Basal insulin ameliorates post-breakfast hyperglycemia via suppression of post-breakfast proinsulin/C-peptide ratio and fasting serum free fatty acid levels in patients with type 2 diabetes
AbstractBackgroundIn general, basal insulin targets fasting plasma glucose (FPG) levels, and prandial insulin targets postprandial glucose (PPG) levels. However, the effects of basal insulin on PPG levels are controversial. We investigated the effect of basal insulin on postprandial hyperglycemia using a test meal at breakfast as well as compared differences between degludec and glargine.MethodsA total of 20 participants with type 2 diabetes were randomly assigned to degludec (n = 10) or glargine (n = 10). We initiated basal–bolus insulin therapy and titrated only basal insulin until FPG was 
Source: Diabetology International - August 3, 2020 Category: Endocrinology Source Type: research

Medical nutrition therapy and dietary counseling for patients with diabetes-energy, carbohydrates, protein intake and dietary counseling
(Source: Diabetology International)
Source: Diabetology International - July 25, 2020 Category: Endocrinology Source Type: research

Japanese Clinical Practice Guideline for Diabetes 2019
(Source: Diabetology International)
Source: Diabetology International - July 24, 2020 Category: Endocrinology Source Type: research

Insulin resistance and exaggerated insulin sensitivity triggered by single-gene mutations in the insulin signaling pathway
AbstractWhereas the genetic basis of insulin sensitivity is determined by variation in multiple genes, mutations of single genes can give rise to profound changes in such sensitivity. Mutations of the insulin receptor gene (INSR) —which trigger type A insulin resistance, Rabson–Mendenhall, or Donohue syndromes—and those of the gene for the p85α regulatory subunit of phosphoinositide 3-kinase (PIK3R1), which give rise to SHORT syndrome, are the most common and second most common causes, respectively, of single-gene insulin resistance. Loss-of-function mutations of the genes for the protein kinase Akt...
Source: Diabetology International - July 15, 2020 Category: Endocrinology Source Type: research

Hereditary spherocytosis diagnosed with extremely low glycated hemoglobin compared to plasma glucose levels
AbstractGlycated hemoglobin (HbA1c) is an important indicator of glycemic control in patients with diabetes. High-performance liquid chromatography (HPLC) is the most commonly used method for measuring HbA1c levels; as HPLC measures all hemoglobin types, the values can be influenced by hemoglobin variants. Moreover, as HPLC-HbA1c levels are low in some diseases, including hemolytic anemia, it may be difficult to differentiate hemoglobin variants from these diseases based on HPLC-HbA1c levels alone. Similar HbA1c values using both HPLC and immunoassays (IAs) are noted for these diseases, while discrepancies are noted in the...
Source: Diabetology International - July 12, 2020 Category: Endocrinology Source Type: research

FIB-4 index-based surveillance for advanced liver fibrosis in diabetes patients
AbstractLiver fibrosis is associated with lifestyle-related diseases, including diabetes. The identification of diabetic patients with severe liver fibrosis is important, but a simple and reliable diagnostic procedure remains to be determined. We conducted an observational study to evaluate the performance of a FIB-4 index-based screening strategy for the diagnosis of advanced liver fibrosis in patients with diabetes or prediabetes. Two hundred and forty-two patients underwent abdominal imaging in our Study. According to the abdominal imaging findings, fatty liver, liver cirrhosis, and hepatocellular carcinoma were defined...
Source: Diabetology International - July 9, 2020 Category: Endocrinology Source Type: research

Impact of dietary counseling on the perception of diet in patients with gestational diabetes mellitus
ConclusionDietary counseling was regarded as helpful and acceptable to most patients with GDM in our hospital, and many suggestions were recognized as informative for modification of previous dietary habits. By providing the results of the questionnaire survey to the dieticians, they can improve the quality of their counseling, which is expected to result in better individual care of the patients. (Source: Diabetology International)
Source: Diabetology International - July 9, 2020 Category: Endocrinology Source Type: research

