In silico Analysis of the Immunological Landscape of Hippocampi in Alzheimer's Disease.
CONCLUSION: AD-afflicted hippocampi present with a distinct immune signature and dendritic cells may play a critical role in the pathogenesis of AD in this brain component. PMID: 32544905 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 17, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Effects of Combined Physical Movement Activity and Multifaceted Cognitive Training in Older People with Mild Neurocognitive Disorder in a Rural Community: A Randomized Control Trial.
CONCLUSIONS: The combined intervention appeared to be effective in delaying/preventing cognitive deterioration and cognitive functional decline in people with mNCD. Further studies on a variation of treatments suited to cultural conditions and their effects are needed. Trials in other communities are also recommended. PMID: 32535601 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 16, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Maintaining Aging Hippocampal Function with Safe and Feasible Shaking Exercise in SAMP10 Mice.
Authors: Yao R, Nishii K, Aizu N, Kito T, Sakai K, Yamada K Abstract INTRODUCTION: The disabling effects of dementia, an incurable disease with little effect on mortality, affect society far more than many other conditions. OBJECTIVE: The aim of this study was to stop or delay the onset of dementia using low-cost methods such as physical exercise. METHODS: Senescence-accelerated model-prone (SAMP) 10 mice were made to perform a user-friendly shaking exercise for 25 weeks. The motor function and hippocampal functions (learning, spatial cognition) of the mice were evaluated using behavioral experiments. The d...
Source: Dementia and Geriatric Cognitive Disorders - June 13, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Eye Tracking Analysis of Visual Cues during Wayfinding in Early Stage Alzheimer's Disease.
CONCLUSION: Individuals with AD may have difficulty selecting relevant information for wayfinding as compared to normally aging individuals and attend more frequently than controls to irrelevant information. This may help explain the wayfinding difficulties seen in AD. PMID: 32516764 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 11, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Translational Scoring of Candidate Treatments for Alzheimer's Disease: A Systematic Approach.
Authors: Cummings JL Abstract BACKGROUND: There are many failures in treatment development for Alzheimer's disease (AD). Some of these failures are the result of development programs that lacked critical information about candidate drugs as these were advanced from one phase of development to the next. Translational scoring (TS) has been proposed as a means of increasing the rigor with which treatment development programs are executed. Previously, these approaches were not specific to AD or to the phase of drug development. Detailed information on the characteristics needed to advance a candidate agent from one pha...
Source: Dementia and Geriatric Cognitive Disorders - June 10, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Comparison of Prodromal Symptoms of Patients with Behavioral Variant Frontotemporal Dementia and Alzheimer Disease.
CONCLUSIONS: Subjective reporting of impaired episodic memory is a poor indicator in differentiating bvFTD from AD. Sleeping disturbances, delusions, hallucinations, and unexplained somatic complaints in a patient with cognitive disturbances should prompt the clinicians to consider bvFTD as a possible diagnostic option behind these symptoms. The spectrum of symptoms in the prodromal stages of bvFTD may be more diverse than the latest criteria suggest. PMID: 32485711 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 4, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Physical Exercise Ameliorates the Cognitive Function and Attenuates the Neuroinflammation of Alzheimer's Disease via miR-129-5p.
CONCLUSION: All data indicated that the expression of miR-129-5p in AD mice and patients is significantly upregulated by physical exercise. The knockdown of miR-129-5p can abrogate the neuroprotective effect of exercise on cognition and neuroinflammation in AD mice. This study provides a novel insight into the molecular mechanisms underlying the neuroprotective effect of physical exercise in AD, and miR-129-5p may provide a novel therapeutic target for AD treatment. PMID: 32434194 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - May 22, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Validation of the Egyptian-Arabic Version of the Addenbrooke's Cognitive Examination III (ACE-III) in Diagnosing Dementia.
Authors: Qassem T, Khater MS, Emara T, Rasheedy D, Tawfik HM, Mohammedin AS, Tolba MF, Abdel Aziz K Abstract INTRODUCTION: The Addenbrooke's Cognitive Examination III (ACE-III) (2012) is a brief cognitive battery that assesses five sub-domains of cognition (attention and orientation, memory, verbal fluency, language, and visuospatial abilities) which are commonly impaired in dementia. OBJECTIVE: We aimed to validate the Egyptian-Arabic ACE-III in dementia patients, and to provide cut-off scores for the ACE-III in diagnosing dementia in Egyptian-Arabic speakers. METHODS: We included 37 patients with dementia...
