The Validity of the Norwegian Version of the Cognitive Function Instrument.
CONCLUSION: The Norwegian CFI was found to be a useful, valid, and robust instrument. PMID: 30336471 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 20, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

An Informant-Based Simple Questionnaire for Language Assessment in Neurodegenerative Disorders.
CONCLUSION: Our study showed that the informant-based simple questionnaire is a practical screening tool and is comparable with the language subscale of CASI. This tool can be applied in clinical practice and in the registration platform for rapid language dysfunction screening. PMID: 30336484 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 20, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Alterations in Intra- and Interregional Intrinsic Brain Connectivity Are Differentially Associated with Memory Performance in Amnestic Mild Cognitive Impairment
Conclusions: By approaching both intra- and interregional intrinsic brain activities in the early stages of AD, the findings of this research provide insights into the early pathogenesis of AD as related to memory performance.Dement Geriatr Cogn Disord 2018;46:229 –242 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 19, 2018 Category: Geriatrics Source Type: research

An Informant-Based Simple Questionnaire for Language Assessment in Neurodegenerative Disorders
Conclusion: Our study showed that the informant-based simple questionnaire is a practical screening tool and is comparable with the language subscale of CASI. This tool can be applied in clinical practice and in the registration platform for rapid language dysfunction screening.Dement Geriatr Cogn Disord 2018;46:207 –216 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 18, 2018 Category: Geriatrics Source Type: research

The Validity of the Norwegian Version of the Cognitive Function Instrument
Conclusion: The Norwegian CFI was found to be a useful, valid, and robust instrument.Dement Geriatr Cogn Disord 2018;46:217 –228 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 18, 2018 Category: Geriatrics Source Type: research

Diabetes, but Not Hypertension and Obesity, Is Associated with Postoperative Cognitive Dysfunction.
CONCLUSION: Diabetes, but not obesity or hypertension, is associated with increased POCD risk. Consideration of diabetes status may be helpful for risk assessment of surgical patients. PMID: 30326480 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 17, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Diabetes, but Not Hypertension and Obesity, Is Associated with Postoperative Cognitive Dysfunction
Conclusion: Diabetes, but not obesity or hypertension, is associated with increased POCD risk. Consideration of diabetes status may be helpful for risk assessment of surgical patients.Dement Geriatr Cogn Disord 2018;46:193 –206 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 16, 2018 Category: Geriatrics Source Type: research

Megestrol Acetate Induces Declarative Memory Changes and Cortisol Suppression in Healthy Volunteers.
Authors: Mason BL, Ivleva EI, Van Enkevort E, Nakamura A, Brown ES Abstract BACKGROUND: The effects of the glucocorticoid and progesterone receptor agonist megestrol on declarative memory, and the ability of phenytoin to block these effects, were assessed. METHODS: Healthy volunteers received each medication combination (placebo and megestrol, phenytoin and megestrol, and placebo and placebo) using a randomized, crossover design. The Rey Auditory Verbal Learning Test assessed declarative memory. RESULTS: Megestrol was associated with a significant reduction in declarative memory (p = 0.0008), which was atte...
Source: Dementia and Geriatric Cognitive Disorders - October 6, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Quantitative Measurements of Motor Function in Alzheimer ’s Disease, Frontotemporal Dementia, and Dementia with Lewy Bodies: A Proof-of-Concept Study
Conclusion: Our results suggest that quantitative measurements provide more objective and sensitive measurements of motor dysfunction in dementia.Dement Geriatr Cogn Disord 2018;46:168 –179 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 5, 2018 Category: Geriatrics Source Type: research

C9orf72 Protein Plasmatic Concentrations Are Similar between < b > < i > C9ORF72 < /i > < /b > Expansion Carriers and Noncarriers in Frontotemporal Dementia
Conclusion: Our results provide new evidence against the hypothesis of haploinsufficiency leading to frontotemporal dementia inC9ORF72 expansion carriers.Dement Geriatr Cogn Disord 2018;46:180 –185 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 5, 2018 Category: Geriatrics Source Type: research

Megestrol Acetate Induces Declarative Memory Changes and Cortisol Suppression in Healthy Volunteers
Conclusion: Changes in memory and cortisol suppression were found in healthy volunteers given megestrol.Dement Geriatr Cogn Disord 2018;46:186 –192 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 5, 2018 Category: Geriatrics Source Type: research