A case of an elderly patient with insulin-dependent diabetes and dementia receiving one basal insulin plus one bolus insulin injections a day for 6  months
AbstractMultiple daily injections of insulin, referred to basal –bolus regimen, are generally essential in achieving glycemic control and preventing ketosis in insulin-dependent diabetes, such as type 1 diabetes (T1D). A 75-year-old man with T1D receiving basal–bolus insulin therapy exhibited symptoms of dementia after hospitalization due to pyelonephritis a nd failed to continue insulin self-injection. Given that his social and familial circumstances allowed insulin injection once a day during the morning, bolus insulin injections needed to be discontinued. Ketonuria was observed the day following discontinuat...
Source: Diabetology International - July 2, 2020 Category: Endocrinology Source Type: research

A review of the current evidence on the sensitivity and specificity of the Ipswich touch test for the screening of loss of protective sensation in patients with diabetes mellitus
ConclusionsThe Ipswich touch test has a high specificity in screening for loss of protective sensation in the feet of patients with diabetes mellitus. It is a useful test to be included in diabetic foot screenings, especially when other sensory tools are not available. However, more rigorous studies need to be conducted as there is currently only a limited pool of research evidence to substantiate it as a screening tool for loss of protective sensation in the diabetic foot. (Source: Diabetology International)
Source: Diabetology International - June 29, 2020 Category: Endocrinology Source Type: research

Evaluation of some oxidative markers in diabetes and diabetic retinopathy
ConclusionThis study concluded that higher levels of uric acid and malondialdehyde were associated with increase in the risk of diabetes and DR development, while bilirubin wasn ’t associated with decreasing the risk of diabetes or DR. However, the combination of malondialdehyde, uric acid and bilirubin may be a valuable addition to the current options for the prognosis of DR. In addition, malondialdehyde may be independent predictor of diabetes and DR as well as uric aci d may be used as independent biomarker to predict the risk of DR. (Source: Diabetology International)
Source: Diabetology International - June 27, 2020 Category: Endocrinology Source Type: research

Effect of linagliptin, a dipeptidyl peptidase-4 inhibitor, compared with the sulfonylurea glimepiride on cardiovascular outcomes in Asians with type 2 diabetes: subgroup analysis of the randomized CAROLINA ® trial
AbstractObjectiveLinagliptin, a dipeptidyl peptidase-4 inhibitor, recently demonstrated cardiovascular (CV) safety versus placebo in Asians with advanced type 2 diabetes mellitus (T2DM) in the CARMELINA® trial. We assessed its CV safety compared with the sulfonylurea glimepiride in Asians with relatively early T2DM in the CAROLINA® trial.MethodsBased on prespecified and post hoc subgroup analyses of the multinational CAROLINA® trial in which adults with relatively early T2DM and elevated CV risk were randomized to linagliptin or glimepiride added to usual care, we analyzed data for participants from Asian count...
Source: Diabetology International - June 27, 2020 Category: Endocrinology Source Type: research

Ethics and practical mitigations for ongoing clinical trials during the COVID-19 pandemic
(Source: Diabetology International)
Source: Diabetology International - June 19, 2020 Category: Endocrinology Source Type: research

The work style and living condition survey of diabetologists and the expectations for the Japan Diabetes Society: results of questionnaires about the current state and the future prospect of their carrier in 2017
AbstractThe Japan Diabetes Society ’s Committee to Promote Female Diabetologists conducted a questionnaire survey from May to June 2017 to investigate the work style and living situation of diabetologists. The survey targeted 5298 Board Certified Diabetologists (diabetologists), with answers obtained from 1566 diabetologists (male,n = 1003: females,n = 563). Ninety-four percent of the males and 72% of the females worked full time. Twenty-one percent of the male subjects and 7% of the female subjects were heads of clinical departments, and 23% of the male subjects and 13% of the female subj...
Source: Diabetology International - June 15, 2020 Category: Endocrinology Source Type: research

Improved insulin sensitivity with sodium-glucose cotransporter 2 inhibitor treatment in a patient with slowly progressive type 1 diabetes mellitus with metabolic syndrome: a case report
AbstractWe herein report the clinical course of a 56-year-old Japanese patient with slowly progressive type 1 diabetes mellitus, metabolic syndrome, non-alcoholic fatty liver disease, and severe insulin resistance. The patient ’s intravenous glucose tolerance test indicated marked reductions in insulin sensitivity and endogenous insulin secretion. Accordingly, administration of ipragliflozinl-proline, a sodium-glucose cotransporter 2 inhibitor, promoted improvements in insulin sensitivity and blood glucose levels, as well as a decrease in visceral fat, improvement in dyslipidemia, and decrease in hepatic lipid conten...
Source: Diabetology International - June 12, 2020 Category: Endocrinology Source Type: research

