Socio-economic inequalities in diabetes and prediabetes among Bangladeshi adults
This study used data from the latest Bangladesh Demographic and Health Survey (BDHS) 2017 –18, a nationally representative survey. A regression-based decomposition method was applied to assess the socioeconomic contributors to inequality. The prevalence of diabetes and prediabetes were about 10 and 15% among Bangladeshi adults, respectively. Both diabetes and prediabetes were significa ntly associated with age, wealth status, suffering from overweight or obesity and administrative divisions of the respondents (p < 0.001). Respondents’ household wealth status accounted for about 74 and 81% of the total inequalit...
Source: Diabetology International - October 25, 2021 Category: Endocrinology Source Type: research
Correction to: Glycemic control of people with diabetes over months after the 2018 North Osaka Earthquake
(Source: Diabetology International)
Source: Diabetology International - October 23, 2021 Category: Endocrinology Source Type: research
Effects of barley intake on glycemic control in Japanese patients with type 2 diabetes mellitus undergoing antidiabetic therapy: a prospective study
ConclusionBarley-mixed rice lowers postprandial glucose concentrations in treatment-naive and metformin-treated T2DM patients, and shows a trend in acarbose-treated patients. Therefore, using barley-containing diets as dietary therapy may be useful in improving glycemic control in diabetes patients.Trial registrationUMIN000028623. (Source: Diabetology International)
Source: Diabetology International - October 20, 2021 Category: Endocrinology Source Type: research
Correction to: Dietary obesity and glycemic excursions cause a parallel increase in STEAP4 and pro-inflammatory gene expression in murine PBMCs
(Source: Diabetology International)
Source: Diabetology International - October 17, 2021 Category: Endocrinology Source Type: research
Production of insulin antibody associated with relapsed hodgkin ’s lymphoma
AbstractA 72-year-old man with type 2 diabetes mellitus with good glucose control for 20 years and maintained on oral hypoglycaemic agents was diagnosed with Hodgkin’s Lymphoma (HL) and started on insulin glargine for glycaemic control. Despite increased doses of insulin, his blood glucose levels went up dramatically. The anti-insulin antibody test proved to be positive, and Scatcha rd plot analysis showed 2 binding sites with relatively low-affinity constants:K1 = 0.0032,K2 = 0.0002 (108/M); and high binding capacities:R1 = 98.4,R2 = 372 (10−8 M), which were compatible with the features of antibody ...
Source: Diabetology International - October 16, 2021 Category: Endocrinology Source Type: research
The epidemiology, clinical, biochemical, immunological and radiological features of youth onset type 2 diabetes mellitus in the state of Qatar
ConclusionObesity, maternal GDM and family history of diabetes were the key risk factors for the development of type 2 diabetes. Autoantibody positivity may be present in youth type 2 diabetes. As youth type 2 diabetes is associated with early onset microvascular and macrovascular complications, these findings have important social and health budget implications for Qatar. Tackling the burden of maternal GDM and childhood obesity and building programmes for early detection and intervention, are therefore, essential to reduce the risk of future complications. (Source: Diabetology International)
Source: Diabetology International - October 11, 2021 Category: Endocrinology Source Type: research
Laser treatment for lipoatrophy in children with diabetes type 1
ConclusionInsulin-induced LA is now a rare skin complication with no effective treatment up to now. Laser treatment seems to be an effective treatment option. (Source: Diabetology International)
Source: Diabetology International - October 3, 2021 Category: Endocrinology Source Type: research
Correction to: Non-autoimmune acute-onset type 1 diabetes mellitus newly developed in an elderly patient presenting elevation of serum pancreatic exocrine enzymes
(Source: Diabetology International)
Source: Diabetology International - September 30, 2021 Category: Endocrinology Source Type: research
Dietary obesity and glycemic excursions cause a parallel increase in STEAP4 and pro-inflammatory gene expression in murine PBMCs
ConclusionsSTEAP4 expression in mononuclear cells is induced by increasing inflammation or oxidative stress. The observed increase in STEAP4 expression in circulating monocytes due to visceral obesity or glycemic excursions is a compensatory response. (Source: Diabetology International)
Source: Diabetology International - September 26, 2021 Category: Endocrinology Source Type: research
Metformin action in the gut ―insight provided by [18F]FDG PET imaging
AbstractSuppression of hepatic gluconeogenesis is thought to largely underlie the antidiabetes action of metformin. However, this drug also exerts various effects on the gut, one of which is the enhancement of the uptake of18F-labeled fluorodeoxyglucose (FDG), a nonmetabolizable glucose derivative, during [18F]FDG positron emission tomography (PET) –computed tomography (CT). Whereas the relevance of this effect to the glucose-lowering action of metformin remains unclear, it is of special interest because it was discovered in humans. Cessation of metformin treatment for several days is required to normalize [18F]FDG uptak...
