Association of family history of type 2 diabetes with blood pressure and resting heart rate in young normal weight Japanese women
AbstractObjectiveWe suggested association of family history of type 2 diabetes (FHD) with microvascular dysfunction, which may cause blood pressure (BP) elevations. We test whether FHD may be associated with higher BP.Research design and methodsResting BP, heart rates (in beats per minute: bpm), body composition and fasting concentrations of glucose, insulin, leptin and adiponectin were measured in 332 Japanese women aged 18 –24 years. They were grouped according to BP category defined by the 2017 American College of Cardiology/American Heart Association Blood Pressure Guideline.ResultsBMI averaged  
Source: Diabetology International - July 23, 2021 Category: Endocrinology Source Type: research

Cut-off values and clinical efficacy of body roundness index and other novel anthropometric indices in identifying metabolic syndrome and its components among Southern-Indian adults
ConclusionsThe optimal cut-off and AUC values attained for BRI, CI, AVI, and WTI have a clinical approach in identifying MetS and its components. The efficacy of these indices to identify MetS differed by gender. (Source: Diabetology International)
Source: Diabetology International - July 18, 2021 Category: Endocrinology Source Type: research

Electrolyzed hydrogen-rich water for oxidative stress suppression and improvement of insulin resistance: a multicenter prospective double-blind randomized control trial
ConclusionThere were no significant effect of EHW in the change in HOMA-IR in this study; larger-scale and longer-term study are needed to verify the effects of EHW in T2DM patients. (Source: Diabetology International)
Source: Diabetology International - July 18, 2021 Category: Endocrinology Source Type: research

Patient characteristics associated with improvement in glycemic control following addition of an oral antidiabetic drug to DPP-4 inhibitor monotherapy in Japanese patients with type 2 diabetes mellitus (JDDM 60)
AbstractAimsThe current study evaluated patient demographics and clinical characteristics that associated with HbA1c reduction following addition of one oral antidiabetic drug (OAD) to DPP4i monotherapy.MethodsA retrospective study was conducted using CoDiC database. Adult T2DM patients treated with sitagliptin monotherapy for  ≥ 6 months and adding one OAD were extracted. Association between patient characteristics at the time of add-on OAD and following HbA1c reduction was assessed.ResultsOf 444 included patients, mean age was 62  years and 33% were female. All add-on OAD classes demonstrated f...
Source: Diabetology International - July 15, 2021 Category: Endocrinology Source Type: research

Cross sectional study on proportion of sulfonylureas among various oral antidiabetic drugs using for Japanese patients with type 2 diabetes, analyzed from NSAID Study-2
ConclusionThe results of this study clearly demonstrated that, among the OADs, sulfonylureas were not frequently used in monotherapy, although the opportunity of using sulfonylurea increased with the number of OADs prescribed in combination therapies by both GPs and SPs in Japan. Moreover, low-dose glimepiride was the most-prescribed sulfonylurea for Japanese T2DM patients, especially for those who were lean and had higher HbA1c levels. (Source: Diabetology International)
Source: Diabetology International - July 11, 2021 Category: Endocrinology Source Type: research

A cross-sectional study of the correlation between diabetic therapy and serum zinc concentrations
AbstractAimZinc, an essential trace element, has various functions in humans. Zinc deficiency is associated with the elderly, patients with diabetes, and patients with frailty, a common geriatric syndrome. As few studies have reported the effects of anti-diabetic medication on zinc levels, we examined serum zinc concentrations in patients with diabetes and their correlation with anti-diabetic medications, especially in the elderly and patients with frailty, in Japan.MethodsThis cross-sectional study was conducted in 2014 and included 1033 patients with diabetes. Blood samples were taken, and a survey for the 8-item Short F...
Source: Diabetology International - July 10, 2021 Category: Endocrinology Source Type: research

