Association of Leukocyte Telomere Length with Mild Cognitive Impairment and Alzheimer's Disease: Role of Folate and Homocysteine.
Authors: Ma F, Lv X, Du Y, Chen H, Liu S, Zhao J, Gao Y, An P, Zhou X, Song A, Sun C, Wang G, Ji Y, Wang X, Xu W, Huang G Abstract BACKGROUND: Leukocyte telomere length (LTL) is associated with the aging process and age-related degenerative diseases. The relation of peripheral blood LTL to mild cognitive impairment (MCI) and Alzheimer's disease (AD) and the role of folate and homocysteine (Hcy) in this relation remain unclear. OBJECTIVES: We aimed to investigate the association between LTL and the risks of MCI/AD, and to explore whether folate and Hcy may play a role in this association. METHODS: This case-...
Source: Dementia and Geriatric Cognitive Disorders - August 24, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Soluble Intercellular Adhesion Molecule-1 (sICAM-1) as a Biomarker of Vascular Cognitive Impairment in Older Adults.
CONCLUSION: High concentrations of sICAM-1 are independently associated with VCI group membership. Efforts to further characterize the relationship between indices of endothelial dysfunction and pathological changes to the aging brain should be further pursued. PMID: 31408858 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 14, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Is Reaction Time Slowing an Early Sign of Alzheimer's Disease? A Meta-Analysis.
CONCLUSION: This meta-analysis showed that SRTs are longer in individuals with MCI. Further studies are needed to determine the mechanism of SRT slowing, its anatomical correlates, and a threshold value for diagnosing prodromal AD. PMID: 31408867 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 14, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Adaptation of the Modified Mini-Mental State Examination (3MS) and Determination of Its Normative Values in Turkey.
CONCLUSIONS: A widely applicable dementia screening test was adapted to Turkish and its normative values were determined. The test will make it possible to evaluate the cognitive performance of both educated and minimally educated elderly individuals based on their age, gender, and educational level. PMID: 31390625 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 8, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Free-Cog: Pragmatic Test Accuracy Study and Comparison with Mini-Addenbrooke's Cognitive Examination.
CONCLUSION: Free-Cog is an acceptable and accurate test for dementia screening in a dedicated cognitive disorders clinic, but it appears less sensitive than MACE for the identification of MCI. PMID: 31315124 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 19, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Albumin and Hemoglobin Trajectories and Incident Disabling Dementia in Community-Dwelling Older Japanese.
CONCLUSION: Dementia risk was higher for individuals with low trajectories for serum albumin and hemoglobin levels. This finding highlights the importance of interventions that improve nutritional status and control relevant diseases in middle-aged and older adults with low serum albumin and hemoglobin levels. PMID: 31315125 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 19, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Responsiveness to Change of the Montreal Cognitive Assessment, Mini-Mental State Examination, and SCOPA-Cog in Non-Demented Patients with Parkinson's Disease.
CONCLUSION: Using neuropsychological testing as a gold standard comparator, the performance of the MoCA, MMSE, and SCOPA-Cog for detecting decline in non-demented PD patients over a 1-year interval is poor. This has implications for clinical practice; stable scores may not be taken as reassurance of the absence of cognitive decline. PMID: 31315127 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 19, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Midlife Forgetfulness and Risk of Dementia in Old Age: Results from the Danish Working Environment Cohort Study.
CONCLUSIONS: This study is the first to investigate midlife forgetfulness and dementia, and the results suggest that midlife forgetfulness is an early indicator of an increased risk of dementia in old age. PMID: 31319407 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 19, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Assessment of Visual Association Memory in Low-Educated, Non-Western Immigrants with the Modified Visual Association Test.
CONCLUSIONS: The mVAT is a reliable and valid measure of memory in non-Western immigrants. Clinicians and researchers should be aware that the memory performance of immigrants may be systematically underestimated when using tests with black-and-white line drawings, such as the original VAT. PMID: 31319408 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 19, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