C9orf72 Protein Plasmatic Concentrations Are Similar between C9ORF72 Expansion Carriers and Noncarriers in Frontotemporal Dementia.
CONCLUSION: Our results provide new evidence against the hypothesis of haploinsufficiency leading to frontotemporal dementia in C9ORF72 expansion carriers. PMID: 30261505 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - September 29, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Quantitative Measurements of Motor Function in Alzheimer's Disease, Frontotemporal Dementia, and Dementia with Lewy Bodies: A Proof-of-Concept Study.
CONCLUSION: Our results suggest that quantitative measurements provide more objective and sensitive measurements of motor dysfunction in dementia. PMID: 30257254 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - September 27, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

A Review of Diagnostic Impact of Amyloid Positron Emission Tomography Imaging in Clinical Practice.
Authors: Kim Y, Rosenberg P, Oh E Abstract BACKGROUND: Molecular imaging of brain amyloid for the diagnosis of Alzheimer's disease (AD) using positron emission tomography (PET) has been approved for use in clinical practice by the Food and Drug Administration (FDA) since 2012. However, the clinical utility and diagnostic impact of amyloid PET imaging remain controversial. We conducted a review of the recent studies investigating clinical utility of amyloid PET imaging with focus on changes in diagnosis, diagnostic confidence, and patient management. SUMMARY: A total of 16 studies were included in the final anal...
Source: Dementia and Geriatric Cognitive Disorders - September 12, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Late-Life Depression versus Amnestic Mild Cognitive Impairment: Alzheimer's Disease Incidence in 4 Years of Follow-Up.
Authors: Lauriola M, Mangiacotti A, D'Onofrio G, Cascavilla L, Paris F, Ciccone F, Greco M, Paroni G, Seripa D, Greco A Abstract BACKGROUND/AIM: The aim of the study was to evaluate the prognostic power of late-life depression (LLD) compared with amnestic mild cognitive impairment (aMCI) for the onset of Alzheimer's disease (AD) within 4 years of follow-up. METHODS: We estimated the incidence of AD in 60 patients presenting with aMCI, 115 patients suffering of LLD treated with antidepressants with good compliance, and 66 healthy control (HC) patients, followed for 4 years. RESULTS: The risk to develop AD, w...
Source: Dementia and Geriatric Cognitive Disorders - September 12, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Late-Life Depression versus Amnestic Mild Cognitive Impairment: Alzheimer ’s Disease Incidence in 4 Years of Follow-Up
Conclusion: In our results, aMCI was the first predictive condition that increased the risk to develop AD. Depression is a potentially preventable medical condition across the lifespan and may be a modifiable risk factor.Dement Geriatr Cogn Disord 2018;46:140 –153 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - September 10, 2018 Category: Geriatrics Source Type: research

A Review of Diagnostic Impact of Amyloid Positron Emission Tomography Imaging in Clinical Practice
Background: Molecular imaging of brain amyloid for the diagnosis of Alzheimer ’s disease (AD) using positron emission tomography (PET) has been approved for use in clinical practice by the Food and Drug Administration (FDA) since 2012. However, the clinical utility and diagnostic impact of amyloid PET imaging remain controversial. We conducted a review of the recent studies investigating clinical utility of amyloid PET imaging with focus on changes in diagnosis, diagnostic confidence, and patient management.Summary: A total of 16 studies were included in the final analysis. Overall rate of changes in diagnosis after ...
Source: Dementia and Geriatric Cognitive Disorders - September 10, 2018 Category: Geriatrics Source Type: research

Psychometric Properties and Factor Analysis of the Engagement and Independence in Dementia Questionnaire (EID-Q)
Conclusions: The EID-Q demonstrated acceptable psychometric properties and the factor solution had an adequate model fit. The strong correlations suggest that social independence is strongly related to depression and quality of life. Future work will entail an analysis of responsiveness to intervention and further large-scale work.Dement Geriatr Cogn Disord 2018;46:119 –127 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - September 7, 2018 Category: Geriatrics Source Type: research

A Dementia Caf é as a Bridgehead for Community-Inclusive Care: Qualitative Analysis of Observations by On-the-Job Training Participants in a Dementia Café
Discussion: The results of the present study identified the elements that make up dementia caf és and their significance and suggest that dementia cafés could be a new type of community resource for dementia care in the future.Dement Geriatr Cogn Disord 2018;46:128 –139 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - September 7, 2018 Category: Geriatrics Source Type: research

