Comprehensive efficacy of ipragliflozin on various conditioned type 2 diabetes compared with dipeptidyl peptidase-4 inhibitors and with both agents, based on a real-world multicenter trial
ConclusionsIpragliflozin is useful and safe, showing some contrastive effects on several clinical parameters which are not shown with DPP-4i, resulting several clinical benefits. The co-administration of ipragliflozin and a DPP-4i has a better clinical outcome than either single-agent therapy. (Source: Diabetology International)
Source: Diabetology International - February 11, 2021 Category: Endocrinology Source Type: research
Evaluation of multiple drug use in patients with type 2 diabetes mellitus
ConclusionThe total number of drugs used by the DM patients showed the presence of polypharmacy. Advanced age, long disease duration, female gender, and presence of comorbidities were predictive factors for polypharmacy in diabetic patients. Before starting additional medication for DM patients, it is necessary to pay attention to the interaction of the drugs to be used and to plan prescriptions considering the medications used by the patient continuously. (Source: Diabetology International)
Source: Diabetology International - February 7, 2021 Category: Endocrinology Source Type: research
Determinants of type 2 diabetes remission after bariatric surgery in obese Japanese patients: a retrospective cohort study
ConclusionPreoperative insulin secretion, improvement in insulin sensitivity, and weight reduction after BS are related to CR of type 2 diabetes after BS. The results better reveal the pathophysiology of and treatment for type 2 diabetes in obese patients who undergo BS. (Source: Diabetology International)
Source: Diabetology International - January 28, 2021 Category: Endocrinology Source Type: research
Correction to: Impact of actual waiting time and perceived waiting time on treatment satisfaction in patients receiving outpatient diabetes care
In the original publication of the article, in Tables 2 and 3,p values should be replaced with No. of patients. (Source: Diabetology International)
Source: Diabetology International - January 27, 2021 Category: Endocrinology Source Type: research
Association of glycemic control and anthropometric measurement among type 2 diabetes mellitus: a cross-sectional study
ConclusionNearly two-thirds of study participants had poor glycemic control. Increased waist circumference, long duration of DM, occupational status, and family history of DM were independently associated with poor glycemic control. Therefore, type 2 DM patients with these identified factors should be strictly monitored to maintain good glycemic control. (Source: Diabetology International)
Source: Diabetology International - January 25, 2021 Category: Endocrinology Source Type: research
“Fighting spirit”: specific personality traits as one of the key factors for sport championship in type 1 diabetes mellitus
AbstractThere is ample evidence that sport is a protective factor against a number of health risks, across all ages, in the general population. An in-depth understanding of energy metabolism has reasonably entailed exercise as a cornerstone in the lifestyle of almost all subjects with type 1 diabetes mellitus (T1DM). Nevertheless, individuals with T1DM often fail in accomplishing exercise guidelines and they are often less active than their peer without diabetes. Two major obstacles are feared: management of blood glucose control and hypoglycemia. Nowadays, strategies, including glucose monitoring technology and insulin pu...
Source: Diabetology International - January 13, 2021 Category: Endocrinology Source Type: research
Effects of short-term calorie restriction on circulating DPP-4/sCD26 concentrations and body composition in patients with type 2 diabetes
In conclusion, our observations suggest that liver enzymes as well as VFA might be associated with the response of DPP-4/sCD26 concentrations. (Source: Diabetology International)
Source: Diabetology International - January 3, 2021 Category: Endocrinology Source Type: research
Can fasting plasma glucose replace oral glucose-tolerance test for diagnosis of gestational diabetes mellitus?
