Thalamic Alterations in Motor Neuron Diseases: A Systematic Review of MRI Findings
CONCLUSIONS: Thalamic alterations provide valuable insights into the pathophysiology and progression of MNDs. Multimodal MRI techniques are potent tools for detecting dynamic thalamic changes, indicating structural integrity, connectivity disruption, and metabolic activity.PMID:38682227 | DOI:10.31083/j.jin2304077 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Sana Mohammadi Sadegh Ghaderi Mahdi Mohammadi Zahra Najafi Asli Pashaki Rahim Khatyal Fatemeh Mohammadian Sahar Mohammadjani Source Type: research
Data-driven decomposition and staging of flortaucipir uptake in Alzheimer's disease
DISCUSSION: Data-driven decomposition of flortaucipir uptake provides a novel framework for tau staging which complements existing systems.HIGHLIGHTS: NMF reveals patterns of tau deposition in AD. Data-driven staging of flortaucipir tracks AD severity. Learned flortaucipir patterns overlap with AD-related gene expression.PMID:38683905 | DOI:10.1002/alz.13769 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 29, 2024 Category: Psychiatry Authors: Tom Earnest Abdalla Bani Sung Min Ha Diana A Hobbs Deydeep Kothapalli Braden Yang John J Lee Tammie L S Benzinger Brian A Gordon Aristeidis Sotiras Alzheimer's Disease Neuroimaging Initiative Source Type: research
Symptom burden, service use and care dissatisfaction among older adults with cancer, cardiovascular disease, respiratory disease, dementia and neurological disease during the last 3 months before death: A pooled analysis of mortality follow-back surveys
CONCLUSIONS: We showed different trajectories towards death depending on cause. Improving symptom burden and satisfaction in patients at the end-of-life is challenging, and the presence of a reliable key health professional may be helpful.PMID:38679837 | DOI:10.1177/02692163241246049 (Source: Palliative Medicine)
Source: Palliative Medicine - April 29, 2024 Category: Palliative Care Authors: Mitsunori Miyashita Catherine J Evans Deokee Yi Barbara Gomes Wei Gao Source Type: research
The effectiveness of structured physical activity on agitation in people with dementia: a rapid review
CONCLUSION: Physical activity can be effective in reducing agitation in older adults with dementia. Further research is needed to clarify the type of intervention that is most beneficial. Strategies to make physical activity more acceptable and available to people with dementia need to be established.PMID:38683159 | DOI:10.1080/13607863.2024.2345129 (Source: Aging and Mental Health)
Source: Aging and Mental Health - April 29, 2024 Category: Geriatrics Authors: A McCartney J Crosswell S B Rafnsson J Hoe Source Type: research
Evaluation of a Digital Dementia Registry's IT Architecture After a Three-Year Period in Practice: digiDEM Bayern
CONCLUSION: Integrating the used systems is therefore recommended for registry studies in other medical areas.PMID:38682503 | DOI:10.3233/SHTI240010 (Source: Studies in Health Technology and Informatics)
Source: Studies in Health Technology and Informatics - April 29, 2024 Category: Information Technology Authors: Michael Zeiler Nikolas Dietzel Peter L Kolominsky-Rabas Elmar Graessel Hans-Ulrich Prokosch Source Type: research
Enhancing Dementia Risk Mitigation: Standardized Digital Monitoring in Clinical Trials and Platform Design for At-Risk Elderly Individuals
CONCLUSION: The interoperability framework was designed in a scalable way and will be regularly updated for future needs.PMID:38682497 | DOI:10.3233/SHTI240004 (Source: Studies in Health Technology and Informatics)
Source: Studies in Health Technology and Informatics - April 29, 2024 Category: Information Technology Authors: Hannes Hilberger Bianca Buchgraber-Schnalzer Simone Huber Theresa Weitlaner Helena Untersteiner Carina Seerainer Sten Hanke Source Type: research
Pharmacotherapeutic Potential of Bitter Gourd ( < em > Momordica charantia < /em > ) in Age-related Neurological Diseases
J Integr Neurosci. 2024 Apr 23;23(4):86. doi: 10.31083/j.jin2304086.ABSTRACTDue to the growth of the elderly population, age-related neurological disorders are an increasing problem. Aging begins very gradually and later leads to several neurological issues such as lower neurotransmitter levels, oxidative stress, neuronal inflammation, and continual neuronal loss. These changes might contribute to brain disorders such as Alzheimer's disease (AD), dementia or mild cognitive impairment, and epilepsy and glioma, and can also aggravate these disorders if they were previously present. Momordica charantia (bitter gourd), a membe...
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Seyed Mohammad Hosein Hosseini Adarmanabadi Orod Jalali Khalil Abadi Amirhossein Amiri Rozhina Tamannaeifar Sahar Balanian Mehdi Rasekhjam Mohammad Sadra Samiazar Sara Hasanpour Samira Peiravi Dorsa Alijanzadeh Mohadeseh Poudineh Hamidreza Amiri Seyed Ami Source Type: research
Microvascular Perfusion Imaging in Alzheimer's Disease
J Integr Neurosci. 2024 Apr 1;23(4):70. doi: 10.31083/j.jin2304070.ABSTRACTAlzheimer's disease (AD) is the leading cause of dementia worldwide and significantly impacts the essential functions of daily life and social activities. Research on AD has found that its pathogenesis is related to the extracellular accumulation of amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles in the cortical and limbic areas of the human brain, as well as cerebrovascular factors. The detection of Aβ or tau can be performed using various probes and methodologies. However, these modalities are expensive to implement and often...