The Loss in Expectation of Life due to Early-Onset Mild Cognitive Impairment and Early-Onset Dementia in Norway.
DISCUSSION: Early-onset MCI was associated with substantial life years lost (5-6 years), but the loss was particularly pronounced for those with early-onset dementia, reducing the expected life length by 2 decades. PMID: 31319412 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 19, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Increased Neuronal Nuclear and Perikaryal Size in the Medial Mamillary Nucleus of Vascular Dementia and Alzheimer's Disease Patients: Relation to Nuclear Estrogen Receptor α.
Increased Neuronal Nuclear and Perikaryal Size in the Medial Mamillary Nucleus of Vascular Dementia and Alzheimer's Disease Patients: Relation to Nuclear Estrogen Receptor α. Dement Geriatr Cogn Disord. 2019 Jul 18;:1-7 Authors: Ishunina TA, Bogolepova IN, Swaab DF Abstract BACKGROUND: The hypothalamic medial mamillary (MMN) and the tuberomamillary (TMN) nuclei are important hubs in memory circuits. Previous studies determining the neuronal Golgi complex size showed decreased metabolic activity of the TMN neurons in both Alzhei-mer's disease (AD) and vascular dementia (VD), and no obvious decline...
Source: Dementia and Geriatric Cognitive Disorders - July 19, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Assessing the Prevalence of Undetected Possible Dementia in Faroese Nursing Homes.
CONCLUSION: A high percentage (49-78%) of the participating nursing home residents without a pre-dementia diagnosis were assessed to have possible dementia based on screening with standardized tools, indicating a high degree of dementia underdiagnoses in Faroese nursing homes. This high prevalence of dementia is of significance for the clinical practice, running, and planning of nursing homes and pinpoints a need to act upon this, not only in the Faroes but also worldwide. PMID: 31319414 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 19, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

In vivo Prevalence of Alzheimer Biomarkers in Dementia with Lewy Bodies.
CONCLUSIONS: Reduction in Αβ42 in DLB may be more common (>80% of patients) than previously thought, and ∼40% may have the typical CSF AD biomarker profile. AD biochemistry in DLB may be an evolving process showing increasing frequency with disease progression. PMID: 31311013 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 18, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Prevalence and Incidence of Mild Cognitive Impairment across Subtypes, Age, and Sex.
CONCLUSION: Our findings concur with previous research advocating that MCI is a heterogeneous concept, since the prevalence and incidence estimates differed substantially according to age, MCI subtype, and severity of cognitive impairment. PMID: 31311017 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 18, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Validation of the Sinhala Version of the Addenbrooke's Cognitive Examination-Revised for the Detection of Dementia in Sri Lanka: Comparison with the Mini-Mental Status Examination and the Montreal Cognitive Assessment.
CONCLUSIONS: The ACE-R s is sensitive, specific and reliable to detect dementia in persons aged ≥50 years in a Sinhala-speaking population and its diagnostic accuracy is superior to previously validated tools (MMSE and MoCA). PMID: 31311022 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 18, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Muscle Strength Is Independently Related to Brain Atrophy in Patients with Alzheimer's Disease.
CONCLUSIONS: Our findings imply a shared underlying pathology relating MS and brain volume and suggest cognitive functional declines through the muscle-brain axis. Further longitudinal studies are needed to find possible and related causes of reduced MS and cortical atrophy in patients with dementia. PMID: 31311027 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 18, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Validity and Utility of the Center for Epidemiological Studies Depression Scale for Detecting Depression in Family Caregivers of Persons with Dementia.
CONCLUSIONS: CES-D is a valid and reliable scale for detecting caregiver depression in dementia. It has added utility, beyond that of a caregiver burden scale, in identifying a subgroup of caregivers with depression but not burden. However, two subscales (Positive affect and Interpersonal problems) may require caution in interpretation among non-Caucasian caregivers. PMID: 31307034 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 16, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Diagnostic Failure of Cognitive Impairment in Nursing Home Residents May Lead to Impaired Medical Care.
This study aimed to estimate the prevalence of diagnostic failure of cognitive impairment in a sample of Swedish nursing home residents and to analyze whether diagnostic failure was associated with impaired medical care. METHOD: A total of 428 nursing home residents were investigated during 2008-2011. Subjects without dementia diagnosis were grouped by result of the Mini Mental State Examination (MMSE), where subjects with
Source: Dementia and Geriatric Cognitive Disorders - July 5, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Diagnostic Failure of Cognitive Impairment in Nursing Home Residents May Lead to Impaired Medical Care
Conclusions: Unnoted cognitive impairment is common in nursing home residents and may conceal other potentially treatable conditions such as heart failure. The results highlight a need to pay increased attention to cognitive impairment among nursing home residents.Dement Geriatr Cogn Disord (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 3, 2019 Category: Geriatrics Source Type: research

