Cerebrospinal Fluid Biomarker-Based Diagnosis of Sporadic Creutzfeldt-Jakob Disease: A Validation Study for Previously Established Cutoffs.
Authors: Llorens F, Karch A, Golanska E, Schmitz M, Lange P, Sikorska B, Liberski PP, Zerr I Abstract BACKGROUND: Several biomarkers have been proposed to discriminate sporadic Creutzfeldt-Jakob disease (sCJD) from other dementias and control cases. However, their clinical accuracy depends on the PRNP codon 129 genotype, leaving it unclear how well established markers behave in untested conditions. METHODS: We analyzed 14-3-3, tau, p-tau levels, and the p-tau/tau ratio in a population sample collected from Polish hospitals including nondementia, dementia, and definite sCJD cases and validated their parameters a...
Source: Dementia and Geriatric Cognitive Disorders - January 6, 2017 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Cerebrospinal Fluid Biomarker-Based Diagnosis of Sporadic Creutzfeldt-Jakob Disease: A Validation Study for Previously Established Cutoffs
Background: Several biomarkers have been proposed to discriminate sporadic Creutzfeldt-Jakob disease (sCJD) from other dementias and control cases. However, their clinical accuracy depends on the PRNP codon 129 genotype, leaving it unclear how well established markers behave in untested conditions.Methods: We analyzed 14-3-3, tau, p-tau levels, and the p-tau/tau ratio in a population sample collected from Polish hospitals including nondementia, dementia, and definite sCJD cases and validated their parameters according to previously established cutoffs. Additionally, the correlation between biomarkers and disease duration a...
Source: Dementia and Geriatric Cognitive Disorders - January 5, 2017 Category: Geriatrics Source Type: research

Why Almost Always Animals Ranking Fluency Tasks for the Detection of Dementia Based on Receiver Operating Characteristic (ROC) and Quality ROC Analyses
Conclusion: Our study might guide the selection of suitable category fluency tasks according to the diagnostic purposes in dementia.Dement Geriatr Cogn Disord 2017;43:59-70 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 27, 2016 Category: Geriatrics Source Type: research

Why Almost Always Animals? Ranking Fluency Tasks for the Detection of Dementia Based on Receiver Operating Characteristic (ROC) and Quality ROC Analyses.
CONCLUSION: Our study might guide the selection of suitable category fluency tasks according to the diagnostic purposes in dementia. PMID: 28013307 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 26, 2016 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Why Almost Always < b > < i > Animals < /i > < /b > ? Ranking Fluency Tasks for the Detection of Dementia Based on Receiver Operating Characteristic (ROC) and Quality ROC Analyses
Conclusion: Our study might guide the selection of suitable category fluency tasks according to the diagnostic purposes in dementia.Dement Geriatr Cogn Disord 2017;43:59-70 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 23, 2016 Category: Geriatrics Source Type: research

Inhibitors of Acetylcholinesterase Derived from 7-Methoxytacrine and Their Effects on the Choline Transporter CHT1.
CONCLUSION: The N-alkylated derivative of 7-MEOTA bearing from C4 side chains appears to be the most promising compound and should be evaluated in future in vivo research. PMID: 27988521 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 20, 2016 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Acetylcholinesterase Activity Measurement and Clinical Features of Delirium.
CONCLUSION: Higher AChE activity was associated with hypoactive delirium but did not predict outcomes. Simple enhancement of cholinergic neurotransmission may not be sufficient to treat delirium. PMID: 27974719 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 16, 2016 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Prognostic Significance of Dementia in Older Adults with Solid Tumors.
CONCLUSIONS: We demonstrated that dementia is associated with shorter overall survival in elderly patients with solid tumors. PMID: 27978516 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 16, 2016 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Inhibitors of Acetylcholinesterase Derived from 7-Methoxytacrine and Their Effects on the Choline Transporter CHT1
Conclusion: TheN-alkylated derivative of 7-MEOTA bearing from C4 side chains appears to be the most promising compound and should be evaluated in future in vivo research.Dement Geriatr Cogn Disord 2017;43:45-58 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 16, 2016 Category: Geriatrics Source Type: research

