Perforated Appendicitis in Children: Management, Microbiology, and Antibiotic Stewardship
Paediatr Drugs. 2024 Apr 24. doi: 10.1007/s40272-024-00630-0. Online ahead of print.ABSTRACTAlthough appendicitis has been described for more than 300 years, its optimal management remains a topic of active investigation. Acute appendicitis is the most common cause of peritonitis in children, and rates of perforated appendicitis are much higher in children than in adults. Increased risk for perforated appendicitis in children is related to a delay in diagnosis due to age, size, access to care, and more. Surgical options include immediate appendectomy versus nonoperative management with intravenous antibiotics ± a drainage...
Source: Paediatric Drugs - April 23, 2024 Category: Pediatrics Authors: Katherine B Snyder Catherine J Hunter Christie L Buonpane Source Type: research
Perforated Appendicitis in Children: Management, Microbiology, and Antibiotic Stewardship
Paediatr Drugs. 2024 Apr 24. doi: 10.1007/s40272-024-00630-0. Online ahead of print.ABSTRACTAlthough appendicitis has been described for more than 300 years, its optimal management remains a topic of active investigation. Acute appendicitis is the most common cause of peritonitis in children, and rates of perforated appendicitis are much higher in children than in adults. Increased risk for perforated appendicitis in children is related to a delay in diagnosis due to age, size, access to care, and more. Surgical options include immediate appendectomy versus nonoperative management with intravenous antibiotics ± a drainage...
Source: Paediatric Drugs - April 23, 2024 Category: Pediatrics Authors: Katherine B Snyder Catherine J Hunter Christie L Buonpane Source Type: research
CROCuS, a Phase II Study Evaluating the Antiviral Activity, Clinical Outcomes, and Safety of Rilematovir in Children Aged ≥ 28 Days and ≤ 3 Years with Acute Respiratory Tract Infection Due to Respiratory Syncytial Virus
CONCLUSIONS: Data from the combined cohort suggest that rilematovir has a small but favorable antiviral effect of indeterminate clinical relevance compared with placebo, as well as a favorable safety profile. Safe and effective therapeutic options for RSV in infants and young children remain an unmet need.CLINICAL TRIAL REGISTRATION: EudraCT Number: 2016-003642-93; ClinicalTrials.gov Identifier: NCT03656510. First posted date: 4 September, 2018.PMID:38649595 | DOI:10.1007/s40272-024-00625-x (Source: Paediatric Drugs)
Source: Paediatric Drugs - April 22, 2024 Category: Pediatrics Authors: Fernando Ferrero Chien-Yu Lin Johannes Liese Kleber Luz Tatyana Stoeva Agnes Nemeth Manuel Gij ón Cristina Calvo Silvina Natalini Teck-Hock Toh Sofie Deleu Bohang Chen Sarah Rusch Beatriz L ópez Sánchez Illse Leipoldt Leen Vijgen Dymphy Huntjens Trista Source Type: research
Dapagliflozin and Empagliflozin in Paediatric Indications: A Systematic Review
CONCLUSION: Early evidence suggests that dapagliflozin and empagliflozin are well tolerated in children. A clinical pharmacology rationale currently exists only for adolescents with diabetes mellitus.PROSPERO REGISTRATION NUMBER: CRD42023438162.PMID:38635113 | DOI:10.1007/s40272-024-00623-z (Source: Paediatric Drugs)
Source: Paediatric Drugs - April 18, 2024 Category: Pediatrics Authors: Sebastiano A G Lava Craig Laurence Alessandro Di Deo Nicole Sekarski Michael Burch Oscar Della Pasqua Source Type: research
Dapagliflozin and Empagliflozin in Paediatric Indications: A Systematic Review
CONCLUSION: Early evidence suggests that dapagliflozin and empagliflozin are well tolerated in children. A clinical pharmacology rationale currently exists only for adolescents with diabetes mellitus.PROSPERO REGISTRATION NUMBER: CRD42023438162.PMID:38635113 | DOI:10.1007/s40272-024-00623-z (Source: Paediatric Drugs)
