The relationship between atherosclerosis and dementia
CONCLUSION: Cognitively impaired individuals, in particular those with vascular cognitive impairment, have poorer quality of life and shorter survival. Risk factors contributing to such impairment are similar to those for ischaemic or haemorrhagic stroke. It may be concluded that most of the analysed risk factors play a role in the development of both atherosclerosis and dementia.PMID:38669152 | DOI:10.21101/cejph.a7848 (Source: Central European Journal of Public Health)
Source: Central European Journal of Public Health - April 26, 2024 Category: International Medicine & Public Health Authors: Jana Janoutov á Ond řej Machaczka Martina Kovalov á Anna Zatloukalov á Petr Ambroz Veronika Koutn á Eva Mr ázková Michal Bar Martin Roubec Petra B ártová Richard Novobilsk ý Martin Sabela Pavl ína Kušnierová David Stejskal Lucie Faldynov á S Source Type: research
Enhanced Spine Stability and Survival Lead to Increases in Dendritic Spine Density as an Early Response to Local Alpha-Synuclein Overexpression in Mouse Prefrontal Cortex
Cell Mol Neurobiol. 2024 Apr 26;44(1):42. doi: 10.1007/s10571-024-01472-7.ABSTRACTLewy Body Dementias (LBD), including Parkinson's disease dementia and Dementia with Lewy Bodies, are characterized by widespread accumulation of intracellular alpha-Synuclein protein deposits in regions beyond the brainstem, including in the cortex. However, the impact of local pathology in the cortex is unknown. To investigate this, we employed viral overexpression of human alpha-Synuclein protein targeting the mouse prefrontal cortex (PFC). We then used in vivo 2-photon microscopy to image awake head-fixed mice via an implanted chronic cran...
Source: Cellular and Molecular Neurobiology - April 26, 2024 Category: Cytology Authors: Peter J Bosch Gemma Kerr Rachel Cole Charles A Warwick Linder H Wendt Akash Pradeep Emma Bagnall Georgina M Aldridge Source Type: research
Role of Amyloidogenic and Non-Amyloidogenic Protein Spaces in Neurodegenerative Diseases and Their Mitigation Using Theranostic Agents
Chembiochem. 2024 Apr 26:e202400224. doi: 10.1002/cbic.202400224. Online ahead of print.ABSTRACTNeurodegenerative diseases (NDDs) refer to a complex heterogeneous group of diseases which are associated with the accumulation of amyloid fibrils or plaques in the brain leading to progressive loss of neuronal functions. Alzheimer's disease is one of the major NDD responsible for 60-80% of all dementia cases. Currently, there are no curative or disease-reversing/modifying molecules for NDDs except a few such as donepezil, rivastigmine, galantamine, carbidopa and levodopa which treat the disease-associated-symptoms. Similarly, t...
Source: Chembiochem - April 26, 2024 Category: Biochemistry Authors: Kapali Suri Madhu Ramesh Mansi Bhandari Vishakha Gupta Virendra Kumar Thimmaiah Govindaraju N Arul Murugan Source Type: research
Genomic stress and impaired DNA repair in Alzheimer disease
DNA Repair (Amst). 2024 Apr 11;139:103678. doi: 10.1016/j.dnarep.2024.103678. Online ahead of print.ABSTRACTAlzheimer disease (AD) is the most prominent form of dementia and has received considerable attention due to its growing burden on economic, healthcare and basic societal infrastructures. The two major neuropathological hallmarks of AD, i.e., extracellular amyloid beta (Aβ) peptide plaques and intracellular hyperphosphorylated Tau neurofibrillary tangles, have been the focus of much research, with an eye on understanding underlying disease mechanisms and identifying novel therapeutic avenues. One often overlooked as...
