The Metabolic Syndrome and Cognitive Decline in the Atherosclerosis Risk in Communities Study (ARIC).
Conclusions: A focus on the individual risk factors as opposed to MetS during midlife is important to reduce the incidence of cognitive impairment in later life. © 2014 S. Karger AG, Basel. PMID: 25171458 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 31, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Effect of Physical Exercise on Cognitive Performance in Older Adults with Mild Cognitive Impairment or Dementia: A Systematic Review.
Authors: Ohman H, Savikko N, Strandberg TE, Pitkälä KH Abstract Numerous studies have shown that physical exercise has positive effects on cognition in healthy adults. Less is known about the effectiveness of exercise interventions in older individuals already suffering from mild cognitive impairment (MCI) or dementia. The aim of this study was to systematically review the evidence from randomized controlled trials (RCTs) of the effects of physical exercise on cognition in older subjects with MCI or dementia. PubMed, Cochrane and DARE databases were systematically searched for RCTs using terms related to ...
Source: Dementia and Geriatric Cognitive Disorders - August 31, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Do Stress Markers and Anesthetic Technique Predict Delirium in the Elderly?
Conclusion: The development of PD depends more on postoperative stress than intraoperative stress or anesthetic. © 2014 S. Karger AG, Basel. PMID: 25171689 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 31, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Increased Serum Levels of Interleukin-18, -23 and -17 in Chinese Patients with Alzheimer's Disease.
Conclusion: Elevated IL-18, IL-23 and IL-17 levels are observed in AD patients and differences may exist between males and females. Besides, IL-18 may correlate with the severity of AD. © 2014 S. Karger AG, Basel. PMID: 25138786 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 21, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Early-Onset Alzheimer's Disease in Two Iranian Families: A Genetic Study.
Conclusion: This mutation demonstrates the importance of γ-secretase, the necessity of early detection of patients with memory decline in the susceptible population and raising public awareness of consanguinity marriages. © 2014 S. Karger AG, Basel. PMID: 25138979 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - August 21, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Total Cholesterol and Neuropsychiatric Symptoms in Alzheimer's Disease: The Impact of Total Cholesterol Level and Gender.
Authors: Hall JR, Wiechmann AR, Johnson LA, Edwards M, Barber RC, Cunningham R, Singh M, O'Bryant SE Abstract Background: Neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) are a major factor in nursing home placement and a primary cause of stress for caregivers. Elevated cholesterol has been linked to psychiatric disorders and has been shown to be a risk factor for AD and to impact disease progression. The present study investigated the relationship between cholesterol and NPS in AD. Methods: Data on cholesterol and NPS from 220 individuals (144 females, 76 males) with mild-to-moderate AD from the Texas A...
Source: Dementia and Geriatric Cognitive Disorders - July 12, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Health-Related Quality of Life and Self-Efficacy of Managing Behavior Problems for Family Caregivers of Vascular Dementia and Alzheimer's Disease Patients.
Conclusion: This study is the first to examine and compare the behavioral problems of AD and VaD patients in a Chinese population, along with their family caregivers' self-efficacy and health outcomes. Family caregivers of patients with VaD might warrant specific attention to their HRQoL, with interventions developed to enhance their self-efficacy. © 2014 S. Karger AG, Basel. PMID: 25011490 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 12, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Risk Factors That Affect Life Expectancy in Alzheimer's Disease: A 15-Year Follow-Up.
Conclusion: AD shortens life expectancy in ChEI-treated patients diagnosed before the age of 85 years, similar to that reported previously for untreated individuals. A longer life span was observed in the eldest patients (≥85 years) compared with untreated cohorts, which did not differ from that observed in the general population. Higher education or carrying two APOE ε4 alleles were risk factors for earlier death. © 2014 S. Karger AG, Basel. PMID: 24992891 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 6, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

The French National Alzheimer Database: A Fast Growing Database for Researchers and Clinicians.
Conclusion: The BNA offers a multitude of research possibilities. In the coming years, the BNA will play a major role in monitoring trends and related risk factors in AD. © 2014 S. Karger AG, Basel. PMID: 24994018 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 6, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Using Magnetic Resonance Imaging in Diagnosing Dementia: A Dutch Outpatient Memory Clinics Survey.
Conclusion: MRI assessment by radiologists in Dutch MC probably underestimates the presence of cerebrovascular and neurodegenerative disease. The validity of standardized assessment protocols in routine clinical practice deserves further study, as the implementation of standardization outside research settings could improve diagnostic accuracy. © 2014 S. Karger AG, Basel. PMID: 24994453 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - July 6, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Galantamine versus Risperidone for Agitation in People with Dementia: A Randomized, Twelve-Week, Single-Center Study.
