Diagnosis, prevention, and treatment of cardiovascular diseases in people with type 2 diabetes and prediabetes: a consensus statement jointly from the Japanese Circulation Society and the Japan Diabetes Society
(Source: Diabetology International)
Source: Diabetology International - November 30, 2020 Category: Endocrinology Source Type: research
Safety and effectiveness of ipragliflozin in Japanese patients with type 2 diabetes mellitus and impaired renal function: subgroup analysis of a 3-year post-marketing surveillance study (STELLA-LONG TERM)
In conclusion, there were no new or unexpected safety findings in Japanese patients treated with ipragliflozin for T2DM, and long-term sustained improvements in HbA1c and bodyweight were observed regardless of the presence of renal impairment. (Source: Diabetology International)
Source: Diabetology International - November 23, 2020 Category: Endocrinology Source Type: research
A study of serum growth differentiation factor 15 in Indian women with and without gestational diabetes mellitus in the third trimester of pregnancy and its association with pro-inflammatory markers and glucose metabolism
In conclusion, our study provides evidence that, in Indian women, serum GDF-15 level is higher in GDM in c omparison to age-matched pregnant subjects without GDM in the early third trimester pregnancy. Moreover, in third trimester, GDF-15 level increases with increase in plasma glucose and insulin resistance. (Source: Diabetology International)
Source: Diabetology International - November 21, 2020 Category: Endocrinology Source Type: research
Comparative effects of insulin glulisine and lispro on postprandial plasma glucose and lipid profile in Japanese patients with type 2 diabetes mellitus
ConclusionInsulin lispro seems superior to glulisine in the control of PPG in Japanese patients with T2DM. (Source: Diabetology International)
Source: Diabetology International - November 17, 2020 Category: Endocrinology Source Type: research
The diabetes quality of life brief clinical inventory in combination with the management strategies in type 1 diabetes mellitus with or without the use of insulin pump
ConclusionDiabetes self-management education plays a key role to a better compliance with the treatment. Client-centered multidisciplinary centers in T1DM education are essential so that they be applicable for all T1DM patients irrespective of the type of insulin delivery they used. (Source: Diabetology International)
Source: Diabetology International - November 16, 2020 Category: Endocrinology Source Type: research
Protective effect of pregabalin on the brain tissue of diabetic rats
ConclusionPregabalin may prevent harmful effects of oxidative damage by decreasing the MDA levels and increasing the SOD levels. In addition, it was thought that PGB may have antiapoptotic properties due to decreased bax and caspase-3 immunoreactivity and TUNEL positivity in PGB groups. Based on these findings, we think that PGB may be effective in reducing the risk of brain damage associated with DM. (Source: Diabetology International)
Source: Diabetology International - November 16, 2020 Category: Endocrinology Source Type: research
Analysis of time-dependent alterations of parameters related to erythrocytes after ipragliflozin initiation
AbstractSodium-glucose cotransporter 2 (SGLT2) inhibitors often increase the hematocrit. It remains unclear whether this increase would be observed in all patients administered SGLT2 inhibitors, however. We therefore used the data from the previous study and investigated time-dependent alterations of various outcomes related to erythrocytes, erythropoiesis, and clinical outcome in type 2 diabetes subjects (n = 89) treated with ipragliflozin for 16 weeks. Among a total of 89 participants, 71 subjects (80.0% of total participants) showed the elevation of the hematocrit and 18 subjects (20.0% of total participants) did n...
Source: Diabetology International - November 10, 2020 Category: Endocrinology Source Type: research
Remogliflozin: the new low cost SGLT-2 inhibitor for type 2 diabetes mellitus
AbstractSGLT-2 inhibitors have recently emerged as an important class of oral drugs for treatment of type 2 diabetes mellitus, especially in patients with cardiovascular or renal impairment, recommended in all recent treatment guidelines. They have additional advantages of weight and blood pressure reduction but also pose problems like genitourinary infections. These drugs generally have a high cost making affordability a major consideration in their prescription in developing countries like India. A new molecule remogliflozin has been approved in India in 2019 after a phase 3 trial proved its efficacy and safety in compar...