ConclusionsPerforming only the FPG and considering FPG cutoffs 75 and 80 mg/dL at first prenatal visit and at 24–28th of gestational weeks can be a useful tool predicting the incidence of GDM, respectively, and had similar diagnostic power. (Source: Diabetology International)
Source: Diabetology International - January 2, 2021 Category: Endocrinology Source Type: research
Impact of actual waiting time and perceived waiting time on treatment satisfaction in patients receiving outpatient diabetes care
ConclusionsThese results suggest that in addition to reducing actual waiting times, shortening perceived waiting times by improving the responses of medical staff could help to increase patient satisfaction. (Source: Diabetology International)
Source: Diabetology International - January 2, 2021 Category: Endocrinology Source Type: research
Psychosocial conditions and the progression of diabetic nephropathy in Japanese with type 2 diabetes mellitus
AbstractWe previously reported the association of positive psychosocial conditions with diabetic nephropathy (DN) in patients with type 2 diabetes in a cross-sectional setting. In the present study, we evaluated the association between six indicators related to psychosocial conditions and the progression of DN assessed by estimated glomerular filtration rate (eGFR) and albuminuria during 2-year observation period in 252 patients with type 2 diabetes. In unadjusted model, the subjects with higher happiness score attenuated reduced eGFR, and those with more social support attenuated increase in alubuminuria and decline eGFR....
Source: Diabetology International - January 2, 2021 Category: Endocrinology Source Type: research
Retrospective study of factors associated with progression and remission/regression of diabetic kidney disease-hypomagnesemia was associated with progression and elevated serum alanine aminotransferase levels were associated with remission or regression-
ConclusionOur findings confirmed previous reports that advancing age and serum HbA1c levels were associated with an increased risk of progression of DKD. Lower serum Mg concentrations were also found to be associated with a high risk of progression of DKD, and interventional studies are needed to confirm a causal relationship. Elevated HbA1c levels and hypomagnesemia were common factors in the decline in eGFR and the appearance of trace or overt proteinuria. Lower serum ALT levels were associated with the decline in eGFR. Since serum ALT is known to decrease as the renal function deteriorates, serum ALT is considered to be...
Source: Diabetology International - January 2, 2021 Category: Endocrinology Source Type: research
Background characteristics and diabetes remission after laparoscopic sleeve gastrectomy in Japanese patients with type 2 diabetes stratified by BMI: subgroup analysis of J-SMART
ConclusionThe patients with 32 –34.9 kg/m2 were characterized by more severe visceral obesity, T2D and the complications, and lower intrinsic insulin secretion capacity. LSG should be considered as a treatment option for patients with BMI 32 –34.9 kg/m2, to improve diabetes control. (Source: Diabetology International)
Source: Diabetology International - January 2, 2021 Category: Endocrinology Source Type: research
Association of abdominal obesity with crossing capillaries in the finger nailfold in type 2 diabetes mellitus
ConclusionsAbdominal obesity may play an important role in the increase in the percentage of crossing capillaries in the finger nailfold in patients with type 2 diabetes mellitus. (Source: Diabetology International)
Source: Diabetology International - January 1, 2021 Category: Endocrinology Source Type: research
Role of fatty acid elongase Elovl6 in the regulation of energy metabolism and pathophysiological significance in diabetes
AbstractType 2 diabetes mellitus (T2DM) is an expanding epidemic, closely linked to obesity. Peripheral insulin resistance and impaired insulin secretion remain the core defects in T2DM. Despite significant advances in unraveling the underlying these defects, many of the metabolic pathways and regulators involved in insulin resistance and β-cell dysfunction are not completely understood. This review proposes that manipulating the fatty acid (FA) composition by blocking ELOVL fatty acid elongase 6 (Elovl6) could protect against insulin resistance, impaired insulin secretion, and obesity-related disorders. The molecular mec...
Source: Diabetology International - December 15, 2020 Category: Endocrinology Source Type: research
The role of adipose tissue M1/M2 macrophages in type 2 diabetes mellitus
AbstractObesity and insulin resistance are closely associated with a state of low-grade inflammation in the body, and adipose tissue macrophages (ATMs) play central roles in this inflammation. ATMs are known to exhibit marked functional heterogeneity. M1 ATMs produce inflammatory cytokines and induce insulin resistance. On the other hand, the majority of ATMs in lean individuals are M2 ATMs, which have anti-inflammatory potential. We found that M1 and M2 ATMs can be clearly distinguished using CD11c and CD206 as markers, and that both the number of the M1 and M2 ATMs and the M1/M2 ratio are correlated with the degree of in...
Source: Diabetology International - December 15, 2020 Category: Endocrinology Source Type: research
