Practical Approach to Diagnosis and Management of IL-1-Mediated Autoinflammatory Diseases (CAPS, TRAPS, MKD, and DIRA)
Paediatr Drugs. 2024 Mar;26(2):113-126. doi: 10.1007/s40272-023-00615-5. Epub 2024 Feb 20.ABSTRACTSystemic autoinflammatory diseases (SAIDs) are a group of rare genetic and nongenetic immune dysregulatory disorders associated with high morbidity and mortality if left untreated. Therefore, early diagnosis and initiation of targeted treatment is vital in SAID patients to control the disease activity and prevent long-term immune-mediated damage. A specific group of genetically defined SAIDs is associated with increased inflammasome-mediated production of active interleukin (IL)-1. Even though progress in immunobiology and gen...
Source: Paediatric Drugs - February 20, 2024 Category: Pediatrics Authors: Kader Cetin Gedik Zehra Serap Arici Ovgu Kul Cinar Facundo Garcia-Bournissen Micol Romano Erkan Demirkaya Source Type: research

Practical Approach to Diagnosis and Management of IL-1-Mediated Autoinflammatory Diseases (CAPS, TRAPS, MKD, and DIRA)
Paediatr Drugs. 2024 Mar;26(2):113-126. doi: 10.1007/s40272-023-00615-5. Epub 2024 Feb 20.ABSTRACTSystemic autoinflammatory diseases (SAIDs) are a group of rare genetic and nongenetic immune dysregulatory disorders associated with high morbidity and mortality if left untreated. Therefore, early diagnosis and initiation of targeted treatment is vital in SAID patients to control the disease activity and prevent long-term immune-mediated damage. A specific group of genetically defined SAIDs is associated with increased inflammasome-mediated production of active interleukin (IL)-1. Even though progress in immunobiology and gen...
Source: Paediatric Drugs - February 20, 2024 Category: Pediatrics Authors: Kader Cetin Gedik Zehra Serap Arici Ovgu Kul Cinar Facundo Garcia-Bournissen Micol Romano Erkan Demirkaya Source Type: research

Practical Approach to Diagnosis and Management of IL-1-Mediated Autoinflammatory Diseases (CAPS, TRAPS, MKD, and DIRA)
Paediatr Drugs. 2024 Mar;26(2):113-126. doi: 10.1007/s40272-023-00615-5. Epub 2024 Feb 20.ABSTRACTSystemic autoinflammatory diseases (SAIDs) are a group of rare genetic and nongenetic immune dysregulatory disorders associated with high morbidity and mortality if left untreated. Therefore, early diagnosis and initiation of targeted treatment is vital in SAID patients to control the disease activity and prevent long-term immune-mediated damage. A specific group of genetically defined SAIDs is associated with increased inflammasome-mediated production of active interleukin (IL)-1. Even though progress in immunobiology and gen...
Source: Paediatric Drugs - February 20, 2024 Category: Pediatrics Authors: Kader Cetin Gedik Zehra Serap Arici Ovgu Kul Cinar Facundo Garcia-Bournissen Micol Romano Erkan Demirkaya Source Type: research

Practical Approach to Diagnosis and Management of IL-1-Mediated Autoinflammatory Diseases (CAPS, TRAPS, MKD, and DIRA)
Paediatr Drugs. 2024 Mar;26(2):113-126. doi: 10.1007/s40272-023-00615-5. Epub 2024 Feb 20.ABSTRACTSystemic autoinflammatory diseases (SAIDs) are a group of rare genetic and nongenetic immune dysregulatory disorders associated with high morbidity and mortality if left untreated. Therefore, early diagnosis and initiation of targeted treatment is vital in SAID patients to control the disease activity and prevent long-term immune-mediated damage. A specific group of genetically defined SAIDs is associated with increased inflammasome-mediated production of active interleukin (IL)-1. Even though progress in immunobiology and gen...
Source: Paediatric Drugs - February 20, 2024 Category: Pediatrics Authors: Kader Cetin Gedik Zehra Serap Arici Ovgu Kul Cinar Facundo Garcia-Bournissen Micol Romano Erkan Demirkaya Source Type: research

Practical Approach to Diagnosis and Management of IL-1-Mediated Autoinflammatory Diseases (CAPS, TRAPS, MKD, and DIRA)
Paediatr Drugs. 2024 Mar;26(2):113-126. doi: 10.1007/s40272-023-00615-5. Epub 2024 Feb 20.ABSTRACTSystemic autoinflammatory diseases (SAIDs) are a group of rare genetic and nongenetic immune dysregulatory disorders associated with high morbidity and mortality if left untreated. Therefore, early diagnosis and initiation of targeted treatment is vital in SAID patients to control the disease activity and prevent long-term immune-mediated damage. A specific group of genetically defined SAIDs is associated with increased inflammasome-mediated production of active interleukin (IL)-1. Even though progress in immunobiology and gen...
Source: Paediatric Drugs - February 20, 2024 Category: Pediatrics Authors: Kader Cetin Gedik Zehra Serap Arici Ovgu Kul Cinar Facundo Garcia-Bournissen Micol Romano Erkan Demirkaya Source Type: research

