A sensor augmented pump may improve awareness of hypoglycemia and quality of life in Japanese patients with type 1 diabetes mellitus
ConclusionSAP therapy was associated with improvement of glycemic control, mainly by reducing hyperglycemia, and patients ’ satisfaction with treatment. (Source: Diabetology International)
Source: Diabetology International - September 2, 2021 Category: Endocrinology Source Type: research
Formation of large abscess tumor including gallstone in ileum during therapy for hyperosmolar hyperglycemic syndrome: a case report
AbstractHyperosmolar hyperglycemic status (HHS) is one of the most serious acute metabolic complications of diabetes mellitus (DM) and the patients with type 2 DM are immunocompromised host, especially when glycemic control is poor. Under hyperglycemic conditions, we have to pay much attention even for rare infection. Bouveret ’s syndrome is a rare type of gallstone ileus together with duodenal obstruction secondary to the passage of a stone through a cholecystoduodenal fistula. Herein, we reported a rare case with formation of large abscess tumor, including necrotic ileum and gallstone after taking therapy for HHS. She ...
Source: Diabetology International - August 31, 2021 Category: Endocrinology Source Type: research
Glycemic control and number of natural teeth: analysis of cross-sectional Japanese employment-based dental insurance claims and medical check-up data
ConclusionsGlycemic control is strongly associated with the number of natural teeth in the real-world setting. Furthermore, there are continuous relationships of HbA1c and FPG with number of natural teeth including individual with impaired fasting glucose. These data emphasize the importance of glycemic control and appropriate oral care for the protection against tooth loss. (Source: Diabetology International)
Source: Diabetology International - August 28, 2021 Category: Endocrinology Source Type: research
Acute esophageal necrosis complicating diabetic ketoacidosis in a patient with type II diabetes mellitus and excessive cola consumption: a case report
In conclusion, clinicians should not disregard AEN in the differential diagnosis of patients with DKA and clinical symptoms of esophagitis. (Source: Diabetology International)
Source: Diabetology International - August 27, 2021 Category: Endocrinology Source Type: research
Tailored notification encouraging examinees with abnormal glucose levels in health checkups to seek medical care
AbstractThe aims of this study were to generate a written notification message using social marketing methods to encourage examinees with abnormal glucose levels to seek medical care and to evaluate the optimized message. A semi-structured interview was conducted among examinees with abnormal glucose levels who had never visited a medical clinic for diagnosis of hyperglycemia. Patients were divided into two segments. A tailored notification letter was developed according to these segments using a social marketing approach. Other examinees were prospectively enrolled as the control group. The tailored notification for Segme...
Source: Diabetology International - August 26, 2021 Category: Endocrinology Source Type: research
Exploring regulatory network of metabolism through liver research
AbstractIn recent years, the techniques in molecular biology have been dramatically advanced, and consequently the landscape of metabolism research has undergone a remarkable change. One of the emerging pictures as the fruits of these advancements is one depicting the regulation of systemic metabolism through inter-organ networks involving multiple tissues, either via humoral factors, which are secreted from one tissue and conveyed to their remote target tissues, or through neuronal networks which are integrated by the central nervous system. In addition, the progress in high-throughput research tools enabled detailed char...
Source: Diabetology International - August 26, 2021 Category: Endocrinology Source Type: research
Non-autoimmune acute-onset type 1 diabetes mellitus newly developed in an elderly patient presenting elevation of serum pancreatic exocrine enzymes
AbstractAn 82 year-old female patient not suffering from diabetes was transported to our hospital with hyperglycemia (HbA1c 8.2%, blood glucose 584 mg/dL) and mildly increased levels of pancreatic exocrine enzymes (amylase 543 IU/L, lipase 59 U/L, elastase-1 479 ng/dL), while there were no findings indicati ng pancreatitis. Under a diagnosis of new-onset diabetes, she was discharged with oral hypoglycemic agents, as retention of insulin secretion function [blood glucose 117 mg/dL, serum connecting peptide immunoreactivity (CPR) 1.63 ng/mL] with normalization of the enzymes was confirmed following adm inistration. H...
