A study on carotid artery intima –media thickness and metabolic risk factors in overweight and obese Indian children
AbstractIntroductionCarotid intima –media thickness (CIMT) serves as an early marker of atherosclerosis. Data on obesity-related risk factors and their association with carotid intima–media thickness among overweight and obese children are lacking.ObjectivesTo compare CIMT of overweight and obese children with CIMT of normal BMI children. To compare various anthropometric and metabolic risk factors associated with increased CIMT among overweight and obese children.MethodsA descriptive study in a paediatric department of a tertiary care hospital including 50 age-matched normal BMI children and 50 overweight and ...
Source: Diabetology International - November 12, 2019 Category: Endocrinology Source Type: research

Sample transport and/or storage can cause falsely low HbA1c levels in blood cells measured by enzymatic assay
AbstractAlthough HbA1c measurement by enzymatic assay (EA-HbA1c) is widely used in health-screening settings in Japan, recent studies have suggested lower EA-HbA1c levels as compared with HbA1c levels measured by high-performance liquid chromatography (HPLC-HbA1c). Hypothesizing that falsely low levels of EA-HbA1c are attributable to hemolysis caused by sample transport and/or storage, we measured EA-HbA1c in blood cells and whole blood after sample transport and compared them with HPLC-HbA1c levels. Blood samples were collected from ten non-diabetic individuals into sodium fluoride-containing blood collection tubes and im...
Source: Diabetology International - November 8, 2019 Category: Endocrinology Source Type: research

Linagliptin and cardiorenal outcomes in Asians with type 2 diabetes mellitus and established cardiovascular and/or kidney disease: subgroup analysis of the randomized CARMELINA ® trial
ConclusionsLinagliptin showed cardiovascular and renal safety in Asian patients with T2DM and established CVD with albuminuria and/or kidney disease. (Source: Diabetology International)
Source: Diabetology International - October 22, 2019 Category: Endocrinology Source Type: research

Association of urinary albumin excretion with periodontal parameters in patients with type 2 diabetes mellitus: a cross-sectional study
AbstractBackgroundOur previous pilot study using patients with type 2 diabetes mellitus in one medical clinic showed an association of urinary albumin excretion, a marker of generalized vascular dysfunction and kidney damage, with periodontitis. The purpose of this study was to confirm the association by increasing the number of patients and medical clinics.MethodsParticipants were 2302 patients (59.9% males, aged 29 –93 years) with type 2 diabetes mellitus from 25 medical clinics. Their medical records and information about socioeconomic status and health behavior were collected. Periodontal status was assessed...
Source: Diabetology International - October 16, 2019 Category: Endocrinology Source Type: research

Islet autoantibodies in disease prediction and pathogenesis
AbstractType 1 diabetes (T1D) is now predictable by measuring specific islet autoantibodies (IAbs). Almost all children who developed multiple IAbs will progress to T1D with time, while individuals with single IAb have a very low risk although it is an important earlier biomarker. The poor prediction of single IAb has been found to be associated with IAb affinity. Majority of single IAb generated in current standard IAb radio-binding assay (RBA) are of low affinity, which have been demonstrated low risk in T1D development. New generation of nonradioactive IAb assay with electrochemiluminescence (ECL) technology has been sh...
Source: Diabetology International - October 16, 2019 Category: Endocrinology Source Type: research

The effect of long-term past glycemic control on executive function among patients with type 2 diabetes mellitus
AbstractObjectivePatients with type 2 diabetes mellitus (T2DM) show more executive dysfunction than nondiabetics. However, how long poor glycemic control affects executive function remains unclear. Thus, we aimed to investigate the relationships in a cross-sectional study.MethodsWe studied 118 T2DM outpatients (age,  ≥ 60 years; excluding history of stroke, dementia and severe hypoglycemia). HbA1c values were recorded every ≤ 12 weeks for ≥ 5 years. All patients underwent verbal-fluency tests (reflecting executive function) and Mini-Mental State Examination ...
Source: Diabetology International - October 3, 2019 Category: Endocrinology Source Type: research