Significance of SGLT2 inhibitors: lessons from renal clinical outcomes in patients with type 2 diabetes and basic researches
AbstractDiabetic kidney disease (DKD), a microvascular complication of diabetes, has been the leading cause of end-stage kidney disease (ESKD). Accordingly, patients with type 2 diabetes mellitus (T2DM) develop renal damage due to multiple metabolic and cardiorenal disease-related risk factors, including hyperglycemia, hypertension, dyslipidemia, hyperuricemia, and overnutrition/obesity. Despite multifactorial management including the administration of renin –angiotensin system inhibitors, patients often do not experience sufficient suppression of DKD progression and, thus, remain at risk for ESKD. Recent studies on ...
Source: Diabetology International - June 11, 2020 Category: Endocrinology Source Type: research

Promising roles of sodium –glucose cotransporter 2 inhibitors in heart failure prevention and treatment
AbstractIn recent years, successive reports have been made on large-scale cardiovascular outcome trials using novel hypoglycemic drugs. Their results have shown that sodium –glucose cotransporter 2 (SGLT2) inhibitors are hypoglycemic drugs that could potentially greatly improve the heart failure-related outcomes in type 2 diabetes patients with a high cardiovascular risk. Further analyses have subsequently been performed from various perspectives, and SGLT2 inhibitor s with their class effect have been indicated to be potentially useful for heart failure in type 2 diabetes patients with extensive clinical background....
Source: Diabetology International - June 11, 2020 Category: Endocrinology Source Type: research

Aldose reductase (AC)n gene polymorphism in Iranian patients with type 2 diabetic microangiopathy; a case –control study
AbstractAim(AC)n promoter region of the aldose reductase (ALR) genes polymorphism has been associated with diabetic microvascular complications (MVCs). The aim of this study was to find the relationship between dinucleotide repeat (AC)n polymorphisms of the ALR gene and the occurrence of MVCs, such as diabetic retinopathy, neuropathy, and nephropathy in Iranian type 2 diabetic (T2D) patients.MethodsThis prospective case –control study was performed on T2D patients who were categorized into two groups based on the presence or absence of diabetic microangiopathy. All patients were provided informed consent. After extra...
Source: Diabetology International - June 10, 2020 Category: Endocrinology Source Type: research

Current understanding of the effect of sodium –glucose co-transporter-2 inhibitors in Asian patients with diabetes mellitus
(Source: Diabetology International)
Source: Diabetology International - June 8, 2020 Category: Endocrinology Source Type: research

Recurrent hyperglycemic hyperosmolar state after re-administration of dose-reduced ceritinib, an anaplastic lymphoma kinase inhibitor
AbstractCeritinib is a second-generation anaplastic lymphoma kinase (ALK) inhibitor with clinical activity in crizotinib-resistant ALK-positive non-small cell lung cancer and in treatment-na ïve ALK-positive disease. Hyperglycemia is a known adverse event, but the mechanism by which ceritinib causes hyperglycemia is unknown, and whether ceritinib causes hyperglycemic emergencies is unclear. Here, we report the case of a patient with a hyperglycemic hyperosmolar state (HHS) recurrence a fter the re-administration of dose-reduced ceritinib. A 78-year-old man with type 2 diabetes diagnosed as having advanced lung adenoca...
Source: Diabetology International - June 2, 2020 Category: Endocrinology Source Type: research

Characteristics of patients who developed glucose intolerance in the early period after partial pancreatectomy
AbstractBackgroundNew-onset diabetes mellitus (DM) often develops after partial pancreatectomy. Little is known regarding how soon patients develop glucose intolerance after partial pancreatectomy. We investigated the incidence of and factors contributing to the development of glucose intolerance during hospitalization after partial pancreatectomy.Patients and methodsWe retrospectively analyzed the cases of 38 patients with normal glucose tolerance pre-surgery who underwent a partial pancreatectomy (pancreaticoduodenectomy,n = 23; distal pancreatectomy,n = 15). The patients’ glucose tolera...
Source: Diabetology International - May 28, 2020 Category: Endocrinology Source Type: research