Practical Approach to Diagnosis and Management of IL-1-Mediated Autoinflammatory Diseases (CAPS, TRAPS, MKD, and DIRA)
Paediatr Drugs. 2024 Mar;26(2):113-126. doi: 10.1007/s40272-023-00615-5. Epub 2024 Feb 20.ABSTRACTSystemic autoinflammatory diseases (SAIDs) are a group of rare genetic and nongenetic immune dysregulatory disorders associated with high morbidity and mortality if left untreated. Therefore, early diagnosis and initiation of targeted treatment is vital in SAID patients to control the disease activity and prevent long-term immune-mediated damage. A specific group of genetically defined SAIDs is associated with increased inflammasome-mediated production of active interleukin (IL)-1. Even though progress in immunobiology and gen...
Source: Paediatric Drugs - February 20, 2024 Category: Pediatrics Authors: Kader Cetin Gedik Zehra Serap Arici Ovgu Kul Cinar Facundo Garcia-Bournissen Micol Romano Erkan Demirkaya Source Type: research

Practical Approach to Diagnosis and Management of IL-1-Mediated Autoinflammatory Diseases (CAPS, TRAPS, MKD, and DIRA)
Paediatr Drugs. 2024 Mar;26(2):113-126. doi: 10.1007/s40272-023-00615-5. Epub 2024 Feb 20.ABSTRACTSystemic autoinflammatory diseases (SAIDs) are a group of rare genetic and nongenetic immune dysregulatory disorders associated with high morbidity and mortality if left untreated. Therefore, early diagnosis and initiation of targeted treatment is vital in SAID patients to control the disease activity and prevent long-term immune-mediated damage. A specific group of genetically defined SAIDs is associated with increased inflammasome-mediated production of active interleukin (IL)-1. Even though progress in immunobiology and gen...
Source: Paediatric Drugs - February 20, 2024 Category: Pediatrics Authors: Kader Cetin Gedik Zehra Serap Arici Ovgu Kul Cinar Facundo Garcia-Bournissen Micol Romano Erkan Demirkaya Source Type: research

Practical Approach to Diagnosis and Management of IL-1-Mediated Autoinflammatory Diseases (CAPS, TRAPS, MKD, and DIRA)
Paediatr Drugs. 2024 Mar;26(2):113-126. doi: 10.1007/s40272-023-00615-5. Epub 2024 Feb 20.ABSTRACTSystemic autoinflammatory diseases (SAIDs) are a group of rare genetic and nongenetic immune dysregulatory disorders associated with high morbidity and mortality if left untreated. Therefore, early diagnosis and initiation of targeted treatment is vital in SAID patients to control the disease activity and prevent long-term immune-mediated damage. A specific group of genetically defined SAIDs is associated with increased inflammasome-mediated production of active interleukin (IL)-1. Even though progress in immunobiology and gen...
Source: Paediatric Drugs - February 20, 2024 Category: Pediatrics Authors: Kader Cetin Gedik Zehra Serap Arici Ovgu Kul Cinar Facundo Garcia-Bournissen Micol Romano Erkan Demirkaya Source Type: research

Practical Approach to Diagnosis and Management of IL-1-Mediated Autoinflammatory Diseases (CAPS, TRAPS, MKD, and DIRA)
Paediatr Drugs. 2024 Mar;26(2):113-126. doi: 10.1007/s40272-023-00615-5. Epub 2024 Feb 20.ABSTRACTSystemic autoinflammatory diseases (SAIDs) are a group of rare genetic and nongenetic immune dysregulatory disorders associated with high morbidity and mortality if left untreated. Therefore, early diagnosis and initiation of targeted treatment is vital in SAID patients to control the disease activity and prevent long-term immune-mediated damage. A specific group of genetically defined SAIDs is associated with increased inflammasome-mediated production of active interleukin (IL)-1. Even though progress in immunobiology and gen...
Source: Paediatric Drugs - February 20, 2024 Category: Pediatrics Authors: Kader Cetin Gedik Zehra Serap Arici Ovgu Kul Cinar Facundo Garcia-Bournissen Micol Romano Erkan Demirkaya Source Type: research

Practical Approach to Diagnosis and Management of IL-1-Mediated Autoinflammatory Diseases (CAPS, TRAPS, MKD, and DIRA)
Paediatr Drugs. 2024 Mar;26(2):113-126. doi: 10.1007/s40272-023-00615-5. Epub 2024 Feb 20.ABSTRACTSystemic autoinflammatory diseases (SAIDs) are a group of rare genetic and nongenetic immune dysregulatory disorders associated with high morbidity and mortality if left untreated. Therefore, early diagnosis and initiation of targeted treatment is vital in SAID patients to control the disease activity and prevent long-term immune-mediated damage. A specific group of genetically defined SAIDs is associated with increased inflammasome-mediated production of active interleukin (IL)-1. Even though progress in immunobiology and gen...
Source: Paediatric Drugs - February 20, 2024 Category: Pediatrics Authors: Kader Cetin Gedik Zehra Serap Arici Ovgu Kul Cinar Facundo Garcia-Bournissen Micol Romano Erkan Demirkaya Source Type: research

