Acknowledgement to Reviewers
Dement Geriatr Cogn Disord 2018;46:385 –386 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - January 17, 2019 Category: Geriatrics Source Type: research

Contents Vol. 46
Dement Geriatr Cogn Disord 2018;46:I –IV (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - January 17, 2019 Category: Geriatrics Source Type: research

Predementia Brain Changes in Progranulin Mutation: A Systematic Review of Neuroimaging Evidence
Background: Mutations in the progranulin (GRN) gene are a major cause of familial frontotemporal dementia. They result in a loss of progranulin levels and inGRN-related brain degenerative changes that unfold over years if not decades. The aim of our review was to summarize the evidence on emerging functional and structural brain abnormalities in carriers ofGRN mutations.Summary: We performed a systematic search for studies that used at least one modality (structural MRI, fMRI, fluorodeoxyglucose positron emission tomography, diffusion tensor imaging) to compare mutation carriers to non-carrier controls. Our search produced...
Source: Dementia and Geriatric Cognitive Disorders - January 13, 2019 Category: Geriatrics Source Type: research

Simultaneous Stimulation of the Globus Pallidus Interna and the Nucleus Basalis of Meynert in the Parkinson-Dementia Syndrome
Conclusion: This case explores an available alternative for complete DBS treatment in PD, stimulating 2 targets at different frequencies with a single electrode lead.Dement Geriatr Cogn Disord 2019;47:19 –28 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - January 13, 2019 Category: Geriatrics Source Type: research

Development of the Central Africa Daily Functioning Interference Scale for Dementia Diagnosis in Older Adults: The EPIDEMCA Study
Conclusions: These results provide valuable support for the reliability and internal validity of an operational 10-item scale for DFI assessment used in Central Africa for the diagnosis of dementia in the elderly.Dement Geriatr Cogn Disord 2019;47:29 –41 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - January 13, 2019 Category: Geriatrics Source Type: research

Evaluating Patient Brain and Behavior Pathways to Caregiver Health in Neurodegenerative Diseases
Conclusions: This study shows the value of patients ’ brain data in identifying caregivers at risk for becoming sick themselves.Dement Geriatr Cogn Disord 2019;47:42 –54 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - January 13, 2019 Category: Geriatrics Source Type: research

Simultaneous Stimulation of the Globus Pallidus Interna and the Nucleus Basalis of Meynert in the Parkinson-Dementia Syndrome.
CONCLUSION: This case explores an available alternative for complete DBS treatment in PD, stimulating 2 targets at different frequencies with a single electrode lead. PMID: 30630160 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - January 12, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Evaluating Patient Brain and Behavior Pathways to Caregiver Health in Neurodegenerative Diseases.
CONCLUSIONS: This study shows the value of patients' brain data in identifying caregivers at risk for becoming sick themselves. PMID: 30630168 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - January 12, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Development of the Central Africa Daily Functioning Interference Scale for Dementia Diagnosis in Older Adults: The EPIDEMCA Study.
CONCLUSIONS: These results provide valuable support for the reliability and internal validity of an operational 10-item scale for DFI assessment used in Central Africa for the diagnosis of dementia in the elderly. PMID: 30630171 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - January 12, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Predementia Brain Changes in Progranulin Mutation: A Systematic Review of Neuroimaging Evidence.
Authors: Alexander C, Pisner D, Jacova C Abstract BACKGROUND: Mutations in the progranulin (GRN) gene are a major cause of familial frontotemporal dementia. They result in a loss of progranulin levels and in GRN-related brain degenerative changes that unfold over years if not decades. The aim of our review was to summarize the evidence on emerging functional and structural brain abnormalities in carriers of GRN mutations. SUMMARY: We performed a systematic search for studies that used at least one modality (structural MRI, fMRI, fluorodeoxyglucose positron emission tomography, diffusion tensor imaging) to compa...
Source: Dementia and Geriatric Cognitive Disorders - January 12, 2019 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Neurofilament Light in Serum and Cerebrospinal Fluid of Hip Fracture Patients with Delirium
Conclusion: Our findings support an association between neuroaxonal injury and delirium. The correlation between serum and CSF NFL supports the use of NFL as a blood biomarker in future delirium studies.Dement Geriatr Cogn Disord 2018;46:346 –357 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 13, 2018 Category: Geriatrics Source Type: research