Source: Dementia and Geriatric Cognitive Disorders - May 18, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Psychometric Cognitive Decline Precedes the Advent of Subjective Cognitive Decline in the Evolution of Alzheimer's Disease.
Authors: Reisberg B, Shao Y, Moosavi M, Kenowsky S, Vedvyas A, Marsh K, Bao J, Buj M, Torossian C, Kluger A, Vedvyas G, Oo T, Malik F, Arain F, Masurkar AV, Wisniewski T Abstract BACKGROUND: We have described the clinical stages of the brain aging and Alzheimer's disease (AD) continuum. In terms of the pre-dementia stages of AD, we introduced the terminology "mild cognitive impairment" (MCI) for the first pre-dementia stage and "subjective cognitive decline" (SCD) for the pre-MCI stage. We now report the characteristics of a pre-SCD condition eventuating in likely AD. OBJECTIVE: The aim of t...
Source: Dementia and Geriatric Cognitive Disorders - May 12, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Cerebrospinal Fluid YKL-40 and Chitotriosidase Levels in Frontotemporal Dementia Vary by Clinical, Genetic and Pathological Subtype.
CONCLUSION: CSF YKL-40 and chitotriosidase levels are increased in individuals with clinical FTD syndromes, particularly due to AD pathology. In a preliminary analysis of genetic groups, levels of both proteins are found to be highly elevated in FTD due to GRN mutations, while YKL-40 is increased in individuals with MAPT mutations. As glia-derived protein levels generally correlate with T-tau and P-tau levels, they may reflect the glial response to neurodegeneration in FTLD. PMID: 32344399 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 29, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Pronounced Impairment of Activities of Daily Living in Posterior Cortical Atrophy.
Authors: Ahmed S, Culley S, Blanco-Duque C, Hodges JR, Butler C, Mioshi E Abstract INTRODUCTION: The impact of several dementia syndromes on activities of daily living (ADLs) has been well documented, but no study has yet investigated functional ability in posterior cortical atrophy (PCA). The primarily visual nature of deficits in this condition is likely to have a pronounced impact on ADLs. OBJECTIVE: The aim of this study was to profile functional change in PCA and identify predictors of change. METHOD: Twenty-nine PCA patients and 25 patients with typical Alzheimer's disease (AD) and their caregivers we...
Source: Dementia and Geriatric Cognitive Disorders - April 24, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

A Study on the Relationship between Cognitive Performance, Hearing Impairment, and Frailty in Older Adults.
CONCLUSIONS: This study highlights the negative relationship between cognitive performance scored on the DSST and the presence of HI. Furthermore, the presence of both frailty and HI is associated with a worse cognitive score than HI alone. PMID: 32320988 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 24, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Neuropsychiatric Symptoms in Mild Cognitive Impairment: A Literature Review.
Authors: Martin E, Velayudhan L Abstract BACKGROUND: Neuropsychiatric symptoms (NPS) in dementia have received much attention due to their high prevalence and their significant implications. NPS in mild cognitive impairment (MCI), a clinical concept proposed as an intermediate state between normal aging and dementia, is now gradually gaining in interest. We aimed to conduct a selective review to examine the prevalence rate of NPS in MCI and associations of NPS symptoms with disease progression. SUMMARY: We searched the PubMed database for articles on NPS in MCI and included articles that fulfilled the inclusion...
Source: Dementia and Geriatric Cognitive Disorders - April 15, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Magnetic Resonance Imaging Texture of Medial Pulvinar in Dementia with Lewy Bodies.
CONCLUSIONS: In DLB, the left PuM may be altered from early stage, which may contribute to the development of executive dysfunction. PMID: 32259816 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 8, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

A Brief Informant Screening Instrument for Dementia in the ICU: The Diagnostic Accuracy of the AD8 in Critically Ill Adults Suspected of Having Pre-Existing Dementia.
CONCLUSIONS: Among critically ill patients judged at risk for pre-existing dementia, the 2- to 3-min AD8 is highly sensitive and has a high NPV. These data indicate that the brief tool can serve to rule out dementia in a specific patient population. PMID: 32259825 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 8, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Demographic Characteristics Associated with the Likelihood to Use Paid Home Care for People with Dementia among South African Muslims.