The forgotten type 2 diabetes mellitus medicine: rosiglitazone
AbstractType 2 diabetes mellitus (T2DM) is a chronic disease prevalent in the world, and it is also one of the overall factors leading to overall morbidity and mortality. Throughout Asia, the proportion of people with T2DM and obesity has increased and this growth rate shows no signs of slowing down. Thiazolidinediones (TZDs) can specifically treat insulin resistance and improve metabolic syndrome, including rosiglitazone, troglitazone and pioglitazone, which are peroxisome proliferator-activated receptor (PPAR) agonists. These drugs have been shown to have better therapeutic effect and glycemic control, but also accompani...
Source: Diabetology International - June 29, 2021 Category: Endocrinology Source Type: research

Variables associated with adherence to the treatment of type 2 diabetes mellitus among elderly people
AbstractAimTo estimate the prevalence and variables associated with the adherence to medical treatment for type 2 diabetes mellitus in elderly people attending the family healthcare units in Ribeir ão Preto, State of São Paulo, Brazil.MethodsThis is a population-based household survey with a random conglomerate sample of 338 elderly people. Treatment adherence was measured with the Brief Medication Questionnaire. Poisson regression model was used for gross and adjusted analyses at 95% confidence intervals andP value.ResultsAdherence to treatment of type 2 diabetes mellitus among elderly people was found to be...
Source: Diabetology International - June 17, 2021 Category: Endocrinology Source Type: research

Sodium-glucose cotransporter inhibitors may reduce the risk of pneumonia: an updated meta-analysis of cardiovascular outcome trials
AbstractThe present meta-analysis included 8 cardiovascular outcome trials with 57,185 patients at high cardiometabolic risk. In comparison with placebo, treatment with sodium-glucose cotransporter inhibitors was associated with a significantly lower risk of pneumonia (RR 0.85, 95% CI 0.76 –0.95,p = 0.004;I2 = 0,p = 0.48). (Source: Diabetology International)
Source: Diabetology International - June 6, 2021 Category: Endocrinology Source Type: research

Dipeptidyl peptidase-4 inhibitor improves glycemic variability in multiple daily insulin-treated type 2 diabetes: a prospective randomized-controlled trial
AbstractAimsTo improve glycemic variability (GV) is crucial in the management of multiple daily insulin (MDI) treatment in diabetes. To evaluate the GV improvement in MDI treated type 2 diabetes (T2D) with low-dose metformin 750  mg/day (LMET), which was popular in the clinical practice in Japan, we compared the effect of adding vildagliptin 100 mg/day (LMET + DPP4i treatment) or increased metformin dose to 1500 mg/day (HMET treatment), in the setting of continuous glucose monitoring (CGM) analysis.Materials and methodsSingle-center, open-label, 12  weeks—two period cross-over design...
Source: Diabetology International - June 5, 2021 Category: Endocrinology Source Type: research

Changes in subjective sleep quality in patients with type 2 diabetes who did not use Sleep agents: a cross-sectional study according to age and clinical background
AbstractAimDiabetes and aging are both well-established risk factors for insomnia. Therefore, we investigated the changes in subjective sleep quality in relation to clinical backgrounds and age in patients with type 2 diabetes mellitus (T2DM).MethodsThis cross-sectional study included 380 participants with T2DM who were between 18 and 79  years of age from our outpatient clinics. Individuals with any symptoms and medical histories associated with obstructive sleep apnea (OSA) were excluded from the interview and analyses. Data were collected using self-administered questionnaires, namely the Pittsburgh Sleep Quality I...
Source: Diabetology International - June 2, 2021 Category: Endocrinology Source Type: research

