Neonatal Necrotizing Enterocolitis: An Update on Pathophysiology, Treatment, and Prevention
Paediatr Drugs. 2024 Apr 2. doi: 10.1007/s40272-024-00626-w. Online ahead of print.ABSTRACTNecrotizing enterocolitis (NEC) is a life-threatening disease predominantly affecting premature and very low birth weight infants resulting in inflammation and necrosis of the small bowel and colon and potentially leading to sepsis, peritonitis, perforation, and death. Numerous research efforts have been made to better understand, treat, and prevent NEC. This review explores a variety of factors involved in the pathogenesis of NEC (prematurity, low birth weight, lack of human breast milk exposure, alterations to the microbiota, mater...
Source: Paediatric Drugs - April 2, 2024 Category: Pediatrics Authors: Annette Gawron Roberts Noelle Younge Rachel Gottron Greenberg Source Type: research
Neonatal Necrotizing Enterocolitis: An Update on Pathophysiology, Treatment, and Prevention
Paediatr Drugs. 2024 Apr 2. doi: 10.1007/s40272-024-00626-w. Online ahead of print.ABSTRACTNecrotizing enterocolitis (NEC) is a life-threatening disease predominantly affecting premature and very low birth weight infants resulting in inflammation and necrosis of the small bowel and colon and potentially leading to sepsis, peritonitis, perforation, and death. Numerous research efforts have been made to better understand, treat, and prevent NEC. This review explores a variety of factors involved in the pathogenesis of NEC (prematurity, low birth weight, lack of human breast milk exposure, alterations to the microbiota, mater...
Source: Paediatric Drugs - April 2, 2024 Category: Pediatrics Authors: Annette Gawron Roberts Noelle Younge Rachel Gottron Greenberg Source Type: research
Comparison of Deep and Moderate Neuromuscular Blockade for Major Laparoscopic Surgery in Children: A Randomized Controlled Trial
CONCLUSIONS: A deep NMB provided better operative conditions and similar recovery profiles compared with a moderate NMB as reversed with sugammadex in children undergoing major laparoscopic surgery.CLINICAL TRIAL REGISTRATION: Chinese Clinical Trial Registry, No. ChiCTR2100053821.PMID:38512578 | DOI:10.1007/s40272-024-00622-0 (Source: Paediatric Drugs)
Source: Paediatric Drugs - March 21, 2024 Category: Pediatrics Authors: Guo Wei Yong-Xin Li Ying Chen Mei Diao John Wei Zhong Shou-Dong Pan Source Type: research
Comparison of Deep and Moderate Neuromuscular Blockade for Major Laparoscopic Surgery in Children: A Randomized Controlled Trial
CONCLUSIONS: A deep NMB provided better operative conditions and similar recovery profiles compared with a moderate NMB as reversed with sugammadex in children undergoing major laparoscopic surgery.CLINICAL TRIAL REGISTRATION: Chinese Clinical Trial Registry, No. ChiCTR2100053821.PMID:38512578 | DOI:10.1007/s40272-024-00622-0 (Source: Paediatric Drugs)
Source: Paediatric Drugs - March 21, 2024 Category: Pediatrics Authors: Guo Wei Yong-Xin Li Ying Chen Mei Diao John Wei Zhong Shou-Dong Pan Source Type: research
Comparison of Deep and Moderate Neuromuscular Blockade for Major Laparoscopic Surgery in Children: A Randomized Controlled Trial
CONCLUSIONS: A deep NMB provided better operative conditions and similar recovery profiles compared with a moderate NMB as reversed with sugammadex in children undergoing major laparoscopic surgery.CLINICAL TRIAL REGISTRATION: Chinese Clinical Trial Registry, No. ChiCTR2100053821.PMID:38512578 | DOI:10.1007/s40272-024-00622-0 (Source: Paediatric Drugs)