CONCLUSION: Home-based care is touted as the next dementia care model. Given that intergenerational mobility is likely to increase as future generations continue to participate more in the labour market, minority groups with a disposition to the same familial social values will require appropriate support in order to cope with the demands of caring for PWD. Suitable interventions for Muslim families who are not open to using external assistance, as well as those who are, need to be administered to enable the caregiver and care recipient to thrive at home. PMID: 32241008 [PubMed - as supplied by publisher] (Source: Deme...
Source: Dementia and Geriatric Cognitive Disorders - April 4, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Diagnostic Stability of Mild Cognitive Impairment, and Predictors of Reversion to Normal Cognitive Functioning.
CONCLUSION: Our findings provide further support that MCI reversion to normal cognitive functioning as well as re-transitioning to MCI is fairly common, suggesting that the MCI trajectory does not necessarily lead straight to dementia. Additionally, assessment of factors associated with reversion can aid clinicians to make accurate MCI progression prognosis. PMID: 32224608 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 2, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Diagnostic Impact of CSF Biomarkers in a Local Hospital Memory Clinic Revisited.
CONCLUSIONS: Our study results corroborate earlier findings that the CSF tool is of added value to the diagnostic workup in daily clinical practice outside tertiary referral centers. CSF levels can best be used in patients under 66 years of age. Given the limited use of this tool in settings outside research facilities, we recommend that the usefulness of CSF biomarkers is studied in a multicenter study. When in the future CSF levels can be reliably measured in plasma, this may become even more relevant. PMID: 32224618 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 2, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Dementia Knowledge and Attitudes of the General Public among the Bangladeshi Community in England: A Focus Group Study.
CONCLUSION: Future research must highlight the importance of raising dementia awareness among, and providing information about dementia caregiving to, Bangladeshi community members, as well as providing religiously sensitive healthcare services. PMID: 32213774 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - March 29, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Cognitive Reserve Attenuates 6-Year Decline in Executive Functioning after Stroke.
CONCLUSION: The detrimental aftereffects of stroke on subsequent decline in executive functioning may be attenuated in individuals who have accumulated greater cognitive reserve through leisure activity engagement across their life. PMID: 32209793 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - March 28, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

White Matter Hyperintensities and Cognitive Impairment in Healthy and Pathological Aging: A Quantified Brain MRI Study.
CONCLUSIONS: WM pathology is strongly associated with impaired processing speed, and our results indicate that these impairments arise from WMH in the temporal and parieto-occipital regions. In MCI and AD patients with temporal WMH, processing speed impairments are especially prominent. The results of this study increase our knowledge of cognitive repercussions stemming from temporal and/or parieto-occipital WM pathology in healthy and pathological aging. PMID: 32209796 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - March 28, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Traditional Gender Roles and Effects of Dementia Caregiving within a South Asian Ethnic Group in England.
CONCLUSION: There is a dearth of research about socioeconomic transformations in South Asian women's migration to Western countries that could contribute to deterring them from providing family care. More research is warranted to understand the ways in which migration shapes gender relations in South Asian families and its impact on care for the frail elderly. PMID: 32208389 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - March 26, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Poststroke Cognitive Impairment in Model-Based Economic Evaluation: A Systematic Review.
CONCLUSIONS: Current stroke models used in economic evaluation are not adequate to model poststroke CI or dementia, and will require adaptation to be used for this purpose. PMID: 32187606 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - March 19, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Dementia Caf és as Hubs to Promote Community-Integrated Care for Dementia through Enhancement of the Competence of Citizen Volunteer Staff Using a New Assessment Tool.
Dementia Cafés as Hubs to Promote Community-Integrated Care for Dementia through Enhancement of the Competence of Citizen Volunteer Staff Using a New Assessment Tool. Dement Geriatr Cogn Disord. 2020 Mar 04;:1-10 Authors: Takechi H, Yamamoto F, Matsunagaa S, Yoshino H, Suzuki Y Abstract INTRODUCTION: Dementia cafés have recently been attracting attention. The increased involvement of citizen volunteers and the competence of dementia café staff could enhance the potential of dementia cafés. The aim of the present study was to examine enhancement of the competence of citizen v...
Source: Dementia and Geriatric Cognitive Disorders - March 6, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Feasibility, Reliability, and Validity of the Vietnamese Version of the Clinical Dementia Rating.