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Yi Song Hang Xing Zhiqi Zhang Source Type: research
Thalamic Alterations in Motor Neuron Diseases: A Systematic Review of MRI Findings
CONCLUSIONS: Thalamic alterations provide valuable insights into the pathophysiology and progression of MNDs. Multimodal MRI techniques are potent tools for detecting dynamic thalamic changes, indicating structural integrity, connectivity disruption, and metabolic activity.PMID:38682227 | DOI:10.31083/j.jin2304077 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Sana Mohammadi Sadegh Ghaderi Mahdi Mohammadi Zahra Najafi Asli Pashaki Rahim Khatyal Fatemeh Mohammadian Sahar Mohammadjani Source Type: research
Insights into designing educational materials for persons living with dementia: a focus group study
Persons living with dementia (PLWD) may experience communication difficulties that impact their ability to process written and pictorial information. Patient-facing education may help promote discontinuation o... (Source: BMC Geriatrics)
Source: BMC Geriatrics - April 29, 2024 Category: Geriatrics Authors: Charity M. Hoffman, Sarah E. Vordenberg, Amanda N. Leggett, Esther Akinyemi, Molly Turnwald and Donovan T. Maust Tags: Research Source Type: research
Use of headphones for the delivery of music programs for people with dementia in long-term care homes: a scoping review protocol
Introduction
Dementia affects the quality of life. Excessive noise in care environments can exacerbate stress and related symptoms. Headphone-based music interventions may help improve the quality of life for people with dementia in long-term care homes. This review aims to explore and synthesise research on headphone-based music interventions for people with dementia in long-term care homes, focusing on enablers and barriers to implementing headphone-based music interventions.
Methods and analysis
Joanna Briggs Institute guidance for scoping review and Preferred Reporting Items for Scoping Reviews and Meta-analyses exten...
Source: BMJ Open - April 29, 2024 Category: General Medicine Authors: Hung, L., Wong, K. L. Y., Huang, K., Cheung, D. S. K., Yeo, M. S., Kim, S. J. Tags: Open access, Geriatric medicine Source Type: research
Interest of a hospital-based geriatric living lab among inpatients with neurocognitive disorders: the ALLEGRIA cross-sectional study
CONCLUSION: Living lab experimentations appear feasible with older adults, even with those with MNCD. Task support can be offered to those with severe MNCD.PMID:38679008 | DOI:10.1159/000538144 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 28, 2024 Category: Psychiatry Authors: Fr édéric Noublanche Gr égory Ben-Sadoun Lena Carcreff Jennifer Gautier Philippe Allain C édric Annweiler Source Type: research
Systemic inflammation in A β < sub > 1-40 < /sub > -induced Alzheimer's disease model: New translational opportunities
This study was aimed to explore systemic inflammatory manifestations in rats with Aβ1-40-induced AD. The impairment of spatial memory and cognitive flexibility in Aβ1-40-lesioned rats was accompanied by pronounced systemic inflammation, which was confirmed by commonly accepted biomarkers: increased hematological indices of systemic inflammation (NLR, dNLR, LMR, PLR and SII), signs of anemia of inflammation or chronic diseases, and pro-inflammatory polarized activation of circulating phagocytes. In addition, markers of systemic inflammation strongly correlated with disorders of remote cognitive flexibility in Aβ1-40-lesi...
Source: Brain Research - April 28, 2024 Category: Neurology Authors: Anastasiia Nefodova Mariia Rudyk Roman Dovhyi Taisa Dovbynchuk Nataliia Dzubenko Ganna Tolstanova Larysa Skivka Source Type: research
Identification of mRNA expression profiles and their characterization in age-related hearing loss
In this study, we analyzed an mRNA expression dataset (GSE49543) from the GEO database. Differentially expressed genes (DEGs) between young control mice and presbycusis mice were analyzed using limma in R and weighted gene co-expression network analysis (WGCNA) methods. Functional enrichment analyses of the DEGs were conducted with the clusterProfiler R package and the results were visualized using ggplot2 R package. The STRING database was used for the construction of the protein-protein interaction (PPI) network of the screened DEGs. Two machine learning algorithms LASSO and SVM-RFE were used to screen the hub genes. We ...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Kanglun Jiang Tan Wang Xinsheng Huang Li Gao Source Type: research
Interest of a hospital-based geriatric living lab among inpatients with neurocognitive disorders: the ALLEGRIA cross-sectional study
CONCLUSION: Living lab experimentations appear feasible with older adults, even with those with MNCD. Task support can be offered to those with severe MNCD.PMID:38679008 | DOI:10.1159/000538144 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 28, 2024 Category: Psychiatry Authors: Fr édéric Noublanche Gr égory Ben-Sadoun Lena Carcreff Jennifer Gautier Philippe Allain C édric Annweiler Source Type: research
