Systemic inflammation in A β < sub > 1-40 < /sub > -induced Alzheimer's disease model: New translational opportunities
This study was aimed to explore systemic inflammatory manifestations in rats with Aβ1-40-induced AD. The impairment of spatial memory and cognitive flexibility in Aβ1-40-lesioned rats was accompanied by pronounced systemic inflammation, which was confirmed by commonly accepted biomarkers: increased hematological indices of systemic inflammation (NLR, dNLR, LMR, PLR and SII), signs of anemia of inflammation or chronic diseases, and pro-inflammatory polarized activation of circulating phagocytes. In addition, markers of systemic inflammation strongly correlated with disorders of remote cognitive flexibility in Aβ1-40-lesi...
Source: Brain Research - April 28, 2024 Category: Neurology Authors: Anastasiia Nefodova Mariia Rudyk Roman Dovhyi Taisa Dovbynchuk Nataliia Dzubenko Ganna Tolstanova Larysa Skivka Source Type: research
Identification of mRNA expression profiles and their characterization in age-related hearing loss
In this study, we analyzed an mRNA expression dataset (GSE49543) from the GEO database. Differentially expressed genes (DEGs) between young control mice and presbycusis mice were analyzed using limma in R and weighted gene co-expression network analysis (WGCNA) methods. Functional enrichment analyses of the DEGs were conducted with the clusterProfiler R package and the results were visualized using ggplot2 R package. The STRING database was used for the construction of the protein-protein interaction (PPI) network of the screened DEGs. Two machine learning algorithms LASSO and SVM-RFE were used to screen the hub genes. We ...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Kanglun Jiang Tan Wang Xinsheng Huang Li Gao Source Type: research
Interest of a hospital-based geriatric living lab among inpatients with neurocognitive disorders: the ALLEGRIA cross-sectional study
CONCLUSION: Living lab experimentations appear feasible with older adults, even with those with MNCD. Task support can be offered to those with severe MNCD.PMID:38679008 | DOI:10.1159/000538144 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 28, 2024 Category: Psychiatry Authors: Fr édéric Noublanche Gr égory Ben-Sadoun Lena Carcreff Jennifer Gautier Philippe Allain C édric Annweiler Source Type: research
Identification of mRNA expression profiles and their characterization in age-related hearing loss
In this study, we analyzed an mRNA expression dataset (GSE49543) from the GEO database. Differentially expressed genes (DEGs) between young control mice and presbycusis mice were analyzed using limma in R and weighted gene co-expression network analysis (WGCNA) methods. Functional enrichment analyses of the DEGs were conducted with the clusterProfiler R package and the results were visualized using ggplot2 R package. The STRING database was used for the construction of the protein-protein interaction (PPI) network of the screened DEGs. Two machine learning algorithms LASSO and SVM-RFE were used to screen the hub genes. We ...
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Kanglun Jiang Tan Wang Xinsheng Huang Li Gao Source Type: research
Genes, Vol. 15, Pages 569: Role of Neurocellular Endoplasmic Reticulum Stress Response in Alzheimer & rsquo;s Disease and Related Dementias Risk
Genes, Vol. 15, Pages 569: Role of Neurocellular Endoplasmic Reticulum Stress Response in Alzheimer’s Disease and Related Dementias Risk
Genes doi: 10.3390/genes15050569
Authors:
Miriam Aceves
Jose Granados
Ana C. Leandro
Juan Peralta
David C. Glahn
Sarah Williams-Blangero
Joanne E. Curran
John Blangero
Satish Kumar
Currently, more than 55 million people around the world suffer from dementia, and Alzheimer&rsquo;s Disease and Related Dementias (ADRD) accounts for nearly 60&ndash;70% of all those cases. The spread of Alzheimer&rsquo;s Disease (AD) pathology and progr...