Source: Diabetology International - October 29, 2020 Category: Endocrinology Source Type: research
COVID-19-associated euglycemic diabetic ketoacidosis in a patient with type 2 diabetes on SGLT2 inhibitor: a case report
In this report, we describe a case of a 56-year-old patient who presented an elevated anion gap metabolic acidosis during a SARS-CoV-2 infection and was diagnosed with SGLT2-associated euglycemic diabetic ketoacidosis. COVID-19 may increase patients ’ insulin demand, present gastrointestinal symptoms, and increase the production of ketone bodies. This situation can be worsened in susceptible diabetic patients on SLGT2 inhibitors, due to the persistent glycosuria, which can cause volume depletion. Recently some authors recommended that insulin -deficient patients or those using SGLT2 inhibitors should monitor for ketosis ...
Source: Diabetology International - October 28, 2020 Category: Endocrinology Source Type: research
A large-scale observational study to investigate the current status of diabetic complications and their prevention in Japan (JDCP study 6): baseline dental and oral findings
In conclusion, patients with diabetes were found to be at high risk of tooth loss, and the poorer the glycemic control, the higher the risk of tooth loss in these patients. (Source: Diabetology International)
Source: Diabetology International - October 15, 2020 Category: Endocrinology Source Type: research
Behavioral changes in patients with diabetes during the COVID-19 pandemic
ConclusionDuring the state of emergency period, decreased physical activity levels negatively affected glycemic control. However, despite changes in physical activity level, maintaining or improving dietary habits could lead to better glycemic control in diabetes patients. During this COVID-19 pandemic, more diabetes patients are likely to shift to teleworking and stay home for longer periods. Therefore, we should develop effective and feasible measures to promote exercise and dietary therapy, especially for those who engage in teleworking. (Source: Diabetology International)
Source: Diabetology International - September 29, 2020 Category: Endocrinology Source Type: research
Fulminant type 1 diabetes: nationwide effort to elucidate genetics, etiology, and pathogenesis since 2000
(Source: Diabetology International)
Source: Diabetology International - September 28, 2020 Category: Endocrinology Source Type: research
Genetics of fulminant type 1 diabetes
AbstractSince fulminant type 1 diabetes was reported as a distinct subtype of type 1 diabetes in 2000, the Committee on Type 1 diabetes, Japan Diabetes Society has continuously recruited patients and conducted genomic research to elucidate the genetic basis of fulminant type 1 diabetes. The contribution of the human leukocyte antigen complex (HLA) to genetic susceptibility to fulminant type 1 diabetes was compared with that of other subtypes in 2009. The alleles and haplotypes associated with fulminant type 1 diabetes were found to be different from acute-onset and slowly progressive type 1 diabetes.DRB1*15:01-DQB1*06:02, ...
Source: Diabetology International - September 20, 2020 Category: Endocrinology Source Type: research
Fulminant type 1 diabetes: recent research progress and future prospects
AbstractTo clarify the clinical and etiological characteristics of fulminant type 1 diabetes, we reviewed data from patients who had developed type 1 diabetes following anti-programmed cell death 1/programmed cell death ligand 1 (anti-PD-1/PD-L1) therapy, and research on pancreatic beta cells derived from induced pluripotent stem (iPS) cells from patients with fulminant type 1 diabetes. As determined from the disease classifications and clinical and genetic characteristics, anti-PD-1/PD-L1 therapy-related type 1 diabetes includes both fulminant type 1 diabetes and acute-onset type 1 diabetes. Using insulin-positive cells d...
Source: Diabetology International - September 15, 2020 Category: Endocrinology Source Type: research
High glucose promotes mineralization via bone morphogenetic protein 4-Smad signals in early stage of osteoblast differentiation
In conclusion, the study demonstrates that continuous HG treatment might enhance early osteoblast differentiation but d isturbs osteoblast maturation, and that BMP-4-Smad signal might be involved in the HG-induced differentiation and mineralization of osteoblasts. (Source: Diabetology International)
Source: Diabetology International - August 29, 2020 Category: Endocrinology Source Type: research