Glycemic control of people with diabetes over months after the 2018 North Osaka Earthquake
AbstractObjectiveOn June 18 2018, Japan experienced the North Osaka Earthquake. The shaking intensity was recorded as level 6 of the Japan Meteorological Agency Seismic Intensity Scale. Despite the severe shaking, damages of lifelines and transportation networks were limited, and they were completely recovered within several days. We investigated whether the glycemic control in patients with diabetes was deteriorated over months after the earthquake.MethodsWe retrospectively analyzed diabetic outpatients attending the department of Metabolic Medicine, Osaka University Hospital, close to the epicenter of the earthquake, in ...
Source: Diabetology International - May 26, 2020 Category: Endocrinology Source Type: research

Correction to: Severe hypoglycemia caused by a small dose of repaglinide and concurrent use of nilotinib and febuxostat in a patient with type 2 diabetes
In the original publication, the unit of C-peptide immunoreactivity. (Source: Diabetology International)
Source: Diabetology International - April 23, 2020 Category: Endocrinology Source Type: research

Effect of tasteless calorie-free gum chewing before meal on postprandial plasma glucose, insulin, glucagon, and gastrointestinal hormones in Japanese men without diagnosed glucose metabolism disorder: a pilot randomized crossover trial
In conclusion, the current pilot study demonstrated that tasteless calorie-free gum chewing before rice eating had a significant but limited impact on the increase of postprandi al active GLP-1 levels in male individuals without diagnosed glucose metabolism disorder. (Source: Diabetology International)
Source: Diabetology International - April 11, 2020 Category: Endocrinology Source Type: research

Severe hypoglycemia caused by a small dose of repaglinide and concurrent use of nilotinib and febuxostat in a patient with type 2 diabetes
We describe a case, in which an extremely low dose of repaglinide caused severe hypoglycemia and novel drug interactions are suggested. A 71-year-old man with type 2 diabetes was taken to the hospital due to consciousness disorder caused by severe hypoglycemia. He was taking repaglinide 0.25  mg once in the morning with nilotinib 400 mg/day and febuxostat 20 mg/day. Endogenous insulin secretion was not suppressed even in hypoglycemia. Detection of plasma repaglinide 10 h after administration in this case indicates delayed elimination of the agent, which might be derived from reduced hepatocyte uptake du...
Source: Diabetology International - April 8, 2020 Category: Endocrinology Source Type: research

Effect of postprandial moderate-intensity walking for 15-min on glucose homeostasis in type 2 diabetes mellitus patients
ConclusionThese results suggest that postprandial moderate-intensity walking, easily performable in daily life activities, was effective for improving glucose homeostasis. Further study should be performed to clarify the relationship between postprandial walk and drug therapy (insulin and OHA), including insulin secretory ability. (Source: Diabetology International)
Source: Diabetology International - April 3, 2020 Category: Endocrinology Source Type: research

Visceral adiposity is associated with the discrepancy between glycated albumin and HbA1c in type 2 diabetes
ConclusionsGA is a useful indicator for glycemic control, while visceral obesity should also be taken into consideration in type 2 diabetes cases. (Source: Diabetology International)
Source: Diabetology International - March 21, 2020 Category: Endocrinology Source Type: research

Effect of a 6-week strength-training program on neuromuscular efficiency in type 2 diabetes mellitus patients
ConclusionA 6-week strength-training program increased the neuromuscular efficiency and peak torque in patients with T2DM; however, the electrical properties of the muscles did not change. These results may be related to increased neural adaptations and motor learning in the early stages of strength training. (Source: Diabetology International)
Source: Diabetology International - March 19, 2020 Category: Endocrinology Source Type: research

Impact of body mass index and age on the relative accuracy of self-reported energy intakes among Japanese patients with type 2 diabetes
This study examined the measurement errors from self-reported dietary history questionnaires (DHQ) in Japanese patients with type 2 diabetes (T2D). Fifty-nine patients with T2D underwent a 24-h urine collection and 3-day dietary record (DR), and completed the DHQ. Intakes of energy, protein, sodium, and potassium were calculated from the DHQ. The estimated energy intake was calculated from the DR, and estimated intakes of protein, sodium, and potassium were determined from the 24-h urine samples. Energy intake values from the DHQ were lower than those from the DR by 12.5% in men and by 14.6% in women, which was significant...
Source: Diabetology International - March 17, 2020 Category: Endocrinology Source Type: research