Source: Genes - April 28, 2024 Category: Genetics & Stem Cells Authors: Miriam Aceves Jose Granados Ana C. Leandro Juan Peralta David C. Glahn Sarah Williams-Blangero Joanne E. Curran John Blangero Satish Kumar Tags: Article Source Type: research
Relationship between Depressive Symptoms, Caregiver Strain, and Social Support with Dementia Grief in Family Caregivers
Conclusions: In family caregivers, depressive symptoms, caregiver strain, and social support are related to the intensity of dementia grief, with a greater influence of depressive symptoms. Moreover, being female, having a low level of education, and caring for a care recipient at an advanced stage of dementia are factors associated with increased dementia grief. Concerning study limitations, the sample was restricted, belonging to a specific region of Spain and to a Provincial Federation of associations. It is necessary to exercise caution in generalizing results due to the sociodemographic and geographical characteristic...
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Miriam S ánchez-Alcón Almudena Garrido-Fern ández Jos é María Cano-Rojas Jos é Luis Sánchez-Ramos Juan Diego Ramos-Pichardo Source Type: research
Delusions of love and passion in the behavioral variant of frontotemporal dementia
We present the unique case of a 59-year-old woman with a strong family history of early-onset dementia in whom erotomania was the initial manifestation that led to a diagnosis of definite Behavioral Variant of Frontotemporal Dementia with a pathogenic missense mutation in the MAPT gene. Based on this case, we propose a hypothetical model for developing erotomania in patients with FTD.PMID:38678305 | DOI:10.1080/13554794.2024.2345110 (Source: Neurocase)
Source: Neurocase - April 27, 2024 Category: Neurology Authors: Miguel Restrepo-Mart ínez Jesus Ramirez-Bermudez Isis So Kristy Coleman Elizabeth Finger Source Type: research
Metabolomics profiling reveals distinct, sex-specific signatures in serum and brain metabolomes in mouse models of Alzheimer's disease
DISCUSSION: Several of our findings were consistent with results in humans, showing glycerophospholipids reduction in serum of apolipoprotein E (apoE) ε4 carriers and replicating the serum metabolic imprint of the APOE ε4 genotype. Our work thus represents a significant step toward translating metabolic dysregulation from model organisms to human AD.HIGHLIGHTS: This was a metabolomic assessment of two mouse models relevant to Alzheimer's disease. Mouse models exhibit broad sex-specific metabolic differences, similar to human study cohorts. The early-onset 5XFAD mouse model primarily alters brain metabolites while the lat...
Source: The Journal of Alzheimers Association - April 27, 2024 Category: Psychiatry Authors: Ravi S Pandey Mattias Arnold Richa Batra Jan Krumsiek Kevin P Kotredes Dylan Garceau Harriet Williams Michael Sasner Gareth R Howell Rima Kaddurah-Daouk Gregory W Carter Source Type: research
Failure of the glymphatic system as possible link between lumbar spinal stenosis and dementia
Alzheimers Dement. 2024 Apr 27. doi: 10.1002/alz.13812. Online ahead of print.NO ABSTRACTPMID:38676574 | DOI:10.1002/alz.13812 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 27, 2024 Category: Psychiatry Authors: Pasquale Gallina Francesco Lolli Berardino Porfirio Source Type: research
Lifestyle and incident dementia: A COSMIC individual participant data meta ‐analysis
DISCUSSION: Modifiable risk and protective factors appear relevant for dementia risk reduction across diverse geographical and sociodemographic groups.HIGHLIGHTS: A two-step individual participant data meta-analysis was conducted. This was done at a global scale using data from 21 ethno-regionally diverse cohorts. The association between a modifiable dementia risk score and dementia was examined. The association was modified by geographical region and age at baseline. Yet, modifiable dementia risk and protective factors appear relevant in all investigated groups and regions.PMID:38676366 | DOI:10.1002/alz.13846 (Source: Th...