CONCLUSIONS: The V-CDR is a feasible, reliable, and valid instrument which should be used in clinical practice for diagnosing and classifying the different dementia stages in the elderly. PMID: 32126553 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - March 5, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Global Mapping of Interventions to Improve Quality of Life of Patients with Alzheimer's Disease during 1990-2018.
This study aimed to identify research trends and landscapes as well as important factors in QOL studies in the field of AD. SUMMARY: English research was extracted from the online database Web of Science to analyze research publications' growth rate and content on AD and QOL. VOSviewer was used to visualize the correlations between terms in titles and abstracts. Research topics were created using Latent Dirichlet Allocation of abstracts' content and disciplines. Major landscapes in the QOL assessment included care and treatment for AD in epidemiological studies and clinical trials. Besides, most studies were conducted ...
Source: Dementia and Geriatric Cognitive Disorders - March 3, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Qualitative and Quantitative Analyses of Brain 18Fluoro-Deoxy-Glucose Positron Emission Tomography in Primary Progressive Aphasia.
CONCLUSIONS: Brain 18F-FDG PET had an elevated performance in the early diagnosis of PPA variants and in the advanced PPA AD/FTD classification. QL clarified the development of AD or FTD in advanced PPA cases and supported the differential diagnosis of a PPA variant in a few early cases. QN 18F-FDG PET evaluation better contributed to the early diagnosis of an unclear metabolic pattern. To correctly identify all cases, patients with diffuse cortical hypometabolism were also included. Larger series are necessary to confirm these data. PMID: 32062656 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - February 20, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Muslims' Affective and Cognitive Attitudes towards Formal Dementia Care in South Africa: Do They Vary according to Family Structure and the Experience of Familial Caregiving?
CONCLUSION: With up to 90% of PWD moving into formal care before they die in some countries, governments and other service providers of formal care need to provide culturally congruent care. There is also a need to build relationships with minority social groups that are not cared for by geriatric service organisations (governmental and non-governmental) in order to break down the negative attitudes that families have about formal care, and provide the families caring for PWD at home with coping strategies and support programmes to enhance the caregiving experience. PMID: 32069454 [PubMed - as supplied by publisher] (S...
Source: Dementia and Geriatric Cognitive Disorders - February 20, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Bilingualism Delays Expression of Alzheimer's Clinical Syndrome.
CONCLUSIONS: In line with published reports worldwide, we found that bilingualism delays the expression of Alzheimer's clinical syndrome. We also found frequent reversion to the first learned language. These findings suggest that, among bilinguals, the availability of an L1 "back-up" either facilitates compensation or masks emergence of the early symptoms of dementia. PMID: 32045913 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - February 12, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Cognitive Reserve Attenuates the Relation between Gastrointestinal Diseases and Subsequent Decline in Executive Functioning.
CONCLUSION: Cognitive reserve may attenuate the detrimental influences of gastrointestinal diseases on subsequent decline in executive functioning. PMID: 32007989 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - February 4, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Why Not a Global Postural Reeducation as an Alternative Therapy Applied to Alzheimer's Patients in Nursing Homes? A Pioneer Randomized Controlled Trial.
CONCLUSION: This study demonstrated a very good tolerance rate on behalf of the significant results achieved. PMID: 32007991 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - February 4, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Preoperative Depression and Plasma Cortisol Levels as Predictors of Delirium after Cardiac Surgery.
The objective of the present study was to determine whether preoperative depression symptoms and increased cortisol level represent risk factors for delirium after cardiac surgery. METHODS: We performed a prospective cohort study in 183 patients aged>50 years undergoing elective cardiac surgery. The Geriatric Depression Scale (GDS) was used to assess patients for depressive symptoms before surgery. Preoperative plasma cortisol levels were available in 145 participants. Delirium was diagnosed using the Confusion Assessment Method for Intensive Care Unit (CAM-ICU) during the first 7 days after surgery. Spearman correl...
Source: Dementia and Geriatric Cognitive Disorders - February 4, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Changes in Plasma Amyloid and Tau in a Longitudinal Study of Normal Aging, Mild Cognitive Impairment, and Alzheimer's Disease.