Psychometric Properties and Factor Analysis of the Engagement and Independence in Dementia Questionnaire (EID-Q).
Authors: Stoner CR, Orrell M, Spector A Abstract BACKGROUND/AIMS: Independence and social engagement are important outcomes for people with dementia. The aim of this study was to conduct an in-depth psychometric assessment of the Engagement and Independence in Dementia Questionnaire (EID-Q), a measure of social independence. METHODS: This was an observational study at five NHS sites across England. Participants completed the EID-Q alongside additional measures. Psychometric analysis included internal consistency, test-retest reliability, convergent validity, and factor analyses. RESULTS: A total of 225 peop...
Source: Dementia and Geriatric Cognitive Disorders - September 6, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

A Dementia Caf é as a Bridgehead for Community-Inclusive Care: Qualitative Analysis of Observations by On-the-Job Training Participants in a Dementia Café.
DISCUSSION: The results of the present study identified the elements that make up dementia cafés and their significance and suggest that dementia cafés could be a new type of community resource for dementia care in the future. PMID: 30179880 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - September 6, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Dementia Patients Are More Sedentary and Less Physically Active than Age- and Sex-Matched Cognitively Healthy Older Adults.
CONCLUSION: We revealed that dementia patients are more sedentary and perform less physical activity than cognitively healthy controls. This may have clinically important consequences, given the observation that sedentary behaviour and little physical activity independently predict all-cause mortality and morbidity. PMID: 30145584 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 27, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Midlife Stress in Relation to Late-Life Cerebrospinal Fluid Biomarkers of Alzheimer's Disease: A 25-Year Follow-Up Study.
CONCLUSION: The findings suggest that longstanding stress stimulates unspecific neurodegenerative processes, but not the core processes of AD, at least not in the early phase of the disease. The association with higher concentration of CSF t-tau may reflect neural degeneration and the association with higher Aβ40 may be an early sign of Aβ overproduction or cerebrovascular processes in the brain. PMID: 30145588 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 27, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Do Reports on Personal Preferences of Persons with Dementia Predict Their Responses to Group Activities?
CONCLUSION: Despite the fact that each topic represents a wide range of possible activities, individualizing group activities based on participants' preferences can optimize the impact. PMID: 30145591 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 27, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Effects of Physical Activity in Nursing Home Residents with Dementia: A Randomized Controlled Trial.
CONCLUSIONS: ADL training appears to be effective for nursing home residents with moderately severe dementia. It remains unclear whether exercise training is an effective type of stimulation. PMID: 30145595 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 27, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Parietal Involvement in Constructional Apraxia as Measured Using the Pentagon Copying Task.
Authors: Van der Stigchel S, de Bresser J, Heinen R, Koek HL, Reijmer YD, Biessels GJ, van den Berg E, on behalf of the Utrecht Vascular Cognitive Impairment (VCI) Study Group Abstract Deficits in copying ("constructional apraxia") is generally defined as a multifaceted deficit. The exact neural correlates of the different types of copying errors are unknown. To assess whether the different categories of errors on the pentagon drawing relate to different neural correlates, we examined the pentagon drawings of the MMSE in persons with subjective cognitive c...
Source: Dementia and Geriatric Cognitive Disorders - August 27, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Psychometric Validation of the Czech Version of the Quality of Life - Alzheimer's Disease Scale in Patients with Early-Stage Dementia.
CONCLUSION: The Czech version of the QoL-AD has good psychometric properties in compliance with international recommendations. PMID: 30145599 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 27, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Parietal Involvement in Constructional Apraxia as Measured Using the Pentagon Copying Task
Deficits in copying ( “constructional apraxia”) is generally defined as a multifaceted deficit. The exact neural correlates of the different types of copying errors are unknown. To assess whether the different categories of errors on the pentagon drawing relate to different neural correlates, we examined the pentagon drawings of the MMSE in persons with subjective cognitive complaints, mild cognitive impairment, or early dementia due to Alzheimer’s disease. We adopted a qualitative scoring method for the pentagon copy test (QSPT) which categorizes different possible errors in copying rather than the dicho...
Source: Dementia and Geriatric Cognitive Disorders - August 24, 2018 Category: Geriatrics Source Type: research

Effects of Physical Activity in Nursing Home Residents with Dementia: A Randomized Controlled Trial
Conclusions: ADL training appears to be effective for nursing home residents with moderately severe dementia. It remains unclear whether exercise training is an effective type of stimulation.Dement Geriatr Cogn Disord 2018;46:60 –80 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 24, 2018 Category: Geriatrics Source Type: research