The Effectiveness of a Virtual Reality-Based Tai Chi Exercise on Cognitive and Physical Function in Older Adults with Cognitive Impairment
Conclusions: The VRTC exercise posed a protective effect for some cognitive and physical functions in older adults with CI. The more engaging the program, the greater the improvement in the cognitive performance.Dement Geriatr Cogn Disord 2018;46:358 –370 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 13, 2018 Category: Geriatrics Source Type: research

Effects of Light Treatment on Sleep, Cognition, Mood, and Behavior in Alzheimer ’s Disease: A Systematic Review
Background: Bright light treatment is a therapeutic intervention mainly used to treat sleep and circadian disturbances in Alzheimer ’s disease (AD) patients. Recently, a handful of studies also focused on the effect on cognition and behavior. Conflicting findings are reported in the literature, and no definite conclusions have been drawn about its specific therapeutic effect.Summary: The aim of this review is to provide a critical evaluation of available evidence in this field, highlighting the specific characteristics of effective bright light treatment. Eligible studies were required to assess at least one of the f...
Source: Dementia and Geriatric Cognitive Disorders - December 13, 2018 Category: Geriatrics Source Type: research

The Effectiveness of a Virtual Reality-Based Tai Chi Exercise on Cognitive and Physical Function in Older Adults with Cognitive Impairment.
CONCLUSIONS: The VRTC exercise posed a protective effect for some cognitive and physical functions in older adults with CI. The more engaging the program, the greater the improvement in the cognitive performance. PMID: 30537752 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 12, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Effects of Light Treatment on Sleep, Cognition, Mood, and Behavior in Alzheimer's Disease: A Systematic Review.
Authors: Mitolo M, Tonon C, La Morgia C, Testa C, Carelli V, Lodi R Abstract BACKGROUND: Bright light treatment is a therapeutic intervention mainly used to treat sleep and circadian disturbances in Alzheimer's disease (AD) patients. Recently, a handful of studies also focused on the effect on cognition and behavior. Conflicting findings are reported in the literature, and no definite conclusions have been drawn about its specific therapeutic effect. SUMMARY: The aim of this review is to provide a critical evaluation of available evidence in this field, highlighting the specific characteristics of effective bri...
Source: Dementia and Geriatric Cognitive Disorders - December 12, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Systematic Review and Meta-Analysis of Prevalence in Post-Stroke Neurocognitive Disorders in Hospital-Based Studies.
CONCLUSION: More than half of stroke survivors experience post-stroke NCD, corresponding to mild post-stroke NCD in two-thirds of cases and major post-stroke NCD in one-third of cases. Harmonization of stroke assessment and cognitive score thresholds is urgently needed to allow more accurate estimation of post-stroke NCD prevalence, especially mild post-stroke NCD. PMID: 30504699 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 8, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Neurofilament Light in the Serum and Cerebrospinal Fluid of Hip Fracture Patients with Delirium.
Authors: Halaas NB, Blennow K, Idland AV, Wyller TB, Ræder J, Frihagen F, Staff AC, Zetterberg H, Watne LO Abstract BACKGROUND: Delirium is associated with new-onset dementia, suggesting that delirium pathophysiology involves neuronal injury. Neurofilament light (NFL) is a sensitive biomarker for neuroaxonal injury. METHODS: NFL was measured in cerebrospinal fluid (CSF) (n = 130), preoperative serum (n = 192), and postoperative serum (n = 280) in hip fracture patients, and in CSF (n = 123) and preoperative serum (n = 134) in cognitively normal older adults undergoing elective surgery. Delirium was diagnos...
Source: Dementia and Geriatric Cognitive Disorders - December 8, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Validation of the Czech Montreal Cognitive Assessment for Mild Cognitive Impairment due to Alzheimer Disease and Czech Norms in 1,552 Elderly Persons.
CONCLUSIONS: The cutoff for AD-MCI and stratified norms are available for the MoCA total score and delayed recall of the Czech version. The cut-off scores of the MoCA-CZ, sensitivity, and specificity are lower than in the original study. PMID: 30513529 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 6, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Neurofilament Light in the Serum and Cerebrospinal Fluid of Hip Fracture Patients with Delirium
Conclusion: Our findings support an association between neuroaxonal injury and delirium. The correlation between serum and CSF NFL supports the use of NFL as a blood biomarker in future delirium studies.Dement Geriatr Cogn Disord 2018;46:346 –357 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 6, 2018 Category: Geriatrics Source Type: research