Source: Paediatric Drugs - March 21, 2024 Category: Pediatrics Authors: Guo Wei Yong-Xin Li Ying Chen Mei Diao John Wei Zhong Shou-Dong Pan Source Type: research
Comparison of Deep and Moderate Neuromuscular Blockade for Major Laparoscopic Surgery in Children: A Randomized Controlled Trial
CONCLUSIONS: A deep NMB provided better operative conditions and similar recovery profiles compared with a moderate NMB as reversed with sugammadex in children undergoing major laparoscopic surgery.CLINICAL TRIAL REGISTRATION: Chinese Clinical Trial Registry, No. ChiCTR2100053821.PMID:38512578 | DOI:10.1007/s40272-024-00622-0 (Source: Paediatric Drugs)
Source: Paediatric Drugs - March 21, 2024 Category: Pediatrics Authors: Guo Wei Yong-Xin Li Ying Chen Mei Diao John Wei Zhong Shou-Dong Pan Source Type: research
Comparison of Deep and Moderate Neuromuscular Blockade for Major Laparoscopic Surgery in Children: A Randomized Controlled Trial
CONCLUSIONS: A deep NMB provided better operative conditions and similar recovery profiles compared with a moderate NMB as reversed with sugammadex in children undergoing major laparoscopic surgery.CLINICAL TRIAL REGISTRATION: Chinese Clinical Trial Registry, No. ChiCTR2100053821.PMID:38512578 | DOI:10.1007/s40272-024-00622-0 (Source: Paediatric Drugs)
Source: Paediatric Drugs - March 21, 2024 Category: Pediatrics Authors: Guo Wei Yong-Xin Li Ying Chen Mei Diao John Wei Zhong Shou-Dong Pan Source Type: research
Comparison of Deep and Moderate Neuromuscular Blockade for Major Laparoscopic Surgery in Children: A Randomized Controlled Trial
CONCLUSIONS: A deep NMB provided better operative conditions and similar recovery profiles compared with a moderate NMB as reversed with sugammadex in children undergoing major laparoscopic surgery.CLINICAL TRIAL REGISTRATION: Chinese Clinical Trial Registry, No. ChiCTR2100053821.PMID:38512578 | DOI:10.1007/s40272-024-00622-0 (Source: Paediatric Drugs)
Source: Paediatric Drugs - March 21, 2024 Category: Pediatrics Authors: Guo Wei Yong-Xin Li Ying Chen Mei Diao John Wei Zhong Shou-Dong Pan Source Type: research
Comparison of Deep and Moderate Neuromuscular Blockade for Major Laparoscopic Surgery in Children: A Randomized Controlled Trial
CONCLUSIONS: A deep NMB provided better operative conditions and similar recovery profiles compared with a moderate NMB as reversed with sugammadex in children undergoing major laparoscopic surgery.CLINICAL TRIAL REGISTRATION: Chinese Clinical Trial Registry, No. ChiCTR2100053821.PMID:38512578 | DOI:10.1007/s40272-024-00622-0 (Source: Paediatric Drugs)
Source: Paediatric Drugs - March 21, 2024 Category: Pediatrics Authors: Guo Wei Yong-Xin Li Ying Chen Mei Diao John Wei Zhong Shou-Dong Pan Source Type: research
Comparison of Deep and Moderate Neuromuscular Blockade for Major Laparoscopic Surgery in Children: A Randomized Controlled Trial
CONCLUSIONS: A deep NMB provided better operative conditions and similar recovery profiles compared with a moderate NMB as reversed with sugammadex in children undergoing major laparoscopic surgery.CLINICAL TRIAL REGISTRATION: Chinese Clinical Trial Registry, No. ChiCTR2100053821.PMID:38512578 | DOI:10.1007/s40272-024-00622-0 (Source: Paediatric Drugs)
Source: Paediatric Drugs - March 21, 2024 Category: Pediatrics Authors: Guo Wei Yong-Xin Li Ying Chen Mei Diao John Wei Zhong Shou-Dong Pan Source Type: research
Comparison of Deep and Moderate Neuromuscular Blockade for Major Laparoscopic Surgery in Children: A Randomized Controlled Trial
