The Head Turning Sign in Dementia and Mild Cognitive Impairment: Its Relationship to Cognition, Behavior, and Cerebrospinal Fluid Biomarkers.
CONCLUSIONS: The presence of the HTS in a cognitively impaired individual suggests a diagnosis of AD. A higher HTS frequency correlates with higher CSF total tau levels, a smaller GDS score, and worse cognitive measures. In the MCI subgroup, the HTS may suggest a higher risk of progression. PMID: 30092564 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 11, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

A Point Prevalence Study of Delirium in Italian Nursing Homes.
CONCLUSION: Delirium is common in older NH residents. Simple assessment tools might facilitate its recognition in this vulnerable population. PMID: 30092581 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 11, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Cognitive Therapy for Dementia Patients: A Systematic Review.
CONCLUSIONS: Skills training trials and mixed trials seem to affect cognitive impairment in a positive way, although the results are inconclusive. Comparison between studies was difficult due to differences in form of intervention. Because findings are inconclusive, more structuralized and comparable randomized controlled trials are needed. PMID: 30092585 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 11, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Acknowledgement to Reviewers
Dement Geriatr Cogn Disord 2018;45:368 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 9, 2018 Category: Geriatrics Source Type: research

Contents Vol.45, 2018
Dement Geriatr Cogn Disord 2018;45:I –IV (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 9, 2018 Category: Geriatrics Source Type: research

Cognitive Therapy for Dementia Patients: A Systematic Review
Conclusions: Skills training trials and mixed trials seem to affect cognitive impairment in a positive way, although the results are inconclusive. Comparison between studies was difficult due to differences in form of intervention. Because findings are inconclusive, more structuralized and comparable randomized controlled trials are needed.Dement Geriatr Cogn Disord 2018;46:1 –26 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 9, 2018 Category: Geriatrics Source Type: research

A Point Prevalence Study of Delirium in Italian Nursing Homes
Conclusion: Delirium is common in older NH residents. Simple assessment tools might facilitate its recognition in this vulnerable population.Dement Geriatr Cogn Disord 2018;46:27 –41 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 9, 2018 Category: Geriatrics Source Type: research

The Head Turning Sign in Dementia and Mild Cognitive Impairment: Its Relationship to Cognition, Behavior, and Cerebrospinal Fluid Biomarkers
Conclusions: The presence of the HTS in a cognitively impaired individual suggests a diagnosis of AD. A higher HTS frequency correlates with higher CSF total tau levels, a smaller GDS score, and worse cognitive measures. In the MCI subgroup, the HTS may suggest a higher risk of progression.Dement Geriatr Cogn Disord 2018;46:42 –49 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 9, 2018 Category: Geriatrics Source Type: research

Clock Drawing Test: A Simple Scoring System for the Accurate Screening of Cognitive Impairment in Patients with Mild Cognitive Impairment and Dementia.
CONCLUSION: A simple, 4-point scoring system may be used as a screening method for fast and accurate detection of cognitive impairment in patients with MCI, AD and MD. PMID: 30036864 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 25, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Combined Exercise and Cognitive Training System for Dementia Patients: A Randomized Controlled Trial.
CONCLUSIONS: The combined system is effective in increasing attention and concentration and improving cognitive function and activities of daily living in dementia patients. PMID: 30036871 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 25, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Quantitative Mobility Assessment for Fall Risk Prediction in Dementia: A Systematic Review.
Authors: Dolatabadi E, Van Ooteghem K, Taati B, Iaboni A Abstract BACKGROUND: Impairments of gait and balance often progress through the course of dementia, and are associated with increased risk of falls. SUMMARY: This systematic review provides a critical analysis of the evidence linking quantitative measures of gait and balance to fall risk in older adults with dementia. Various instrumented measures of gait and postural stability including gait speed and non-instrumented performance measures including Timed Up and Go were shown to be capable of distinguishing fallers from non-fallers. Key Messages: Existing...
Source: Dementia and Geriatric Cognitive Disorders - July 25, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Effect of Apolipoprotein E ɛ4 Carrier Status on Cognitive Response to Acetylcholinesterase Inhibitors in Patients with Alzheimer's Disease: A Systematic Review and Meta-Analysis.
CONCLUSIONS: APOE ɛ4 carrier status had no significant influence on the treatment response to AChEIs in patients with AD. AChEIs had a positive therapeutic effect compared with placebo regardless of APOE ε4 carrier status. PMID: 30041236 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 25, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Effect of Apolipoprotein E ɛ4 Carrier Status on Cognitive Response to Acetylcholinesterase Inhibitors in Patients with Alzheimer’s Disease: A Systematic Review and Meta-Analysis
Conclusions:APOEɛ4 carrier status had no significant influence on the treatment response to AChEIs in patients with AD. AChEIs had a positive therapeutic effect compared with placebo regardless ofAPOEε4 carrier status.Dement Geriatr Cogn Disord 2018;45:335 –352 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 24, 2018 Category: Geriatrics Source Type: research

