Association of family history of type 2 diabetes with blood pressure and resting heart rate in young normal weight Japanese women
ConclusionsFHD was associated with higher BP and higher prevalence of elevated BP and hypertension, suggesting contribution of microvascular dysfunction in BP elevations in normal weight young Japanese women. FHD may be associated with reduced heart rate response to endurance training as well. (Source: Diabetology International)
Source: Diabetology International - July 23, 2021 Category: Endocrinology Source Type: research
Cut-off values and clinical efficacy of body roundness index and other novel anthropometric indices in identifying metabolic syndrome and its components among Southern-Indian adults
ConclusionsThe optimal cut-off and AUC values attained for BRI, CI, AVI, and WTI have a clinical approach in identifying MetS and its components. The efficacy of these indices to identify MetS differed by gender. (Source: Diabetology International)
Source: Diabetology International - July 18, 2021 Category: Endocrinology Source Type: research
Electrolyzed hydrogen-rich water for oxidative stress suppression and improvement of insulin resistance: a multicenter prospective double-blind randomized control trial
ConclusionThere were no significant effect of EHW in the change in HOMA-IR in this study; larger-scale and longer-term study are needed to verify the effects of EHW in T2DM patients. (Source: Diabetology International)
Source: Diabetology International - July 18, 2021 Category: Endocrinology Source Type: research
Patient characteristics associated with improvement in glycemic control following addition of an oral antidiabetic drug to DPP-4 inhibitor monotherapy in Japanese patients with type 2 diabetes mellitus (JDDM 60)
ConclusionThe majority of Japanese T2DM patients on sitagliptin monotherapy who require an add-on OAD utilized BG or SU. There were 2 determinants of glycemic response: baseline HbA1c with BG and SU and gender with SU during add-on OAD therapy. (Source: Diabetology International)
Source: Diabetology International - July 15, 2021 Category: Endocrinology Source Type: research
Cross sectional study on proportion of sulfonylureas among various oral antidiabetic drugs using for Japanese patients with type 2 diabetes, analyzed from NSAID Study-2
ConclusionThe results of this study clearly demonstrated that, among the OADs, sulfonylureas were not frequently used in monotherapy, although the opportunity of using sulfonylurea increased with the number of OADs prescribed in combination therapies by both GPs and SPs in Japan. Moreover, low-dose glimepiride was the most-prescribed sulfonylurea for Japanese T2DM patients, especially for those who were lean and had higher HbA1c levels. (Source: Diabetology International)
Source: Diabetology International - July 11, 2021 Category: Endocrinology Source Type: research
A cross-sectional study of the correlation between diabetic therapy and serum zinc concentrations
ConclusionsOral administration of metformin in the elderly with diabetes and non-progressive renal dysfunction was not associated with hypozincemia, even at high doses. (Source: Diabetology International)
Source: Diabetology International - July 10, 2021 Category: Endocrinology Source Type: research
The forgotten type 2 diabetes mellitus medicine: rosiglitazone
AbstractType 2 diabetes mellitus (T2DM) is a chronic disease prevalent in the world, and it is also one of the overall factors leading to overall morbidity and mortality. Throughout Asia, the proportion of people with T2DM and obesity has increased and this growth rate shows no signs of slowing down. Thiazolidinediones (TZDs) can specifically treat insulin resistance and improve metabolic syndrome, including rosiglitazone, troglitazone and pioglitazone, which are peroxisome proliferator-activated receptor (PPAR) agonists. These drugs have been shown to have better therapeutic effect and glycemic control, but also accompani...
Source: Diabetology International - June 29, 2021 Category: Endocrinology Source Type: research
Variables associated with adherence to the treatment of type 2 diabetes mellitus among elderly people
ConclusionLow treatment adherence was found to be important and it was also possible to know the variables influencing this process. Strategies aimed at improving adherence to medical treatment should be a priority in the family healthcare units for the control of diabetes. (Source: Diabetology International)
Source: Diabetology International - June 17, 2021 Category: Endocrinology Source Type: research
Sodium-glucose cotransporter inhibitors may reduce the risk of pneumonia: an updated meta-analysis of cardiovascular outcome trials
AbstractThe present meta-analysis included 8 cardiovascular outcome trials with 57,185 patients at high cardiometabolic risk. In comparison with placebo, treatment with sodium-glucose cotransporter inhibitors was associated with a significantly lower risk of pneumonia (RR 0.85, 95% CI 0.76 –0.95,p = 0.004;I2 = 0,p = 0.48). (Source: Diabetology International)
Source: Diabetology International - June 6, 2021 Category: Endocrinology Source Type: research
Dipeptidyl peptidase-4 inhibitor improves glycemic variability in multiple daily insulin-treated type 2 diabetes: a prospective randomized-controlled trial
ConclusionThe GV metrics regarding daily and nocturnal hypoglycemia were not significantly different between LMET + DPP4i treatment and HMET treatment. LMET + DPP4i treatment decreased GV associated with hyperglycemia. Adding DPP-4-inhibitor to the lower dose of metformin is an alternative approach to the stable GV in MDI compared to additional high-dose metformin. National Clinical Trial registration in Japan, number is JPRN-UMIN000024663. (Source: Diabetology International)
Source: Diabetology International - June 5, 2021 Category: Endocrinology Source Type: research
Changes in subjective sleep quality in patients with type 2 diabetes who did not use Sleep agents: a cross-sectional study according to age and clinical background
ConclusionYounger T2DM patients had poorer sleep quality and higher BMI. Our findings suggest that insomnia should be accounted for as a potential comorbidity when examining or treating patients with T2DM and obesity even in the younger population. (Source: Diabetology International)
Source: Diabetology International - June 2, 2021 Category: Endocrinology Source Type: research
Two-year administration of sodium-glucose co-transporter 2 inhibitor brought about marked reduction of body fat independent of skeletal muscle amount or glycemic improvement in Japanese patients with type 2 diabetes
ConclusionSGLT2i can effectively reduce body weight and body fat mass independent of the blood glucose improvement or the renal function. Under the periodical instruction for nutrition and exercise this oral hypoglycemic agent can be safely administered for a long term without a risk for sarcopenia. (Source: Diabetology International)
Source: Diabetology International - May 21, 2021 Category: Endocrinology Source Type: research
Prevalence and predictors of atrial fibrillation in Japanese patients with type 2 diabetes
ConclusionHigher prevalence of AF was observed in Japanese patients with type 2 diabetes than the general population. Advanced age, male sex, and hypertension were independent predictive factors for AF. (Source: Diabetology International)
Source: Diabetology International - May 16, 2021 Category: Endocrinology Source Type: research
Evaluation of perceived fears of COVID-19 virus infection and its relationship to health-related quality of life among patients with diabetes mellitus in Egypt during pandemic: a developing country single-center study
ConclusionQoL, either physical or mental, was adversely affected among patients with DM during pandemic. FCV was negatively correlated with all QOL domains. Longitudinal studies are warranted to explore the long-term effect of pandemic on the physical and mental well-being of patients with DM. (Source: Diabetology International)
Source: Diabetology International - May 12, 2021 Category: Endocrinology Source Type: research
Hypoglycemic coma in an elderly adult switched from twice-daily vildagliptin to once-daily glimepiride to improve drug adherence
ConclusionsIt is important to note that anti-diabetes drugs should be carefully selected based on each patient ’s cognitive function and ADL, and that the reasoning should be shared with the general practitioners involved to avoid severe hypoglycemic events. (Source: Diabetology International)
Source: Diabetology International - May 5, 2021 Category: Endocrinology Source Type: research