Associations among work-related stress and mental fatigue, and regular exercise in Japanese employees with or without diabetes
ConclusionsWork-related mental fatigue was negatively associated with regular exercise in employees with and without diabetes. (Source: Diabetology International)
Source: Diabetology International - October 1, 2019 Category: Endocrinology Source Type: research

Drug development research for novel adiponectin receptor-targeted antidiabetic drugs contributing to healthy longevity
AbstractIt is well recognized that the decrease of adiponectin associated with high-fat diet and lack of exercise accounts for the onset of insulin resistance, type 2 diabetes, the metabolic syndrome, and cardiovascular disease. Our research efforts have led to the identification of adiponectin receptors, AdipoR1 and AdipoR2, with the former shown to activate AMP kinase in the liver and the latter shown to activate peroxisome proliferator-activated receptor- α signaling thereby increasing fatty acid oxidation. Again, adiponectin upregulates mitochondrial function in the skeletal muscle thereby improving glucose/lipid...
Source: Diabetology International - September 19, 2019 Category: Endocrinology Source Type: research

The hypoglycemia-prevention effect of sensor-augmented pump therapy with predictive low glucose management in Japanese patients with type 1 diabetes mellitus: a short-term study
AbstractAims/introductionThe predictive low glucose management (PLGM) system was introduced in March 2018 in Japan. Although there are some reports demonstrating the benefit of PLGM in preventing hypoglycemia, no data are currently available in Japanese patients with type 1 diabetes mellitus (T1DM). The aim of the present study is to evaluate the effect of PLGM with sensor-augmented pump therapy in the prevention of hypoglycemia in Japanese patients.Materials and methodsWe included 16 patients with T1DM who used the MiniMed®640G system after switching from the MiniMed®620G system. We retrospectively analysed the da...
Source: Diabetology International - September 16, 2019 Category: Endocrinology Source Type: research

HbA1c levels measured by enzymatic assay during off-site health checkups are lower than those measured by on-site HPLC assay
AbstractHbA1c is widely used as a therapeutic target marker and as a diagnostic marker for diabetes mellitus. This has led to an increasing frequency of HbA1c measurements in current health checkups throughout Japan. In the present study, we compared the HbA1c levels measured by an enzymatic assay (EA-HbA1c) off-site during health checkups with the HbA1c levels measured by on-site ion-exchange high-performance liquid chromatography (HPLC; HPLC-HbA1c) in a hospital. A total of 96 individuals (53 males and 43 females; age, 68.9  ± 8.4 years old; 70 diabetic and 26 non-diabetic individuals) whose HbA...
Source: Diabetology International - August 27, 2019 Category: Endocrinology Source Type: research

Incidence and causes of mildly to moderately elevated aminotransferase in Japanese patients with type 2 diabetes
AbstractObjectivesTo identify the association of type 2 diabetes (T2DM) and liver disease with elevated ALT and factors associated with increased ALT in patients with and without T2DM.Design and settingWe performed a retrospective study in adults with ≥ 2 claims for blood tests recorded in the Medical Data Vision claims database between 2010 and 2016.ParticipantsPatients were entered into T2DM and non-DM groups based on diagnosis and medication claim codes.Primary outcome measureThe primary endpoint was the first follow-up ALT elevation over three times the normal value, and etiologies were categorized by subsequ...
Source: Diabetology International - August 14, 2019 Category: Endocrinology Source Type: research

Pathophysiological roles of nutrient-sensing mechanisms in diabetes and its complications
AbstractDiabetic nephropathy, which is characterized by increased albuminuria, has been the most common cause of end-stage kidney disease for many years in Japan and many other countries. Although the renal prognosis of the disease has been improving in recent years because of the clinical implementation of strict glucose, blood pressure, and lipid controls, some diabetes patients continue to exhibit treatment-resistant macroalbuminuria leading to end-stage kidney disease. Furthermore, renal function decline without macroalbuminuria in diabetes is an emerging issue in Japan, which might be partly due to aging. Thus, a nove...
Source: Diabetology International - August 13, 2019 Category: Endocrinology Source Type: research

