Efficacy of dulaglutide after switching from incretin-related drugs in patients with type 2 diabetes and inadequate glycemic control
ConclusionsDulaglutide is considered effective in patients with type 2 diabetes and inadequate glycemic control, regardless of whether their pretreatment includes daily GLP-1 RA treatment. (Source: Diabetology International)
Source: Diabetology International - April 29, 2021 Category: Endocrinology Source Type: research
A randomized controlled trial of a structured program combining aerobic and resistance exercise for adults with type 2 diabetes in Japan
ConclusionsA structured, supervised, aerobic and resistance exercise program improved HbA1c and was well accepted among patients with T2DM. (Source: Diabetology International)
Source: Diabetology International - April 28, 2021 Category: Endocrinology Source Type: research
Glycemic control status, diabetes management patterns, and clinical characteristics of adults with type 1 diabetes in Japan: Study of Adults ’ Glycemia in T1DM subanalysis
ConclusionGlycemic control was suboptimal; the low incidence of severe hypoglycemia suggests careful glycemic control, balancing benefits and risks, particularly in Japanese adults aged ≥ 65 years with type 1 diabetes. (Source: Diabetology International)
Source: Diabetology International - April 25, 2021 Category: Endocrinology Source Type: research
Study on the effects of changes in lifestyle of patients with diabetes on glycaemic control before and after the declaration of the state of emergency in Japan
ConclusionIn the absence of serious economic stagnation or completely disrupted distribution, patients are allowed time to do what they like and can probably improve their glycaemic control status if they see this time as an opportunity. (Source: Diabetology International)
Source: Diabetology International - April 20, 2021 Category: Endocrinology Source Type: research
The effect of COVID-19 pandemic on the lifestyle and glycemic control in patients with type 1 diabetes: a retrospective cohort study
ConclusionsMany patients experienced stress and exercised less due to the COVID-19 pandemic. Glycemic control in patients with T1D was worse than that in the previous year. Since the pandemic is currently ongoing, more attention should be paid to stress and lifestyle factor management in patients with T1D. (Source: Diabetology International)
Source: Diabetology International - April 19, 2021 Category: Endocrinology Source Type: research
Unilateral adrenalectomy partially improved hyperglycemia in a patient with primary bilateral macronodular adrenal hyperplasia
AbstractPrimary bilateral macronodular adrenal hyperplasia (PBMAH) is characterized by bilateral multiple adrenal macro-nodules that often cause mild over-secretion of cortisol in the form of subclinical Cushing ’s syndrome. We herein describe a case, wherein unilateral adrenalectomy partially improved hyperglycemia in a patient with PBMAH and suggest the usefulness and limitations of this surgical strategy. A 64-year-old woman with type 2 diabetes had an incidental diagnosis of bilateral adrenal lesions. She had a family history of type 2 diabetes, and her HbA1c level was 8.9% under insulin therapy. She did not present ...
Source: Diabetology International - April 10, 2021 Category: Endocrinology Source Type: research
Real-world evidence for long-term safety and effectiveness of ipragliflozin in treatment-na ïve versus non-naïve Japanese patients with type 2 diabetes mellitus: subgroup analysis of a 3-year post-marketing surveillance study (STELLA-LONG TERM)
ConclusionsOver 3 years, ipragliflozin was better tolerated in treatment-naive than in non-naive Japanese patients with T2DM and had similar efficacy in these populations. Therefore, ipragliflozin is a useful first-line treatment option for patients with T2DM.Clinical trial registrationClinicalTrials.gov: NCT02479399. (Source: Diabetology International)
Source: Diabetology International - March 24, 2021 Category: Endocrinology Source Type: research
Diabetes-related acute metabolic emergencies in COVID-19 patients: a systematic review and meta-analysis
ConclusionAcute diabetes-related metabolic emergencies in COVID-19 patients lead to increased mortality; key determinants are critical COVID-19 illness, coexistence of DKA/HHS and AKI. Previous SGLT-2i treatment, though associated with EDKA, might preserve renal function in COVID-19 patients. (Source: Diabetology International)
Source: Diabetology International - March 23, 2021 Category: Endocrinology Source Type: research
Type 1 diabetes woman with repeated miscarriages successfully gave birth after introducing an insulin pump with a predictive low glucose suspend feature
AbstractSensor-augmented insulin pump therapy with a predictive low glucose suspend (SAP-PLGS) feature is a remarkably progressed modality for the glycemic management of patients with type 1 diabetes. This technology avoids nocturnal hypoglycemia and severe hypoglycemia. A Brazilian woman developed type 1 diabetes at age 11 and was treated with multiple daily insulin injections. At age 20, she was admitted to our internal medicine department for her first pregnancy. Her HbA1c was 7.9% in the 6 weeks of gestation. Although the combination of continuous subcutaneous insulin infusion and a sensor-augmented pump was introduc...