Quantitative Mobility Assessment for Fall Risk Prediction in Dementia: A Systematic Review
Background: Impairments of gait and balance often progress through the course of dementia, and are associated with increased risk of falls.Summary: This systematic review provides a critical analysis of the evidence linking quantitative measures of gait and balance to fall risk in older adults with dementia. Various instrumented measures of gait and postural stability including gait speed and non-instrumented performance measures including Timed Up and Go were shown to be capable of distinguishing fallers from non-fallers.Key Messages: Existing reviews indicate that impairments of gait and balance are associated with incre...
Source: Dementia and Geriatric Cognitive Disorders - July 24, 2018 Category: Geriatrics Source Type: research

Combined Exercise and Cognitive Training System for Dementia Patients: A Randomized Controlled Trial
Conclusions: The combined system is effective in increasing attention and concentration and improving cognitive function and activities of daily living in dementia patients.Dement Geriatr Cogn Disord 2018;45:318 –325 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 23, 2018 Category: Geriatrics Source Type: research

Clock Drawing Test: A Simple Scoring System for the Accurate Screening of Cognitive Impairment in Patients with Mild Cognitive Impairment and Dementia
Conclusion: A simple, 4-point scoring system may be used as a screening method for fast and accurate detection of cognitive impairment in patients with MCI, AD and MD.Dement Geriatr Cogn Disord 2018;45:326 –334 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 23, 2018 Category: Geriatrics Source Type: research

Increasing the Sensitivity of Functional Status Assessment in the Preclinical Range (Normal to Mild Cognitive Impairment): Exploring the IADL-Extended Approach.
We examined the predictive power (Cox regression; n = 2,471) of a unidimensional IADL-extended (IADL-x) scale for incident mild cognitive impairment (MCI). We also examined "time to MCI" as an outcome measure. RESULTS: Each additional task endorsed on the IADL-x hierarchy (e.g., endorsing participation in 6 vs. 5 activities) resulted in a 10% reduction in MCI risk (HR 0.90, 95% CI 0.85-0.94, p
Source: Dementia and Geriatric Cognitive Disorders - July 12, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Influence of Age and Education on the Performance of Elderly in the Brazilian Version of the Montreal Cognitive Assessment Battery.
Authors: Pinto TCC, Machado L, Bulgacov TM, Rodrigues-Júnior AL, Costa MLG, Ximenes RCC, Sougey EB Abstract AIMS: To provide normative data for the Brazilian version of the Montreal Cognitive Assessment (MoCA-BR) and to measure the effect of sociodemographic variables on the cognitive performance of cognitively healthy elderly people. METHODS: A sample of 110 cognitively healthy individuals, aged over 65 years, with at least 4 years of schooling were recruited from 3 health care centers for the elderly in Recife, Brazil. The cognitive performance was assessed using MoCA-BR. RESULTS: The average score...
Source: Dementia and Geriatric Cognitive Disorders - July 12, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

The Pentagon Copying Test and the Clock Drawing Test as Prognostic Markers in Dementia with Lewy Bodies.
Authors: Vergouw LJM, Salomé M, Kerklaan AG, Kies C, Roks G, van den Berg E, de Jong FJ Abstract AIMS: To determine whether the pentagon copying test (PCT) and the clock drawing test (CDT) are associated with nursing home admission or survival in dementia with Lewy bodies (DLB). METHODS: The PCT and/or the CDT were retrospectively collected from 103 clinically diagnosed probable DLB patients at a university medical center and general hospital. Patients with high versus low scores on these tests were compared. RESULTS: Kaplan-Meier analysis showed that patients with a low score on the PCT had a shorte...
Source: Dementia and Geriatric Cognitive Disorders - July 12, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

