Mortality in childhood-onset type 1 diabetes mellitus with onset between 1959 and 1996: A population-based study in Hokkaido, Japan
ConclusionsThis cohort study revealed a decrease in the mortality rate between 1959 —1979 and 1990—1996 in patients with childhood-onset type 1 diabetes in Japan. Patients with onset after puberty had a higher mortality rate than those with onset before puberty. (Source: Diabetology International)
Source: Diabetology International - January 24, 2024 Category: Endocrinology Source Type: research
Associations of ALT/AST, a marker of hepatosteatosis, with pulse rate in young women and with blood pressure in middle-aged women independently of abdominal fat accumulation and insulin resistance
In conclusion, ALT/AST was assoc iated with pulse rate in young women and with systolic BP in middle-aged women independently of abdominal fat accumulation and insulin resistance. It is noted that their waist circumference averaged < 80 cm and ALT < 30 U/L, suggesting minimum accumulation of abdominal and hepatic fat, respectively, key drivers of insulin resistance and metabolic syndrome. (Source: Diabetology International)
Source: Diabetology International - January 24, 2024 Category: Endocrinology Source Type: research
Effects of simultaneous pancreas and kidney transplantation in Japanese individuals with type 1 diabetes and end-stage kidney disease
AbstractThis single-center observational cohort study aimed to assess the potential benefits of simultaneous pancreas and kidney transplantation (SPK) in terms of mortality and kidney graft outcomes in Japanese individuals with type 1 diabetes (T1D) and end-stage kidney disease (ESKD). We first compared all-cause mortality rates between 78 SPK recipients and 108 non-transplanted individuals with T1D and ESKD. To mitigate the bias stemming from immortal time before receiving SPK, we utilized Cox regression models treating SPK as a time-dependent covariate. Next, we compared all-cause mortality rates and kidney graft loss ra...
Source: Diabetology International - January 24, 2024 Category: Endocrinology Source Type: research
Predictive patterns of lower urinary tract symptoms and bacteriuria in adults with type 2 diabetes
ConclusionThis study ’s random forest model highlighted distinct essential predictors for each urological condition. The predictors were consistent before and after SGLT2i became commercially available. (Source: Diabetology International)
Source: Diabetology International - January 23, 2024 Category: Endocrinology Source Type: research
Impacts of “Diabetes Theater,” a participative educational workshop for health care professionals, on participants: a patient empowerment perspective
DiscussionDiabetes Theater appears to be a useful method for healthcare professionals to accurately understand the philosophy of patient empowerment in diabetes. (Source: Diabetology International)
Source: Diabetology International - January 23, 2024 Category: Endocrinology Source Type: research
Acknowledgement to the Reviewers
(Source: Diabetology International)
Source: Diabetology International - January 12, 2024 Category: Endocrinology Source Type: research
Prevalence and characteristics of diabetic symmetric sensorimotor polyneuropathy in Japanese patients with type 2 diabetes: the Japan Diabetes Complication and its Prevention Prospective study (JDCP study 10)
ConclusionsThe baseline survey clarified the prevalence and characteristics of DSPN in Japanese patients with type 2 diabetes. The survey also revealed the risk factors of DSPN. (Source: Diabetology International)
Source: Diabetology International - January 12, 2024 Category: Endocrinology Source Type: research
Third Report of the Japan Diabetes Society (JDS)/Japanese Cancer Association (JCA) Joint Committee on diabetes and cancer: summary of the results of a questionnaire survey of oncologists and diabetologists —secondary publication
AbstractThe Japan Diabetes Society (JDS) and the Japan Cancer Association (JCA) launched a joint committee and published their “First Joint Committee Report on Diabetes and Cancer” in 2013, compiling recommendations for physicians and healthcare providers as well as for the general population. In 2016, the “Second Joint Committee Report on Diabetes and Cancer” summarized the current evidence on glycemic control and cancer risk in patients with diabetes. The current “Third Joint Committee Report on Diabetes and Cancer”, for which the joint committee also enlisted the assistance of the Japanese Society of Clinica...