Prognostic Significance of Dementia in Older Adults with Solid Tumors
Conclusions: We demonstrated that dementia is associated with shorter overall survival in elderly patients with solid tumors.Dement Geriatr Cogn Disord 2017;43:38-44 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 15, 2016 Category: Geriatrics Source Type: research

Acetylcholinesterase Activity Measurement and Clinical Features of Delirium
Conclusion: Higher AChE activity was associated with hypoactive delirium but did not predict outcomes. Simple enhancement of cholinergic neurotransmission may not be sufficient to treat delirium.Dement Geriatr Cogn Disord 2017;43:29-37 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 14, 2016 Category: Geriatrics Source Type: research

Screening Younger Individuals in a Primary Care Setting Flags Putative Dementia Cases and Correlates Gastrointestinal Diseases with Poor Cognitive Performance.
CONCLUSIONS: This study shows the merit of carrying out a dementia screening on younger subjects. Significantly, 71 subjects in the age group of 50-65 years were flagged for follow-up studies; furthermore, these cases with a potentially early onset of dementia were identified in a primary care setting. PMID: 27907913 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 3, 2016 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Screening Younger Individuals in a Primary Care Setting Flags Putative Dementia Cases and Correlates Gastrointestinal Diseases with Poor Cognitive Performance
Conclusions: This study shows the merit of carrying out a dementia screening on younger subjects. Significantly, 71 subjects in the age group of 50-65 years were flagged for follow-up studies; furthermore, these cases with a potentially early onset of dementia were identified in a primary care setting.Dement Geriatr Cogn Disord 2017;43:15-28 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 2, 2016 Category: Geriatrics Source Type: research

Acknowledgement to Reviewers
Dement Geriatr Cogn Disord 2016;42:369-370 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 1, 2016 Category: Geriatrics Source Type: research

Contents Vol. 42, 2016
Dement Geriatr Cogn Disord 2016;42:I-IV (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 1, 2016 Category: Geriatrics Source Type: research

Usefulness of Discriminability and Response Bias Indices for the Evaluation of Recognition Memory in Mild Cognitive Impairment and Alzheimer Disease.
Authors: Russo MJ, Cohen G, Campos J, Martin ME, Clarens MF, Sabe L, Barcelo E, Allegri RF Abstract BACKGROUND: Most studies examining episodic memory in Alzheimer disease (AD) have focused on patients' impaired ability to remember information. This approach provides only a partial picture of memory deficits since other factors involved are not considered. OBJECTIVE: To evaluate the recognition memory performance by using a yes/no procedure to examine the effect of discriminability and response bias measures in amnestic mild cognitive impairment (a-MCI), AD dementia, and normal-aging subjects. METHODS: We i...
Source: Dementia and Geriatric Cognitive Disorders - November 29, 2016 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Usefulness of Discriminability and Response Bias Indices for the Evaluation of Recognition Memory in Mild Cognitive Impairment and Alzheimer Disease
Background: Most studies examining episodic memory in Alzheimer disease (AD) have focused on patients' impaired ability to remember information. This approach provides only a partial picture of memory deficits since other factors involved are not considered.Objective: To evaluate the recognition memory performance by using a yes/no procedure to examine the effect of discriminability and response bias measures in amnestic mild cognitive impairment (a-MCI), AD dementia, and normal-aging subjects.Methods: We included 43 controls and 45 a-MCI and 51 mild AD dementia patients. Based on the proportions of correct responses (hits...
Source: Dementia and Geriatric Cognitive Disorders - November 25, 2016 Category: Geriatrics Source Type: research