Author Index
Dement Geriatr Cogn Disord 2019;47:185 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 3, 2019 Category: Geriatrics Source Type: research

Prelims
Dement Geriatr Cogn Disord 2019;47:125 –127 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 3, 2019 Category: Geriatrics Source Type: research

EVALUATE-AD and Tele-STAR: Novel Methodologies for Assessment of Caregiver Burden in a Telehealth Caregiver Intervention - A Case Study.
CONCLUSION: Unobtrusive home-based monitoring may provide a novel, objective method to assess the effectiveness of caregiver intervention programs. PMID: 31247618 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 29, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

The Value of Including People with Dementia in the Co-Design of Personalized eHealth Technologies.
CONCLUSIONS: The Connected Health Summer School early-stage researchers developed 6 app mock-ups based on their discussions and co-creation activities with the two experts with dementia. The reflections on this experience highlight a number of important issues that demand consideration when undertaking eHealth and mHealth research, co-design, and development with and for people with dementia. The evolution in design research from a user-centered approach to co-designing should pave the way to the development of technologies that neither disempower nor reinforce stigma, but instead provide a reliable support to living a lif...
Source: Dementia and Geriatric Cognitive Disorders - June 29, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Methods for Involving People Living with Dementia and Their Informal Carers as Co-Developers of Technological Solutions.
Authors: Kort HSM, Steunenberg B, van Hoof J Abstract This paper reports on the research methods used in five different projects aimed at supporting people living with dementia in their everyday lives and activities of daily living. In all five projects, people living with dementia and their informal carers were involved. Applied methods ranged from passive involvement in the form of observations to very active involvement consisting of consultation rounds and think-aloud sessions. The projects highlighted that people living with dementia can still contribute to the development of solutions that support them in the...
Source: Dementia and Geriatric Cognitive Disorders - June 29, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Technology and Dementia: The Future is Now.
CONCLUSIONS: The pace of technology development requires urgent policy, funding and practice change, away from a narrow medical approach, to a holistic model that facilitates future risk reduction and prevention strategies, enables earlier detection and supports implementation at scale for a meaningful and fulfilling life with dementia. PMID: 31247624 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 29, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Incorporating Conversational Strategies in a Social Robot to Interact with People with Dementia.
CONCLUSIONS: PwDs who participated in the study engaged and enjoyed the interaction with the SAR. The results provide evidence of the importance of incorporating appropriate conversational strategies in SARs that support interventions for the care and social stimulation of PwDs. PMID: 31247627 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 29, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

From Smart Homes to Smart-Ready Homes and Communities.
CONCLUSIONS: There is a great need to integrate technology with living spaces to provide assistance and independent living, but to smarten these spaces for lifelong living, the technology and the smart home applications must be flexible, adaptive, and changeable over time. However, people do not just live at home, they live in communities. Looking at the big picture (communities), as well as the small (homes), we consider how to progress beyond smart-ready homes towards smart-ready communities. PMID: 31247628 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 29, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

EVALUATE-AD and Tele-STAR: Novel Methodologies for Assessment of Caregiver Burden in a Telehealth Caregiver Intervention – A Case Study
Conclusion: Unobtrusive home-based monitoring may provide a novel, objective method to assess the effectiveness of caregiver intervention programs.Dement Geriatr Cogn Disord 2019;47:176 –184 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 27, 2019 Category: Geriatrics Source Type: research

The Value of Including People with Dementia in the Co-Design of Personalized eHealth Technologies
Conclusions: The Connected Health Summer School early-stage researchers developed 6 app mock-ups based on their discussions and co-creation activities with the two experts with dementia. The reflections on this experience highlight a number of important issues that demand consideration when undertaking eHealth and mHealth research, co-design, and development with and for people with dementia. The evolution in design research from a user-centered approach to co-designing should pave the way to the development of technologies that neither disempower nor reinforce stigma, but instead provide a reliable support to living a lif...
Source: Dementia and Geriatric Cognitive Disorders - June 27, 2019 Category: Geriatrics Source Type: research