Source: The Journal of Alzheimers Association - April 27, 2024 Category: Psychiatry Authors: Stephanie Van Asbroeck Sebastian K öhler Martin P J van Boxtel Darren M Lipnicki John D Crawford Erico Castro-Costa Maria Fernanda Lima-Costa Sergio Luis Blay Xiao Shifu Tao Wang Ling Yue Richard B Lipton Mindy J Katz Carol A Derby Ma ëlenn Guerchet Pie Source Type: research
Delusions of love and passion in the behavioral variant of frontotemporal dementia
We present the unique case of a 59-year-old woman with a strong family history of early-onset dementia in whom erotomania was the initial manifestation that led to a diagnosis of definite Behavioral Variant of Frontotemporal Dementia with a pathogenic missense mutation in the MAPT gene. Based on this case, we propose a hypothetical model for developing erotomania in patients with FTD.PMID:38678305 | DOI:10.1080/13554794.2024.2345110 (Source: Neurocase)
Source: Neurocase - April 27, 2024 Category: Neurology Authors: Miguel Restrepo-Mart ínez Jesus Ramirez-Bermudez Isis So Kristy Coleman Elizabeth Finger Source Type: research
CK1 δ/ε kinases regulate TDP-43 phosphorylation and are therapeutic targets for ALS-related TDP-43 hyperphosphorylation
Neurobiol Dis. 2024 Apr 25;196:106516. doi: 10.1016/j.nbd.2024.106516. Online ahead of print.ABSTRACTHyperphosphorylated TAR DNA-binding protein 43 (TDP-43) aggregates in the cytoplasm of neurons is the neuropathological hallmark of amyotrophic lateral sclerosis (ALS) and a group of neurodegenerative diseases collectively referred to as TDP-43 proteinopathies that includes frontotemporal dementia, Alzheimer's disease, and limbic onset age-related TDP-43 encephalopathy. The mechanism of TDP-43 phosphorylation is poorly understood. Previously we reported casein kinase 1 epsilon gene (CSNK1E gene encoding CK1ε protein) as be...
Source: Neurobiology of Disease - April 27, 2024 Category: Neurology Authors: Vivian I Ko Kailee Ong Don W Cleveland Haiyang Yu John M Ravits Source Type: research
Relationship between Depressive Symptoms, Caregiver Strain, and Social Support with Dementia Grief in Family Caregivers
Conclusions: In family caregivers, depressive symptoms, caregiver strain, and social support are related to the intensity of dementia grief, with a greater influence of depressive symptoms. Moreover, being female, having a low level of education, and caring for a care recipient at an advanced stage of dementia are factors associated with increased dementia grief. Concerning study limitations, the sample was restricted, belonging to a specific region of Spain and to a Provincial Federation of associations. It is necessary to exercise caution in generalizing results due to the sociodemographic and geographical characteristic...
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Miriam S ánchez-Alcón Almudena Garrido-Fern ández Jos é María Cano-Rojas Jos é Luis Sánchez-Ramos Juan Diego Ramos-Pichardo Source Type: research
Lifestyle and incident dementia: A COSMIC individual participant data meta ‐analysis
DISCUSSION: Modifiable risk and protective factors appear relevant for dementia risk reduction across diverse geographical and sociodemographic groups.HIGHLIGHTS: A two-step individual participant data meta-analysis was conducted. This was done at a global scale using data from 21 ethno-regionally diverse cohorts. The association between a modifiable dementia risk score and dementia was examined. The association was modified by geographical region and age at baseline. Yet, modifiable dementia risk and protective factors appear relevant in all investigated groups and regions.PMID:38676366 | DOI:10.1002/alz.13846 (Source: Th...
Source: The Journal of Alzheimers Association - April 27, 2024 Category: Psychiatry Authors: Stephanie Van Asbroeck Sebastian K öhler Martin P J van Boxtel Darren M Lipnicki John D Crawford Erico Castro-Costa Maria Fernanda Lima-Costa Sergio Luis Blay Xiao Shifu Tao Wang Ling Yue Richard B Lipton Mindy J Katz Carol A Derby Ma ëlenn Guerchet Pie Source Type: research
Failure of the glymphatic system as possible link between lumbar spinal stenosis and dementia
Alzheimers Dement. 2024 Apr 27. doi: 10.1002/alz.13812. Online ahead of print.NO ABSTRACTPMID:38676574 | DOI:10.1002/alz.13812 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 27, 2024 Category: Psychiatry Authors: Pasquale Gallina Francesco Lolli Berardino Porfirio Source Type: research