Combination use of liraglutide and insulin to Japanese patients with multiple insulin injection: efficacy and cost
AbstractObjectivesThe introduction of liraglutide in the treatment of patients with type 2 diabetes already taking insulin is still subject to discussion in terms of timing and benefits. Gradually intensive insulin therapy is hastily prescribed. Switching from multiple insulin injection (MII) to insulin and liraglutide is evaluated in this study.MethodologyWe studied 92 patients with type 2 diabetes previously under MII, C-peptide  ≥ 1.5 ng/ml, divided into a group with reasonable glycemic control [RC: HbA1c 
Source: Diabetology International - July 8, 2019 Category: Endocrinology Source Type: research

Factors involved in body weight loss and its maintenance in morbidly obese inpatients
ConclusionThese results suggest that EWL in morbidly obese inpatients is greater than those with lower baseline BMI and fat mass. The presence of diabetes had no effects on EWL during hospitalization. EWL during hospitalization was not correlated with its maintenance after discharge. Diabetic patients displayed lesser degree of body weight gain after discharge, possibly due to the effects of anti-diabetic medications. (Source: Diabetology International)
Source: Diabetology International - July 6, 2019 Category: Endocrinology Source Type: research

A diabetic patient in whom Hb Weesp was incidentally detected when her HbA1c level was measured
We report the case of a patient with type 2 diabetes mellitus, who was incidentally found to having an extremely rare Hb variant. A 69-year-old Japanese female visited our clinic and was diagnosed with diabetes mellitus. Her HbA1c level, which was measured using HPLC at our clinic, could not be determined. DNA sequencing revealed a heterozygous mutation in the α1 globin gene (HBA1: c.301C >  T, p.Leu101Phe). Hb Weesp was detected. Many Hb variants have been reported; however, to the best of our knowledge, this is only the second report about Hb Weesp in the world and the first from Japan. Clinicians ...
Source: Diabetology International - July 5, 2019 Category: Endocrinology Source Type: research

A case of mediastinal teratoma with pancreatic islets accompanied by discontinuation of insulin treatment in insulin-dependent diabetes mellitus
AbstractA 74-year-old woman of insulin-dependent diabetes mellitus presented with gradually improvement of blood glucose control and finally discontinuation of insulin therapy, for some unknown reason. During follow-up period, she was admitted with hemoptysis. CT imaging showed a heterogeneous enhancement mass in the middle mediastinum with cyst and calcification, suggesting the diagnosis of mediastinal teratoma. Immediately after excision of the tumor, her plasma glucose levels again increased, and she required insulin therapy for glycemic control. Immunohistochemical examination showed that the tumor contained pancreatic...
Source: Diabetology International - July 2, 2019 Category: Endocrinology Source Type: research

Clinical impact of sarcopenia and dynapenia on diabetes
AbstractSarcopenia as a progressive and generalized skeletal muscle disorder that is associated with an increased likelihood of adverse outcomes, including falls, fractures, physical disability, and mortality. On the other hand, an age-related decline in muscle strength prior to the reduction of muscle mass, is proposed to be “dynapenia”. Sarcopenia and dynapenia have recently been recognized as a diabetic complications in type 2 diabetes. We firstly indicated that sarcopenia was frequently observed in 16.6% of patients with type 1 diabetes aged even over 40 years. Additionally, we recently reported that the pr...
Source: Diabetology International - June 19, 2019 Category: Endocrinology Source Type: research