From Smart Homes to Smart-Ready Homes and Communities
Conclusions: There is a great need to integrate technology with living spaces to provide assistance and independent living, but to smarten these spaces for lifelong living, the technology and the smart home applications must be flexible, adaptive, and changeable over time. However, people do not just live at home, they live in communities. Looking at the big picture (communities), as well as the small (homes), we consider how to progress beyond smart-ready homes towards smart-ready communities.Dement Geriatr Cogn Disord 2019;47:157 –163 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 27, 2019 Category: Geriatrics Source Type: research

Methods for Involving People Living with Dementia and Their Informal Carers as Co-Developers of Technological Solutions
This paper reports on the research methods used in five different projects aimed at supporting people living with dementia in their everyday lives and activities of daily living. In all five projects, people living with dementia and their informal carers were involved. Applied methods ranged from passive involvement in the form of observations to very active involvement consisting of consultation rounds and think-aloud sessions. The projects highlighted that people living with dementia can still contribute to the development of solutions that support them in the self-management of their symptoms and challenges, as well as ...
Source: Dementia and Geriatric Cognitive Disorders - June 27, 2019 Category: Geriatrics Source Type: research

Incorporating Conversational Strategies in a Social Robot to Interact with People with Dementia
Conclusions: PwDs who participated in the study engaged and enjoyed the interaction with the SAR. The results provide evidence of the importance of incorporating appropriate conversational strategies in SARs that support interventions for the care and social stimulation of PwDs.Dement Geriatr Cogn Disord 2019;47:140 –148 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 27, 2019 Category: Geriatrics Source Type: research

Technology and Dementia: The Future is Now
Conclusions: The pace of technology development requires urgent policy, funding and practice change, away from a narrow medical approach, to a holistic model that facilitates future risk reduction and prevention strategies, enables earlier detection and supports implementation at scale for a meaningful and fulfilling life with dementia.Dement Geriatr Cogn Disord 2019;47:131 –139 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 27, 2019 Category: Geriatrics Source Type: research

Technology and Dementia: The Future Is Now.
Authors: Astell AJ PMID: 31234175 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 25, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Technology and Dementia: The Future Is Now
Dement Geriatr Cogn Disord 2019;47:129 –130 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 24, 2019 Category: Geriatrics Source Type: research

Factors Associated with the Prevalence of Cognitive Impairment in a Rural Elderly Cameroonian Population: A Community-Based Study in Sub-Saharan Africa
Conclusion: The identification of modifiable factors would inform evidence-based policy to decrease the health and social burdens of cognitive impairment and dementia in the elderly in rural Cameroon.Dement Geriatr Cogn Disord 2019;47:104 –113 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 15, 2019 Category: Geriatrics Source Type: research

Amyloid β42 and Total Tau Levels in Cerebrospinal Fluid Associate with Survival in an 85-Year-Old Population-Based Cohort Followed until Death
Conclusions: Biological markers of AD are associated with mortality in octogenarians. The reason for this needs further study. Our findings highlight the importance to consider the competing risk of death when evaluating biological markers of AD in the very old.Dement Geriatr Cogn Disord 2019;47:114 –123 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 15, 2019 Category: Geriatrics Source Type: research

Amyloid β42 and Total Tau Levels in Cerebrospinal Fluid Associate with Survival in an 85-Year-Old Population-Based Cohort Followed until Death.
CONCLUSIONS: Biological markers of AD are associated with mortality in octogenarians. The reason for this needs further study. Our findings highlight the importance to consider the competing risk of death when evaluating biological markers of AD in the very old. PMID: 30970371 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 12, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Factors Associated with the Prevalence of Cognitive Impairment in a Rural Elderly Cameroonian Population: A Community-Based Study in Sub-Saharan Africa.
CONCLUSION: The identification of modifiable factors would inform evidence-based policy to decrease the health and social burdens of cognitive impairment and dementia in the elderly in rural Cameroon. PMID: 30965322 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 11, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Distinctive and Pervasive Alterations of Functional Brain Networks in Cerebral Small Vessel Disease with and without Cognitive Impairment
Conclusion: These findings suggest that cognitive alterations of CSVD subjects may be mainly regulated by the FPCN that correlates with DWMH burden, and shed light on the investigation of surrogate markers of CSVD.Dement Geriatr Cogn Disord 2019;47:55 –67 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - March 14, 2019 Category: Geriatrics Source Type: research