Source: Paediatric Drugs - April 18, 2024 Category: Pediatrics Authors: Sebastiano A G Lava Craig Laurence Alessandro Di Deo Nicole Sekarski Michael Burch Oscar Della Pasqua Source Type: research
Population Pharmacokinetics of Adalimumab in Juvenile Idiopathic Arthritis Patients: A Retrospective Cohort Study Using Clinical Care Data
CONCLUSIONS: Five literature models effectively described adalimumab PK in this pediatric cohort, highlighting the potential for extrapolating existing models to the pediatric population. The new JIA model confirmed the effect of several known covariates and found a novel association for drug clearance with methotrexate use (lower) and uveitis (higher), which might have clinical relevance for personalized dosing in JIA.PMID:38630199 | DOI:10.1007/s40272-024-00629-7 (Source: Paediatric Drugs)
Source: Paediatric Drugs - April 17, 2024 Category: Pediatrics Authors: Amara Nassar-Sheikh Rashid Femke Hooijberg Sandy C Bergkamp Mariken P Gruppen Taco W Kuijpers Mike Nurmohamed Theo Rispens Gertjan Wolbink J Merlijn van den Berg Dieneke Schonenberg-Meinema Ron A A Math ôt Source Type: research
Distribution of Bevacizumab into the Cerebrospinal Fluid of Children and Adolescents with Recurrent Brain Tumors
CONCLUSIONS: This pharmacokinetic pilot study indicated penetration of bevacizumab into the CSF in a population of children, adolescents, and young adults with recurrent brain tumors.PMID:38587585 | DOI:10.1007/s40272-024-00624-y (Source: Paediatric Drugs)
Source: Paediatric Drugs - April 8, 2024 Category: Pediatrics Authors: Iris K Minichmayr Ursula Knaack Johannes Gojo Daniel Senfter Christine Haberler Amedeo A Azizi Lisa Mayr Markus Zeitlinger Andreas Peyrl Source Type: research
Distribution of Bevacizumab into the Cerebrospinal Fluid of Children and Adolescents with Recurrent Brain Tumors
CONCLUSIONS: This pharmacokinetic pilot study indicated penetration of bevacizumab into the CSF in a population of children, adolescents, and young adults with recurrent brain tumors.PMID:38587585 | DOI:10.1007/s40272-024-00624-y (Source: Paediatric Drugs)
Source: Paediatric Drugs - April 8, 2024 Category: Pediatrics Authors: Iris K Minichmayr Ursula Knaack Johannes Gojo Daniel Senfter Christine Haberler Amedeo A Azizi Lisa Mayr Markus Zeitlinger Andreas Peyrl Source Type: research
Distribution of Bevacizumab into the Cerebrospinal Fluid of Children and Adolescents with Recurrent Brain Tumors
CONCLUSIONS: This pharmacokinetic pilot study indicated penetration of bevacizumab into the CSF in a population of children, adolescents, and young adults with recurrent brain tumors.PMID:38587585 | DOI:10.1007/s40272-024-00624-y (Source: Paediatric Drugs)
Source: Paediatric Drugs - April 8, 2024 Category: Pediatrics Authors: Iris K Minichmayr Ursula Knaack Johannes Gojo Daniel Senfter Christine Haberler Amedeo A Azizi Lisa Mayr Markus Zeitlinger Andreas Peyrl Source Type: research
Distribution of Bevacizumab into the Cerebrospinal Fluid of Children and Adolescents with Recurrent Brain Tumors
CONCLUSIONS: This pharmacokinetic pilot study indicated penetration of bevacizumab into the CSF in a population of children, adolescents, and young adults with recurrent brain tumors.PMID:38587585 | DOI:10.1007/s40272-024-00624-y (Source: Paediatric Drugs)
Source: Paediatric Drugs - April 8, 2024 Category: Pediatrics Authors: Iris K Minichmayr Ursula Knaack Johannes Gojo Daniel Senfter Christine Haberler Amedeo A Azizi Lisa Mayr Markus Zeitlinger Andreas Peyrl Source Type: research
Distribution of Bevacizumab into the Cerebrospinal Fluid of Children and Adolescents with Recurrent Brain Tumors