The Experience of Relations in Persons with Dementia: A Systematic Meta-Synthesis.
Authors: Eriksen S, Helvik AS, Juvet LK, Skovdahl K, Førsund LH, Grov EK Abstract BACKGROUND: Dementia influences a person's experience of social relationships, as described in several studies. In this systematic meta-synthesis of qualitative studies, we aim to interpret and synthesize the experiences of persons with dementias and their relations with others. SUMMARY: Living with dementia changes life, leading to new social roles and different social statuses. Persons with dementia experience being disconnected and dependent on others, feeling like being a burden, and being a person who is treated in pat...
Source: Dementia and Geriatric Cognitive Disorders - November 22, 2016 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Frontal Assessment Battery as a Useful Tool to Differentiate Mild Cognitive Impairment due to Subcortical Ischemic Vascular Disease from Alzheimer Disease.
CONCLUSION: The TFAB, and especially its 1-min Orthographical Fluency subtest, is a useful screening procedure to differentiate MCI due to SIVD from MCI due to AD. The discriminative ability is probably due to frontosubcortical white matter pathologies disproportionately involved in the two disease entities. PMID: 27866203 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - November 22, 2016 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

The Experience of Relations in Persons with Dementia: A Systematic Meta-Synthesis
Background: Dementia influences a person's experience of social relationships, as described in several studies. In this systematic meta-synthesis of qualitative studies, we aim to interpret and synthesize the experiences of persons with dementias and their relations with others.Summary: Living with dementia changes life, leading to new social roles and different social statuses. Persons with dementia experience being disconnected and dependent on others, feeling like being a burden, and being a person who is treated in paternalistic ways. Family, friends and others with dementia might play significant roles in their abilit...
Source: Dementia and Geriatric Cognitive Disorders - November 18, 2016 Category: Geriatrics Source Type: research

Frontal Assessment Battery as a Useful Tool to Differentiate Mild Cognitive Impairment due to Subcortical Ischemic Vascular Disease from Alzheimer Disease
Conclusion: The TFAB, and especially its 1-min Orthographical Fluency subtest, is a useful screening procedure to differentiate MCI due to SIVD from MCI due to AD. The discriminative ability is probably due to frontosubcortical white matter pathologies disproportionately involved in the two disease entities.Dement Geriatr Cogn Disord 2016;42:331-341 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - November 18, 2016 Category: Geriatrics Source Type: research

Screening for Dementia in Primary Care: A Comparison of the GPCOG and the MMSE.
CONCLUSION: The GPCOG is an effective screening tool for dementia in primary care. It appears to be a viable alternative to the MMSE, whilst also requiring less time to administer. PMID: 27811463 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - November 6, 2016 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Symptoms of Anxiety in Older Adults with Depression, Dementia, or Psychosis: A Principal Component Analysis of the Geriatric Anxiety Inventory.
CONCLUSION: The results indicate that in old age, anxiety is especially prevalent in depression. The 2-component solution indicates that the GAI measures 2 different aspects of anxiety with different symptomatology. PMID: 27811466 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - November 6, 2016 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Symptoms of Anxiety in Older Adults with Depression, Dementia, or Psychosis: A Principal Component Analysis of the Geriatric Anxiety Inventory
Conclusion: The results indicate that in old age, anxiety is especially prevalent in depression. The 2-component solution indicates that the GAI measures 2 different aspects of anxiety with different symptomatology.Dement Geriatr Cogn Disord 2016;42:310-322 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - November 4, 2016 Category: Geriatrics Source Type: research

Screening for Dementia in Primary Care: A Comparison of the GPCOG and the MMSE
Conclusion: The GPCOG is an effective screening tool for dementia in primary care. It appears to be a viable alternative to the MMSE, whilst also requiring less time to administer.Dement Geriatr Cogn Disord 2016;42:323-330 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - November 4, 2016 Category: Geriatrics Source Type: research

Blood-Based Oxidative Stress Markers and Cognitive Performance in Early Old Age: The HAPIEE Study.
CONCLUSION: This study found modest evidence for a relationship between serum d-ROMs and cognitive function in a population sample of older adults. PMID: 27802435 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - November 3, 2016 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Blood-Based Oxidative Stress Markers and Cognitive Performance in Early Old Age: The HAPIEE Study
Conclusion: This study found modest evidence for a relationship between serum d-ROMs and cognitive function in a population sample of older adults.Dement Geriatr Cogn Disord 2016;42:297-309 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - November 1, 2016 Category: Geriatrics Source Type: research

