A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia.
Authors: Knight R, Khondoker M, Magill N, Stewart R, Landau S Abstract BACKGROUND: Acetylcholinesterase inhibitors (AChEIs) and memantine are commonly used in the management of dementia. In routine clinical practice, dementia is often monitored via the Mini-Mental State Examination (MMSE). We conducted a systematic review and meta-analysis of the effects of these drugs on MMSE scores. SUMMARY: Eighty trials were identified. Pooled effect estimates were in favour of both AChEIs and memantine at 6 months. Meta-regression indicated that dementia subtype was a moderator of AChEI treatment effect, with the effect of...
Source: Dementia and Geriatric Cognitive Disorders - May 9, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia
Background: Acetylcholinesterase inhibitors (AChEIs) and memantine are commonly used in the management of dementia. In routine clinical practice, dementia is often monitored via the Mini-Mental State Examination (MMSE). We conducted a systematic review and meta-analysis of the effects of these drugs on MMSE scores.Summary: Eighty trials were identified. Pooled effect estimates were in favour of both AChEIs and memantine at 6 months. Meta-regression indicated that dementia subtype was a moderator of AChEI treatment effect, with the effect of treatment versus control twice as high for patients with Parkinson disease dementia...
Source: Dementia and Geriatric Cognitive Disorders - May 7, 2018 Category: Geriatrics Source Type: research

Risk Factors and Outcomes of Delirium in Older Patients Admitted to Postacute Care with and without Dementia.
Authors: Gual N, Morandi A, Pérez LM, Brítez L, Burbano P, Man F, Inzitari M Abstract BACKGROUND: Delirium research is poorly studied in postacute care, a growing setting due to aging populations, as well as in dementia, a critical risk factor for delirium and particularly prevalent in postacute care. We investigated risk factors for delirium and its outcomes in older adults with and without dementia admitted to a subacute care unit (SCU) after exacerbated chronic conditions. METHODS: This is a prospective cohort study including patients ≥65 years old admitted to an SCU for 12 months. We collec...
Source: Dementia and Geriatric Cognitive Disorders - May 5, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Functional Disconnectivity during Inter-Task Resting State in Dementia with Lewy Bodies.
CONCLUSION: We found a specific functional profile in the switching between task and resting state conditions in DLB patients. This result could help better characterize functional impairments in DLB and their contribution to several core symptoms of this pathology such as visual hallucinations and cognitive fluctuations. PMID: 29723870 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - May 5, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Functional Disconnectivity during Inter-Task Resting State in Dementia with Lewy Bodies
Conclusion: We found a specific functional profile in the switching between task and resting state conditions in DLB patients. This result could help better characterize functional impairments in DLB and their contribution to several core symptoms of this pathology such as visual hallucinations and cognitive fluctuations.Dement Geriatr Cogn Disord 2018;45:105 –120 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - May 3, 2018 Category: Geriatrics Source Type: research

Risk Factors and Outcomes of Delirium in Older Patients Admitted to Postacute Care with and without Dementia
Conclusions: In older patients admitted to postacute care, dementia is the main risk factor for delirium, and delirium carries worse clinical and functional outcomes. In patients with dementia, delirium is also relevant, since it entails a functional loss at admission and lower functional recovery.Dement Geriatr Cogn Disord 2018;45:121 –129 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - May 3, 2018 Category: Geriatrics Source Type: research