Prospective study on clinical characteristics of Japanese diabetic patients with chronic limb-threatening ischemia presenting Fontaine stage IV
AbstractThe aim of this prospective cross-sectional study was to reveal clinical characteristics of Japanese diabetic patients with chronic limb-threatening ischemia (CLTI) presenting ischemic unhealed ulcer/gangrene (Fontaine stage IV) in the real-world settings. The present study included 132 Japanese diabetic patients who underwent endovascular therapy for CLTI presenting Fontaine stage IV. The prevalence of diabetes-related complications, as well as prior history of ankle-brachial index (ABI) measurement before CLTI onset, was evaluated adopting multiple imputation (50 times). Duration of diabetes was referred to as ti...
Source: Diabetology International - June 17, 2019 Category: Endocrinology Source Type: research

Diabetes care providers ’ manual for disaster diabetes care
AbstractTo ensure that experiences and lessons learned from the unprecedented 2011 Great East Japan Earthquake are used to improve future disaster planning, the Japan Diabetes Society (JDS) launched the “Research and Survey Committee for Establishing Disaster Diabetes Care Systems Based on Relevant Findings from the Great East Japan Earthquake” under the supervision of the Chairman of the JDS. The Committee conducted a questionnaire survey among patients with diabetes, physicians, disaster medi cal assistance teams (DMATs), nurses, pharmacists, and nutritionists in disaster areas about the events they saw happe...
Source: Diabetology International - June 14, 2019 Category: Endocrinology Source Type: research

Higher circulating orosomucoid and lower early-phase insulin secretion in midlife Japanese with slower glucose disposal during oral glucose tolerance tests
We examined whether serum orosomucoid, an acute phase protein as with C-reactive protein, in addition to insulin resistance and beta-cell dysfunction, was involved in glucose disposal during oral glucose tolerance tests.Research design and methods124 midlife Japanese (65 women, 66% with normal glucose tolerance) received dual-energy X-ray absorptiometry and 75  g oral glucose tolerance tests with multiple postload glucose and insulin measurements. Subjects were divided based on the relationship between postload and fasting glucose. Obesity measures, insulin resistance, insulin secretion, serum orosomucoid and adiponec...
Source: Diabetology International - May 16, 2019 Category: Endocrinology Source Type: research

The correlation between blood oxidative stress and sialic acid content in diabetic patients with nephropathy, hypertension, and hyperlipidemia
AbstractThis clinical study was designed to find out the correlation between oxidative stress and sialic acid (SA) content of plasma and RBCs in patients with type 2 diabetes. We evaluated SA concentration and oxidative stress biomarkers in healthy subjects and diabetic patients with and without complications in a cross-sectional survey. Significant changes in oxidative stress biomarkers and RBC-SA were revealed in the diabetic patients compared to those in the healthy group. Plasma SA significantly increased with an increase in lipid peroxidation of RBCs (LPO-RBC) (P 
Source: Diabetology International - May 9, 2019 Category: Endocrinology Source Type: research

Proposal of classification of “chronic kidney disease (CKD) with diabetes” in clinical setting
AbstractThe natural history of typical and classical “diabetic nephropathy” has been described as high levels of albuminuria and subsequent renal function decline. However, recent decades, the cases, who show the reduced glomerular filtration rate (GFR) without the progression of albuminuria, has been increased. “Diabetic kidney disease (DKD)” is a concept that widely recognizes the pathophysiological change induced by diabetes as the onset and progressive factor of renal injury and renal function decline, regardless of the level of albuminuria. However, we may confuse that “chronic kidney dis...
Source: Diabetology International - April 29, 2019 Category: Endocrinology Source Type: research

Recommended configuration for personal health records by standardized data item sets for diabetes mellitus and associated chronic diseases: a report from a collaborative initiative by six Japanese associations
AbstractIt is expected that a large amount of data related to diabetes and other chronic diseases will be generated. However, databases constructed without standardized data item sets can be limited in their usefulness. To address this, the Collaborative Committee of Clinical Informatization in Diabetes Mellitus was established in 2011 by the Japan Diabetes Society and Japan Association for Medical Informatics. The committee has developed core item sets and self-management item sets for diabetes mellitus, hypertension, dyslipidemia, and chronic kidney disease in collaboration with the Japanese Society of Hypertension, Ja...
Source: Diabetology International - April 25, 2019 Category: Endocrinology Source Type: research

