Ewing Sarcoma Drug Therapy: Current Standard of Care and Emerging Agents
Paediatr Drugs. 2023 Apr 4. doi: 10.1007/s40272-023-00568-9. Online ahead of print.ABSTRACTEwing sarcoma is a translocation-associated sarcoma mainly impacting adolescents and young adults. The classic translocation (EWSR1::FLI1) leads to a fusion oncoprotein that functions as an aberrant transcription factor. As such, the oncogenic driver of this disease has been difficult to target pharmacologically and, therefore, the systemic therapies used to treat patients with Ewing sarcoma have typically been non-selective cytotoxic chemotherapy agents. The current review highlights recent clinical trials from the last decade that ...
Source: Paediatric Drugs - April 4, 2023 Category: Pediatrics Authors: Bhuvana A Setty Ajami Gikandi Steven G DuBois Source Type: research
Ewing Sarcoma Drug Therapy: Current Standard of Care and Emerging Agents
Paediatr Drugs. 2023 Apr 4. doi: 10.1007/s40272-023-00568-9. Online ahead of print.ABSTRACTEwing sarcoma is a translocation-associated sarcoma mainly impacting adolescents and young adults. The classic translocation (EWSR1::FLI1) leads to a fusion oncoprotein that functions as an aberrant transcription factor. As such, the oncogenic driver of this disease has been difficult to target pharmacologically and, therefore, the systemic therapies used to treat patients with Ewing sarcoma have typically been non-selective cytotoxic chemotherapy agents. The current review highlights recent clinical trials from the last decade that ...
Source: Paediatric Drugs - April 4, 2023 Category: Pediatrics Authors: Bhuvana A Setty Ajami Gikandi Steven G DuBois Source Type: research
Ewing Sarcoma Drug Therapy: Current Standard of Care and Emerging Agents
Paediatr Drugs. 2023 Apr 4. doi: 10.1007/s40272-023-00568-9. Online ahead of print.ABSTRACTEwing sarcoma is a translocation-associated sarcoma mainly impacting adolescents and young adults. The classic translocation (EWSR1::FLI1) leads to a fusion oncoprotein that functions as an aberrant transcription factor. As such, the oncogenic driver of this disease has been difficult to target pharmacologically and, therefore, the systemic therapies used to treat patients with Ewing sarcoma have typically been non-selective cytotoxic chemotherapy agents. The current review highlights recent clinical trials from the last decade that ...
Source: Paediatric Drugs - April 4, 2023 Category: Pediatrics Authors: Bhuvana A Setty Ajami Gikandi Steven G DuBois Source Type: research
Ewing Sarcoma Drug Therapy: Current Standard of Care and Emerging Agents
Paediatr Drugs. 2023 Apr 4. doi: 10.1007/s40272-023-00568-9. Online ahead of print.ABSTRACTEwing sarcoma is a translocation-associated sarcoma mainly impacting adolescents and young adults. The classic translocation (EWSR1::FLI1) leads to a fusion oncoprotein that functions as an aberrant transcription factor. As such, the oncogenic driver of this disease has been difficult to target pharmacologically and, therefore, the systemic therapies used to treat patients with Ewing sarcoma have typically been non-selective cytotoxic chemotherapy agents. The current review highlights recent clinical trials from the last decade that ...
Source: Paediatric Drugs - April 4, 2023 Category: Pediatrics Authors: Bhuvana A Setty Ajami Gikandi Steven G DuBois Source Type: research
Ewing Sarcoma Drug Therapy: Current Standard of Care and Emerging Agents
Paediatr Drugs. 2023 Apr 4. doi: 10.1007/s40272-023-00568-9. Online ahead of print.ABSTRACTEwing sarcoma is a translocation-associated sarcoma mainly impacting adolescents and young adults. The classic translocation (EWSR1::FLI1) leads to a fusion oncoprotein that functions as an aberrant transcription factor. As such, the oncogenic driver of this disease has been difficult to target pharmacologically and, therefore, the systemic therapies used to treat patients with Ewing sarcoma have typically been non-selective cytotoxic chemotherapy agents. The current review highlights recent clinical trials from the last decade that ...
Source: Paediatric Drugs - April 4, 2023 Category: Pediatrics Authors: Bhuvana A Setty Ajami Gikandi Steven G DuBois Source Type: research