MACE for the Diagnosis of Dementia and MCI: 3-Year Pragmatic Diagnostic Test Accuracy Study.
Authors: Williamson JC, Larner AJ Abstract BACKGROUND/AIMS: The Mini-Addenbrooke's Cognitive Examination (MACE) is a relatively new short cognitive screening instrument for the detection of patients with dementia and mild cognitive impairment (MCI). Few studies of the MACE have been reported hitherto. The aim of this study was to undertake a pragmatic diagnostic test accuracy study of MACE in a large cohort of patients seen in a dedicated cognitive disorders clinic. METHODS: MACE was administered to consecutive patients referred to a neurology-led Cognitive Function Clinic over the course of 3 years to assess i...
Source: Dementia and Geriatric Cognitive Disorders - July 12, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Increasing the Sensitivity of Functional Status Assessment in the Preclinical Range (Normal to Mild Cognitive Impairment): Exploring the IADL-Extended Approach
Conclusion: The IADL-x metric appears to be a valid approach for determining the risk of MCI based on one ’s position along a formal hierarchy of function.Dement Geriatr Cogn Disord 2018;45:282 –289 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 11, 2018 Category: Geriatrics Source Type: research

Influence of Age and Education on the Performance of Elderly in the Brazilian Version of the Montreal Cognitive Assessment Battery
Conclusions: The cognitive performance of healthy elderly was evaluated and was strongly influenced by schooling and, to a lower degree, by age.Dement Geriatr Cogn Disord 2018;45:290 –299 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 11, 2018 Category: Geriatrics Source Type: research

MACE for the Diagnosis of Dementia and MCI: 3-Year Pragmatic Diagnostic Test Accuracy Study
Conclusion: MACE is an acceptable test for the assessment of cognitive complaints in a secondary care setting with good metrics for identifying cases of both dementia and MCI.Dement Geriatr Cogn Disord 2018;45:300 –307 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 11, 2018 Category: Geriatrics Source Type: research

The Pentagon Copying Test and the Clock Drawing Test as Prognostic Markers in Dementia with Lewy Bodies
Conclusion: The PCT and the CDT may function as prognostic markers in DLB. This finding is clinically relevant as these tests can be applied easily in the clinical setting and can provide valuable prognostic information. Furthermore, it may improve disease management and patient selection for research purposes.Dement Geriatr Cogn Disord 2018;45:308 –317 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 11, 2018 Category: Geriatrics Source Type: research

Multimorbidity Is Associated with Preclinical Alzheimer's Disease Neuroimaging Biomarkers.
CONCLUSION: Multimorbidity is associated with preclinical AD imaging markers of neurodegeneration, but not with amyloid. PMID: 29953971 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 30, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Etoricoxib and Diclofenac Might Reduce the Risk of Dementia in Patients with Osteoarthritis: A Nation-Wide, Population-Based Retrospective Cohort Study.
CONCLUSION: Patients with OA might have a higher risk of dementia. Both etoricoxib and diclofenac might lower the risk of dementia in patients with OA. PMID: 29953974 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 30, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Gait Variability Can Predict the Risk of Cognitive Decline in Cognitively Normal Older People.
CONCLUSIONS: Gait variability may be a better predictor of cognitive decline than gait speed in cognitively normal elderly individuals without cerebral ischemic burden or Parkinsonism. PMID: 29953979 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 30, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Gait Variability Can Predict the Risk of Cognitive Decline in Cognitively Normal Older People
Conclusions: Gait variability may be a better predictor of cognitive decline than gait speed in cognitively normal elderly individuals without cerebral ischemic burden or Parkinsonism.Dement Geriatr Cogn Disord 2018;45:251 –261 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 28, 2018 Category: Geriatrics Source Type: research