CONCLUSIONS: A deep NMB provided better operative conditions and similar recovery profiles compared with a moderate NMB as reversed with sugammadex in children undergoing major laparoscopic surgery.CLINICAL TRIAL REGISTRATION: Chinese Clinical Trial Registry, No. ChiCTR2100053821.PMID:38512578 | DOI:10.1007/s40272-024-00622-0 (Source: Paediatric Drugs)
Source: Paediatric Drugs - March 21, 2024 Category: Pediatrics Authors: Guo Wei Yong-Xin Li Ying Chen Mei Diao John Wei Zhong Shou-Dong Pan Source Type: research
The Effect of Polymorphisms and Other Biomarkers on Infliximab Exposure in Paediatric Inflammatory Bowel Disease: Development of a Population Pharmacokinetic Model
CONCLUSIONS: A popPK model utilising weight, albumin, FC, ESR, and the SNP rs1048610 accurately predicted infliximab trough concentrations in children with IBD.PMID:38507036 | DOI:10.1007/s40272-024-00621-1 (Source: Paediatric Drugs)
Source: Paediatric Drugs - March 20, 2024 Category: Pediatrics Authors: Susana Clemente-Bautista I ñaki F Trocóniz Óscar Segarra-Cantón Sara Salvador-Mar ín Carlos J Parram ón-Teixidó Marina Álvarez-Beltrán Lu ís A López-Fernández Helena Colom Maria J Caba ñas-Poy Maria Q Gorgas-Torner Marta Miarons Source Type: research
The Effect of Polymorphisms and Other Biomarkers on Infliximab Exposure in Paediatric Inflammatory Bowel Disease: Development of a Population Pharmacokinetic Model
CONCLUSIONS: A popPK model utilising weight, albumin, FC, ESR, and the SNP rs1048610 accurately predicted infliximab trough concentrations in children with IBD.PMID:38507036 | DOI:10.1007/s40272-024-00621-1 (Source: Paediatric Drugs)
Source: Paediatric Drugs - March 20, 2024 Category: Pediatrics Authors: Susana Clemente-Bautista I ñaki F Trocóniz Óscar Segarra-Cantón Sara Salvador-Mar ín Carlos J Parram ón-Teixidó Marina Álvarez-Beltrán Lu ís A López-Fernández Helena Colom Maria J Caba ñas-Poy Maria Q Gorgas-Torner Marta Miarons Source Type: research
Treatment Options for Alopecia Areata in Children and Adolescents
Paediatr Drugs. 2024 Mar 11. doi: 10.1007/s40272-024-00620-2. Online ahead of print.ABSTRACTAlopecia areata (AA) lifetime incidence is around 2%, with many patients first experiencing symptoms during childhood. However, ritlecitinib is the only FDA-approved treatment for pediatric patients 12 years and older. This review outlines reported topical, injectable, and oral treatment options for pediatric patients with AA. Clinical studies were obtained via a PubMed search using the following search terms: alopecia areata, areata, universalis, or totalis and medication, therapy, treatment, drug, or management. Only studies with ...
Source: Paediatric Drugs - March 11, 2024 Category: Pediatrics Authors: Linnea L Westerkam Diana B McShane Elizabeth L Nieman Dean S Morrell Source Type: research
Treatment Options for Alopecia Areata in Children and Adolescents
Paediatr Drugs. 2024 Mar 11. doi: 10.1007/s40272-024-00620-2. Online ahead of print.ABSTRACTAlopecia areata (AA) lifetime incidence is around 2%, with many patients first experiencing symptoms during childhood. However, ritlecitinib is the only FDA-approved treatment for pediatric patients 12 years and older. This review outlines reported topical, injectable, and oral treatment options for pediatric patients with AA. Clinical studies were obtained via a PubMed search using the following search terms: alopecia areata, areata, universalis, or totalis and medication, therapy, treatment, drug, or management. Only studies with ...
Source: Paediatric Drugs - March 11, 2024 Category: Pediatrics Authors: Linnea L Westerkam Diana B McShane Elizabeth L Nieman Dean S Morrell Source Type: research