Dementia Patients Are More Sedentary and Less Physically Active than Age- and Sex-Matched Cognitively Healthy Older Adults
Conclusion: We revealed that dementia patients are more sedentary and perform less physical activity than cognitively healthy controls. This may have clinically important consequences, given the observation that sedentary behaviour and little physical activity independently predict all-cause mortality and morbidity.Dement Geriatr Cogn Disord 2018;46:81 –89 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 24, 2018 Category: Geriatrics Source Type: research

Midlife Stress in Relation to Late-Life Cerebrospinal Fluid Biomarkers of Alzheimer ’s Disease: A 25-Year Follow-Up Study
Conclusion: The findings suggest that longstanding stress stimulates unspecific neurodegenerative processes, but not the core processes of AD, at least not in the early phase of the disease. The association with higher concentration of CSF t-tau may reflect neural degeneration and the association with higher A β40 may be an early sign of Aβ overproduction or cerebrovascular processes in the brain.Dement Geriatr Cogn Disord 2018;46:90 –99 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 24, 2018 Category: Geriatrics Source Type: research

Do Reports on Personal Preferences of Persons with Dementia Predict Their Responses to Group Activities?
Conclusion: Despite the fact that each topic represents a wide range of possible activities, individualizing group activities based on participants ’ preferences can optimize the impact.Dement Geriatr Cogn Disord 2018;46:100 –108 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 24, 2018 Category: Geriatrics Source Type: research

Psychometric Validation of the Czech Version of the Quality of Life – Alzheimer’s Disease Scale in Patients with Early-Stage Dementia
Conclusion: The Czech version of the QoL-AD has good psychometric properties in compliance with international recommendations.Dement Geriatr Cogn Disord 2018;46:109 –118 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 24, 2018 Category: Geriatrics Source Type: research

The Head Turning Sign in Dementia and Mild Cognitive Impairment: Its Relationship to Cognition, Behavior, and Cerebrospinal Fluid Biomarkers.
CONCLUSIONS: The presence of the HTS in a cognitively impaired individual suggests a diagnosis of AD. A higher HTS frequency correlates with higher CSF total tau levels, a smaller GDS score, and worse cognitive measures. In the MCI subgroup, the HTS may suggest a higher risk of progression. PMID: 30092564 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 11, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

A Point Prevalence Study of Delirium in Italian Nursing Homes.
CONCLUSION: Delirium is common in older NH residents. Simple assessment tools might facilitate its recognition in this vulnerable population. PMID: 30092581 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 11, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Cognitive Therapy for Dementia Patients: A Systematic Review.
CONCLUSIONS: Skills training trials and mixed trials seem to affect cognitive impairment in a positive way, although the results are inconclusive. Comparison between studies was difficult due to differences in form of intervention. Because findings are inconclusive, more structuralized and comparable randomized controlled trials are needed. PMID: 30092585 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 11, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Acknowledgement to Reviewers
Dement Geriatr Cogn Disord 2018;45:368 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 9, 2018 Category: Geriatrics Source Type: research

Contents Vol.45, 2018
Dement Geriatr Cogn Disord 2018;45:I –IV (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 9, 2018 Category: Geriatrics Source Type: research

Cognitive Therapy for Dementia Patients: A Systematic Review
Conclusions: Skills training trials and mixed trials seem to affect cognitive impairment in a positive way, although the results are inconclusive. Comparison between studies was difficult due to differences in form of intervention. Because findings are inconclusive, more structuralized and comparable randomized controlled trials are needed.Dement Geriatr Cogn Disord 2018;46:1 –26 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 9, 2018 Category: Geriatrics Source Type: research

A Point Prevalence Study of Delirium in Italian Nursing Homes
Conclusion: Delirium is common in older NH residents. Simple assessment tools might facilitate its recognition in this vulnerable population.Dement Geriatr Cogn Disord 2018;46:27 –41 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 9, 2018 Category: Geriatrics Source Type: research

The Head Turning Sign in Dementia and Mild Cognitive Impairment: Its Relationship to Cognition, Behavior, and Cerebrospinal Fluid Biomarkers
Conclusions: The presence of the HTS in a cognitively impaired individual suggests a diagnosis of AD. A higher HTS frequency correlates with higher CSF total tau levels, a smaller GDS score, and worse cognitive measures. In the MCI subgroup, the HTS may suggest a higher risk of progression.Dement Geriatr Cogn Disord 2018;46:42 –49 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 9, 2018 Category: Geriatrics Source Type: research