Source: Diabetology International - March 6, 2021 Category: Endocrinology Source Type: research
Understanding the quality of diabetes care in Japan: a systematic review of the literature
ConclusionDespite the improvement in diabetes related process measures, there is limited data on clinical measures. It is necessary to shed more light on the assessment of the quality of diabetes care. (Source: Diabetology International)
Source: Diabetology International - March 1, 2021 Category: Endocrinology Source Type: research
Clinical features resembling subcutaneous insulin resistance observed in a patient with type 2 diabetes and severe COVID-19-associated pneumonia: a case report
We report the case of a 52-year-old hyperglycemic woman with type 2 diabetes and severe coronavirus disease 2019 (COVID-19)-associated pneumonia, possibly involving the subcutaneous insulin resistance (SIR) syndrome. After admission for pneumonia, her average daily blood glucose (BG) levels remained at 300 –400 mg/dL, although the required dosage of subcutaneous insulin markedly increased (~ 150 units/day; ~ 2.63 units/kg/day). Furthermore, the patient had generalized edema along with hypoalbuminemia, developed extensive abdominal purpuras, and had increased plasma D-dimer levels during treat ment, suggestive of c...
Source: Diabetology International - March 1, 2021 Category: Endocrinology Source Type: research
Prevalence of obesity in prepubertal and pubertal with Turkish population type 1 diabetes
AbstractTo determine the prevalence of prepubertal and pubertal obesity in children and adolescents with type 1 Diabetes Mellitus (Type 1 DM). One hundred fifty children and adolescents aged 6 –18 years with Type 1 DM who attended the Pediatric Endocrinology Polyclinic and were diagnosed with type 1 DM were included in the study. Tanner staging was used to estimate pubertal status. Age- and gender-specific body mass index (BMI) percentile between 85 and 95% was accepted as overweight a nd > 95% as obese. It was determined that the overweight prevalence rates in children and adolescents with type 1 DM were 13.3%...
Source: Diabetology International - February 18, 2021 Category: Endocrinology Source Type: research
Increased nutrition-related risk as an independent predictor of the incidence of hypoglycemia in the hospitalized older individuals with type 2 diabetes: a single-center cohort study
ConclusionsHypoglycemia increased with increasing nutrition-related risk among older individuals with T2D using diabetes medication. The GNRI is a simple and useful assessment tool in the clinical setting. (Source: Diabetology International)
Source: Diabetology International - February 17, 2021 Category: Endocrinology Source Type: research
Sodium-glucose cotransporter 2 inhibitor canagliflozin attenuates lung cancer cell proliferation in vitro
In conclusion, SGLT2 is expressed in human lung cancer tissue and cell lines, and the SGLT2 inhibitor, canagliflozin, attenuated prolife ration of A549 lung cancer cells by inhibiting cell cycle progression in vitro but not in vivo. (Source: Diabetology International)
Source: Diabetology International - February 16, 2021 Category: Endocrinology Source Type: research
Associations of serum transthyretin with triglyceride in non-obese elderly Japanese women independently of insulin resistance, HDL cholesterol, and adiponectin
ConclusionsFasting and nonfasting TG showed positive association with TTR in community-dwelling elderly non-obese women independently of insulin resistance, HDL cholesterol, and adiponectin. These findings may provide a clue as to a physiological function of circulating TTR in human: an influence factor of TG-rich lipoproteins in the circulation. (Source: Diabetology International)
Source: Diabetology International - February 13, 2021 Category: Endocrinology Source Type: research