Two-year administration of sodium-glucose co-transporter 2 inhibitor brought about marked reduction of body fat independent of skeletal muscle amount or glycemic improvement in Japanese patients with type 2 diabetes
AbstractAimTo investigate long-term effects of sodium-glucose co-transporter 2 inhibitor (SGLT2i) on anthropometric and metabolic factors in Japanese patients with type 2 diabetes (T2DM).Patients and MethodsThis is a retrospective observation study. Forty-six outpatients with T2DM (32 men and 14 women, 51  ± 13 years old, BMI 27.9 ± 4.8, means ± S.D.) who had been treated by SGLT2i for 2 years were selected and their metabolic and anthropometric data were retrieved from medical records retrospectively. Regular instruction for diet and exercise had bee...
Source: Diabetology International - May 21, 2021 Category: Endocrinology Source Type: research

Prevalence and predictors of atrial fibrillation in Japanese patients with type 2 diabetes
ConclusionHigher prevalence of AF was observed in Japanese patients with type 2 diabetes than the general population. Advanced age, male sex, and hypertension were independent predictive factors for AF. (Source: Diabetology International)
Source: Diabetology International - May 16, 2021 Category: Endocrinology Source Type: research

Evaluation of perceived fears of COVID-19 virus infection and its relationship to health-related quality of life among patients with diabetes mellitus in Egypt during pandemic: a developing country single-center study
ConclusionQoL, either physical or mental, was adversely affected among patients with DM during pandemic. FCV was negatively correlated with all QOL domains. Longitudinal studies are warranted to explore the long-term effect of pandemic on the physical and mental well-being of patients with DM. (Source: Diabetology International)
Source: Diabetology International - May 12, 2021 Category: Endocrinology Source Type: research

Hypoglycemic coma in an elderly adult switched from twice-daily vildagliptin to once-daily glimepiride to improve drug adherence
ConclusionsIt is important to note that anti-diabetes drugs should be carefully selected based on each patient ’s cognitive function and ADL, and that the reasoning should be shared with the general practitioners involved to avoid severe hypoglycemic events. (Source: Diabetology International)
Source: Diabetology International - May 5, 2021 Category: Endocrinology Source Type: research

Efficacy of dulaglutide after switching from incretin-related drugs in patients with type 2 diabetes and inadequate glycemic control
ConclusionsDulaglutide is considered effective in patients with type 2 diabetes and inadequate glycemic control, regardless of whether their pretreatment includes daily GLP-1 RA treatment. (Source: Diabetology International)
Source: Diabetology International - April 29, 2021 Category: Endocrinology Source Type: research

A randomized controlled trial of a structured program combining aerobic and resistance exercise for adults with type 2 diabetes in Japan
AbstractBackgroundWe assessed the effect of supervised, combined aerobic and resistance exercise on diabetic parameters in Japanese patients with type 2 diabetes mellitus (T2DM).MethodsThis 12-week, multicenter (17 medical institutions), open-label, parallel-group study (clinicaltrials.jp; JapicCTI-184002), randomized (1:1) Japanese patients aged 20 –75 years with T2DM and hemoglobin A1c (HbA1c) of 7.0–10.0% to supervised exercise (n = 113) or standard therapy (n = 115). The supervised exercise group undertook supervised aerobic (30 min) and resistance exercise 3 times/week...
Source: Diabetology International - April 28, 2021 Category: Endocrinology Source Type: research

Glycemic control status, diabetes management patterns, and clinical characteristics of adults with type 1 diabetes in Japan: Study of Adults ’ Glycemia in T1DM subanalysis
AbstractAims/introductionType 1 diabetes is rare in the general Japanese population, but becoming more common in adults with increased longevity owing to advancements in treatment. We aimed to examine the current state of glycemic control and diabetes management using real-world data on Japanese adults with type 1 diabetes in different age groups.Materials and methodsThis was a subanalysis of Japanese participants from a multinational, cross-sectional, observational study of adults with type 1 diabetes aged  ≥ 26 years conducted in 2018 (Study of Adults’ Glycemia in T1DM). Glycemic control achie...
Source: Diabetology International - April 25, 2021 Category: Endocrinology Source Type: research