Clinical background of Japanese patients with type 1 diabetes mellitus who have received insulin therapy for 50  years or longer
ConclusionsIt became possible for patients with T1DM to live more than 50  years in Japan. (Source: Diabetology International)
Source: Diabetology International - April 11, 2019 Category: Endocrinology Source Type: research

Association between changes in the mRNA expression of platelet-activating factor receptor in peripheral blood mononuclear cells and progression of diabetic nephropathy
ConclusionOur findings indicate that even though no causal relationship exists between diabetic nephropathy and elevated expression of PAFR in PBMCs, their close association signifies the presence of another common mechanism that could induce both events. Given these findings, the PAF/PAFR interaction could clarify corresponding mechanisms involved in diabetic complications. (Source: Diabetology International)
Source: Diabetology International - April 11, 2019 Category: Endocrinology Source Type: research

Temporal trends in the prevalence of albuminuria and reduced eGFR in Japanese patients with type 2 diabetes
This study included adult Japanese patients with type 2 diabetes who first visited our institute between 2004 and 2013. Temporal changes during the 10  years in the frequency of albuminuria ( ≥ 30 mg/g creatinine) and reduced eGFR ( 
Source: Diabetology International - March 15, 2019 Category: Endocrinology Source Type: research

Low resting energy expenditure in postmenopausal Japanese women with type 2 diabetes mellitus
ConclusionThe previously reported pREE overestimates mREE in Japanese patients with T2DM, especially in postmenopausal women. (Source: Diabetology International)
Source: Diabetology International - February 28, 2019 Category: Endocrinology Source Type: research

Prospective study of cancer in Japanese patients with type 2 diabetes: the Fukuoka Diabetes Registry
ConclusionsSince the leading cause of death in patients with type 2 diabetes is cancer in Japan, clinicians should be aware of epidemiological data regarding cancer besides diabetic complications. (Source: Diabetology International)
Source: Diabetology International - February 20, 2019 Category: Endocrinology Source Type: research

Albuminuria, C-reactive protein, and socioeconomic factors are associated with periodontal status in subjects with type 2 diabetes
AbstractDiabetes and periodontitis may increase risk of cardiovascular disease. Whether albuminuria, C-reactive protein (CRP), and socioeconomic factors, known as cardiovascular risks in subjects with poorly controlled diabetes, are independently associated with periodontal status in well-controlled diabetes remains to be elucidated. In 503 subjects with type 2 diabetes, the cross-sectional associations of clinical and socioeconomic factors with periodontal parameters were investigated. Periodontal parameters on all teeth included the probing pocket depth at 6 sites per tooth, bleeding on probing, the plaque score, tooth m...
Source: Diabetology International - December 12, 2018 Category: Endocrinology Source Type: research

Clinical characteristics of Japanese diabetic patients with critical limb ischemia presenting Fontaine stage IV
AbstractThe aim of the current study was to reveal the clinical characteristics of Japanese diabetic patients with critical limb ischemia (CLI) presenting ischemic unhealed ulcer/gangrene (Fontaine stage IV) in the real-world settings. The current retrospective cross-sectional study included consecutive 282 Japanese diabetic patients who underwent endovascular therapy for CLI presenting Fontaine stage IV. The prevalence of diabetes-related complications was estimated adopting multiple imputation (50 times). The patients were aged 70  ± 10 years. Median duration of diabetes was 21 (interquartile ra...
Source: Diabetology International - December 8, 2018 Category: Endocrinology Source Type: research