Associations of Pulse and Blood Pressure with Hippocampal Volume by APOE and Cognitive Phenotype: The Alzheimer's Disease Neuroimaging Initiative (ADNI).
CONCLUSION: Changes in PPR, SBP, and DBP differentially influenced hippocampal volumes depending on the cognitive and APOE genotypic categories. PMID: 29694964 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 26, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Scores Obtained from a Simple Cognitive Test of Visuospatial Episodic Memory Performed Decades before Death Are Associated with the Ultimate Presence of Alzheimer Disease Pathology.
CONCLUSIONS: The results raise the possibility of identifying individuals at future risk of the neuropathological changes associated with AD over 20 years before death using a simple cognitive test. This work may facilitate early interventions, therapeutics and treatments for AD by identifying at-risk and minimally affected (in pathological terms) individuals. PMID: 29694971 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 26, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Quality of Life in People with Young-Onset Alzheimer's Dementia and Frontotemporal Dementia.
CONCLUSION: The QOL in Nordic people with YOD was better compared to people with LOD. Our results show depressive symptoms to be associated with QOL irrespective of age and diagnosis. PMID: 29694972 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 26, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Predictors of Rapid Cognitive Decline in Patients with Mild-to-Moderate Alzheimer Disease: A Prospective Cohort Study with 12-Month Follow-Up Performed in Memory Clinics.
Authors: Tchalla AE, Clément JP, Saulnier I, Beaumatin B, Lachal F, Gayot C, Bosetti A, Desormais I, Perrochon A, Preux PM, Couratier P, Dantoine T Abstract BACKGROUND/AIMS: Alzheimer disease (AD) is particularly devastating, with no cure, no means of prevention, and no proven way to slow progression. AD is associated with the worsening of cognitive function attributable to a variety of factors of which little is known. Our main objective was to determine factors associated with rapid cognitive decline (RCD) in older AD patients. METHODS: We conducted a 12-month, prospective, multi-centre cohort study. C...
Source: Dementia and Geriatric Cognitive Disorders - April 25, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Associations of Pulse and Blood Pressure with Hippocampal Volume by APOE and Cognitive Phenotype: The Alzheimer ’s Disease Neuroimaging Initiative (ADNI)
Conclusion: Changes in PPR, SBP, and DBP differentially influenced hippocampal volumes depending on the cognitive and APOE genotypic categories.Dement Geriatr Cogn Disord 2018;45:66 –78 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 25, 2018 Category: Geriatrics Source Type: research

Scores Obtained from a Simple Cognitive Test of Visuospatial Episodic Memory Performed Decades before Death Are Associated with the Ultimate Presence of Alzheimer Disease Pathology
Conclusions: The results raise the possibility of identifying individuals at future risk of the neuropathological changes associated with AD over 20 years before death using a simple cognitive test. This work may facilitate early interventions, therapeutics and treatments for AD by identifying at-risk and minimally affected (in pathological terms) individuals.Dement Geriatr Cogn Disord 2018;45:79 –90 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 25, 2018 Category: Geriatrics Source Type: research

Quality of Life in People with Young-Onset Alzheimer ’s Dementia and Frontotemporal Dementia
Conclusion: The QOL in Nordic people with YOD was better compared to people with LOD. Our results show depressive symptoms to be associated with QOL irrespective of age and diagnosis.Dement Geriatr Cogn Disord 2018;45:91 –104 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 25, 2018 Category: Geriatrics Source Type: research

Predictors of Rapid Cognitive Decline in Patients with Mild-to-Moderate Alzheimer Disease: A Prospective Cohort Study with 12-Month Follow-Up Performed in Memory Clinics
Conclusion: The factors associated with RCD were an MMSE score #x3c; 20 at treatment onset, female gender, psychotic symptoms, malnutrition, and a family history of dementia. These results may be directly relevant to patients, their families, and their physicians, enabling early anticipation of difficult clinical trajectories and poor functional outcomes.Dement Geriatr Cogn Disord 2018;45:1 –10 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 23, 2018 Category: Geriatrics Source Type: research

Acknowledgement to Reviewers
Dement Geriatr Cogn Disord 2017;44:354 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 18, 2018 Category: Geriatrics Source Type: research

Contents Vol. 44, 2017
Dement Geriatr Cogn Disord 2017;44:I –VI (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 18, 2018 Category: Geriatrics Source Type: research

Incremental Validity of Montreal Cognitive Assessment Index Scores in Mild Cognitive Impairment and Alzheimer Disease.
CONCLUSION: Administration of the entire MoCA is more informative than the index scores, especially in distinguishing normal cognition versus MCI. A combined score has stronger incremental validity than the individual index scores. PMID: 29642074 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 14, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Incremental Validity of Montreal Cognitive Assessment Index Scores in Mild Cognitive Impairment and Alzheimer Disease
Conclusion: Administration of the entire MoCA is more informative than the index scores, especially in distinguishing normal cognition versus MCI. A combined score has stronger incremental validity than the individual index scores.Dement Geriatr Cogn Disord 2018;45:49 –55 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 11, 2018 Category: Geriatrics Source Type: research

Characteristics of Mild Cognitive Impairment Using the Thai Version of the Consortium to Establish a Registry for Alzheimer's Disease Tests: A Multivariate and Machine Learning Study.
CONCLUSIONS: The most important features of the CERAD-NP differentiating MCI from normal controls indicate impairments in episodic and semantic memory and recall. While these features significantly discriminate MCI patients from normal controls, the tests are not predictive of MCI. PMID: 29617684 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 5, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Characteristics of Mild Cognitive Impairment Using the Thai Version of the Consortium to Establish a Registry for Alzheimer ’s Disease Tests: A Multivariate and Machine Learning Study
Conclusions: The most important features of the CERAD-NP differentiating MCI from normal controls indicate impairments in episodic and semantic memory and recall. While these features significantly discriminate MCI patients from normal controls, the tests are not predictive of MCI.Dement Geriatr Cogn Disord 2018;45:38 –48 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 4, 2018 Category: Geriatrics Source Type: research