Conclusions: Agitation improved in both groups, even if the treatment effects were more pronounced in the risperidone group; however, the effects on cognition and other aspects of tolerability were stronger with galantamine. © 2014 S. Karger AG, Basel. PMID: 24969380 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 28, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Is HCRTR2 a Genetic Risk Factor for Alzheimer's Disease?
Conclusion: Our data support the hypothesis that the HCRTR2 gene is likely to be a risk factor for AD. The increased risk inferred is quite small, but in the context of a multi-factorial disease, the presence of this polymorphism may significantly contribute to influencing the susceptibility for AD by interacting with other unknown genetic or environmental factors in sleep regulation. © 2014 S. Karger AG, Basel. PMID: 24969517 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 28, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Serum 25-Hydroxyvitamin D and Cognitive Decline: A Longitudinal Study among Non-Demented Older Adults.
Conclusions: This study indicates that low levels of vitamin D might be associated with cognitive decline among non-demented elderly individuals and highlights the need for further large-scale prospective studies to clarify the potential role of vitamin D in cognitive function at an old age. © 2014 S. Karger AG, Basel. PMID: 24969663 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 28, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Motor Cortex Excitability Changes in Mild Alzheimer's Disease Are Reversed by Donepezil.
Conclusions: The results suggest an early functional impairment of cholinergic neurotransmission in AD, which is associated to early changes in the excitability of the motor system. © 2014 S. Karger AG, Basel. PMID: 24969819 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 28, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Higher Working Memory Predicts Slower Functional Decline in Autopsy-Confirmed Alzheimer's Disease.
Discussion: These findings are relevant for estimating the rate of decline in AD clinical trials and in counseling patients and families. Improving working memory performance as a possible avenue to decrease the rate of functional decline in AD dementia warrants closer investigation. © 2014 S. Karger AG, Basel. PMID: 24903099 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - June 7, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Evaluation of the New Consensus Criteria for the Diagnosis of Primary Progressive Aphasia Using Fluorodeoxyglucose Positron Emission Tomography.
Conclusions: A high correlation with the diagnosis obtained using FDG-PET was found. However, an overdiagnosis of the logopenic variant was observed. These results support the use of the new criteria, but some modifications or complementary studies may still be necessary. © 2014 S. Karger AG, Basel. PMID: 24732287 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 17, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Correlation between both Morphologic and Functional Changes and Anxiety in Alzheimer's Disease.
Conclusion: Our results suggest that anxiety in AD could overlap with the neural correlates of anxiety disorders, and that the specific degeneration associated with AD might be associated with anxiety. © 2014 S. Karger AG, Basel. PMID: 24732302 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 17, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Long-Term Mortality in a Cohort of Home-Dwelling Elderly with Mild Alzheimer's Disease and Lewy Body Dementia.
Conclusion: Dementia patients had an increased mortality, particularly those with LBD. © 2014 S. Karger AG, Basel. PMID: 24732348 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 17, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

The Potentially Protective Effect of Donepezil in Alzheimer's Disease.
Conclusion: Donepezil affects the relationship between hippocampal volume and cognitive function and may therefore have a pharmacologic effect as a disease modifier. © 2014 S. Karger AG, Basel. PMID: 24732387 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 17, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Thyroid Status and Cognitive Function in Euthyroid Patients with Early Parkinson's Disease.
Conclusions: This study supports a relationship between the thyroid status and cognitive function in euthyroid early PD patients, with higher concentrations of fT4 being associated with a poor performance of executive function. © 2014 S. Karger AG, Basel. PMID: 24732425 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 17, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Present Status and Road Map to Achieve Inclusive and Holistic Care for Dementia in a Japanese Community: Analysis Using the Delphi Method.
Conclusion: Further effective collaboration to promote dementia care is required. © 2014 S. Karger AG, Basel. PMID: 24732454 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 17, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Estrogen Receptor α Variants Affect Age at Onset of Alzheimer's Disease in a Multiethnic Female Cohort.
Conclusions: ESR1 polymorphisms affect age of onset of AD in women, and risk alleles vary by ethnicity. These effects are possibly due to different linkage disequilibrium patterns or differences in comorbid environmental or cultural risk factors mediating the SNP effect on risk for AD. © 2014 S. Karger AG, Basel. PMID: 24732579 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 17, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Frequency and Severity of Semantic Deficits in a Consecutive Memory Clinic Cohort.