Study on the effects of changes in lifestyle of patients with diabetes on glycaemic control before and after the declaration of the state of emergency in Japan
This study was a collaborative study in two diabetes clinics. A total of 1000 subjects responded to the questionnaire. In addition, data on HbA1c and body weight before and after the declaration of the state of emergency were collected.ResultsHbA1c levels significantly decreased from 7.28  ± 0.97% before the declaration of the state of emergency to 7.07 ± 0.86% after the declaration (p 
Source: Diabetology International - April 20, 2021 Category: Endocrinology Source Type: research

The effect of COVID-19 pandemic on the lifestyle and glycemic control in patients with type 1 diabetes: a retrospective cohort study
ConclusionsMany patients experienced stress and exercised less due to the COVID-19 pandemic. Glycemic control in patients with T1D was worse than that in the previous year. Since the pandemic is currently ongoing, more attention should be paid to stress and lifestyle factor management in patients with T1D. (Source: Diabetology International)
Source: Diabetology International - April 19, 2021 Category: Endocrinology Source Type: research

Unilateral adrenalectomy partially improved hyperglycemia in a patient with primary bilateral macronodular adrenal hyperplasia
AbstractPrimary bilateral macronodular adrenal hyperplasia (PBMAH) is characterized by bilateral multiple adrenal macro-nodules that often cause mild over-secretion of cortisol in the form of subclinical Cushing ’s syndrome. We herein describe a case, wherein unilateral adrenalectomy partially improved hyperglycemia in a patient with PBMAH and suggest the usefulness and limitations of this surgical strategy. A 64-year-old woman with type 2 diabetes had an incidental diagnosis of bilateral adrenal lesions. She had a family history of type 2 diabetes, and her HbA1c level was 8.9% under insulin therapy. She did not pres...
Source: Diabetology International - April 10, 2021 Category: Endocrinology Source Type: research

Real-world evidence for long-term safety and effectiveness of ipragliflozin in treatment-na ïve versus non-naïve Japanese patients with type 2 diabetes mellitus: subgroup analysis of a 3-year post-marketing surveillance study (STELLA-LONG TERM)
AbstractBackgroundSTELLA-LONG TERM was a 3-year post-marketing surveillance study that evaluated the long-term safety and effectiveness of ipragliflozin in Japanese patients with type 2 diabetes mellitus (T2DM). This subgroup analysis examined the safety and effectiveness of ipragliflozin in treatment-na ïve and non-naïve patients.Materials and methodsPatients were stratified into two subgroups: treatment-na ïve (patients who had not received any antidiabetic drugs before starting ipragliflozin monotherapy) and non-naïve (all other patients). Patients who had added or switched antidiabetic drugs during ...
Source: Diabetology International - March 24, 2021 Category: Endocrinology Source Type: research

Diabetes-related acute metabolic emergencies in COVID-19 patients: a systematic review and meta-analysis
AbstractAimsCOVID-19 is associated with diabetic ketoacidosis (DKA), hyperglycaemic hyperosmolar state (HHS) and euglycaemic DKA (EDKA); however, evidence regarding parameters affecting outcome and mortality rates is scarce.MethodsA systematic literature review was conducted using EMBASE, PubMed/Medline, and Google Scholar from January 2020 to 7 January 2021 to identify all studies describing clinical profile, outcome and mortality rates regarding DKA, HHS, DKA/HHS and EDKA cases in COVID-19 patients. The appropriate Joanna Briggs Institute tools were used for quality assessment; quality of evidence was approached using GR...
Source: Diabetology International - March 23, 2021 Category: Endocrinology Source Type: research