Small-intestinal necrosis due to non-occlusive mesenteric ischemia with diabetic ketoacidosis after quetiapine treatment
We report a 66-year-old male who developed diabetic ketoacidosis (DKA) and necrosis of the small intestine due to non-occlusive mesenteric ischemia (NOMI), 3  months after starting quetiapine treatment. He was transferred to our hospital and diagnosed as diabetic for the first time, associated with DKA. Despite improvement in DKA, abdominal pain worsened gradually 10 h after hospitalization. Computed tomography (CT) revealed bowel emphysema, and gas ou t of the gut wall, in the mesenteric veins and the intrahepatic portal vein, suggesting intestinal necrosis. He survived because of resection of necrotic small-int...
Source: Diabetology International - December 5, 2018 Category: Endocrinology Source Type: research

Correction to: Japanese Clinical Practice Guideline for Diabetes 2016
Correction to: Diabetology International. (Source: Diabetology International)
Source: Diabetology International - December 4, 2018 Category: Endocrinology Source Type: research

Self-management behavior concerning physical activity of Japanese type 2 diabetes patients, characterized by sex, daily energy intake and body mass index
ConclusionsBMI and dietary intake were associated with frequencies of physical activity self-management strategies in men. Self-management behavior peculiar to male NO/OE group is “Exercising to stimulate the enjoyment of eating”. Health professionals should assess sex, BMI, and dietary intake of patients and endeavor to improve individuals’ ability to regulate their caloric balance based on physical activity level. (Source: Diabetology International)
Source: Diabetology International - November 26, 2018 Category: Endocrinology Source Type: research

A case of variant hemoglobin (Hb Agenogi) with type 2 diabetes mellitus showed high HbA1c levels measured by immunoassay due to enhanced antigenicity
AbstractHbA1c is a widely utilized biomarker for the management of diabetes mellitus. The presence of variant hemoglobins might interfere with HbA1c measurement using different methods. We herein describe Hb Agenogi ( β90Glu → Lys) with type 2 diabetes mellitus whose HbA1c measured by immunoassay (IA) showed falsely high levels while HbA1c measured by high-performance liquid chromatography (HPLC) in the standard mode (SM) showed falsely low levels. To clarify the cause of the falsely high-IA-HbA1c levels, HbA1c was measured by various methods. Glycated albumin was slightly higher than the reference ...
Source: Diabetology International - November 20, 2018 Category: Endocrinology Source Type: research

The association between glycemic control and lung function impairment in individuals with diabetes: the Saku study
AbstractAimThough diabetes is a risk factor for lung function impairment, whether the glycemic control level affects lung function in individuals with diabetes remains unclear. The present study aimed to assess the association between glycemic control level and restrictive or obstructive lung function impairment in individuals with diabetes.MethodsThis cross-sectional study included 1028 individuals with diabetes, aged 40 –69 years, who underwent a medical checkup between April 2008 and March 2014. Hemoglobin A1c (HbA1c) was categorized as  
Source: Diabetology International - November 19, 2018 Category: Endocrinology Source Type: research

Low muscle mass and inflammation among patients with type 2 diabetes mellitus in Indonesia
AbstractIntroductionChronic inflammation, as observed in type 2 diabetes mellitus (T2DM), is associated with complications. How chronic inflammation influences body composition in patients with T2DM remains to be investigated. Our study aimed to evaluate the difference of skeletal muscle mass between patients with and without inflammation indicated by plasma high sensitivity C-reactive protein (hs-CRP).MethodsPatients with T2DM were recruited from primary health care in Sleman district, Indonesia. Measurements were performed to obtain information on body weight, body mass index, waist circumference, waist-to-height ratio, ...
Source: Diabetology International - November 19, 2018 Category: Endocrinology Source Type: research

