Changes in glucagon secretion induced by food intake in fulminant type 1 diabetes mellitus: a case report

We examined his insulin and glucagon secretions induced by a liquid meal test at the onset of F T1DM and 1 year later. The results suggested severely attenuated insulin secretion and an undetectable level of serum insulin 1 year after onset. In contrast, glucagon secretion, which was highly impaired at onset, increased in response to food intake. Although previous reports have suggested that both β- and α-cells of pancreatic islets are damaged in patients with FT1DM, the number of α-cells may increase over time after the onset of FT1DM.
Source: Diabetology International - Category: Endocrinology Source Type: research