Reduced Frontal Activations at High Working Memory Load in Mild Cognitive Impairment: Near-Infrared Spectroscopy.
The objective of the present study was to utilize near-infrared spectroscopy (NIRS), an alternative imaging technique, to examine neural processing during WM performance in individuals with MCI. METHODS: Twenty-six older adults with MCI (7 males; mean age 69.15 years) were compared with 26 age-, gender-, handedness-, and education-matched older adults with normal cognition (NC; 7 males; mean age 68.87 years). All of the participants undertook an n-back task with a low (i.e., 0-back) and a high (i.e., 2-back) WM load condition while their prefrontal dynamics were recorded by a 16-channel NIRS system. RESULTS: Althou...
Source: Dementia and Geriatric Cognitive Disorders - October 28, 2016 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Reduced Frontal Activations at High Working Memory Load in Mild Cognitive Impairment: Near-Infrared Spectroscopy
The objective of the present study was to utilize near-infrared spectroscopy (NIRS), an alternative imaging technique, to examine neural processing during WM performance in individuals with MCI.Methods: Twenty-six older adults with MCI (7 males; mean age 69.15 years) were compared with 26 age-, gender-, handedness-, and education-matched older adults with normal cognition (NC; 7 males; mean age 68.87 years). All of the participants undertook ann-back task with a low (i.e., 0-back) and a high (i.e., 2-back) WM load condition while their prefrontal dynamics were recorded by a 16-channel NIRS system.Results: Although behavior...
Source: Dementia and Geriatric Cognitive Disorders - October 26, 2016 Category: Geriatrics Source Type: research

The Relational and Item-Specific Encoding Task in Mild Cognitive Impairment and Alzheimer Disease.
CONCLUSION: The RISE measures significantly predicted diagnosis and predicted everyday functional competence. The RISE offers unique advantages in the assessment of HC and individuals with preclinical AD. PMID: 27723653 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 12, 2016 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

The Relational and Item-Specific Encoding Task in Mild Cognitive Impairment and Alzheimer Disease
Conclusion: The RISE measures significantly predicted diagnosis and predicted everyday functional competence. The RISE offers unique advantages in the assessment of HC and individuals with preclinical AD.Dement Geriatr Cogn Disord 2016;42:265-277 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 11, 2016 Category: Geriatrics Source Type: research

Correlation or Limits of Agreement Applying the Bland-Altman Approach to the Comparison of Cognitive Screening Instruments
Conclusion: Correlation is not agreement. Highly correlated test scores may conceal broad limits of agreement, consistent with the different emphases of different tests with respect to the cognitive domains examined. Routine incorporation of limits of agreement into diagnostic accuracy studies which compare different tests merits consideration, to enable clinicians to judge whether or not their agreement is close.Dement Geriatr Cogn Disord 2016;42:247-254 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 6, 2016 Category: Geriatrics Source Type: research

Cognitive Impairment Is Associated with a Low Omega-3 Index in the Elderly: Results from the KORA-Age Study.
CONCLUSION: A robust association was found between low omega-3 levels and cognitive impairment in an elderly population. Further research is needed to understand the link between omega-3 PUFA and cognitive functioning. PMID: 27701160 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 6, 2016 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