Erratum
Dement Geriatr Cogn Disord 2018;46:265 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 4, 2018 Category: Geriatrics Source Type: research

Validation of the Czech Montreal Cognitive Assessment for Mild Cognitive Impairment due to Alzheimer Disease and Czech Norms in 1,552 Elderly Persons
Conclusions: The cutoff for AD-MCI and stratified norms are available for the MoCA total score and delayed recall of the Czech version. The cut-off scores of the MoCA-CZ, sensitivity, and specificity are lower than in the original study.Dement Geriatr Cogn Disord 2018;46:335 –345 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 4, 2018 Category: Geriatrics Source Type: research

Systematic Review and Meta-Analysis of Prevalence in Post-Stroke Neurocognitive Disorders in Hospital-Based Studies
Conclusion: More than half of stroke survivors experience post-stroke NCD, corresponding to mild post-stroke NCD in two-thirds of cases and major post-stroke NCD in one-third of cases. Harmonization of stroke assessment and cognitive score thresholds is urgently needed to allow more accurate estimation of post-stroke NCD prevalence, especially mild post-stroke NCD.Dement Geriatr Cogn Disord 2018;46:322 –334 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - November 30, 2018 Category: Geriatrics Source Type: research

The D épistage Cognitif de Québec: A New Clinician's Tool for Early Recognition of Atypical Dementia.
DISCUSSION: The DCQ is a better tool to detect atypical dementia than standard cognitive screening tests. Expanding the clinician's tool kit with the DCQ could reduce missed/delayed identification of atypical dementia and accelerate therapeutic intervention. PMID: 30481754 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - November 29, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

The D épistage Cognitif de Québec: A New Clinician’s Tool for Early Recognition of Atypical Dementia
Discussion: The DCQ is a better tool to detect atypical dementia than standard cognitive screening tests. Expanding the clinician ’s tool kit with the DCQ could reduce missed/delayed identification of atypical dementia and accelerate therapeutic intervention.Dement Geriatr Cogn Disord 2018;46:310 –321 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - November 27, 2018 Category: Geriatrics Source Type: research

Factors Associated with the Caregivers' Desire to Institutionalize Persons with Dementia: A Cross-Sectional Study.
CONCLUSION: Although no causality can be assumed, several practical recommendations can be suggested. First of all, these results reconfirm the importance of multicomponent strategies, especially support aimed at decreasing burden and in learning coping strategies. Also, CG might benefit from information about support options, such as respite care services. Finally, special attention should be given to older and working CG. In the latter, flexible and adaptive working conditions might alleviate burden and therefore reduce the DTI of the PWD. PMID: 30453298 [PubMed - as supplied by publisher] (Source: Dementia and Geria...
Source: Dementia and Geriatric Cognitive Disorders - November 21, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Factors Associated with the Caregivers ’ Desire to Institutionalize Persons with Dementia: A Cross-Sectional Study
Conclusion: Although no causality can be assumed, several practical recommendations can be suggested. First of all, these results reconfirm the importance of multicomponent strategies, especially support aimed at decreasing burden and in learning coping strategies. Also, CG might benefit from information about support options, such as respite care services. Finally, special attention should be given to older and working CG. In the latter, flexible and adaptive working conditions might alleviate burden and therefore reduce the DTI of the PWD.Dement Geriatr Cogn Disord 2018;46:298 –309 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - November 20, 2018 Category: Geriatrics Source Type: research

A Review: Mealtime Difficulties following Frontotemporal Lobar Degeneration.
Authors: Lewis C, Walterfang M, Velakoulis D, Vogel AP Abstract BACKGROUND: Frontotemporal lobar degeneration (FTLD) can result in a decline in behavior, language, and motor function. Mealtime disturbances are a common and significant outcome of FTLD. Disturbances during mealtimes can arise from dysphagia or may occur secondary to behavioral changes such as rapid eating, mealtime rigidity, and altered diet preferences. SUMMARY: Few studies have comprehensively evaluated eating behavior or dysphagia in individuals presenting with FTLD pathology despite the potential impact on medical safety and individual qualit...
Source: Dementia and Geriatric Cognitive Disorders - November 15, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