Conclusion: Short tests with semantic memory content are sensitive to changes in dementia and MCI, but impairments on such tests may also be found in other diseases, e.g. affective disorders. © 2014 S. Karger AG, Basel. PMID: 24732647 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 17, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

The BEHAVE-AD Assessment System: A Perspective, A Commentary on New Findings, and A Historical Review.
The objective of this paper is to provide a framework for further advances in the treatment of BPSD and associated behavioral disturbances in AD and, consequently, a framework for continuing improvements in the lives of individuals with AD and those who share the burden of the disease with the AD person. © 2014 S. Karger AG, Basel. PMID: 24714384 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 10, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Apraxia in Mild Cognitive Impairment and Alzheimer's Disease: Validity and Reliability of the Van Heugten Test for Apraxia.
Authors: Smits LL, Flapper M, Sistermans N, Pijnenburg YA, Scheltens P, van der Flier WM Abstract Aim: To assess the reliability and validity of the Van Heugten test for apraxia (VHA), developed for and used in stroke patients, in a memory clinic population. Furthermore, we assess the presence and severity of apraxia in mild cognitive impairment (MCI) and Alzheimer's disease (AD) and investigate which AD patients are likely to develop apraxia. Methods: We included 90 controls (age: 60 ± 9 years, MMSE: 28 ± 2), 90 MCI patients (age: 65 ± 7 years, MMSE: 26 ± 2) and 158 AD patients (age: 66...
Source: Dementia and Geriatric Cognitive Disorders - March 10, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Mild Cognitive Impairment with Associated Inflammatory and Cortisol Alterations as Independent Risk Factor for Postoperative Delirium.
Conclusion: MCI is associated with a higher risk of postoperative delirium. Perioperative cortisol and inflammatory alterations observed in MCI may provide a physiological explanation for this increased risk. © 2014 S. Karger AG, Basel. PMID: 24603477 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - March 10, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Evaluation of Emotional Blunting in Behavioral Variant Frontotemporal Dementia Compared to Alzheimer's Disease.
Conclusions: Changes in the caregiver assessment of emotional blunting with dementia onset can distinguish patients with bvFTD from those with AD, and they may better reflect the impact of emotional blunting than similar assessments made by clinicians/investigators. © 2014 S. Karger AG, Basel. PMID: 24603498 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - March 10, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Phosphatidylserine Containing Omega-3 Fatty Acids May Improve Memory Abilities in Nondemented Elderly Individuals with Memory Complaints: Results from an Open-Label Extension Study.
Conclusions: The results demonstrate that consumption of 100 mg/day of PS-DHA might be associated with improving or maintaining cognitive status in elderly subjects with memory complaints. © 2014 S. Karger AG, Basel. PMID: 24577097 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - March 1, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Diagnostic Validity of the Alzheimer's Disease Functional Assessment and Change Scale in Mild Cognitive Impairment and Mild to Moderate Alzheimer's Disease.
Conclusion: The ADFACS is a reliable, valid, and sensitive instrument to assess functional abilities; it is useful in dementia assessment for elderly populations. © 2013 S. Karger AG, Basel. PMID: 24556708 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - February 22, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Verbal Fluency Patterns in Mild Cognitive Impairment and Alzheimer's Disease.
Conclusion: MCI using a category
Source: Dementia and Geriatric Cognitive Disorders - February 22, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

DNA Methylation of the TNF-α Promoter Region in Peripheral Blood Monocytes and the Cortex of Human Alzheimer's Disease Patients.
Conclusion: In AD patients, epigenetic mechanisms of TNF-α gene regulation, like aberrant DNA methylation, are not relevant in blood. © 2014 S. Karger AG, Basel. PMID: 24556805 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - February 22, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Emergence of Mild Cognitive Impairment in Late Middle-Aged Adults in the Wisconsin Registry for Alzheimer's Prevention.
Conclusion: Both cross-sectional methods showed instability over time, with many reverting to normal performance after baseline. The multiwave approach identified a group who showed progressive memory declines over 3 visits. Being able to detect progressive decline in late middle age is a critical step in improving prevention efforts. © 2014 S. Karger AG, Basel. PMID: 24556849 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - February 22, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Variability of Cognitive Performance during Hemodialysis: Standardization of Cognitive Assessment.
Authors: Tholen S, Schmaderer C, Kusmenkov E, Chmielewski S, Förstl H, Kehl V, Heemann U, Baumann M, Grimmer T Abstract Background/Aims: Up to 70% of hemodialysis patients over the age of 54 have relevant cognitive impairment. No standardized protocol for the evaluation and monitoring of this population is available today. We hypothesized that the dialysis procedure and the testing environment induce fluctuations of cognitive performance. Methods: 26 hemodialysis patients were randomly tested using the Montreal Cognitive Assessment (MoCA) before, during and after hemodialysis and inside the dialysis room or al...