Trends in the prevalence of type 2 diabetes and prediabetes in a Japanese community, 1988 –2012: the Hisayama Study
ConclusionsOur findings suggest that in Japanese, there was no further increase in the prevalence of T2DM or prediabetes in either men or women in the 2000s. Secular change in the BMI level was likely to contribute to trends in the prevalence of T2DM, and thus the management of obesity may be important to reduce the prevalence of T2DM. (Source: Diabetology International)
Source: Diabetology International - November 3, 2018 Category: Endocrinology Source Type: research

Evaluation of the Diabetes Regional Coordination Path using the Diabetes Coordination Notebook in community-based diabetes care
AbstractAimsA number of epidemiologic surveys have demonstrated that improving lifestyle habits, providing patient education, and regular screening of patients for early diabetic symptoms and complications through multidisciplinary collaboration are crucial for the management of diabetes.MethodsTo evaluate the Diabetes Coordination Notebook and the Diabetes Regional Coordination Path in management of diabetes, 217 community pharmacies conducted a survey by questionnaire in Gifu Prefecture, Japan.ResultsA reply to the questionnaire was obtained from 27,016 individuals, of whom 5,572 claimed to have diabetes or prediabetes. ...
Source: Diabetology International - October 20, 2018 Category: Endocrinology Source Type: research

Psychometric properties of the Escala de Autoeficacia para la Depresi ón en Adolescentes (EADA) among Latino youth with type 1 diabetes
We examined the psychometric properties of theEscala de Autoeficacia para la Depresi ón en Adolescentes (EADA) with 51 T1D youth (aged 12 –17 years), enrolled in a depression treatment study. Adolescents and one parent each completed several measures. Youth completed the EADA. We used alpha coefficient to estimate its internal consistency and Pearson correlation to assess its concurrent and construct validity. We found an internal consistency of 0.93 for the EADA total score, with alpha values ranging from 0.71 to 0.85 for its subscales. EADA scores significantly (p  ≤ 0.05) diverged from s...
Source: Diabetology International - October 5, 2018 Category: Endocrinology Source Type: research

The relationship of one-leg standing time with peripheral nerve function and clinical neuropathy in patients with type 2 diabetes
ConclusionsShort one-leg standing time was associated with peripheral and cardiac autonomic nerve dysfunction and clinical neuropathy in patients with type 2 diabetes, independent of age. (Source: Diabetology International)
Source: Diabetology International - October 1, 2018 Category: Endocrinology Source Type: research

Pathophysiological significance of hepatokine overproduction in type 2 diabetes
AbstractCurrently, many studies draw attention to novel secretory factors, such as adipokines or myokines, derived from the tissues that were not originally recognized as endocrine organs. The liver may contribute to the onset of various kinds of pathologies of type 2 diabetes by way of the production of secretory proteins “hepatokines.” Using the comprehensive gene expression analyses in human livers, we have rediscovered selenoprotein P and LECT2 as hepatokines involved in the onset of dysregulated glucose metabolism. Overproduction of selenoprotein P, previously reported as a transport protein of selenium, i...
Source: Diabetology International - October 1, 2018 Category: Endocrinology Source Type: research

Diffusion-weighted magnetic resonance imaging in the pancreas of fulminant type 1 diabetes
AbstractAbrupt disease onset and severe metabolic disorders are main characteristics of fulminant type 1 diabetes. Diffusion-weighted magnetic resonance imaging (DWI) is an imaging technique that reflects restricted diffusion in organs and can detect mononuclear cell infiltration into the pancreas at the onset of the disease. Fourteen patients with fulminant type 1 diabetes who underwent abdominal magnetic resonance imaging were recruited for the measurement of apparent diffusion coefficient (ADC) values of the pancreas that were compared with those of 21 non-diabetic controls. The ADC values of all parts of the pancreas w...
Source: Diabetology International - October 1, 2018 Category: Endocrinology Source Type: research

The still persistent stigma around diabetes: is there something we can do to make it disappear?
(Source: Diabetology International)
Source: Diabetology International - October 1, 2018 Category: Endocrinology Source Type: research