Patient decision aids in clinical practice for people with diabetes: a scoping review
ConclusionPatient decision aids can offer a simple and easy-to-use method to potentially improve diabetes health literacy, through the process of shared decision-making and two-way conversations. However, there are current limitations on using them to positively influence clinical outcomes or long-term changes in self-care behaviors within the management of diabetes. Further research to explore the validity of using patient decision aids long term in these areas is required. (Source: Diabetology International)
Source: Diabetology International - March 13, 2020 Category: Endocrinology Source Type: research

Plasma lipopolysaccharide binding protein level statistically mediates between body mass index and chronic microinflammation in Japanese patients with type 1 diabetes
In this study, we evaluated the plasma LBP levels and investigated its clinical significance in 67 Japanese patients with type 1 diabetes. Univariable analysis showed that LBP levels were significantly associated with body mass index (BMI;r = 0.43,p 
Source: Diabetology International - March 9, 2020 Category: Endocrinology Source Type: research

Turkish version of the Michigan Neuropathy Screening Instrument in the assessment of diabetic peripheral neuropathy: a validity and reliability study
AbstractBackground/aimDiabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus (DM). The Michigan Neuropathy Screening Instrument (MNSI) is a simple, brief, and useful screening tool that was designed to assess DPN. The aim of this study was to develop a Turkish version of the MNSI and assess its reliability and validity.Materials and methodsEighty-three patients with DM who were divided into two groups according the results of nerve conduction studies (NCS) as having DPN or without DPN were enrolled in this cross-sectional study. The Toronto clinical scoring system, pain detect questionnai...
Source: Diabetology International - February 21, 2020 Category: Endocrinology Source Type: research

Efficacy and safety of a combination of an insulin secretagogue and a dipeptidyl peptidase-4 inhibitor in Japanese patients with type 2 diabetes mellitus; the repaglinide glucose oscillation study in Fukuoka (REGO-F)
This study was an investigator-initiated, open-label, randomized, multi-center prospective study. Patients with T2DM, which was inadequately controlled using a DPP-4I, were randomized to a repaglinide group or a glimepiride group and treated for 48  weeks. The primary outcomes were the reductions in glycated hemoglobin (HbA1c) and glucose oscillation, identified using continuous glucose monitoring, after 12 weeks. The secondary outcome was the change in carotid intima-media thickness (IMT), measured by ultrasonography, after 48 weeks. A tot al of 61 patients were recruited and analyzed in the study. Twelve w...
Source: Diabetology International - February 14, 2020 Category: Endocrinology Source Type: research

Pathophysiology of gestational diabetes mellitus in lean Japanese pregnant women in relation to insulin secretion or insulin resistance
AbstractTo determine the pathophysiology of gestational diabetes (GDM) in lean Japanese pregnant women in relation to insulin secretion or insulin resistance. The 75-g oral glucose tolerance test (OGTT) was performed in case of positive results of universal screening of a 50-g glucose challenge test at 24 –28 weeks’ gestation in Japanese pregnant women. These women were treated in our hospital between 2012 and 2016. Among these women, 30 with a body mass index of
Source: Diabetology International - February 8, 2020 Category: Endocrinology Source Type: research

Spectrum of diabetic neuropathies
AbstractThe diabetic state results in neuropathy. The main causative mechanism is hyperglycemia, although microvascular involvement, hypertriglyceridemia, as well as genetic and immune mechanisms may be contributory. There is a growing spectrum of types of diabetic neuropathies that differ based on the type of fibers involved (e.g. myelinated, unmyelinated, autonomic, somatic), distribution of nerves involved, and mechanisms of neuropathy. The most common type is distal sensory neuropathy (DSN), which affects the distal ends of large myelinated fibers, more often sensory than motor, and is often asymptomatic. The next-most...
Source: Diabetology International - January 8, 2020 Category: Endocrinology Source Type: research

The development of oral semaglutide, an oral GLP-1 analog, for the treatment of type 2 diabetes
AbstractGlucagon-like peptide-1 receptor agonists (GLP-1RA) are effective agents for achieving glycemic control. Oral semaglutide is the first oral formulation of a GLP-1RA to be approved in the USA. This agent may lead to earlier initiation of GLP-1RA therapy in the type 2 diabetes continuum of care, and represents a valuable treatment option for patients with a preference for oral therapy. The efficacy and safety of oral semaglutide was assessed in the PIONEER clinical trial program, which included 9543 patients (1293 Japanese). The program included 10 trials, two of which were conducted specifically in Japan. Across the...
Source: Diabetology International - January 4, 2020 Category: Endocrinology Source Type: research

