orlistat is infrequently prescribed and often taken for <12 weeks. Orlistat may be a useful adjunct to lifestyle modifications in T2DM/prediabetes however barriers to continuing orlistat means it may not be effective for everyone in managing weight loss.PMID:38621802 | DOI:10.3399/BJGP.2023.0684 (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - April 15, 2024 Category: Primary Care Authors: Shraboni Ghosal Neil Heron Kayleigh Mason James Bailey Kelvin Jordan Source Type: research
Weight Management with Orlistat in Type 2 Diabetes - An Electronic Healthcare Records Study
CONCLUSIONS: Orlistat was significantly associated with weight loss in T2DM/prediabetes when taken for at least 12 weeks. However, orlistat is infrequently prescribed and often taken for <12 weeks. Orlistat may be a useful adjunct to lifestyle modifications in T2DM/prediabetes however barriers to continuing orlistat means it may not be effective for everyone in managing weight loss.PMID:38621802 | DOI:10.3399/BJGP.2023.0684 (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - April 15, 2024 Category: Primary Care Authors: Shraboni Ghosal Neil Heron Kayleigh Mason James Bailey Kelvin Jordan Source Type: research
