Prodromal and Overt Parkinson ’s Disease Epidemiological Study in Brazil (PROBE-PD study): Preliminary Results
Background: Research on the prevalence of Parkinson's Disease (PD) has predominantly focused on high-income countries, while this data is poorly described in middle- and lower-income countries. The Prodromal and overt Parkinson's Disease Epidemiological Study in Brazil (PROBE-PD) aims to estimate the prevalence of PD and other parkinsonisms (drug-induced, vascular, multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, dementia with Lewy bodies) in Brazil. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: L.R.R. Pedrosa, J.S. Duarte, G. Pereira, I. Oliveira, S. Titze-de-Almeida, A. Schuh, C. Reider, G. Valen ça, L.V. Krejcová, B.L. Santos-Lobato Source Type: research
Frontotemporal dementia associated with SQSTM1 gene mutation and lower amyloid beta 1-42
Background: Frontotemporal dementia (FTD) is a highly heritable group of neurodegenerative disorders, with a heterogeneous clinical and genetic profile. Ever since the first identified genetic mutation to cause FTD in 1998, more than a dozen genes have been linked. There is a strong genetic influence on the clinicopathological phenotypes, but to which extent it remains elusive. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: A. Angelova, G. Novotni, D. Plaseska Karanfilska, F. Trpcheski, I. Jacheva, G. Hristovska, G. Gashpar, V. Nikoloska Source Type: research
Plasma neurofilament light chain level in isolated REM sleep behavior disorders, Parkinson ’s disease and multiple system atrophy
Background: Rapid-Eye-Movement (REM) sleep behavior disorder (RBD) has emerged as a specific prodromal sign of α-synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Individuals with isolated RBD represent an ideal population for the identification of biomarkers capable of monitoring the neurodegenerative process. The neurofilament light chain protein (NfL), a neuron-specific component of the axons, is a promising biomarker in various neurodegenerative diseases. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: A. Calculli, D. Di Martino, G. Ongari, S. Gagliardi, P. Grillo, E. Capriglia, C. Fazio, D. Comolli, M. Terzaghi, A. Pisani Source Type: research
Intranasal delivery of insulin for the restoration of memory signaling in Alzheimer's disease
Background: Alzheimer's disease(AD), form of dementia, is progressive, degenerative brain disease characterized by marked atrophy of cerebral cortex and loss of cortical and sub-cortical neurons. Weakening of insulin receptor signaling is involved in ageing-related brain degeneration such as AD. Objective of this study is to develop delivery-system to overcome BBB by employing novel, non-invasive approach via nasal route. Olfactory neural pathway provides both intraneuronal and extraneuronal pathway into brain. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: T. Nema, S. Bhargava Source Type: research
Psychomotor delay: Expanding the neurological phenotype of ATP13A2-related disorders
Background: Biallelic variants in ATP13A2 were first described as causing the Kufor-Rakeb syndrome (PARK9), a rare disease in children of consanguineous parents, characterized by juvenile-onset Parkinsonism with dementia, pallidopyramidal degeneration and supranuclear ophthalmoplegia. The phenotype expanded since then, to include early-onset hereditary spastic paraparesis, dystonia, ataxia, and peripheral neuropathy. We now describe a presentation with psychomotor delay. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: L. Silva, A. Sardoeira, E. Brand ão, M. Rocha, S. Pina, S. Cavaco, R. Felgueiras, I. Alonso, J. Barros, J. Sequeiros, H. Costa, J. Leal Loureiro, J. Damásio Source Type: research
The role of neurotrophic factors in development Parkinson's disease dementia
Background: The purpose of our study is to evaluate NGF in the development of cognitive impairment and dementia in patients with PDD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: D. Okhunova, G. Rakhimbaeva Source Type: research
The impact of short-term blood pressure variability on dementia in Parkinson ’s disease in relation to the renin-angiotensin system
Background: Cardiovascular dysautonomy and dementia are common non-motor features of Parkinson ’s disease (PD). Apart from orthostatic hypotension, supine hypertension (SH) and abnormal nocturnal blood pressure profile, also short-term blood pressure variability (BPV) may play a role in the pathogenesis of dementia. Role of the renin-angiotensin system (RAS) in this process remains unclear. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: M. Kwasniak-Butowska, J. Slawek, A. Konkel, A. Skrzypkowska, D. Wieczorek, M. Bialecka, E. Szurowska, M. Tomczyk, R. Smolenski Source Type: research
Caudate dopamine loss, occipital hypoperfusion, and dementia conversion in Parkinson ’s disease: A dual-phase 18F-FP-CIT PET Study