Source: DNA Repair - April 26, 2024 Category: Genetics & Stem Cells Authors: Jolien Neven Luidy Kazuo Issayama Ilse Dewachter David M Wilson Source Type: research
'Too young to sit at home': a qualitative study conducted among employees with young-onset dementia and their relatives
CONCLUSION: The findings highlight a strong desire to work post-YOD diagnosis, serving as a foundation for developing workplace support tools and guidance. This has the potential to help individuals with YOD preserve their self-confidence and identity while working within their capabilities.PMID:38669151 | DOI:10.1080/13607863.2024.2345132 (Source: Aging and Mental Health)
Source: Aging and Mental Health - April 26, 2024 Category: Geriatrics Authors: Bo Smeets Niels Janssen Kirsten Peetoom Lizzy Boots Christian Bakker Marjolein de Vugt Source Type: research
The Role of Mental Health Conditions in Early Detection and Treatment of Veterans With Alzheimer's Dementia
CONCLUSIONS: Mental health conditions were more likely in veterans with UD vs. AD diagnoses; comorbid MHC may contribute to delayed AD diagnosis.PMID:38668648 | DOI:10.1093/milmed/usae161 (Source: Military Medicine)
Source: Military Medicine - April 26, 2024 Category: International Medicine & Public Health Authors: Maureen K O'Connor Byron J Aguilar Andrew Nguyen Dan Berlowitz Raymond Zhang Amir Abbas Tahami Monfared Quanwu Zhang Weiming Xia Source Type: research
Enhanced Spine Stability and Survival Lead to Increases in Dendritic Spine Density as an Early Response to Local Alpha-Synuclein Overexpression in Mouse Prefrontal Cortex
Cell Mol Neurobiol. 2024 Apr 26;44(1):42. doi: 10.1007/s10571-024-01472-7.ABSTRACTLewy Body Dementias (LBD), including Parkinson's disease dementia and Dementia with Lewy Bodies, are characterized by widespread accumulation of intracellular alpha-Synuclein protein deposits in regions beyond the brainstem, including in the cortex. However, the impact of local pathology in the cortex is unknown. To investigate this, we employed viral overexpression of human alpha-Synuclein protein targeting the mouse prefrontal cortex (PFC). We then used in vivo 2-photon microscopy to image awake head-fixed mice via an implanted chronic cran...
Source: Cellular and Molecular Neurobiology - April 26, 2024 Category: Cytology Authors: Peter J Bosch Gemma Kerr Rachel Cole Charles A Warwick Linder H Wendt Akash Pradeep Emma Bagnall Georgina M Aldridge Source Type: research
The relationship between atherosclerosis and dementia
CONCLUSION: Cognitively impaired individuals, in particular those with vascular cognitive impairment, have poorer quality of life and shorter survival. Risk factors contributing to such impairment are similar to those for ischaemic or haemorrhagic stroke. It may be concluded that most of the analysed risk factors play a role in the development of both atherosclerosis and dementia.PMID:38669152 | DOI:10.21101/cejph.a7848 (Source: Central European Journal of Public Health)
Source: Central European Journal of Public Health - April 26, 2024 Category: International Medicine & Public Health Authors: Jana Janoutov á Ond řej Machaczka Martina Kovalov á Anna Zatloukalov á Petr Ambroz Veronika Koutn á Eva Mr ázková Michal Bar Martin Roubec Petra B ártová Richard Novobilsk ý Martin Sabela Pavl ína Kušnierová David Stejskal Lucie Faldynov á S Source Type: research
Role of Amyloidogenic and Non-Amyloidogenic Protein Spaces in Neurodegenerative Diseases and Their Mitigation Using Theranostic Agents
Chembiochem. 2024 Apr 26:e202400224. doi: 10.1002/cbic.202400224. Online ahead of print.ABSTRACTNeurodegenerative diseases (NDDs) refer to a complex heterogeneous group of diseases which are associated with the accumulation of amyloid fibrils or plaques in the brain leading to progressive loss of neuronal functions. Alzheimer's disease is one of the major NDD responsible for 60-80% of all dementia cases. Currently, there are no curative or disease-reversing/modifying molecules for NDDs except a few such as donepezil, rivastigmine, galantamine, carbidopa and levodopa which treat the disease-associated-symptoms. Similarly, t...
Source: Chembiochem - April 26, 2024 Category: Biochemistry Authors: Kapali Suri Madhu Ramesh Mansi Bhandari Vishakha Gupta Virendra Kumar Thimmaiah Govindaraju N Arul Murugan Source Type: research
Genomic stress and impaired DNA repair in Alzheimer disease
DNA Repair (Amst). 2024 Apr 11;139:103678. doi: 10.1016/j.dnarep.2024.103678. Online ahead of print.ABSTRACTAlzheimer disease (AD) is the most prominent form of dementia and has received considerable attention due to its growing burden on economic, healthcare and basic societal infrastructures. The two major neuropathological hallmarks of AD, i.e., extracellular amyloid beta (Aβ) peptide plaques and intracellular hyperphosphorylated Tau neurofibrillary tangles, have been the focus of much research, with an eye on understanding underlying disease mechanisms and identifying novel therapeutic avenues. One often overlooked as...