A closer inspection of diabetes-related stigma: why more research is needed
AbstractIn the past few years, diabetes-related stigma has rapidly gained attention around the world. Many studies, including our study, show that a diabetes population is globally impacted by disease-specific stigma across age, gender, educational levels, employment status, and race/ethnicity. However, it still remains unclear whether some of these socioeconomic factors are more influential in terms of the social vulnerability of the exposed individuals with type 2 diabetes. Understanding how diabetes-related stigma influences patients through these socioeconomic and racial/ethnic factors, and how these impacts vary accor...
Source: Diabetology International - December 21, 2019 Category: Endocrinology Source Type: research

Correction to: Japanese Clinical Practice Guideline for Diabetes 2016
In the original version of the article, Table  5 was published incorrectly. (Source: Diabetology International)
Source: Diabetology International - December 20, 2019 Category: Endocrinology Source Type: research

Work-related, personal, and diabetes-related factors relevant to dropout from outpatient diabetes treatment visits among Japanese male employees with diabetes
ConclusionsOur findings suggest that supervisor support, age, and metabolic syndrome are important factors related to dropout from outpatient diabetes treatment visits among Japanese male employees with diabetes. (Source: Diabetology International)
Source: Diabetology International - December 16, 2019 Category: Endocrinology Source Type: research

Cognitive dysfunction during hypoglycemia in an elderly subject without diabetes
AbstractThe aim of the present study was to examine whether an elderly subject without diabetes experiences hypoglycemia during his daily life or after an oral glucose tolerance test (OGTT), and investigate whether hypoglycemic episodes affect cognitive function. The 85-year-old healthy subject, who is a sports enthusiast, showed lower than normal (
Source: Diabetology International - December 10, 2019 Category: Endocrinology Source Type: research

The best outcomes for going through pregnancy with diabetes —Clinical features of four recipients of the Lilly Insulin 50-Year Award—
This report focuses on the clinical features of these recipients with succ essful delivery of newborns at Tokyo Women’s Medical University approximately 40–50 years ago. Three of the recipients [type 2 diabetes,n  =  2 (cases 1 and 3); type 1 diabetes,n  =  1 (case 4)] were treated before, during and after pregnancy, whereas one patient with type 2 diabetes (case 2) was only treated during pregnancy. Even though three recipients had a past history of stillbirth due to insufficient control of diabetes, all four recipients were directed to try to main tain normoglycemia before and...
Source: Diabetology International - November 30, 2019 Category: Endocrinology Source Type: research

Recommendations on the proper use of SGLT2 inhibitors
(Source: Diabetology International)
Source: Diabetology International - November 15, 2019 Category: Endocrinology Source Type: research

A study on carotid artery intima –media thickness and metabolic risk factors in overweight and obese Indian children
AbstractIntroductionCarotid intima –media thickness (CIMT) serves as an early marker of atherosclerosis. Data on obesity-related risk factors and their association with carotid intima–media thickness among overweight and obese children are lacking.ObjectivesTo compare CIMT of overweight and obese children with CIMT of normal BMI children. To compare various anthropometric and metabolic risk factors associated with increased CIMT among overweight and obese children.MethodsA descriptive study in a paediatric department of a tertiary care hospital including 50 age-matched normal BMI children and 50 overweight and ...
Source: Diabetology International - November 12, 2019 Category: Endocrinology Source Type: research

Sample transport and/or storage can cause falsely low HbA1c levels in blood cells measured by enzymatic assay
AbstractAlthough HbA1c measurement by enzymatic assay (EA-HbA1c) is widely used in health-screening settings in Japan, recent studies have suggested lower EA-HbA1c levels as compared with HbA1c levels measured by high-performance liquid chromatography (HPLC-HbA1c). Hypothesizing that falsely low levels of EA-HbA1c are attributable to hemolysis caused by sample transport and/or storage, we measured EA-HbA1c in blood cells and whole blood after sample transport and compared them with HPLC-HbA1c levels. Blood samples were collected from ten non-diabetic individuals into sodium fluoride-containing blood collection tubes and im...
Source: Diabetology International - November 8, 2019 Category: Endocrinology Source Type: research