A Review: Mealtime Difficulties following Frontotemporal Lobar Degeneration
Background: Frontotemporal lobar degeneration (FTLD) can result in a decline in behavior, language, and motor function. Mealtime disturbances are a common and significant outcome of FTLD. Disturbances during mealtimes can arise from dysphagia or may occur secondary to behavioral changes such as rapid eating, mealtime rigidity, and altered diet preferences.Summary: Few studies have comprehensively evaluated eating behavior or dysphagia in individuals presenting with FTLD pathology despite the potential impact on medical safety and individual quality of life. Dysphagia is reported in the late stages of frontotemporal dementi...
Source: Dementia and Geriatric Cognitive Disorders - November 13, 2018 Category: Geriatrics Source Type: research

EEG and Clinical Factors Associated with Mild Cognitive Impairment in Coronary Artery Disease Patients.
CONCLUSIONS: The findings of our study show that a theta activity increase in frontal and occipital sites, as well as high theta/alpha ratios, may be considered as the earliest EEG markers of vascular cognitive disorders. PMID: 30404079 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - November 9, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Perceptual Inhibition Associated with Sensory Integration for Balance in Older Adults.
CONCLUSION: Measures of perceptual inhibition are associated with reduced sensory integration capability for balance during sensory conflict conditions in older adults. PMID: 30404094 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - November 9, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Perceptual Inhibition Associated with Sensory Integration for Balance in Older Adults
Conclusion: Measures of perceptual inhibition are associated with reduced sensory integration capability for balance during sensory conflict conditions in older adults.Dement Geriatr Cogn Disord 2018;46:266 –274 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - November 7, 2018 Category: Geriatrics Source Type: research

EEG and Clinical Factors Associated with Mild Cognitive Impairment in Coronary Artery Disease Patients
Conclusions: The findings of our study show that a theta activity increase in frontal and occipital sites, as well as high theta/alpha ratios, may be considered as the earliest EEG markers of vascular cognitive disorders.Dement Geriatr Cogn Disord 2018;46:275 –284 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - November 7, 2018 Category: Geriatrics Source Type: research

Neuropsychological Criteria for Mild Cognitive Impairment in the Framingham Heart Study's Old-Old.
CONCLUSIONS: Our findings are consistent with previous research on the Jak/Bondi criteria and support the use of a comprehensive neuropsychological diagnostic approach for MCI among old-old individuals. PMID: 30391953 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - November 6, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Neuropsychological Criteria for Mild Cognitive Impairment in the Framingham Heart Study ’s Old-Old
Conclusions: Our findings are consistent with previous research on the Jak/Bondi criteria and support the use of a comprehensive neuropsychological diagnostic approach for MCI among old-old individuals.Dement Geriatr Cogn Disord 2018;46:253 –265 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - November 2, 2018 Category: Geriatrics Source Type: research

Screening for Aphasia in NeuroDegeneration for the Diagnosis of Patients with Primary Progressive Aphasia: Clinical Validity and Psychometric Properties.
CONCLUSION: These results indicate that the SAND battery is an adequate, reliable, and valid diagnostic tool for PPA. PMID: 30352431 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 24, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Screening for Aphasia in NeuroDegeneration for the Diagnosis of Patients with Primary Progressive Aphasia: Clinical Validity and Psychometric Properties
Conclusion: These results indicate that the SAND battery is an adequate, reliable, and valid diagnostic tool for PPA.Dement Geriatr Cogn Disord 2018;46:243 –252 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 24, 2018 Category: Geriatrics Source Type: research

Alterations in Intra- and Interregional Intrinsic Brain Connectivity Are Differentially Associated with Memory Performance in Amnestic Mild Cognitive Impairment.
CONCLUSIONS: By approaching both intra- and interregional intrinsic brain activities in the early stages of AD, the findings of this research provide insights into the early pathogenesis of AD as related to memory performance. PMID: 30343307 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 23, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

The Validity of the Norwegian Version of the Cognitive Function Instrument.
CONCLUSION: The Norwegian CFI was found to be a useful, valid, and robust instrument. PMID: 30336471 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 20, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

An Informant-Based Simple Questionnaire for Language Assessment in Neurodegenerative Disorders.
CONCLUSION: Our study showed that the informant-based simple questionnaire is a practical screening tool and is comparable with the language subscale of CASI. This tool can be applied in clinical practice and in the registration platform for rapid language dysfunction screening. PMID: 30336484 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 20, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Alterations in Intra- and Interregional Intrinsic Brain Connectivity Are Differentially Associated with Memory Performance in Amnestic Mild Cognitive Impairment
Conclusions: By approaching both intra- and interregional intrinsic brain activities in the early stages of AD, the findings of this research provide insights into the early pathogenesis of AD as related to memory performance.Dement Geriatr Cogn Disord 2018;46:229 –242 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 19, 2018 Category: Geriatrics Source Type: research

