Japan-Multimodal Intervention Trial for the Prevention of Dementia: A randomized controlled trial
We examined the efficacy of a multidomain intervention in preventing cognitive decline among Japanese older adults with mild cognitive impairment (MCI).METHODS: Participants aged 65-85 years with MCI were randomized into intervention (management of vascular risk factors, exercise, nutritional counseling, and cognitive training) and control groups. The primary outcome was changes in the cognitive composite score over a period of 18 months.RESULTS: Of 531 participants, 406 completed the trial. The between-group difference in composite score changes was 0.047 (95% CI: -0.029 to 0.124). Secondary analyses indicated positive im...
Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Takashi Sakurai Taiki Sugimoto Hiroyasu Akatsu Takehiko Doi Yoshinori Fujiwara Akihiro Hirakawa Fumie Kinoshita Masafumi Kuzuya Sangyoon Lee Nanae Matsumoto Koichiro Matsuo Makoto Michikawa Akinori Nakamura Susumu Ogawa Rei Otsuka Kenji Sato Hiroyuki Shim Source Type: research
Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial
DISCUSSION: AD-GRS and APOE4 may have different impacts on potential intervention effects on amyloid, that is, less accumulation in the higher-risk group (AD-GRS) versus lower-risk group (APOE).HIGHLIGHTS: First study of neuroimaging and AD genetics in a multidomain lifestyle intervention. Possible intervention effect on brain amyloid deposition may rely on genetic risk. AD-GRS and APOE4 allele may have different impacts on amyloid during intervention.PMID:38647197 | DOI:10.1002/alz.13843 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Gazi Saadmaan Maria Carolina Dalmasso Alfredo Ramirez Mikko Hiltunen Nina Kemppainen Jenni Lehtisalo Francesca Mangialasche Tiia Ngandu Juha Rinne Hilkka Soininen Ruth Stephen Miia Kivipelto Alina Solomon Source Type: research
A Toolkit for Delirium Identification and Promoting Partnerships Between Carers and Nurses: A Pilot Pre –Post Feasibility Study
ConclusionThe prevention and management of delirium are imperative for safe and quality care for patients, carers, and staff. Further comprehensive and in-depth research is required to better understand underlying mechanisms of change and explore facets of nursing practice influenced by this innovative approach. (Source: Journal of General Internal Medicine)
Source: Journal of General Internal Medicine - April 22, 2024 Category: Internal Medicine Source Type: research
A Scoping Review of Dementia Interventions in Home-Based Primary Care
Home-based primary care (HBPC) provides interdisciplinary, longitudinal, comprehensive care at home to homebound older adults. The prevalence of dementia among HBPC recipients is approximately 50%. To date, little research has been performed to determine whether dementia-specific interventions have been conducted in HBPC or their efficacy. We performed a scoping review to assess the landscape of dementia interventions in HBPC. (Source: Journal of the American Medical Directors Association)
Source: Journal of the American Medical Directors Association - April 22, 2024 Category: Health Management Authors: Jeffrey D. Weiner, Bruce Leff, Christine S. Ritchie Tags: Review Article Source Type: research
IJERPH, Vol. 21, Pages 513: Peer Support for Caregivers of People Living with Posterior Cortical Atrophy in Melbourne, Australia: A Feasibility Study
ntha M. Loi
Posterior Cortical Atrophy (PCA) is a rare form of young-onset dementia that causes early visuospatial and visuoperceptual deficits. The symptom profile of Posterior Cortical Atrophy leads to very specific care needs for those affected, who often rely on informal caregivers (including friends and family). Rare dementia support groups can be useful for both patients and their caregivers to assist with knowledge sharing, psychoeducation, and the provision of psychosocial support. Despite this, few such support groups exist. The purpose of this study was to examine a PCA support group for caregivers of individ...
Source: International Journal of Environmental Research and Public Health - April 22, 2024 Category: Environmental Health Authors: Alexander Mitchell Wendy Kelso Camille Paynter Leanne Hayes Dennis Velakoulis Samantha M. Loi Tags: Article Source Type: research
Blood Pressure Management and Falls in Nursing Home Residents
In this study, Dave et al harness national Veterans Health Administration (VHA) clinical data to examine the association between initiation of a new antihypertensive agent with the incidence of fall-related fractures in residents at VHA nursing homes, or community living centers. In this carefully designed study, residents who received a new antihypertensive agent had more than 2-fold greater risk of fractures compared with those who did not (adjusted hazard ratio [aHR], 2.42 [95% CI, 1.43-4.08]). This practice was also associated with 1.8-fold greater risk of serious falls (HR, 1.80 [95% CI, 1.52-2.13]) and 1.7-fold great...
Source: JAMA Internal Medicine - April 22, 2024 Category: Internal Medicine Source Type: research
A dynamic computational model of the parallel circuit on the basal ganglia-cortex associated with Parkinson's disease dementia
Biol Cybern. 2024 Apr 21. doi: 10.1007/s00422-024-00988-x. Online ahead of print.ABSTRACTThe cognitive impairment will gradually appear over time in Parkinson's patients, which is closely related to the basal ganglia-cortex network. This network contains two parallel circuits mediated by putamen and caudate nucleus, respectively. Based on the biophysical mean-field model, we construct a dynamic computational model of the parallel circuit in the basal ganglia-cortex network associated with Parkinson's disease dementia. The simulated results show that the decrease of power ratio in the prefrontal cortex is mainly caused by d...