Type 1 diabetes woman with repeated miscarriages successfully gave birth after introducing an insulin pump with a predictive low glucose suspend feature
AbstractSensor-augmented insulin pump therapy with a predictive low glucose suspend (SAP-PLGS) feature is a remarkably progressed modality for the glycemic management of patients with type 1 diabetes. This technology avoids nocturnal hypoglycemia and severe hypoglycemia. A Brazilian woman developed type 1 diabetes at age 11 and was treated with multiple daily insulin injections. At age 20, she was admitted to our internal medicine department for her first pregnancy. Her HbA1c was 7.9% in the 6  weeks of gestation. Although the combination of continuous subcutaneous insulin infusion and a sensor-augmented pump was intr...
Source: Diabetology International - March 6, 2021 Category: Endocrinology Source Type: research

Understanding the quality of diabetes care in Japan: a systematic review of the literature
ConclusionDespite the improvement in diabetes related process measures, there is limited data on clinical measures. It is necessary to shed more light on the assessment of the quality of diabetes care. (Source: Diabetology International)
Source: Diabetology International - March 1, 2021 Category: Endocrinology Source Type: research

Clinical features resembling subcutaneous insulin resistance observed in a patient with type 2 diabetes and severe COVID-19-associated pneumonia: a case report
We report the case of a 52-year-old hyperglycemic woman with type 2 diabetes and severe coronavirus disease 2019 (COVID-19)-associated pneumonia, possibly involving the subcutaneous insulin resistance (SIR) syndrome. After admission for pneumonia, her average daily blood glucose (BG) levels remained at 300 –400 mg/dL, although the required dosage of subcutaneous insulin markedly increased (~ 150 units/day; ~ 2.63 units/kg/day). Furthermore, the patient had generalized edema along with hypoalbuminemia, developed extensive abdominal purpuras, and had increased plasma D-dimer levels during trea...
Source: Diabetology International - March 1, 2021 Category: Endocrinology Source Type: research

Prevalence of obesity in prepubertal and pubertal with Turkish population type 1 diabetes
AbstractTo determine the prevalence of prepubertal and pubertal obesity in children and adolescents with type 1 Diabetes Mellitus (Type 1 DM). One hundred fifty children and adolescents aged 6 –18 years with Type 1 DM who attended the Pediatric Endocrinology Polyclinic and were diagnosed with type 1 DM were included in the study. Tanner staging was used to estimate pubertal status. Age- and gender-specific body mass index (BMI) percentile between 85 and 95% was accepted as overweight a nd  >  95% as obese. It was determined that the overweight prevalence rates in children and adolescents with ty...
Source: Diabetology International - February 18, 2021 Category: Endocrinology Source Type: research

Increased nutrition-related risk as an independent predictor of the incidence of hypoglycemia in the hospitalized older individuals with type 2 diabetes: a single-center cohort study
This study examined the associations between nutrition-related risk and hypoglycemia among older individuals with type 2 diabetes (T2D) using diabetes medication.MethodsThis single-center historical cohort study included hospitalized patients aged  ≥ 65 years with T2D on medication. Nutrition-related risk was assessed using the GNRI and classified into four risk groups. Hypoglycemia and serious hypoglycemia were determined by oral or intravenous glucose intake and blood glucose 
Source: Diabetology International - February 17, 2021 Category: Endocrinology Source Type: research

Sodium-glucose cotransporter 2 inhibitor canagliflozin attenuates lung cancer cell proliferation in vitro
In conclusion, SGLT2 is expressed in human lung cancer tissue and cell lines, and the SGLT2 inhibitor, canagliflozin, attenuated prolife ration of A549 lung cancer cells by inhibiting cell cycle progression in vitro but not in vivo. (Source: Diabetology International)
Source: Diabetology International - February 16, 2021 Category: Endocrinology Source Type: research

Associations of serum transthyretin with triglyceride in non-obese elderly Japanese women independently of insulin resistance, HDL cholesterol, and adiponectin
ConclusionsFasting and nonfasting TG showed positive association with TTR in community-dwelling elderly non-obese women independently of insulin resistance, HDL cholesterol, and adiponectin. These findings may provide a clue as to a physiological function of circulating TTR in human: an influence factor of TG-rich lipoproteins in the circulation. (Source: Diabetology International)
Source: Diabetology International - February 13, 2021 Category: Endocrinology Source Type: research