Histone demethylases regulate adipocyte thermogenesis
AbstractAdipocytes play a pivotal role in the regulation of energy metabolism. While white adipocyte stores energy, brown adipocyte dissipates energy by producing heat. In addition, another type of heat-producing adipocyte, beige adipocyte, emerges in white adipose tissue in response to chronic coldness. This phenotypic adaptation to the cold environment is considered to be attributed to the epigenetic modifications. Histone methylation is a chemically stable epigenetic modification and thus a proper mechanism for long-lasting cellular memory. Several histone methyl-modifying enzymes such as EHMT1, JMJD1A, JMJD3, and LSD1 ...
Source: Diabetology International - October 1, 2018 Category: Endocrinology Source Type: research

Taurine improves glucose tolerance in STZ-induced insulin-deficient diabetic mice
AbstractBlood glucose levels fluctuate considerably in diabetic patients with reduced secretion of endogenous insulin. We previously reported that glucagon is secreted excessively in these patients and that taurine increases glucagon secretion in vitro. Therefore, we hypothesized that glucose tolerance would further deteriorate when taurine was administered to diabetic mice incapable of insulin secretion. We generated four groups of streptozotocin (STZ)-treated C57BL/6J mice (STZ-mice): STZ-mice without taurine treatment (STZ-Con), STZ-mice treated with 0.5% (w/v) taurine (STZ-0.5% Tau), STZ-mice treated with 1% (w/v) taur...
Source: Diabetology International - October 1, 2018 Category: Endocrinology Source Type: research

Pleiotropic effects of SGLT2 inhibitors beyond the effect on glycemic control
This report discusses the results of cardiovascular and renal outcomes from the two landmark trials. (Source: Diabetology International)
Source: Diabetology International - October 1, 2018 Category: Endocrinology Source Type: research

Correction to: IAPP/amylin and β‑cell failure: implication of the risk factors of type 2 diabetes
In the original publication of the article, corresponding author ’s email address was published incorrectly. The correct email address is azumaka@yahoo.co.jp. (Source: Diabetology International)
Source: Diabetology International - October 1, 2018 Category: Endocrinology Source Type: research

Development and validity testing of the revised diabetes self-care inventory for children and adolescents
AbstractRecently, self-care in children and adolescents with type 1 diabetes has changed with regard to both adherence to treatment and self-management. Only one diabetes self-care scale for children and adolescents is used in Japan which lacks reflection on flexible regimens. The aims of this study were to modify and subsequently test the validity of the revised diabetes self-care inventory (R-DSCI) for children and adolescents, and to construct the diabetes self-care model on the R-DSCI, HbA1c, duration of diabetes and age. Based on qualitative secondary analysis of the self-care framework for teenagers and a literature ...
Source: Diabetology International - September 28, 2018 Category: Endocrinology Source Type: research

Effect of linagliptin on oxidative stress markers in patients with type 2 diabetes: a pilot study
ConclusionIn this study, we demonstrated that linagliptin partially attenuated oxidative stress. We also demonstrated that linagliptin treatment reduced urinary L-FABP excretion, suggesting that renal tubule-interstitial injury may be attenuated by linagliptin (UMIN 000015308). (Source: Diabetology International)
Source: Diabetology International - September 28, 2018 Category: Endocrinology Source Type: research

Development and validity testing of the revised diabetes self-care inventory for children and adolescents
AbstractRecently, self-care in children and adolescents with type 1 diabetes has changed with regard to both adherence to treatment and self-management. Only one diabetes self-care scale for children and adolescents is used in Japan which lacks reflection on flexible regimens. The aims of this study were to modify and subsequently test the validity of the revised diabetes self-care inventory (R-DSCI) for children and adolescents, and to construct the diabetes self-care model on the R-DSCI, HbA1c, duration of diabetes and age. Based on qualitative secondary analysis of the self-care framework for teenagers and a literature ...
Source: Diabetology International - September 28, 2018 Category: Endocrinology Source Type: research