Source: Biological Cybernetics - April 21, 2024 Category: Science Authors: Hao Yang XiaoLi Yang SiLu Yan Source Type: research
A dynamic computational model of the parallel circuit on the basal ganglia-cortex associated with Parkinson's disease dementia
Biol Cybern. 2024 Apr 21. doi: 10.1007/s00422-024-00988-x. Online ahead of print.ABSTRACTThe cognitive impairment will gradually appear over time in Parkinson's patients, which is closely related to the basal ganglia-cortex network. This network contains two parallel circuits mediated by putamen and caudate nucleus, respectively. Based on the biophysical mean-field model, we construct a dynamic computational model of the parallel circuit in the basal ganglia-cortex network associated with Parkinson's disease dementia. The simulated results show that the decrease of power ratio in the prefrontal cortex is mainly caused by d...
Source: Biological Cybernetics - April 21, 2024 Category: Science Authors: Hao Yang XiaoLi Yang SiLu Yan Source Type: research
A dynamic computational model of the parallel circuit on the basal ganglia-cortex associated with Parkinson's disease dementia
Biol Cybern. 2024 Apr 21. doi: 10.1007/s00422-024-00988-x. Online ahead of print.ABSTRACTThe cognitive impairment will gradually appear over time in Parkinson's patients, which is closely related to the basal ganglia-cortex network. This network contains two parallel circuits mediated by putamen and caudate nucleus, respectively. Based on the biophysical mean-field model, we construct a dynamic computational model of the parallel circuit in the basal ganglia-cortex network associated with Parkinson's disease dementia. The simulated results show that the decrease of power ratio in the prefrontal cortex is mainly caused by d...
Source: Biological Cybernetics - April 21, 2024 Category: Science Authors: Hao Yang XiaoLi Yang SiLu Yan Source Type: research
A dynamic computational model of the parallel circuit on the basal ganglia-cortex associated with Parkinson's disease dementia
Biol Cybern. 2024 Apr 21. doi: 10.1007/s00422-024-00988-x. Online ahead of print.ABSTRACTThe cognitive impairment will gradually appear over time in Parkinson's patients, which is closely related to the basal ganglia-cortex network. This network contains two parallel circuits mediated by putamen and caudate nucleus, respectively. Based on the biophysical mean-field model, we construct a dynamic computational model of the parallel circuit in the basal ganglia-cortex network associated with Parkinson's disease dementia. The simulated results show that the decrease of power ratio in the prefrontal cortex is mainly caused by d...
Source: Biological Cybernetics - April 21, 2024 Category: Science Authors: Hao Yang XiaoLi Yang SiLu Yan Source Type: research
A dynamic computational model of the parallel circuit on the basal ganglia-cortex associated with Parkinson's disease dementia
Biol Cybern. 2024 Apr 21. doi: 10.1007/s00422-024-00988-x. Online ahead of print.ABSTRACTThe cognitive impairment will gradually appear over time in Parkinson's patients, which is closely related to the basal ganglia-cortex network. This network contains two parallel circuits mediated by putamen and caudate nucleus, respectively. Based on the biophysical mean-field model, we construct a dynamic computational model of the parallel circuit in the basal ganglia-cortex network associated with Parkinson's disease dementia. The simulated results show that the decrease of power ratio in the prefrontal cortex is mainly caused by d...
Source: Biological Cybernetics - April 21, 2024 Category: Science Authors: Hao Yang XiaoLi Yang SiLu Yan Source Type: research
A dynamic computational model of the parallel circuit on the basal ganglia-cortex associated with Parkinson's disease dementia
Biol Cybern. 2024 Apr 21. doi: 10.1007/s00422-024-00988-x. Online ahead of print.ABSTRACTThe cognitive impairment will gradually appear over time in Parkinson's patients, which is closely related to the basal ganglia-cortex network. This network contains two parallel circuits mediated by putamen and caudate nucleus, respectively. Based on the biophysical mean-field model, we construct a dynamic computational model of the parallel circuit in the basal ganglia-cortex network associated with Parkinson's disease dementia. The simulated results show that the decrease of power ratio in the prefrontal cortex is mainly caused by d...
Source: Biological Cybernetics - April 21, 2024 Category: Science Authors: Hao Yang XiaoLi Yang SiLu Yan Source Type: research
Molecular mechanisms linking type 2 diabetes mellitus and late-onset Alzheimer's disease: A systematic review and qualitative meta-analysis
Neurobiol Dis. 2024 Apr 19:106485. doi: 10.1016/j.nbd.2024.106485. Online ahead of print.ABSTRACTResearch evidence indicating common metabolic mechanisms through which type 2 diabetes mellitus (T2DM) increases risk of late-onset Alzheimer's dementia (LOAD) has accumulated over recent decades. The aim of this systematic review is to provide a comprehensive review of common mechanisms, which have hitherto been discussed in separate perspectives, and to assemble and evaluate candidate loci and epigenetic modifications contributing to polygenic risk linkages between T2DM and LOAD. For the systematic review on pathophysiologica...
Source: Neurobiology of Disease - April 21, 2024 Category: Neurology Authors: Erwin Lemche Richard Killick Jackie Mitchell Paul W Caton Pratik Choudhary Jane K Howard Source Type: research
Age-specific prevalence of the different clinical presentations of AD and FTD in young-onset dementia
ConclusionsAmnestic AD is the clinical presentation that increases the most with advancing age, followed by bvFTD, suggesting that there is a differential vulnerability to the effect of ageing within the same neurodegenerative disease. (Source: Journal of Neurology)
Source: Journal of Neurology - April 21, 2024 Category: Neurology Source Type: research
Beyond the stethoscope: Reflections from a dementia unit
Australas J Ageing. 2024 Apr 19. doi: 10.1111/ajag.13319. Online ahead of print.NO ABSTRACTPMID:38641891 | DOI:10.1111/ajag.13319 (Source: Australasian Journal on Ageing)
Source: Australasian Journal on Ageing - April 20, 2024 Category: Geriatrics Authors: Eleanor Tkh Dunn Source Type: research