Comprehensive efficacy of ipragliflozin on various conditioned type 2 diabetes compared with dipeptidyl peptidase-4 inhibitors and with both agents, based on a real-world multicenter trial
AbstractAimsThe effects of ipragliflozin, the first sodium-glucose co-transporter 2 inhibitors (SGLT2i) launched in Japan in 2014, and with dipeptidyl peptidase-4 inhibitors (DPP-4i) on glycemic control and metabolic changes were investigated comprehensively on various conditioned type 2 diabetes (T2DM) by evaluating various clinical parameters in a real-world setting.Materials and methodsA total of 101 patients with T2DM aged 20 –80 years with 7.0% ≤ HbA1c 
Source: Diabetology International - February 11, 2021 Category: Endocrinology Source Type: research

Evaluation of multiple drug use in patients with type 2 diabetes mellitus
ConclusionThe total number of drugs used by the DM patients showed the presence of polypharmacy. Advanced age, long disease duration, female gender, and presence of comorbidities were predictive factors for polypharmacy in diabetic patients. Before starting additional medication for DM patients, it is necessary to pay attention to the interaction of the drugs to be used and to plan prescriptions considering the medications used by the patient continuously. (Source: Diabetology International)
Source: Diabetology International - February 7, 2021 Category: Endocrinology Source Type: research

Determinants of type 2 diabetes remission after bariatric surgery in obese Japanese patients: a retrospective cohort study
ConclusionPreoperative insulin secretion, improvement in insulin sensitivity, and weight reduction after BS are related to CR of type 2 diabetes after BS. The results better reveal the pathophysiology of and treatment for type 2 diabetes in obese patients who undergo BS. (Source: Diabetology International)
Source: Diabetology International - January 28, 2021 Category: Endocrinology Source Type: research

Correction to: Impact of actual waiting time and perceived waiting time on treatment satisfaction in patients receiving outpatient diabetes care
In the original publication of the article, in Tables 2 and 3,p values should be replaced with No. of patients. (Source: Diabetology International)
Source: Diabetology International - January 27, 2021 Category: Endocrinology Source Type: research

Association of glycemic control and anthropometric measurement among type 2 diabetes mellitus: a cross-sectional study
ConclusionNearly two-thirds of study participants had poor glycemic control. Increased waist circumference, long duration of DM, occupational status, and family history of DM were independently associated with poor glycemic control. Therefore, type 2 DM patients with these identified factors should be strictly monitored to maintain good glycemic control. (Source: Diabetology International)
Source: Diabetology International - January 25, 2021 Category: Endocrinology Source Type: research

“Fighting spirit”: specific personality traits as one of the key factors for sport championship in type 1 diabetes mellitus
AbstractThere is ample evidence that sport is a protective factor against a number of health risks, across all ages, in the general population. An in-depth understanding of energy metabolism has reasonably entailed exercise as a cornerstone in the lifestyle of almost all subjects with type 1 diabetes mellitus (T1DM). Nevertheless, individuals with T1DM often fail in accomplishing exercise guidelines and they are often less active than their peer without diabetes. Two major obstacles are feared: management of blood glucose control and hypoglycemia. Nowadays, strategies, including glucose monitoring technology and insulin pu...
Source: Diabetology International - January 13, 2021 Category: Endocrinology Source Type: research

Effects of short-term calorie restriction on circulating DPP-4/sCD26 concentrations and body composition in patients with type 2 diabetes
In conclusion, our observations suggest that liver enzymes as well as VFA might be associated with the response of DPP-4/sCD26 concentrations. (Source: Diabetology International)
Source: Diabetology International - January 3, 2021 Category: Endocrinology Source Type: research