Source: Dementia and Geriatric Cognitive Disorders - February 22, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

'Residence Is Not Home' Is a Particular Type of Delusion Associated with Cognitive Decline of Alzheimer's Disease.
Conclusion: Our findings suggest that the 'residence is not home' delusion is a particular symptom that has a cognitive background, particularly disorientation, and should be discriminated from other delusional phenomena. We should cope with delusions specifying what types of delusions are present since the content of delusions may critically mark the symptomatology of AD. For this purpose, the BEHAVE-AD-FW may be suitable. © 2014 S. Karger AG, Basel. PMID: 24556941 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - February 22, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Risk of Subsequent Dementia in Patients with Hypertensive Encephalopathy: A Nationwide Population-Based Study in Taiwan.
Conclusion: Hypertensive patients with HE displayed a significantly higher risk for dementia than those without HE. The risk increased further in those with the comorbidities of head injury and diabetes. Physicians should be aware of the link between HE and dementia when assessing patients with HE. © 2014 S. Karger AG, Basel. PMID: 24513673 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - February 13, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Factors to Make the VIPS Practice Model More Effective in the Treatment of Neuropsychiatric Symptoms in Nursing Home Residents with Dementia.
Conclusion: The unit is the most influential level when implementing person-centred dementia care by use of the VPM. The unit size explains most of the variance of the effect of the VPM, and the effects were best in the small units. © 2014 S. Karger AG, Basel. PMID: 24503517 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - February 8, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

A New Scoring Method of the Mini-Mental Status Examination to Screen for Dementia.
Authors: Choe JY, Han JW, Kim TH, Kim JL, Moon SW, Park JH, Kim SG, Kim BJ, Kwak KP, Ryu SH, Yoon JC, Lee DY, Lee DW, Lee SB, Lee JJ, Jhoo JH, Kim KW Abstract Background: Although the Mini-Mental Status Examination (MMSE) is the most widely used screening instrument for dementia, it has several limitations. Methods: We developed and validated a new scoring method of the MMSE, namely the short form of the MMSE (MMSE-S). Results: The MMSE-S was more robust to demographic influences than the MMSE. The influence of education, in particular, was smaller in the MMSE-S compared to the MMSE (p
Source: Dementia and Geriatric Cognitive Disorders - February 8, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Risk Factors for Behavioral Abnormalities in Mild Cognitive Impairment and Mild Alzheimer's Disease.
Conclusions: Younger age, male gender and greater functional impairment were associated with higher overall presence of behavioral abnormalities in MCI and mild AD. Marital status, lower education and race had an effect on selected behaviors. © 2014 S. Karger AG, Basel. PMID: 24481207 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - February 3, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Speech in Alzheimer's Disease: Can Temporal and Acoustic Parameters Discriminate Dementia?
Discussion: These measures offer a sensitive method of assessing spontaneous speech output in AD, and they discriminate well between people with AD and healthy older adults. This method of evaluation is a promising tool for AD diagnosis and prognosis, and it could be used as a dependent measure in clinical trials. © 2014 S. Karger AG, Basel. PMID: 24481220 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - February 3, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Self-Reported Head Injury and Risk of Late-Life Impairment and AD Pathology in an AD Center Cohort.
Conclusions: Self-reported head injury is associated with earlier onset, increased risk of cognitive impairment and dementia, increased risk of mortality, and AD-type pathological changes. © 2013 S. Karger AG, Basel. PMID: 24401791 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - January 11, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Cerebrospinal Fluid Biomarkers in Clinical Subtypes of Early-Onset Alzheimer's Disease.
Conclusions: The Aβ42 and ATI data confirm the commonality of the Aβ pathology in EOAD. The lower tau indices in PCA patients may reflect differences in the distribution of neurofibrillary tangles or rates of neurodegeneration. © 2013 S. Karger AG, Basel. PMID: 24401901 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - January 11, 2014 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Principal Component Analysis of the Norwegian Version of the Quality of Life in Late-Stage Dementia Scale.
Authors: Mjørud M, Kirkevold M, Røsvik J, Engedal K Abstract Aims: To investigate which factors the Quality of Life in Late-Stage Dementia (QUALID) scale holds when used among people with dementia (pwd) in nursing homes and to find out how the symptom load varies across the different severity levels of dementia. Methods: We included 661 pwd [mean age ± SD, 85.3 ± 8.6 years; 71.4% women]. The QUALID and the Clinical Dementia Rating (CDR) scale were applied. A principal component analysis (PCA) with varimax rotation and Kaiser normalization was applied to test the factor structure. Nonpara...