Linagliptin and cardiorenal outcomes in Asians with type 2 diabetes mellitus and established cardiovascular and/or kidney disease: subgroup analysis of the randomized CARMELINA ® trial
ConclusionsLinagliptin showed cardiovascular and renal safety in Asian patients with T2DM and established CVD with albuminuria and/or kidney disease. (Source: Diabetology International)
Source: Diabetology International - October 22, 2019 Category: Endocrinology Source Type: research

Association of urinary albumin excretion with periodontal parameters in patients with type 2 diabetes mellitus: a cross-sectional study
AbstractBackgroundOur previous pilot study using patients with type 2 diabetes mellitus in one medical clinic showed an association of urinary albumin excretion, a marker of generalized vascular dysfunction and kidney damage, with periodontitis. The purpose of this study was to confirm the association by increasing the number of patients and medical clinics.MethodsParticipants were 2302 patients (59.9% males, aged 29 –93 years) with type 2 diabetes mellitus from 25 medical clinics. Their medical records and information about socioeconomic status and health behavior were collected. Periodontal status was assessed...
Source: Diabetology International - October 16, 2019 Category: Endocrinology Source Type: research

Islet autoantibodies in disease prediction and pathogenesis
AbstractType 1 diabetes (T1D) is now predictable by measuring specific islet autoantibodies (IAbs). Almost all children who developed multiple IAbs will progress to T1D with time, while individuals with single IAb have a very low risk although it is an important earlier biomarker. The poor prediction of single IAb has been found to be associated with IAb affinity. Majority of single IAb generated in current standard IAb radio-binding assay (RBA) are of low affinity, which have been demonstrated low risk in T1D development. New generation of nonradioactive IAb assay with electrochemiluminescence (ECL) technology has been sh...
Source: Diabetology International - October 16, 2019 Category: Endocrinology Source Type: research

The effect of long-term past glycemic control on executive function among patients with type 2 diabetes mellitus
AbstractObjectivePatients with type 2 diabetes mellitus (T2DM) show more executive dysfunction than nondiabetics. However, how long poor glycemic control affects executive function remains unclear. Thus, we aimed to investigate the relationships in a cross-sectional study.MethodsWe studied 118 T2DM outpatients (age,  ≥ 60 years; excluding history of stroke, dementia and severe hypoglycemia). HbA1c values were recorded every ≤ 12 weeks for ≥ 5 years. All patients underwent verbal-fluency tests (reflecting executive function) and Mini-Mental State Examination ...
Source: Diabetology International - October 3, 2019 Category: Endocrinology Source Type: research

Associations among work-related stress and mental fatigue, and regular exercise in Japanese employees with or without diabetes
ConclusionsWork-related mental fatigue was negatively associated with regular exercise in employees with and without diabetes. (Source: Diabetology International)
Source: Diabetology International - October 1, 2019 Category: Endocrinology Source Type: research

Drug development research for novel adiponectin receptor-targeted antidiabetic drugs contributing to healthy longevity
AbstractIt is well recognized that the decrease of adiponectin associated with high-fat diet and lack of exercise accounts for the onset of insulin resistance, type 2 diabetes, the metabolic syndrome, and cardiovascular disease. Our research efforts have led to the identification of adiponectin receptors, AdipoR1 and AdipoR2, with the former shown to activate AMP kinase in the liver and the latter shown to activate peroxisome proliferator-activated receptor- α signaling thereby increasing fatty acid oxidation. Again, adiponectin upregulates mitochondrial function in the skeletal muscle thereby improving glucose/lipid...
Source: Diabetology International - September 19, 2019 Category: Endocrinology Source Type: research

The hypoglycemia-prevention effect of sensor-augmented pump therapy with predictive low glucose management in Japanese patients with type 1 diabetes mellitus: a short-term study
AbstractAims/introductionThe predictive low glucose management (PLGM) system was introduced in March 2018 in Japan. Although there are some reports demonstrating the benefit of PLGM in preventing hypoglycemia, no data are currently available in Japanese patients with type 1 diabetes mellitus (T1DM). The aim of the present study is to evaluate the effect of PLGM with sensor-augmented pump therapy in the prevention of hypoglycemia in Japanese patients.Materials and methodsWe included 16 patients with T1DM who used the MiniMed®640G system after switching from the MiniMed®620G system. We retrospectively analysed the da...
Source: Diabetology International - September 16, 2019 Category: Endocrinology Source Type: research