Source: Diabetology International - August 26, 2021 Category: Endocrinology Source Type: research
Work-related factors related to forgetting to take oral diabetes medication during the working day among Japanese male employees with diabetes
ConclusionsOur findings suggest that irregular meal times and skipping meals during the working day are important factors related to forgetting to take oral diabetes medication during the working day among Japanese male employees with diabetes. (Source: Diabetology International)
Source: Diabetology International - August 21, 2021 Category: Endocrinology Source Type: research
Glycated albumin (GA) and the GA/HbA1c ratio are higher in diabetic patients positive for insulin antibodies with high binding capacity and low affinity
AbstractPatients with diabetes mellitus having insulin antibodies (InsAb) with properties of high binding capacity and low affinity, which are observed in insulin autoimmune syndrome (IAS), are known to have greater plasma glucose fluctuations. Glycated albumin (GA) and the GA/HbA1c ratio have been demonstrated to reflect plasma glucose fluctuations. Hence, we hypothesized that GA or the GA/HbA1c ratio in diabetic patients having InsAb with properties of high binding capacity and low affinity may be higher than those in InsAb-negative diabetic patients, and we verified this hypothesis. Subjects were 12 diabetic patients wh...
Source: Diabetology International - August 18, 2021 Category: Endocrinology Source Type: research
Translational research on human pancreatic β-cell mass expansion for the treatment of diabetes
AbstractThe structural, functional, and pathological differences between human islets and rodent islets, such as mouse or rat islets, have been clarified, and research using human islets is becoming more important for elucidating the pathophysiology of diabetes and developing therapeutic strategies for diabetes. Increasing the functional human β-cell mass is a feasible method for the treatment of both type 1 and type 2 diabetes. The glucokinase-mediated glucose signaling pathway is known to promote β-cell proliferation not only in rodent models but also in humans. However, little is known about the signaling components o...
Source: Diabetology International - August 17, 2021 Category: Endocrinology Source Type: research
A case of α-chain variant hemoglobin (Hb Chad) with falsely high HbA1c levels measured by immunoassay
AbstractVariant hemoglobin is often detected during the diagnosis and treatment of diabetes mellitus. We here describe a case of α2-chain variant hemoglobin (Hb Chad) that was identified as a result of differences in HbA1cs values determined by different assays. HbA1c measured by immunoassay was thus falsely high, whereas that measured by high-performance liquid chromatography (HPLC) was slightly low. Sequencing analysis rev ealed a heterozygous GAG (glutamic acid) → AAG (lysine) mutation at amino acid position 23 of the α2-globin gene. This residue is located at the surface of the α-chain in the crystal structure...
Source: Diabetology International - August 13, 2021 Category: Endocrinology Source Type: research
Association of a SNP in the IAPP gene and hyperglycemia on β-cell dysfunction in type 2 diabetes: the Toon Genome Study
ConclusionsThe possibility that the association betweenIAPP genotype and basal insulin level is modified by variation in plasma glucose, resulting in a decreased basal insulin in type 2 diabetes, cannot be excluded. (Source: Diabetology International)
Source: Diabetology International - August 12, 2021 Category: Endocrinology Source Type: research
Dupilumab-related type 1 diabetes in a patient with atopic dermatitis: a case report
AbstractDupilumab, a humanized monoclonal antibody that inhibits both interleukin (IL)-4 and IL-13 signals, is used as a treatment for a variety of allergic diseases including atopic dermatitis. We experienced a case of dupilumab-related type 1 diabetes in a patient with atopic dermatitis. An 18-year-old female presented with thirst and polydipsia seven months after initiating dupilumab therapy for atopic dermatitis and was found to have marked hyperglycemia with ketosis. She was positive for anti-glutamic acid decarboxylase antibody, leading to the diagnosis of type 1 diabetes. She carried human leukocyte antigen (HLA) ge...
Source: Diabetology International - August 10, 2021 Category: Endocrinology Source Type: research
Changes in glucagon secretion induced by food intake in fulminant type 1 diabetes mellitus: a case report
We examined his insulin and glucagon secretions induced by a liquid meal test at the onset of F T1DM and 1 year later. The results suggested severely attenuated insulin secretion and an undetectable level of serum insulin 1 year after onset. In contrast, glucagon secretion, which was highly impaired at onset, increased in response to food intake. Although previous reports have suggested that both β- and α-cells of pancreatic islets are damaged in patients with FT1DM, the number of α-cells may increase over time after the onset of FT1DM. (Source: Diabetology International)
Source: Diabetology International - August 6, 2021 Category: Endocrinology Source Type: research
Decline in the estimated glomerular filtration rate (eGFR) following metabolic control and its relationship with baseline eGFR in type 2 diabetes with microalbuminuria or macroalbuminuria
ConclusionsIn MI, even in maintained eGFR, the continued increase in eGFR in response to hyperglycemia (HbA1c ≧ 7.5%) led to a faster decline in renal function and in MA, lower eGFR, with an increase in proteinuria, contributed to rapid decline of renal function. (Source: Diabetology International)
Source: Diabetology International - July 29, 2021 Category: Endocrinology Source Type: research