White Matter Changes May Precede Gray Matter Loss in Elderly with Subjective Memory Impairment.
CONCLUSION: SMI subjects with a high risk of progression had more WM microstructural disruption than those with a low risk, and the changes were not explained by GM atrophy. Our findings suggest that the degree of microstructural alterations in SMI may be distinctive according to the risk factors and may precede GM atrophy. PMID: 27701163 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 6, 2016 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Interaction with the MAPT H1H1 Genotype Increases Dementia Risk in APOE ε4 Carriers in a Population of Southern India.
This study delineates the role of the interaction of apolipoprotein E (APOE) and MAPT alleles in contributing to disease risks of dementia in a southern Indian population. METHODS: A sample of 419 patients comprising Alzheimer's disease (AD; n = 156), mild cognitive impairment (MCI; n = 87), frontotemporal dementia (FTD; n = 127), vascular dementia (VD; n = 37), and dementia with Lewy bodies (DLB; n = 12) was analysed in comparison with a control group (n = 138). APOE genotyping and MAPT haplotyping were performed on all study subjects. RESULTS: Multivariate logistic regression analysis showed that variability on t...
Source: Dementia and Geriatric Cognitive Disorders - October 6, 2016 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Correlation or Limits of Agreement? Applying the Bland-Altman Approach to the Comparison of Cognitive Screening Instruments.
CONCLUSION: Correlation is not agreement. Highly correlated test scores may conceal broad limits of agreement, consistent with the different emphases of different tests with respect to the cognitive domains examined. Routine incorporation of limits of agreement into diagnostic accuracy studies which compare different tests merits consideration, to enable clinicians to judge whether or not their agreement is close. PMID: 27705978 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 6, 2016 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Interaction with the MAPT H1H1 Genotype Increases Dementia Risk in APOE ε4 Carriers in a Population of Southern India
This study delineates the role of the interaction of apolipoprotein E (APOE) and MAPT alleles in contributing to disease risks of dementia in a southern Indian population.Methods: A sample of 419 patients comprising Alzheimer's disease (AD; n = 156), mild cognitive impairment (MCI; n = 87), frontotemporal dementia (FTD; n = 127), vascular dementia (VD; n = 37), and dementia with Lewy bodies (DLB; n = 12) was analysed in comparison with a control group (n = 138). APOE genotyping and MAPT haplotyping were performed on all study subjects.Results: Multivariate logistic regression analysis showed that variability on the APOE lo...
Source: Dementia and Geriatric Cognitive Disorders - October 5, 2016 Category: Geriatrics Source Type: research

Correlation or Limits of Agreement? Applying the Bland-Altman Approach to the Comparison of Cognitive Screening Instruments
Conclusion: Correlation is not agreement. Highly correlated test scores may conceal broad limits of agreement, consistent with the different emphases of different tests with respect to the cognitive domains examined. Routine incorporation of limits of agreement into diagnostic accuracy studies which compare different tests merits consideration, to enable clinicians to judge whether or not their agreement is close.Dement Geriatr Cogn Disord 2016;42:247-254 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 5, 2016 Category: Geriatrics Source Type: research

White Matter Changes May Precede Gray Matter Loss in Elderly with Subjective Memory Impairment
Conclusion: SMI subjects with a high risk of progression had more WM microstructural disruption than those with a low risk, and the changes were not explained by GM atrophy. Our findings suggest that the degree of microstructural alterations in SMI may be distinctive according to the risk factors and may precede GM atrophy.Dement Geriatr Cogn Disord 2016;42:227-235 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 4, 2016 Category: Geriatrics Source Type: research

Cognitive Impairment Is Associated with a Low Omega-3 Index in the Elderly: Results from the KORA-Age Study
Conclusion: A robust association was found between low omega-3 levels and cognitive impairment in an elderly population. Further research is needed to understand the link between omega-3 PUFA and cognitive functioning.Dement Geriatr Cogn Disord 2016;42:236-245 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 4, 2016 Category: Geriatrics Source Type: research

The Relationship between Behavioural Changes, Cognitive Symptoms, and Functional Disability in Primary Progressive Aphasia: A Longitudinal Study.
CONCLUSIONS: The presentation and interplay of behavioural changes and functional disability differ in svPPA and nfvPPA. These varying factors should be taken into account when considering prognosis, disease management, and selection of outcome measures for interventions. PMID: 27684067 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - September 30, 2016 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