Vascular Depression and Cognition in Mexican Americans
Conclusion: The results of this study indicated that comorbid depression and a high CVD risk were associated with poorer cognitive performance and increased risk of MCI in Mexican Americans.Dement Geriatr Cogn Disord 2019;47:68 –78 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - March 14, 2019 Category: Geriatrics Source Type: research

Feasibility of Remote Assessment of Human Prion Diseases for Research and Surveillance
Conclusions: We demonstrate the feasibility and preference of teleneurology as a modality in which subjects with prion disease can partake in clinical research. Technological aspects sometimes interfered with research assessments.Dement Geriatr Cogn Disord 2019;47:79 –90 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - March 14, 2019 Category: Geriatrics Source Type: research

Prevalence of < b > < i > C9ORF72 < /i > < /b > Expansion in a Large Series of Patients with Idiopathic Normal-Pressure Hydrocephalus
Conclusion: This is the first study cohort identifying the underlyingC9ORF72 expansion in patients with iNPH providing evidence for the potential comorbidity between iNPH and the FTLD-ALS spectrum. Analysis of theC9ORF72 expansion should be considered for patients with probable iNPH presenting with frontal atrophy and personality changes or other severe psychiatric symptoms.Dement Geriatr Cogn Disord 2019;47:91 –103 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - March 14, 2019 Category: Geriatrics Source Type: research

Vascular Depression and Cognition in Mexican Americans.
CONCLUSION: The results of this study indicated that comorbid depression and a high CVD risk were associated with poorer cognitive performance and increased risk of MCI in Mexican Americans. PMID: 30861514 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - March 13, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Prevalence of C9ORF72 Expansion in a Large Series of Patients with Idiopathic Normal-Pressure Hydrocephalus.
CONCLUSION: This is the first study cohort identifying the underlying C9ORF72 expansion in patients with iNPH providing evidence for the potential comorbidity between iNPH and the FTLD-ALS spectrum. Analysis of the C9ORF72 expansion should be considered for patients with probable iNPH presenting with frontal atrophy and personality changes or other severe psychiatric symptoms. PMID: 30861516 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - March 13, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Distinctive and Pervasive Alterations of Functional Brain Networks in Cerebral Small Vessel Disease with and without Cognitive Impairment.
CONCLUSION: These findings suggest that cognitive alterations of CSVD subjects may be mainly regulated by the FPCN that correlates with DWMH burden, and shed light on the investigation of surrogate markers of CSVD. PMID: 30861519 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - March 13, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Feasibility of Remote Assessment of Human Prion Diseases for Research and Surveillance.
CONCLUSIONS: We demonstrate the feasibility and preference of teleneurology as a modality in which subjects with prion disease can partake in clinical research. Technological aspects sometimes interfered with research assessments. PMID: 30861521 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - March 13, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Acknowledgement to Reviewers
Dement Geriatr Cogn Disord 2018;46:385 –386 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - January 17, 2019 Category: Geriatrics Source Type: research

Contents Vol. 46
Dement Geriatr Cogn Disord 2018;46:I –IV (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - January 17, 2019 Category: Geriatrics Source Type: research

Predementia Brain Changes in Progranulin Mutation: A Systematic Review of Neuroimaging Evidence
Background: Mutations in the progranulin (GRN) gene are a major cause of familial frontotemporal dementia. They result in a loss of progranulin levels and inGRN-related brain degenerative changes that unfold over years if not decades. The aim of our review was to summarize the evidence on emerging functional and structural brain abnormalities in carriers ofGRN mutations.Summary: We performed a systematic search for studies that used at least one modality (structural MRI, fMRI, fluorodeoxyglucose positron emission tomography, diffusion tensor imaging) to compare mutation carriers to non-carrier controls. Our search produced...
Source: Dementia and Geriatric Cognitive Disorders - January 13, 2019 Category: Geriatrics Source Type: research