Source: Diabetology International - January 8, 2024 Category: Endocrinology Source Type: research
Glycemic control and dementia risk in patients aged above and below 75 years
ConclusionThe achieved glycemic level with the lowest risk for dementia and mortality was lower in older patients, and absolute risk increase related to poorly controlled glucose was greater in the elderly compared with younger patients. (Source: Diabetology International)
Source: Diabetology International - January 8, 2024 Category: Endocrinology Source Type: research
Effectiveness of insulin degludec/liraglutide versus insulin degludec/insulin aspart in Japanese patients with type 2 diabetes
ConclusionsOnce-daily IDegLira had greater effects on HbA1c and a lesser increase in insulin doses than IDegAsp when patients are switched from basal insulin therapy. Moreover, the effect on HbA1c was enhanced in patients with high HbA1c levels at baseline. (Source: Diabetology International)
Source: Diabetology International - January 8, 2024 Category: Endocrinology Source Type: research
New diagnostic criteria (2023) for slowly progressive type 1 diabetes (SPIDDM): Report from Committee on Type 1 Diabetes in Japan Diabetes Society (English version)
AbstractThe diagnostic criteria for slowly progressive type 1 diabetes (slowly progressive insulin-dependent diabetes mellitus; SPIDDM) have been revised by the Committee on Type 1 Diabetes of the Japan Diabetes Society. All of the following three criteria must be met for “a definitive diagnosis of SPIDDM”: (1) presence of anti-islet autoantibodies at some point in time during the disease course; (2) absence of ketosis or ketoacidosis at the diagnosis of diabetes with no requirement of insulin treatment to correct hyperglycemia immediately after diagnosis in prin ciple; and (3) gradual decrease of insulin secretion ove...
Source: Diabetology International - January 8, 2024 Category: Endocrinology Source Type: research
Two patients with α-chain hemoglobin variant Hb Q-Iran detected by measuring hemoglobin A1c using the variant mode of the HA-8180V HPLC analyzer
AbstractHemoglobin variants are often discovered when hemoglobin A1c (HbA1c) levels measured with a high-performance liquid chromatography (HPLC) system in fast mode are found to be low. The HA-8180V HPLC analyzer by Arkray offers two measurement modes: fast mode (FM) and variant mode (VM). Two Japanese patients with α-chain variant Hb Q-Iran detected incidentally after analyses with the HA-8180V in VM showed an abnormal peak, are presented. The first patient was a man in his 70 s, and the second patient was a man in his 50 s. Both were non-diabetic, but their results from HbA1c measurement in VM showed an ab normal pea...
Source: Diabetology International - January 6, 2024 Category: Endocrinology Source Type: research
Biomarkers and signaling pathways of diabetic nephropathy and peripheral neuropathy: possible therapeutic intervention of rutin and quercetin
AbstractDiabetic nephropathy and peripheral neuropathy are the two main complications of chronic diabetes that contribute to high morbidity and mortality. These conditions are characterized by the dysregulation of multiple molecular signaling pathways and the presence of specific biomarkers such as inflammatory cytokines, indicators of oxidative stress, and components of the renin –angiotensin system. In this review, we systematically collected and collated the relevant information from MEDLINE, EMBASE, ELSEVIER, PUBMED, GOOGLE, WEB OF SCIENCE, and SCOPUS databases. This review was conceived with primary objective of rev...
Source: Diabetology International - December 19, 2023 Category: Endocrinology Source Type: research
Adipose Tissue Plasticity and Insulin Signaling in the Pathogenesis of Type 2 Diabetes
AbstractObesity is a major cause of various metabolic disorders, including type 2 diabetes, nonalcoholic fatty liver disease (NAFLD) and cardiovascular diseases, in modern times. Fat tissue originally evolved as an organ to prepare for food shortages. However, when individuals consume excessive calories and engage in insufficient physical activity, it can lead to the excessive accumulation of lipids in white adipose tissue, potentially causing problems. In response to this excessive lipid accumulation extending to other tissues, insulin resistance is triggered in the body as a physiological response to prevent harmful effe...
Source: Diabetology International - December 18, 2023 Category: Endocrinology Source Type: research
Exploring mechanisms underlying diabetes comorbidities and strategies to prevent vascular complications
AbstractIt is important to prevent not only diabetic complications but also diabetic comorbidities in diabetes care. We have elucidated multifaceted insulin action in various tissues mainly by means of model mice, and it was revealed that insulin regulates endoplasmic reticulum (ER) stress response during feeding, whereas ER stress ‘response failure’ contributes to the development of steatohepatitis, one of the major diabetic comorbidities. Insulin regulates gluconeogenesis not only in the liver but also in the proximal tubules of the kidney, which is also suppressed by reabsorbed glucose in the latter. In skeletal mus...
Source: Diabetology International - December 18, 2023 Category: Endocrinology Source Type: research