Prevalence, Recognition, and Treatment of Dementia in Assisted Living Facilities.
CONCLUSION: Cognitive deficit and dementia are significantly underdiagnosed and undertreated in assisted living settings. In the second cross-sectional study we detected significant but not complete improvement in the primary recognition and adequate therapy of dementia. PMID: 29566372 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - March 27, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Prevalence, Recognition, and Treatment of Dementia in Assisted Living Facilities
Conclusion: Cognitive deficit and dementia are significantly underdiagnosed and undertreated in assisted living settings. In the second cross-sectional study we detected significant but not complete improvement in the primary recognition and adequate therapy of dementia.Dement Geriatr Cogn Disord 2018;45:27 –37 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - March 23, 2018 Category: Geriatrics Source Type: research

Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project.
CONCLUSIONS: Pathogenic variants in dementia genes were predominantly rare and conserved coding changes. Pathogenic variants within ARSA, CSF1R, and GRN were observed, and candidate variants in GRN and CHMP2B were nominated in ADSP families. An independent case-control study provided evidence of an association between variants in TREM2, APOE, ARSA, CSF1R, PSEN1, and MAPT and risk of AD. Variants in genes which cause dementing disorders may influence the clinical diagnosis of AD in a small proportion of cases within the ADSP. PMID: 29486463 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - February 28, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Use of Vitamin K Antagonists and Brain Morphological Changes in Older Adults: An Exposed/Unexposed Voxel-Based Morphometric Study.
CONCLUSION: We found focal atrophies in older adults exposed to VKA. These findings provide new insights elucidating the effects of VKAs on brain health and function in older adults. PMID: 29486479 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - February 28, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer ’s Disease Sequencing Project
Conclusions: Pathogenic variants in dementia genes were predominantly rare and conserved coding changes. Pathogenic variants withinARSA,CSF1R, andGRN were observed, and candidate variants inGRN andCHMP2B were nominated in ADSP families. An independent case-control study provided evidence of an association between variants inTREM2,APOE,ARSA,CSF1R,PSEN1, andMAPT and risk of AD. Variants in genes which cause dementing disorders may influence the clinical diagnosis of AD in a small proportion of cases within the ADSP.Dement Geriatr Cogn Disord 2018;45:1 –17 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - February 28, 2018 Category: Geriatrics Source Type: research

Use of Vitamin K Antagonists and Brain Morphological Changes in Older Adults: An Exposed/Unexposed Voxel-Based Morphometric Study
Conclusion: We found focal atrophies in older adults exposed to VKA. These findings provide new insights elucidating the effects of VKAs on brain health and function in older adults.Dement Geriatr Cogn Disord 2018;45:18 –26 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - February 28, 2018 Category: Geriatrics Source Type: research

Complement Activation in Capillary Cerebral Amyloid Angiopathy.
CONCLUSION: Complement, MSR, and ApoE were only coexpressed in the presence of Aβ accumulation in capillaries, suggesting a role for complement activation in the propagation of Aβ. Additionally, C5b-9 expression may be associated with hemorrhagic brain injury in CAA. PMID: 29421784 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - February 10, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

APOE ε4 Genotype and Cognitive Reserve Effects on the Cognitive Functioning of Healthy Elders.
APOE ε4 Genotype and Cognitive Reserve Effects on the Cognitive Functioning of Healthy Elders. Dement Geriatr Cogn Disord. 2018 Feb 07;44(5-6):328-342 Authors: López ME, Turrero A, Delgado ML, Rodríguez-Rojo IC, Arrazola J, Barabash A, Maestú F, Fernández A Abstract AIM: To test the association between cognitive performance and APOE genotype, and to assess potential modifications of this association by sociodemographic and neuroanatomical factors in a sample of 74 healthy elders. METHODS: Firstly, we explored the isolated role of the APOE ɛ4 genotype (i.e., APOE...
Source: Dementia and Geriatric Cognitive Disorders - February 8, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Complement Activation in Capillary Cerebral Amyloid Angiopathy
Conclusion: Complement, MSR, and ApoE were only coexpressed in the presence of A β accumulation in capillaries, suggesting a role for complement activation in the propagation of Aβ. Additionally, C5b-9 expression may be associated with hemorrhagic brain injury in CAA.Dement Geriatr Cogn Disord 2017;44:343 –353 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - February 8, 2018 Category: Geriatrics Source Type: research