Etoricoxib and Diclofenac Might Reduce the Risk of Dementia in Patients with Osteoarthritis: A Nation-Wide, Population-Based Retrospective Cohort Study
Conclusion: Patients with OA might have a higher risk of dementia. Both etoricoxib and diclofenac might lower the risk of dementia in patients with OA.Dement Geriatr Cogn Disord 2018;45:262 –271 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 28, 2018 Category: Geriatrics Source Type: research

Multimorbidity Is Associated with Preclinical Alzheimer ’s Disease Neuroimaging Biomarkers
Conclusion: Multimorbidity is associated with preclinical AD imaging markers of neurodegeneration, but not with amyloid.Dement Geriatr Cogn Disord 2018;45:272 –281 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 28, 2018 Category: Geriatrics Source Type: research

Lower Cognitive Function in Older Patients with Lower Muscle Strength and Muscle Mass.
CONCLUSION: This study further strengthens evidence for an association between lower cognitive functioning and lower muscle strength and muscle mass, but without a further decline during hospitalization. PMID: 29913450 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 20, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Lower Cognitive Function in Older Patients with Lower Muscle Strength and Muscle Mass
Conclusion: This study further strengthens evidence for an association between lower cognitive functioning and lower muscle strength and muscle mass, but without a further decline during hospitalization.Dement Geriatr Cogn Disord 2018;45:243 –250 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 18, 2018 Category: Geriatrics Source Type: research

Distinct Clinical Features and Outcomes in Motor Neuron Disease Associated with Behavioural Variant Frontotemporal Dementia.
CONCLUSIONS: The MND-FTD patients frequently displayed a distinctive motor pattern characterized by weakness and atrophy in distal upper limb muscles and dysphagia, with no or little spreading to other regions. These features may help to define specific subgroups of patients, which is important with regard to clinical management, outcome, and research. PMID: 29886477 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 11, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

The Protective Effect of Cantonese/Mandarin Bilingualism on the Onset of Alzheimer Disease.
CONCLUSION: Constantly speaking both Cantonese and Mandarin from at least early adulthood can delay the onset of AD. PMID: 29886485 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 11, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Sleep Disturbance and the Risk of Cognitive Decline or Clinical Conversion in the ADNI Cohort.
CONCLUSION: This study investigated the effect of sleep disturbance on cognitive decline using several outcomes and does not support the hypothesis that sleep disturbance predicts subsequent cognitive decline. PMID: 29886490 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 11, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Fully Automatic Speech-Based Analysis of the Semantic Verbal Fluency Task.
CONCLUSION: The results show that it is possible to automate fine-grained analyses of SVF data for the assessment of cognitive decline. PMID: 29886493 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 11, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Fully Automatic Speech-Based Analysis of the Semantic Verbal Fluency Task
Conclusion: The results show that it is possible to automate fine-grained analyses of SVF data for the assessment of cognitive decline.Dement Geriatr Cogn Disord 2018;45:198 –209 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 8, 2018 Category: Geriatrics Source Type: research

The Protective Effect of Cantonese/Mandarin Bilingualism on the Onset of Alzheimer Disease
Conclusion: Constantly speaking both Cantonese and Mandarin from at least early adulthood can delay the onset of AD.Dement Geriatr Cogn Disord 2018;45:210 –219 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 8, 2018 Category: Geriatrics Source Type: research

Distinct Clinical Features and Outcomes in Motor Neuron Disease Associated with Behavioural Variant Frontotemporal Dementia
Conclusions: The MND-FTD patients frequently displayed a distinctive motor pattern characterized by weakness and atrophy in distal upper limb muscles and dysphagia, with no or little spreading to other regions. These features may help to define specific subgroups of patients, which is important with regard to clinical management, outcome, and research.Dement Geriatr Cogn Disord 2018;45:220 –231 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 8, 2018 Category: Geriatrics Source Type: research

Sleep Disturbance and the Risk of Cognitive Decline or Clinical Conversion in the ADNI Cohort
Conclusion: This study investigated the effect of sleep disturbance on cognitive decline using several outcomes and does not support the hypothesis that sleep disturbance predicts subsequent cognitive decline.Dement Geriatr Cogn Disord 2018;45:232 –242 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 8, 2018 Category: Geriatrics Source Type: research