CONCLUSION: Plasma Aβ and tau levels change in a dynamic, nonlinear, nonparallel manner over the AD continuum. Changes in plasma Aβ concentration are time-dependent, whereas changes in hyperphosphorylated tau protein levels paralleled the clinical progression of MCI. It remains to be clarified whether diagnostic efficiency can be improved by combining multiple plasma markers or combining plasma markers with other diagnostic biomarkers. PMID: 31991443 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - January 29, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Lifestyle Factors and Subjective Cognitive Impairment in Patients Seeking Help at a Memory Disorder Clinic: The Role of Negative Life Events.
CONCLUSIONS: Lifestyle subgroups of patients were determined by stress, emotional problems, and age. The groups were significantly associated with Aβ42 and diagnostic outcome. This pattern may confound the differentiation between objective and subjective memory problems. Asking about lifestyle variables, in conjunction with neuropsychological testing, could potentially identify individuals who are not likely to have objective memory impairment and guide interventions. PMID: 31982880 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - January 28, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

The CAIDE Dementia Risk Score and the Honolulu-Asia Aging Study.
Authors: Chosy EJ, Edland SD, Gross N, Meyer MJ, Liu CY, Launer LJ, White LR Abstract INTRODUCTION: The CAIDE (Cardiovascular Risk Factors, Aging, and Incidence of Dementia) dementia risk score is based on demographic, genetic, and modifiable risk factors in midlife and has been shown to be predictive of later-life dementia. OBJECTIVE: To test the predictive capacity of the CAIDE dementia risk score among a cohort of Japanese-American men. METHODS: Midlife measures were obtained from a sample of 3,582 Japanese-American men in the Honolulu Heart Program (1965-1968, average age = 53.1 years). A follow-up exam...
Source: Dementia and Geriatric Cognitive Disorders - January 23, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Donepezil Attenuates Obesity-Associated Oxidative Stress and Central Inflammation and Improves Memory Deficit in Mice Fed a High-Fat Diet.
CONCLUSION: Our results indicate that donepezil may reverse obesity-related central inflammation and oxidative damage and improve memory deficit in HFD-fed mice. PMID: 31940604 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - January 16, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Improving Engagement of Mild to Moderate Dementia Alzheimer's Disease Patients Using Evidence-Based Visual Cognitive Stimulation Exercises.
CONCLUSIONS: The type and characteristics of CS exercises have an impact on the engagement level of AD patients with mild to moderate dementia. Further studies are necessary to better understand which characteristics of the exercises affect the engagement of the patient according to their particularities. This kind of study may help the design of CS sessions and improve the results obtained. PMID: 31940610 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - January 16, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Neurodegenerative Patterns of Cognitive Clusters of Early-Onset Alzheimer's Disease Subjects: Evidence for Disease Heterogeneity.
Authors: Phillips ML, Stage EC, Lane KA, Gao S, Risacher SL, Goukasian N, Saykin AJ, Carrillo MC, Dickerson BC, Rabinovici GD, Apostolova LG, Alzheimer’s Disease Neuroimaging Initiative Abstract BACKGROUND/AIMS: Alzheimer's disease (AD) with onset before 65 (early-onset AD [EOAD]) occurs in approximately 6% of cases and can affect nonmemory domains. Here, we analyze patterns of impairment in amnestic EOAD individuals using data-driven statistical analyses. METHODS: Cognitive data of 146 EOAD subjects were Z-normalized to 395 cognitively normal (CN) individuals. Domain-averaged Z-scores were...
Source: Dementia and Geriatric Cognitive Disorders - January 8, 2020 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Incidental Findings Identified on Head MRI for Investigation of Cognitive Impairment: A Retrospective Review.
CONCLUSION: Incidental findings are common in patients with cognitive impairment from this large clinic-based series; however, few required additional medical evaluation. These data could help inform discussions between clinicians and people with cognitive symptoms regarding the likelihood and potential implications of incidental imaging findings. PMID: 31805574 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 6, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Validation Prognostic of the Baylor Profound Mental Status Examination.
CONCLUSIONS: BPMSE has a limited predictive value for the variables studied. PMID: 31739306 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - November 20, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Review of Gait, Cognition, and Fall Risks with Implications for Fall Prevention in Older Adults with Dementia.