Can fasting plasma glucose replace oral glucose-tolerance test for diagnosis of gestational diabetes mellitus?
ConclusionsPerforming only the FPG and considering FPG cutoffs 75 and 80  mg/dL at first prenatal visit and at 24–28th of gestational weeks can be a useful tool predicting the incidence of GDM, respectively, and had similar diagnostic power. (Source: Diabetology International)
Source: Diabetology International - January 2, 2021 Category: Endocrinology Source Type: research

Impact of actual waiting time and perceived waiting time on treatment satisfaction in patients receiving outpatient diabetes care
AbstractAimsWe investigated the impact of actual waiting time and perceived waiting time on treatment satisfaction in patients with diabetes receiving outpatient care.MethodsThree hundred and thirty-six outpatients diagnosed with diabetes mellitus or impaired glucose tolerance were selected and the time they spent in reception, blood collection, consultation, and accounting were recorded to measure the time they spent waiting in the hospital (actual waiting time). Simultaneously, we conducted a questionnaire survey that included questions on their perceptions of the waiting time (perceived waiting time) and satisfaction wi...
Source: Diabetology International - January 2, 2021 Category: Endocrinology Source Type: research

Psychosocial conditions and the progression of diabetic nephropathy in Japanese with type 2 diabetes mellitus
AbstractWe previously reported the association of positive psychosocial conditions with diabetic nephropathy (DN) in patients with type 2 diabetes in a cross-sectional setting. In the present study, we evaluated the association between six indicators related to psychosocial conditions and the progression of DN assessed by estimated glomerular filtration rate (eGFR) and albuminuria during 2-year observation period in 252 patients with type 2 diabetes. In unadjusted model, the subjects with higher happiness score attenuated reduced eGFR, and those with more social support attenuated increase in alubuminuria and decline eGFR....
Source: Diabetology International - January 2, 2021 Category: Endocrinology Source Type: research

Retrospective study of factors associated with progression and remission/regression of diabetic kidney disease-hypomagnesemia was associated with progression and elevated serum alanine aminotransferase levels were associated with remission or regression-
This study was aimed at retrospectively investigating some common clinical factors, including the serum level of magnesium (Mg), associated with progression and remission/regression of diabetic kidney disease (DKD).MethodsThe subjects were 690 Japanese patients with type 2 diabetes mellitus who were receiving treatment with oral antidiabetic drugs other than SGLT2 inhibitors. Routine clinical data were collected on the first and last day of the observation period. The prognosis of DKD is categorized into four stages according to the Kidney Disease Improving Global Outcomes classification. Progression was defined as transit...
Source: Diabetology International - January 2, 2021 Category: Endocrinology Source Type: research

Background characteristics and diabetes remission after laparoscopic sleeve gastrectomy in Japanese patients with type 2 diabetes stratified by BMI: subgroup analysis of J-SMART
ConclusionThe patients with 32 –34.9 kg/m2 were characterized by more severe visceral obesity, T2D and the complications, and lower intrinsic insulin secretion capacity. LSG should be considered as a treatment option for patients with BMI 32 –34.9 kg/m2, to improve diabetes control. (Source: Diabetology International)
Source: Diabetology International - January 2, 2021 Category: Endocrinology Source Type: research

Association of abdominal obesity with crossing capillaries in the finger nailfold in type 2 diabetes mellitus
ConclusionsAbdominal obesity may play an important role in the increase in the percentage of crossing capillaries in the finger nailfold in patients with type 2 diabetes mellitus. (Source: Diabetology International)
Source: Diabetology International - January 1, 2021 Category: Endocrinology Source Type: research

Role of fatty acid elongase Elovl6 in the regulation of energy metabolism and pathophysiological significance in diabetes
AbstractType 2 diabetes mellitus (T2DM) is an expanding epidemic, closely linked to obesity. Peripheral insulin resistance and impaired insulin secretion remain the core defects in T2DM. Despite significant advances in unraveling the underlying these defects, many of the metabolic pathways and regulators involved in insulin resistance and β-cell dysfunction are not completely understood. This review proposes that manipulating the fatty acid (FA) composition by blocking ELOVL fatty acid elongase 6 (Elovl6) could protect against insulin resistance, impaired insulin secretion, and obesity-related disorders. The molecular...
Source: Diabetology International - December 15, 2020 Category: Endocrinology Source Type: research