< b > < i > APOE < /i > < /b > ε4 Genotype and Cognitive Reserve Effects on the Cognitive Functioning of Healthy Elders
Conclusions: Current results point out that APOE4 genotype influences healthy aged cognition, although factors such age or educational attainment seem to modulate its effects.Dement Geriatr Cogn Disord 2017;44:328 –342 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - February 7, 2018 Category: Geriatrics Source Type: research

Validation of the Cuban Version of Addenbrooke's Cognitive Examination-Revised for Screening Mild Cognitive Impairment.
CONCLUSION: The Cuban ACE-R is a valid screening tool for detecting cognitive impairment. It is more sensitive and accurate in screening for MCI than MMSE. PMID: 29393151 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - February 4, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

A Methodological Perspective on the Longitudinal Cognitive Change after Stroke.
CONCLUSIONS: This study shows that defining outcomes as changes over time and reflecting correlations between outcomes may affect the identification of predictors of PSCI. PMID: 29393166 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - February 4, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Saccular Impairment in Alzheimer's Disease Is Associated with Driving Difficulty.
CONCLUSION: This study suggests a novel link between saccular impairment and driving difficulty in MCI and AD patients and demonstrates that driving difficulty may be a real-world manifestation of impaired spatial cognition associated with saccular impairment. PMID: 29393172 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - February 4, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Importance of Proactive Treatment of Depression in Lewy Body Dementias: The Impact on Hippocampal Neurogenesis and Cognition in a Post-Mortem Study.
CONCLUSION: SSRI treatment was associated with increased hippocampal neurogenesis and preservation of cognition in DLB/PDD patients. PMID: 29393203 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - February 4, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Psychometric Evaluation of the Electronic Pain Assessment Tool: An Innovative Instrument for Individuals with Moderate-to-Severe Dementia.
CONCLUSION: The ePAT is a suitable tool for the assessment of pain in this vulnerable population. PMID: 29393207 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - February 4, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Higher Serum Endocan Level Is Associated with Alzheimer Disease.
Authors: Varan HD, Guner G, Kizilarslanoglu MC, Sumer F, Dogrul RT, Sagir A, Ozsurekci C, Caliskan H, Balci C, Aycicek GS, Akbiyik F, Halil M, Cankurtaran M, Yavuz BB Abstract BACKGROUND: The novel molecule endocan, which is released by endothelium and is regulated by proangiogenic and proinflammatory cytokines, may have a role in the pathophysiology of Alzheimer disease (AD). The aim of this study was to evaluate the relationship between serum endocan levels and AD. METHODS: A total of 134 patients (47 AD, 42 amnestic mild cognitive impairment [aMCI], and 45 control patients) 65 years of age and older were rec...
Source: Dementia and Geriatric Cognitive Disorders - February 4, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Validation of the Cuban Version of Addenbrooke ’s Cognitive Examination-Revised for < b > < /b > Screening < b > < /b > Mild Cognitive Impairment
Conclusion: The Cuban ACE-R is a valid screening tool for detecting cognitive impairment. It is more sensitive and accurate in screening for MCI than MMSE.Dement Geriatr Cogn Disord 2017;44:320 –327 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - January 30, 2018 Category: Geriatrics Source Type: research

Saccular Impairment in Alzheimer ’s Disease Is Associated with Driving Difficulty
Conclusion: This study suggests a novel link between saccular impairment and driving difficulty in MCI and AD patients and demonstrates that driving difficulty may be a real-world manifestation of impaired spatial cognition associated with saccular impairment.Dement Geriatr Cogn Disord 2017;44:294 –302 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - January 26, 2018 Category: Geriatrics Source Type: research

Higher Serum Endocan Level Is Associated with Alzheimer Disease
Conclusion: Higher serum endocan levels may be associated with the pathogenesis of AD.Dement Geriatr Cogn Disord 2017;44:303 –310 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - January 26, 2018 Category: Geriatrics Source Type: research

A Methodological Perspective on the Longitudinal Cognitive Change after Stroke
Conclusions: This study shows that defining outcomes as changes over time and reflecting correlations between outcomes may affect the identification of predictors of PSCI.Dement Geriatr Cogn Disord 2017;44:311 –319 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - January 26, 2018 Category: Geriatrics Source Type: research