Clock Drawing Test: A Simple Scoring System for the Accurate Screening of Cognitive Impairment in Patients with Mild Cognitive Impairment and Dementia.
CONCLUSION: A simple, 4-point scoring system may be used as a screening method for fast and accurate detection of cognitive impairment in patients with MCI, AD and MD. PMID: 30036864 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 25, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Combined Exercise and Cognitive Training System for Dementia Patients: A Randomized Controlled Trial.
CONCLUSIONS: The combined system is effective in increasing attention and concentration and improving cognitive function and activities of daily living in dementia patients. PMID: 30036871 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 25, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Quantitative Mobility Assessment for Fall Risk Prediction in Dementia: A Systematic Review.
Authors: Dolatabadi E, Van Ooteghem K, Taati B, Iaboni A Abstract BACKGROUND: Impairments of gait and balance often progress through the course of dementia, and are associated with increased risk of falls. SUMMARY: This systematic review provides a critical analysis of the evidence linking quantitative measures of gait and balance to fall risk in older adults with dementia. Various instrumented measures of gait and postural stability including gait speed and non-instrumented performance measures including Timed Up and Go were shown to be capable of distinguishing fallers from non-fallers. Key Messages: Existing...
Source: Dementia and Geriatric Cognitive Disorders - July 25, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Effect of Apolipoprotein E ɛ4 Carrier Status on Cognitive Response to Acetylcholinesterase Inhibitors in Patients with Alzheimer's Disease: A Systematic Review and Meta-Analysis.
CONCLUSIONS: APOE ɛ4 carrier status had no significant influence on the treatment response to AChEIs in patients with AD. AChEIs had a positive therapeutic effect compared with placebo regardless of APOE ε4 carrier status. PMID: 30041236 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 25, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Effect of Apolipoprotein E ɛ4 Carrier Status on Cognitive Response to Acetylcholinesterase Inhibitors in Patients with Alzheimer’s Disease: A Systematic Review and Meta-Analysis
Conclusions:APOEɛ4 carrier status had no significant influence on the treatment response to AChEIs in patients with AD. AChEIs had a positive therapeutic effect compared with placebo regardless ofAPOEε4 carrier status.Dement Geriatr Cogn Disord 2018;45:335 –352 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 24, 2018 Category: Geriatrics Source Type: research

Quantitative Mobility Assessment for Fall Risk Prediction in Dementia: A Systematic Review
Background: Impairments of gait and balance often progress through the course of dementia, and are associated with increased risk of falls.Summary: This systematic review provides a critical analysis of the evidence linking quantitative measures of gait and balance to fall risk in older adults with dementia. Various instrumented measures of gait and postural stability including gait speed and non-instrumented performance measures including Timed Up and Go were shown to be capable of distinguishing fallers from non-fallers.Key Messages: Existing reviews indicate that impairments of gait and balance are associated with incre...
Source: Dementia and Geriatric Cognitive Disorders - July 24, 2018 Category: Geriatrics Source Type: research

Combined Exercise and Cognitive Training System for Dementia Patients: A Randomized Controlled Trial
Conclusions: The combined system is effective in increasing attention and concentration and improving cognitive function and activities of daily living in dementia patients.Dement Geriatr Cogn Disord 2018;45:318 –325 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 23, 2018 Category: Geriatrics Source Type: research

Clock Drawing Test: A Simple Scoring System for the Accurate Screening of Cognitive Impairment in Patients with Mild Cognitive Impairment and Dementia
Conclusion: A simple, 4-point scoring system may be used as a screening method for fast and accurate detection of cognitive impairment in patients with MCI, AD and MD.Dement Geriatr Cogn Disord 2018;45:326 –334 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 23, 2018 Category: Geriatrics Source Type: research

Increasing the Sensitivity of Functional Status Assessment in the Preclinical Range (Normal to Mild Cognitive Impairment): Exploring the IADL-Extended Approach.
We examined the predictive power (Cox regression; n = 2,471) of a unidimensional IADL-extended (IADL-x) scale for incident mild cognitive impairment (MCI). We also examined "time to MCI" as an outcome measure. RESULTS: Each additional task endorsed on the IADL-x hierarchy (e.g., endorsing participation in 6 vs. 5 activities) resulted in a 10% reduction in MCI risk (HR 0.90, 95% CI 0.85-0.94, p
Source: Dementia and Geriatric Cognitive Disorders - July 12, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research