This study aimed to investigate the association between dopamine depletion in the caudate, occipital hypoperfusion, and longitudinal cognitive decline in patients with Parkinson's disease (PD). (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: S.J. Chung, S.H. Kim, J.S. Jung, S.R. Lee, C.W. Park, S.H. Jeong, Y. Jeong, Y.J. KIM Source Type: research
Olfactory and Gustatory Function is Associated with Global Cognition in Early-stage Parkinson's Disease
Background: Hyposmia is a prevalent non-motor symptom of Parkinson ’s disease (PD). Recent studies have recognized hypogeusia as an additional non-motor symptom in PD. Although there have been reports linking hyposmia to the development of dementia in PD, the association between cognitive function in the early stage of PD and olfactory and gustatory function rema ins largely unexplored. To shed light on this subject, the present study aimed to evaluate the olfactory and gustatory function in early-stage of PD patients without dementia. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: Y.E. Kim, H.-i. Ma Source Type: research
Psychometric Validation of the Mild Behavioral Impairment Checklist (MBI-C) in Parkinson ’s Disease
Background: Mild Behavioral Impairment (MBI) is a syndrome characterized by the later-life onset of neuropsychiatric symptoms and serves as a potential marker for the risk of dementia. In Parkinson's disease (PD), the presence of MBI has been associated with worse cognitive function and increased cortical atrophy. The Mild Behavioral Impairment Checklist (MBI-C) has been developed to explicitly measure MBI, however, its psychometric properties have never been tested in PD. The purpose of this study is to validate the construct measured by the MBI-C in a multi-centre Canadian PD sample. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: G.D. Pinilla-Monsalve, Y. Song, Z. Ismail, O. Monchi Source Type: research
Unveiling Cholinergic Brain changes associated with Visuo-Constructive Deficits in Parkinson's Disease: A Focus on the Hooper Test
This study aims to explore the cholinergic neural correlates, using the presynaptic vesicular acetylcholine transporter (V AChT) tracer [18F]Fluoroethoxybenzovesamicol ([18F]FEOBV), of visuo-spatial and visuoconstructive deficits as evaluated by the Hooper test. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: M. van Emde Boas, G. Carli, P. Kanel, T. Brown, S. Roytman, R. Albin, P. Scott, N. Bohnen Source Type: research
Are peripheral α-synuclein isoforms biomarkers for diagnosis and prognosis of isolated REM sleep behavior disorder?
Background: Isolated REM sleep behavior disorder (IRBD), a parasomnia characterized by nightmares and vigorous behaviors during REM sleep, is an early manifestation of synucleinopathies including Multiple System Atrophy, Parkinso ńs disease (PD) and dementia with Lewy bodies (DLB). PD and DLB are Lewy body diseases characterized by Lewy body pathology developing through the abnormal oligomerization and aggregation of α-synuclein in vulnerable brain areas. Increased α-synuclein gene (SNCA) expression in the brain is crucia l during the development these diseases. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: L. Arnaldo, D. Vilas, L. Ispierto, R. Alvarez, P. Pastor, A. Iranzo, K. Beyer Source Type: research
Normative modelling reveals distinct neural correlates of olfactory and cognitive impairments in patients with Parkinson's disease: A retrospective observational study
Background: Hyposmia is predictive of dementia but typically unaware in patients with Parkinson ’s disease (PD). The olfactory and cognitive impairments can be independent processes, possibly due to varied neuropathological changes and confounded by the presence of olfactory anosognosia (OA). (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: R. Ye, F. Xing, J. Feng, J. Liu, J. Sun, T. Liu, R. Ma, K. Wang, P. Hu Source Type: research
Parkinson ’s Disease with Hyposmia and Dysautonomia: Does It Represent a Distinct Subtype?
Background: Olfactory dysfunction or dysautonomia is one of PD's earliest prodromal non-motor symptoms. We aimed to investigate whether PD patients with dysautonomia and hyposmia at the de novo stage present different prognoses regarding PD dementia (PDD) conversion, motor complication development, and change in levodopa-equivalent doses (LED). (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: S.H. Yoon, D.H. You, H. Na, S. Kang, K. Baik, M. Park, C.H. Lyoo, Y.H. Sohn, P.H. Lee Source Type: research
Exploring the Role of Genetic Mutations and Clinical Features in the Conversion to α-Synucleinopathies
This study aims to evaluate the influence of genetic mutations and clinical symptoms on the risk of conversion to α-synucleinopathies. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: J. Qin, M. Zhang Source Type: research