Importance of Proactive Treatment of Depression in Lewy Body Dementias: The Impact on Hippocampal Neurogenesis and Cognition in a Post-Mortem Study
Conclusion: SSRI treatment was associated with increased hippocampal neurogenesis and preservation of cognition in DLB/PDD patients.Dement Geriatr Cogn Disord 2017;44:283-293 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - January 26, 2018 Category: Geriatrics Source Type: research

Psychometric Evaluation of the Electronic Pain Assessment Tool: An Innovative Instrument for Individuals with Moderate-to-Severe Dementia
Conclusion: The ePAT is a suitable tool for the assessment of pain in this vulnerable population.Dement Geriatr Cogn Disord 2017;44:256 –267 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - January 23, 2018 Category: Geriatrics Source Type: research

Microstructure of Strategic White Matter Tracts and Cognition in Memory Clinic Patients with Vascular Brain Injury.
Authors: Biesbroek JM, Leemans A, den Bakker H, Duering M, Gesierich B, Koek HL, van den Berg E, Postma A, Biessels GJ, on behalf of the Utrecht Vascular Cognitive Impairment (VCI) study group Abstract BACKGROUND: White matter injury is an important factor for cognitive impairment in memory clinic patients. We determined the added value of diffusion tensor imaging (DTI) of strategic white matter tracts in explaining variance in cognition in memory clinic patients with vascular brain injury. METHODS: We included 159 patients. Conventional MRI markers (white matte...
Source: Dementia and Geriatric Cognitive Disorders - January 22, 2018 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Microstructure of Strategic White Matter Tracts and Cognition in Memory Clinic Patients with Vascular Brain Injury
Conclusion: In memory clinic patients with vascular brain injury, DTI of strategic white matter tracts has a significant added value in explaining variance in cognitive functioning.Dement Geriatr Cogn Disord 2017;44:268 –282 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - January 19, 2018 Category: Geriatrics Source Type: research

Greater Experience of Negative Non-Target Emotions by Patients with Neurodegenerative Diseases Is Related to Lower Emotional Well-Being in Caregivers.
CONCLUSION: The findings reveal a previously unstudied patient behavior that is related to worse caregiver emotional well-being. Future research and clinical assessment may benefit from evaluating non-target emotions in patients. PMID: 29216633 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 9, 2017 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Greater Experience of Negative Non-Target Emotions by Patients with Neurodegenerative Diseases Is Related to Lower Emotional Well-Being in Caregivers
Conclusion: The findings reveal a previously unstudied patient behavior that is related to worse caregiver emotional well-being. Future research and clinical assessment may benefit from evaluating non-target emotions in patients.Dement Geriatr Cogn Disord 2017;44:245-255 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 7, 2017 Category: Geriatrics Source Type: research

Comparative Effects of Education and Bilingualism on the Onset of Mild Cognitive Impairment.
CONCLUSION: The effect of bilingualism is protective against cognitive decline, and lies along a continuum from normal to pathological states. In comparison, the role of years of education is less robust. PMID: 29207387 [PubMed - in process] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 6, 2017 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Cerebrospinal Fluid TAR DNA-Binding Protein 43 Combined with Tau Proteins as a Candidate Biomarker for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Spectrum Disorders
Conclusion: Combined analysis of TDP-43, τT, and τP-181 in CSF may be useful for the antemortem diagnosis of ALS and FTD.Dement Geriatr Cogn Disord 2017;44:144-152 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 25, 2017 Category: Geriatrics Source Type: research

Cortical Functional Connections and Fluid Intelligence in Adolescent APOE ε4 Carriers
Conclusion:ε4 carriers have lower corticocortical communication than noncarriers during an intelligence task, implying that carrying the ε4 allele may reduce brain networking in adolescence, several decades before the onset of Alzheimer disease.Dement Geriatr Cogn Disord 2017;44:153-159 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - October 25, 2017 Category: Geriatrics Source Type: research

Screening of Cognitive Impairment in the Dialysis Population: A Scoping Review
Conclusion: While cognitive impairment is recognised in the dialysis population, there is paucity of screening data. The design of prospective comparisons ideally includes established screening instruments, particularly the Montreal Cognitive Assessment, to determine the optimal results for this population. Translation of established screening tools to increase the inclusion of people from other cultural and language groups is required. Regular screening can enhance the timing to introduce home-based care support and advance care planning discussions.Dement Geriatr Cogn Disord 2017;44:182-195 (Source: Dementia and Geriatri...
Source: Dementia and Geriatric Cognitive Disorders - October 25, 2017 Category: Geriatrics Source Type: research