The Relationship between Behavioural Changes, Cognitive Symptoms, and Functional Disability in Primary Progressive Aphasia: A Longitudinal Study
Conclusions: The presentation and interplay of behavioural changes and functional disability differ in svPPA and nfvPPA. These varying factors should be taken into account when considering prognosis, disease management, and selection of outcome measures for interventions.Dement Geriatr Cogn Disord 2016;42:215-226 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - September 29, 2016 Category: Geriatrics Source Type: research

Characteristics Associated with Quality of Life in Long-Term Care Residents with Dementia: A Cross-Sectional Study.
CONCLUSION: QOL in dementia is independently associated with age, ADL, dementia severity, pain, psychiatric disorders, pulmonary diseases and neuropsychiatric symptoms. It is possible to detect persons with dementia at risk for a lower QOL. This information is important for developing personalized interventions to improve QOL in persons with dementia in LTCFs. PMID: 27668927 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - September 27, 2016 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Factors of Resilience in Informal Caregivers of People with Dementia from Integrative International Data Analysis.
CONCLUSION: Caregivers have the capacity to demonstrate resilience despite significant challenges. This study demonstrates how harmonization of data from multiple existing studies can be used to increase power and explore the consistency of findings. This contributes to a better understanding of which factors are likely to facilitate caregiver resilience and offers insights for developing services. PMID: 27669054 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - September 27, 2016 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Factors of Resilience in Informal Caregivers of People with Dementia from Integrative International Data Analysis
Conclusion: Caregivers have the capacity to demonstrate resilience despite significant challenges. This study demonstrates how harmonization of data from multiple existing studies can be used to increase power and explore the consistency of findings. This contributes to a better understanding of which factors are likely to facilitate caregiver resilience and offers insights for developing services.Dement Geriatr Cogn Disord 2016;42:198-214 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - September 26, 2016 Category: Geriatrics Source Type: research

Characteristics Associated with Quality of Life in Long-Term Care Residents with Dementia: A Cross-Sectional Study
Conclusion: QOL in dementia is independently associated with age, ADL, dementia severity, pain, psychiatric disorders, pulmonary diseases and neuropsychiatric symptoms. It is possible to detect persons with dementia at risk for a lower QOL. This information is important for developing personalized interventions to improve QOL in persons with dementia in LTCFs.Dement Geriatr Cogn Disord 2016;42:186-197 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - September 26, 2016 Category: Geriatrics Source Type: research

White Matter Lesions: Prevalence and Clinical Phenotype in Asymptomatic Individuals Aged ≥50 Years.
CONCLUSION: ec/cWMLs are common in asymptomatic community-dwelling individuals aged ≥50 years. They are associated with cardiovascular risk factors, impairments in global and executive cognitive function, and Scheltens score elevation. PMID: 27649085 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - September 22, 2016 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Cognitive Function, APOE Gene Polymorphisms, and Thyroid Status Associations in Postmenopausal Women in Poland.
CONCLUSION: Lower results of cognitive functions were associated with the presence of the ε4 APOE allele in postmenopausal women. The ε4 APOE polymorphism was associated with a higher concentration of thyroid-stimulating hormone and lower concentrations of free triiodothyronine and total triiodothyronine. PMID: 27649316 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - September 22, 2016 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Cognitive Function, APOE Gene Polymorphisms, and Thyroid Status Associations in Postmenopausal Women in Poland
Conclusion: Lower results of cognitive functions were associated with the presence of the ε4APOE allele in postmenopausal women. The ε4APOE polymorphism was associated with a higher concentration of thyroid-stimulating hormone and lower concentrations of free triiodothyronine and total triiodothyronine.Dement Geriatr Cogn Disord 2016;42:169-185 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - September 21, 2016 Category: Geriatrics Source Type: research

White Matter Lesions: Prevalence and Clinical Phenotype in Asymptomatic Individuals Aged ≥50 Years
Conclusion: ec/cWMLs are common in asymptomatic community-dwelling individuals aged ≥50 years. They are associated with cardiovascular risk factors, impairments in global and executive cognitive function, and Scheltens score elevation.Dement Geriatr Cogn Disord 2016;42:159-168 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - September 21, 2016 Category: Geriatrics Source Type: research