Authors: Zhang W, Low LF, Schwenk M, Mills N, Gwynn JD, Clemson L Abstract BACKGROUND: Older people with cognitive impairment are at increased risk of falls; however, fall prevention strategies have limited success in this population. The aim of this paper is to review the literature to inform a theoretical framework for fall prevention in older adults with dementia. SUMMARY: A narrative review was conducted on fall risk factors in people with cognitive impairment, the relationship between cognition and gait, and their joint impact on the risk of falls. This was used to develop a theoretical framework for fall ...
Source: Dementia and Geriatric Cognitive Disorders - November 20, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Long-Term Occupational Sleep Loss and Post-Retirement Cognitive Decline or Dementia.
CONCLUSION: We found no evidence that long-term exposure to work-related sleep loss had resulted in cognitive decline or early dementia symptoms in this sample of retired maritime pilots. PMID: 31726459 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - November 16, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

A Systematic Review of Multimodal Non-Pharmacological Interventions for Cognitive Function in Older People with Dementia in Nursing Homes.
CONCLUSION: Our review suggests that MNPIs may improve the global, executive function and memory of PWD in NHs. The combination of exercise, cognitive training and activities of daily living, and intervention at least 3 times a week over at least 8 weeks with, at least 30 min per session using the integrated form is recommended for improving the global and specific cognitive functions of PWD in NHs. PMID: 31634894 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 23, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Predictors of Mortality in the Oldest Old Patients with Newly Diagnosed Alzheimer Disease in a Residential Aged Care Facility.
CONCLUSION: Comorbidity burden, nutritional status, and physical functional status at the time of dementia diagnosis are important contributors to poor outcome in the oldest old. Efforts to control concurrent chronic disorders, nutritional interventions, and physical independency as a long-term care strategy for dementia may provide survival benefit. PMID: 31600747 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 11, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Prospective Memory Relates to Attentional Control: Differential Patterns in Old Age.
CONCLUSION: YO may be able to better (than OO) achieve a good PM performance with good attentional control. PMID: 31590167 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 9, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Cognitive Impairment Is Associated with Absolute Intraoperative Frontal α-Band Power but Not with Baseline α-Band Power: A Pilot Study.
CONCLUSIONS: Preoperative cognitive impairment in older adults is associated with intraoperative absolute frontal α-band power, but not baseline α-band power. PMID: 31578031 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 4, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Association between Deep Gray Matter Changes and Neurocognitive Function in Mild Cognitive Impairment and Alzheimer's Disease: A Tensor-Based Morphometric MRI Study.
CONCLUSIONS: Atrophy of the DGM structures, especially the thalamus and caudate nucleus, is related to cognitive impairment in AD. DGM atrophy is associated with tests reflecting both subcortical and cortical cognitive functions. PMID: 31514198 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - September 14, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Cognitive Reserve Mediates the Relation between Openness to Experience and Smaller Decline in Executive Functioning.
CONCLUSION: Individuals with higher openness to experience show greater activity engagement in old age. By enhancing their cognitive reserve, this activity engagement may finally result in smaller subsequent decline in executive functioning. PMID: 31509829 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - September 13, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Microstructural Correlates and Laterality Effect of Prospective Memory in Non-Demented Adults with Memory Complaints.
CONCLUSIONS: ProM was related to the integrity of interhemispheric commissural fibers and association fibers that connect the frontal lobe with posterior regions, with a task-specific laterality effect. Time-based ProM tasks and self-reported ProM questionnaire may be sensitive to early pathological cognitive deterioration, while the concomitant aging process and individual awareness level may respectively confound the results of evaluation. PMID: 31466053 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 31, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Is Low Psychomotor Speed a Marker of Brain Vulnerability in Late Life? Digit Symbol Substitution Test in the Prediction of Alzheimer, Parkinson, Stroke, Disability, and Depression.
Authors: Amieva H, Meillon C, Proust-Lima C, Dartigues JF Abstract BACKGROUND: Dementia, stroke, depression, and disability are frequent in late life and are major causes of quality of life disruption and family burden. Even though each of these disorders relies on specific pathogenic processes, a common clinical manifestation is psychomotor slowing. OBJECTIVE: We assessed the relevance of a simple marker of low psychomotor speed in predicting several brain outcomes: dementia, Alzheimer's disease (AD), Parkinson's disease (PD), stroke, depressive symptoms, and disability in activities of daily living (ADL) and ...
Source: Dementia and Geriatric Cognitive Disorders - August 31, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research