CONCLUSIONS: This pharmacokinetic pilot study indicated penetration of bevacizumab into the CSF in a population of children, adolescents, and young adults with recurrent brain tumors.PMID:38587585 | DOI:10.1007/s40272-024-00624-y (Source: Paediatric Drugs)
Source: Paediatric Drugs - April 8, 2024 Category: Pediatrics Authors: Iris K Minichmayr Ursula Knaack Johannes Gojo Daniel Senfter Christine Haberler Amedeo A Azizi Lisa Mayr Markus Zeitlinger Andreas Peyrl Source Type: research
Distribution of Bevacizumab into the Cerebrospinal Fluid of Children and Adolescents with Recurrent Brain Tumors
CONCLUSIONS: This pharmacokinetic pilot study indicated penetration of bevacizumab into the CSF in a population of children, adolescents, and young adults with recurrent brain tumors.PMID:38587585 | DOI:10.1007/s40272-024-00624-y (Source: Paediatric Drugs)
Source: Paediatric Drugs - April 8, 2024 Category: Pediatrics Authors: Iris K Minichmayr Ursula Knaack Johannes Gojo Daniel Senfter Christine Haberler Amedeo A Azizi Lisa Mayr Markus Zeitlinger Andreas Peyrl Source Type: research
Neonatal Necrotizing Enterocolitis: An Update on Pathophysiology, Treatment, and Prevention
Paediatr Drugs. 2024 Apr 2. doi: 10.1007/s40272-024-00626-w. Online ahead of print.ABSTRACTNecrotizing enterocolitis (NEC) is a life-threatening disease predominantly affecting premature and very low birth weight infants resulting in inflammation and necrosis of the small bowel and colon and potentially leading to sepsis, peritonitis, perforation, and death. Numerous research efforts have been made to better understand, treat, and prevent NEC. This review explores a variety of factors involved in the pathogenesis of NEC (prematurity, low birth weight, lack of human breast milk exposure, alterations to the microbiota, mater...
Source: Paediatric Drugs - April 2, 2024 Category: Pediatrics Authors: Annette Gawron Roberts Noelle Younge Rachel Gottron Greenberg Source Type: research
Neonatal Necrotizing Enterocolitis: An Update on Pathophysiology, Treatment, and Prevention
Paediatr Drugs. 2024 Apr 2. doi: 10.1007/s40272-024-00626-w. Online ahead of print.ABSTRACTNecrotizing enterocolitis (NEC) is a life-threatening disease predominantly affecting premature and very low birth weight infants resulting in inflammation and necrosis of the small bowel and colon and potentially leading to sepsis, peritonitis, perforation, and death. Numerous research efforts have been made to better understand, treat, and prevent NEC. This review explores a variety of factors involved in the pathogenesis of NEC (prematurity, low birth weight, lack of human breast milk exposure, alterations to the microbiota, mater...
Source: Paediatric Drugs - April 2, 2024 Category: Pediatrics Authors: Annette Gawron Roberts Noelle Younge Rachel Gottron Greenberg Source Type: research
Neonatal Necrotizing Enterocolitis: An Update on Pathophysiology, Treatment, and Prevention
Paediatr Drugs. 2024 Apr 2. doi: 10.1007/s40272-024-00626-w. Online ahead of print.ABSTRACTNecrotizing enterocolitis (NEC) is a life-threatening disease predominantly affecting premature and very low birth weight infants resulting in inflammation and necrosis of the small bowel and colon and potentially leading to sepsis, peritonitis, perforation, and death. Numerous research efforts have been made to better understand, treat, and prevent NEC. This review explores a variety of factors involved in the pathogenesis of NEC (prematurity, low birth weight, lack of human breast milk exposure, alterations to the microbiota, mater...
Source: Paediatric Drugs - April 2, 2024 Category: Pediatrics Authors: Annette Gawron Roberts Noelle Younge Rachel Gottron Greenberg Source Type: research