The role of adipose tissue M1/M2 macrophages in type 2 diabetes mellitus
AbstractObesity and insulin resistance are closely associated with a state of low-grade inflammation in the body, and adipose tissue macrophages (ATMs) play central roles in this inflammation. ATMs are known to exhibit marked functional heterogeneity. M1 ATMs produce inflammatory cytokines and induce insulin resistance. On the other hand, the majority of ATMs in lean individuals are M2 ATMs, which have anti-inflammatory potential. We found that M1 and M2 ATMs can be clearly distinguished using CD11c and CD206 as markers, and that both the number of the M1 and M2 ATMs and the M1/M2 ratio are correlated with the degree of in...
Source: Diabetology International - December 15, 2020 Category: Endocrinology Source Type: research

Diagnosis, prevention, and treatment of cardiovascular diseases in people with type 2 diabetes and prediabetes: a consensus statement jointly from the Japanese Circulation Society and the Japan Diabetes Society
(Source: Diabetology International)
Source: Diabetology International - November 30, 2020 Category: Endocrinology Source Type: research

Safety and effectiveness of ipragliflozin in Japanese patients with type 2 diabetes mellitus and impaired renal function: subgroup analysis of a 3-year post-marketing surveillance study (STELLA-LONG TERM)
AbstractSTELLA-LONG TERM, a 3-year post-marketing surveillance study, evaluated the safety and effectiveness of the sodium-glucose cotransporter 2 inhibitor ipragliflozin in Japanese type 2 diabetes mellitus (T2DM) patients. Final results in the safety (n = 6697) and effectiveness populations (n = 5625) were analyzed by stratifying patients by baseline estimated glomerular filtration rate (eGFR, mL/min/1.73 m2) into four subgroups ( ≥ 90, 60 to 
Source: Diabetology International - November 23, 2020 Category: Endocrinology Source Type: research

A study of serum growth differentiation factor 15 in Indian women with and without gestational diabetes mellitus in the third trimester of pregnancy and its association with pro-inflammatory markers and glucose metabolism
In conclusion, our study provides evidence that, in Indian women, serum GDF-15 level is higher in GDM in c omparison to age-matched pregnant subjects without GDM in the early third trimester pregnancy. Moreover, in third trimester, GDF-15 level increases with increase in plasma glucose and insulin resistance. (Source: Diabetology International)
Source: Diabetology International - November 21, 2020 Category: Endocrinology Source Type: research

Comparative effects of insulin glulisine and lispro on postprandial plasma glucose and lipid profile in Japanese patients with type 2 diabetes mellitus
ConclusionInsulin lispro seems superior to glulisine in the control of PPG in Japanese patients with T2DM. (Source: Diabetology International)
Source: Diabetology International - November 17, 2020 Category: Endocrinology Source Type: research

The diabetes quality of life brief clinical inventory in combination with the management strategies in type 1 diabetes mellitus with or without the use of insulin pump
AbstractAimsThe aims of this study are to evaluate any differences in the Quality of life among Continuous Subcutaneous Insulin Infusion (CSII) and Multiple Dose Injection (MDI) insulin delivery, applying the Diabetes Quality of life Brief Clinical Inventory (DQoL-BCI) questionnaire, and assess the diabetes management strategies between the two groups.MethodsOne hundred and ten adult participants (male/female ratio 1:2.7) with type 1 diabetes were recruited in this online survey. Forty-eight of them were using CSII and the rest 62 (were using) MDI insulin delivery. A 23-item socio-demographic/diabetes management strategies...
Source: Diabetology International - November 16, 2020 Category: Endocrinology Source Type: research