Cognitive Reserve and Social Capital Accrued in Early and Midlife Moderate the Relation of Psychological Stress to Cognitive Performance in Old Age.
CONCLUSION: Cognitive reserve and social capital accrued in early and midlife may reduce the detrimental influences of psychological stress on cognitive functioning in old age. PMID: 29870984 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 7, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Cognitive Reserve and Social Capital Accrued in Early and Midlife Moderate the Relation of Psychological Stress to Cognitive Performance in Old Age
Conclusion: Cognitive reserve and social capital accrued in early and midlife may reduce the detrimental influences of psychological stress on cognitive functioning in old age.Dement Geriatr Cogn Disord 2018;45:190 –197 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 5, 2018 Category: Geriatrics Source Type: research

Anxiety Symptoms in Older Adults with Depression Are Associated with Suicidality.
CONCLUSION: The severity of anxiety symptoms was associated with the severity of depression and suicidality in older adults with depressive disorders. The results could indicate a need to focus greater attention on the treatment of anxiety and suicidality in older patients with depression. PMID: 29860257 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 5, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Anxiety Symptoms in Older Adults with Depression Are Associated with Suicidality
Conclusion: The severity of anxiety symptoms was associated with the severity of depression and suicidality in older adults with depressive disorders. The results could indicate a need to focus greater attention on the treatment of anxiety and suicidality in older patients with depression.Dement Geriatr Cogn Disord 2018;45:180 –189 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 1, 2018 Category: Geriatrics Source Type: research

Effect of Emotion and Type of Encoding on Memory for Actions: Verbal and Subject-Performed Tasks.
CONCLUSION: These results confirm effects observed in normal ageing and indicate a more subtle effect on AD. PMID: 29843134 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 1, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Cerebrospinal Fluid BACE1 Activity and sA βPPβ as Biomarker Candidates of Alzheimer’s Disease
Conclusions: Further studies using biomarker-underpinned diagnoses are warranted to shed more light on the potential diagnostic utility of BACE1 activity as AD biomarker candidate in MCI.Dement Geriatr Cogn Disord 2018;45:152 –161 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - May 29, 2018 Category: Geriatrics Source Type: research

Effect of Emotion and Type of Encoding on Memory for Actions: Verbal and Subject-Performed Tasks
Conclusion: These results confirm effects observed in normal ageing and indicate a more subtle effect on AD.Dement Geriatr Cogn Disord 2018;45:162 –179 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - May 29, 2018 Category: Geriatrics Source Type: research

Cerebrospinal Fluid BACE1 Activity and sA βPPβ as Biomarker Candidates of Alzheimer's Disease.
CONCLUSIONS: Further studies using biomarker-underpinned diagnoses are warranted to shed more light on the potential diagnostic utility of BACE1 activity as AD biomarker candidate in MCI. PMID: 29788013 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - May 23, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia.
Authors: Knight R, Khondoker M, Magill N, Stewart R, Landau S Abstract BACKGROUND: Acetylcholinesterase inhibitors (AChEIs) and memantine are commonly used in the management of dementia. In routine clinical practice, dementia is often monitored via the Mini-Mental State Examination (MMSE). We conducted a systematic review and meta-analysis of the effects of these drugs on MMSE scores. SUMMARY: Eighty trials were identified. Pooled effect estimates were in favour of both AChEIs and memantine at 6 months. Meta-regression indicated that dementia subtype was a moderator of AChEI treatment effect, with the effect of...
Source: Dementia and Geriatric Cognitive Disorders - May 9, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia
Background: Acetylcholinesterase inhibitors (AChEIs) and memantine are commonly used in the management of dementia. In routine clinical practice, dementia is often monitored via the Mini-Mental State Examination (MMSE). We conducted a systematic review and meta-analysis of the effects of these drugs on MMSE scores.Summary: Eighty trials were identified. Pooled effect estimates were in favour of both AChEIs and memantine at 6 months. Meta-regression indicated that dementia subtype was a moderator of AChEI treatment effect, with the effect of treatment versus control twice as high for patients with Parkinson disease dementia...
Source: Dementia and Geriatric Cognitive Disorders - May 7, 2018 Category: Geriatrics Source Type: research