Source: Diabetology International - September 23, 2021 Category: Endocrinology Source Type: research
Birth weight was associated positively with gluteofemoral fat mass and inversely with 2-h postglucose insulin concentrations, a marker of insulin resistance, in young normal-weight Japanese women
ConclusionsBirth weight was associated positively with gluteofemoral fat mass and inversely with 2-h postglucose insulin concentrations, a marker of insulin resistance. (Source: Diabetology International)
Source: Diabetology International - September 16, 2021 Category: Endocrinology Source Type: research
Antidiabetic effects of hydroxychloroquine in two Japanese patients with systemic lupus erythematosus
We present herein the cases of two Japanese women with SLE and diabetes mellitus (DM) who were treated using HCQ and achieved reductions in glycosylated hemoglobin (HbA1c). A 48 year-old Japanese woman with SLE and DM (patient 1) received oral HCQ at 200 mg/day for the treatment of lupus nephritis. HbA1c levels decreased from 7.2–6.2% after 14 months of HCQ without any loss of body weight or alterations in doses of glucocorticoid or hypoglycemic agents. A 64 year-old Japanese woman with SLE and DM (patient 2) received oral HCQ at 200 mg and 400 mg on alternate days for the treatment of erythema. She also received ...
Source: Diabetology International - September 16, 2021 Category: Endocrinology Source Type: research
Explaining the obesity paradox in healthcare utilization among people with type 2 diabetes
ConclusionThe obesity paradox does not exist at the utilization level and is due to the presence of statistical biases such as confounding and reverse causation. Physicians should continue to focus on efforts to prevent obesity in patients with diabetes. (Source: Diabetology International)
Source: Diabetology International - September 7, 2021 Category: Endocrinology Source Type: research
Japanese Type 1 Diabetes Database Study (TIDE-J): rationale and study design
AbstractType 1 diabetes (T1D) is classified into three subtypes: acute-onset, slowly progressive, and fulminant T1D, according to the heterogeneity of clinical course in Japan. Although several cross-sectional databases of T1D have been reported, prospective longitudinal databases to investigate clinical outcomes are lacking in our country. Therefore, we herein construct multi-center prospective longitudinal database of the three subtypes of T1D, accompanied with genetic information and biobanking, which is named Japanese Type 1 Diabetes Database Study (TIDE-J). Inclusion criteria of this study are as follows: (1) the dura...
Source: Diabetology International - September 6, 2021 Category: Endocrinology Source Type: research
Vomiting and hyperkalemia are novel clues for emergency room diagnosis of type 1 diabetic ketoacidosis: a retrospective comparison between diabetes types
ConclusionsTo prevent DKA, it is important to provide social support for elderly patients with T1DM DKA and lifestyle intervention for younger T2DM or obese patients. Vomiting and serum potassium levels contribute to the classification of diabetes type and subsequent initial treatment in the emergency room. (Source: Diabetology International)
Source: Diabetology International - September 5, 2021 Category: Endocrinology Source Type: research