Source: Dementia and Geriatric Cognitive Disorders - December 22, 2013 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Early Diagnosis of Alzheimer's Disease and Parkinson's Disease Associated with Dementia Using Cerebral Perfusion SPECT.
Conclusion: The observation of a significant decrease in cerebral perfusion in occipital and cerebellar regions in patients with mild PDD is likely useful to differentiate between PDD and AD at the earliest stages. © 2013 S. Karger AG, Basel. PMID: 24356537 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 22, 2013 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Hypovitaminosis D and Executive Dysfunction in Older Adults with Memory Complaint: A Memory Clinic-Based Study.
Conclusion: Vitamin D deficiency was associated with poorer mental flexibility among older community dwellers with memory complaint. © 2013 S. Karger AG, Basel. PMID: 24356580 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - December 22, 2013 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Association Study of Cathepsin D Gene Polymorphism in Iranian Patients with Sporadic Late-Onset Alzheimer's Disease.
Authors: Sayad A, Noruzinia M, Zamani M, Harirchian MH, Kazemnejad A Abstract One of the most prevalent forms of dementia is Alzheimer's disease (AD). Complex inheritance and multifactorial patterns of late-onset AD (LOAD) along with its heterogeneity are due to the presence of different AD-predisposing genes with different influence on disease development among various populations. A key event in the pathogenesis of AD is the deposition of β-amyloid peptide, which is derived from the amyloid precursor protein by β- and γ-secretases. Cathepsin D (CTSD) is an acid protease with β- and γ-se...
Source: Dementia and Geriatric Cognitive Disorders - November 28, 2013 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Phase II Crossover Trial of Varenicline in Mild-to-Moderate Alzheimer's Disease.
Conclusions: Varenicline did not improve cognition, behavior or global change in this population. The most frequent varenicline-associated AEs were gastrointestinal; psychiatric AEs were rare and similar between the groups. © 2013 S. Karger AG, Basel. PMID: 24247022 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - November 20, 2013 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Serum Lycopene, Lutein and Zeaxanthin, and the Risk of Alzheimer's Disease Mortality in Older Adults.
Conclusion: High serum levels of lycopene and lutein+zeaxanthin are associated with a lower risk of AD mortality in adults. Our findings suggest that a high intake of lycopene- or lutein+zeaxanthin-rich food may be important for reducing the AD mortality risk. © 2013 S. Karger AG, Basel. PMID: 24247062 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - November 20, 2013 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Application of the PredictAD Decision Support Tool to a Danish Cohort of Patients with Alzheimer's Disease and Other Dementias.
Authors: Simonsen AH, Mattila J, Hejl AM, Garde E, van Gils M, Thomsen C, Lötjönen J, Soininen H, Waldemar G Abstract Background: The diagnosis of Alzheimer's disease (AD) is based on an ever-increasing body of data and knowledge making it a complex task. The PredictAD tool integrates heterogeneous patient data using an interactive user interface to provide decision support. The aim of this project was to investigate the performance of the tool in distinguishing AD from non-AD dementia using a realistic clinical dataset. Methods: We retrieved clinical data from a group of patients diagnosed with AD (n = 7...
Source: Dementia and Geriatric Cognitive Disorders - November 7, 2013 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Corpus Callosum Atrophy and Cognitive Decline in Early Alzheimer's Disease: Longitudinal MRI Study.
Authors: Zhu M, Wang X, Gao W, Shi C, Ge H, Shen H, Lin Z Abstract Background: We investigated the rate of corpus callosum (CC) atrophy and its association with cognitive decline in early Alzheimer's disease (AD). Methods: We used publicly available longitudinal MRI data corresponding to 2 or more visits from 137 subjects characterized using the Clinical Dementia Rating (CDR) score. We classified these subjects into 3 groups according to the progression of their cognitive status: a healthy control group (CDR 0→0, n = 72), a decliner group (CDR 0→0.5, n = 14) and an AD group (CDR 0.5→0.5/1, n = 51). W...
Source: Dementia and Geriatric Cognitive Disorders - November 7, 2013 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

Validation of the Chinese Version of Addenbrooke's Cognitive Examination-Revised for Screening Mild Alzheimer's Disease and Mild Cognitive Impairment.
Conclusion: The Chinese ACE-R is a reliable assessment tool for cognitive impairment. It is more sensitive and accurate in screening for a-MCI rather than for AD compared to the MMSE. © 2013 S. Karger AG, Basel. PMID: 24193223 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - November 7, 2013 Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research