Source: DNA Repair - April 26, 2024 Category: Genetics & Stem Cells Authors: Jolien Neven Luidy Kazuo Issayama Ilse Dewachter David M Wilson Source Type: research
Second antiseizure medication monotherapy in patients with adult-onset epilepsy: A register-based analysis
Epilepsy Behav. 2024 Apr 25;155:109792. doi: 10.1016/j.yebeh.2024.109792. Online ahead of print.ABSTRACTOBJECTIVE: Revision of therapy is fundamental in epilepsy care, since only half of patients achieve seizure freedom and tolerate the first antiseizure medication (ASM). We studied the selection and retention of second antiseizure medication monotherapy in adults who discontinued treatment with one of the three most frequently prescribed first ASMs, and the impact of age or brain comorbidities.METHODS: Using Swedish national registers, we conducted a population-based, retrospective cohort study from 2007 to 2019 on patien...
Source: Epilepsy and Behaviour - April 26, 2024 Category: Neurology Authors: Konstantinos Polychronidis Samuel H åkansson Saman Hosseini Ashtiani Andr é Idegård David Larsson Johan Zelano Source Type: research
'Too young to sit at home': a qualitative study conducted among employees with young-onset dementia and their relatives
CONCLUSION: The findings highlight a strong desire to work post-YOD diagnosis, serving as a foundation for developing workplace support tools and guidance. This has the potential to help individuals with YOD preserve their self-confidence and identity while working within their capabilities.PMID:38669151 | DOI:10.1080/13607863.2024.2345132 (Source: Aging and Mental Health)
Source: Aging and Mental Health - April 26, 2024 Category: Geriatrics Authors: Bo Smeets Niels Janssen Kirsten Peetoom Lizzy Boots Christian Bakker Marjolein de Vugt Source Type: research
The relationship between atherosclerosis and dementia
CONCLUSION: Cognitively impaired individuals, in particular those with vascular cognitive impairment, have poorer quality of life and shorter survival. Risk factors contributing to such impairment are similar to those for ischaemic or haemorrhagic stroke. It may be concluded that most of the analysed risk factors play a role in the development of both atherosclerosis and dementia.PMID:38669152 | DOI:10.21101/cejph.a7848 (Source: Atherosclerosis)
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Jana Janoutov á Ond řej Machaczka Martina Kovalov á Anna Zatloukalov á Petr Ambroz Veronika Koutn á Eva Mr ázková Michal Bar Martin Roubec Petra B ártová Richard Novobilsk ý Martin Sabela Pavl ína Kušnierová David Stejskal Lucie Faldynov á S Source Type: research
The Role of Mental Health Conditions in Early Detection and Treatment of Veterans With Alzheimer's Dementia
CONCLUSIONS: Mental health conditions were more likely in veterans with UD vs. AD diagnoses; comorbid MHC may contribute to delayed AD diagnosis.PMID:38668648 | DOI:10.1093/milmed/usae161 (Source: Military Medicine)
Source: Military Medicine - April 26, 2024 Category: International Medicine & Public Health Authors: Maureen K O'Connor Byron J Aguilar Andrew Nguyen Dan Berlowitz Raymond Zhang Amir Abbas Tahami Monfared Quanwu Zhang Weiming Xia Source Type: research
Enhanced Spine Stability and Survival Lead to Increases in Dendritic Spine Density as an Early Response to Local Alpha-Synuclein Overexpression in Mouse Prefrontal Cortex
Cell Mol Neurobiol. 2024 Apr 26;44(1):42. doi: 10.1007/s10571-024-01472-7.ABSTRACTLewy Body Dementias (LBD), including Parkinson's disease dementia and Dementia with Lewy Bodies, are characterized by widespread accumulation of intracellular alpha-Synuclein protein deposits in regions beyond the brainstem, including in the cortex. However, the impact of local pathology in the cortex is unknown. To investigate this, we employed viral overexpression of human alpha-Synuclein protein targeting the mouse prefrontal cortex (PFC). We then used in vivo 2-photon microscopy to image awake head-fixed mice via an implanted chronic cran...
Source: Cellular and Molecular Neurobiology - April 26, 2024 Category: Cytology Authors: Peter J Bosch Gemma Kerr Rachel Cole Charles A Warwick Linder H Wendt Akash Pradeep Emma Bagnall Georgina M Aldridge Source Type: research