An Informant-Based Simple Questionnaire for Language Assessment in Neurodegenerative Disorders
Conclusion: Our study showed that the informant-based simple questionnaire is a practical screening tool and is comparable with the language subscale of CASI. This tool can be applied in clinical practice and in the registration platform for rapid language dysfunction screening.Dement Geriatr Cogn Disord 2018;46:207 –216 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 18, 2018 Category: Geriatrics Source Type: research

The Validity of the Norwegian Version of the Cognitive Function Instrument
Conclusion: The Norwegian CFI was found to be a useful, valid, and robust instrument.Dement Geriatr Cogn Disord 2018;46:217 –228 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 18, 2018 Category: Geriatrics Source Type: research

Diabetes, but Not Hypertension and Obesity, Is Associated with Postoperative Cognitive Dysfunction.
CONCLUSION: Diabetes, but not obesity or hypertension, is associated with increased POCD risk. Consideration of diabetes status may be helpful for risk assessment of surgical patients. PMID: 30326480 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 17, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Diabetes, but Not Hypertension and Obesity, Is Associated with Postoperative Cognitive Dysfunction
Conclusion: Diabetes, but not obesity or hypertension, is associated with increased POCD risk. Consideration of diabetes status may be helpful for risk assessment of surgical patients.Dement Geriatr Cogn Disord 2018;46:193 –206 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 16, 2018 Category: Geriatrics Source Type: research

Megestrol Acetate Induces Declarative Memory Changes and Cortisol Suppression in Healthy Volunteers.
Authors: Mason BL, Ivleva EI, Van Enkevort E, Nakamura A, Brown ES Abstract BACKGROUND: The effects of the glucocorticoid and progesterone receptor agonist megestrol on declarative memory, and the ability of phenytoin to block these effects, were assessed. METHODS: Healthy volunteers received each medication combination (placebo and megestrol, phenytoin and megestrol, and placebo and placebo) using a randomized, crossover design. The Rey Auditory Verbal Learning Test assessed declarative memory. RESULTS: Megestrol was associated with a significant reduction in declarative memory (p = 0.0008), which was atte...
Source: Dementia and Geriatric Cognitive Disorders - October 6, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Quantitative Measurements of Motor Function in Alzheimer ’s Disease, Frontotemporal Dementia, and Dementia with Lewy Bodies: A Proof-of-Concept Study
Conclusion: Our results suggest that quantitative measurements provide more objective and sensitive measurements of motor dysfunction in dementia.Dement Geriatr Cogn Disord 2018;46:168 –179 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 5, 2018 Category: Geriatrics Source Type: research

C9orf72 Protein Plasmatic Concentrations Are Similar between < b > < i > C9ORF72 < /i > < /b > Expansion Carriers and Noncarriers in Frontotemporal Dementia
Conclusion: Our results provide new evidence against the hypothesis of haploinsufficiency leading to frontotemporal dementia inC9ORF72 expansion carriers.Dement Geriatr Cogn Disord 2018;46:180 –185 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 5, 2018 Category: Geriatrics Source Type: research

Megestrol Acetate Induces Declarative Memory Changes and Cortisol Suppression in Healthy Volunteers
Conclusion: Changes in memory and cortisol suppression were found in healthy volunteers given megestrol.Dement Geriatr Cogn Disord 2018;46:186 –192 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 5, 2018 Category: Geriatrics Source Type: research

C9orf72 Protein Plasmatic Concentrations Are Similar between C9ORF72 Expansion Carriers and Noncarriers in Frontotemporal Dementia.
CONCLUSION: Our results provide new evidence against the hypothesis of haploinsufficiency leading to frontotemporal dementia in C9ORF72 expansion carriers. PMID: 30261505 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - September 29, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Quantitative Measurements of Motor Function in Alzheimer's Disease, Frontotemporal Dementia, and Dementia with Lewy Bodies: A Proof-of-Concept Study.
CONCLUSION: Our results suggest that quantitative measurements provide more objective and sensitive measurements of motor dysfunction in dementia. PMID: 30257254 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - September 27, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research