Practical Approach to Diagnosis and Management of IL-1-Mediated Autoinflammatory Diseases (CAPS, TRAPS, MKD, and DIRA)
Paediatr Drugs. 2024 Mar;26(2):113-126. doi: 10.1007/s40272-023-00615-5. Epub 2024 Feb 20.ABSTRACTSystemic autoinflammatory diseases (SAIDs) are a group of rare genetic and nongenetic immune dysregulatory disorders associated with high morbidity and mortality if left untreated. Therefore, early diagnosis and initiation of targeted treatment is vital in SAID patients to control the disease activity and prevent long-term immune-mediated damage. A specific group of genetically defined SAIDs is associated with increased inflammasome-mediated production of active interleukin (IL)-1. Even though progress in immunobiology and gen...
Source: Paediatric Drugs - February 20, 2024 Category: Pediatrics Authors: Kader Cetin Gedik Zehra Serap Arici Ovgu Kul Cinar Facundo Garcia-Bournissen Micol Romano Erkan Demirkaya Source Type: research

Practical Approach to Diagnosis and Management of IL-1-Mediated Autoinflammatory Diseases (CAPS, TRAPS, MKD, and DIRA)
Paediatr Drugs. 2024 Mar;26(2):113-126. doi: 10.1007/s40272-023-00615-5. Epub 2024 Feb 20.ABSTRACTSystemic autoinflammatory diseases (SAIDs) are a group of rare genetic and nongenetic immune dysregulatory disorders associated with high morbidity and mortality if left untreated. Therefore, early diagnosis and initiation of targeted treatment is vital in SAID patients to control the disease activity and prevent long-term immune-mediated damage. A specific group of genetically defined SAIDs is associated with increased inflammasome-mediated production of active interleukin (IL)-1. Even though progress in immunobiology and gen...
Source: Paediatric Drugs - February 20, 2024 Category: Pediatrics Authors: Kader Cetin Gedik Zehra Serap Arici Ovgu Kul Cinar Facundo Garcia-Bournissen Micol Romano Erkan Demirkaya Source Type: research

Practical Approach to Diagnosis and Management of IL-1-Mediated Autoinflammatory Diseases (CAPS, TRAPS, MKD, and DIRA)
Paediatr Drugs. 2024 Feb 20. doi: 10.1007/s40272-023-00615-5. Online ahead of print.ABSTRACTSystemic autoinflammatory diseases (SAIDs) are a group of rare genetic and nongenetic immune dysregulatory disorders associated with high morbidity and mortality if left untreated. Therefore, early diagnosis and initiation of targeted treatment is vital in SAID patients to control the disease activity and prevent long-term immune-mediated damage. A specific group of genetically defined SAIDs is associated with increased inflammasome-mediated production of active interleukin (IL)-1. Even though progress in immunobiology and genetics ...
Source: Paediatric Drugs - February 20, 2024 Category: Pediatrics Authors: Kader Cetin Gedik Zehra Serap Arici Ovgu Kul Cinar Facundo Garcia-Bournissen Micol Romano Erkan Demirkaya Source Type: research

Practical Approach to Diagnosis and Management of IL-1-Mediated Autoinflammatory Diseases (CAPS, TRAPS, MKD, and DIRA)
Paediatr Drugs. 2024 Feb 20. doi: 10.1007/s40272-023-00615-5. Online ahead of print.ABSTRACTSystemic autoinflammatory diseases (SAIDs) are a group of rare genetic and nongenetic immune dysregulatory disorders associated with high morbidity and mortality if left untreated. Therefore, early diagnosis and initiation of targeted treatment is vital in SAID patients to control the disease activity and prevent long-term immune-mediated damage. A specific group of genetically defined SAIDs is associated with increased inflammasome-mediated production of active interleukin (IL)-1. Even though progress in immunobiology and genetics ...
Source: Paediatric Drugs - February 20, 2024 Category: Pediatrics Authors: Kader Cetin Gedik Zehra Serap Arici Ovgu Kul Cinar Facundo Garcia-Bournissen Micol Romano Erkan Demirkaya Source Type: research

Correction: Enteral and Parenteral Treatment with Caffeine for Preterm Infants in the Delivery Room: A Randomised Trial
Paediatr Drugs. 2024 Feb 16. doi: 10.1007/s40272-024-00619-9. Online ahead of print.NO ABSTRACTPMID:38363546 | DOI:10.1007/s40272-024-00619-9 (Source: Paediatric Drugs)
Source: Paediatric Drugs - February 16, 2024 Category: Pediatrics Authors: Carlo Dani Alessandra Cecchi Martina Ciarci à Francesca Miselli Michele Luzzati Giulia Remaschi Maria Della Bona Giancarlo la Marca Luca Boni Source Type: research