Delusions of love and passion in the behavioral variant of frontotemporal dementia
We present the unique case of a 59-year-old woman with a strong family history of early-onset dementia in whom erotomania was the initial manifestation that led to a diagnosis of definite Behavioral Variant of Frontotemporal Dementia with a pathogenic missense mutation in the MAPT gene. Based on this case, we propose a hypothetical model for developing erotomania in patients with FTD.PMID:38678305 | DOI:10.1080/13554794.2024.2345110 (Source: Neurocase)
Source: Neurocase - April 27, 2024 Category: Neurology Authors: Miguel Restrepo-Mart ínez Jesus Ramirez-Bermudez Isis So Kristy Coleman Elizabeth Finger Source Type: research
CK1 δ/ε kinases regulate TDP-43 phosphorylation and are therapeutic targets for ALS-related TDP-43 hyperphosphorylation
Neurobiol Dis. 2024 Apr 25;196:106516. doi: 10.1016/j.nbd.2024.106516. Online ahead of print.ABSTRACTHyperphosphorylated TAR DNA-binding protein 43 (TDP-43) aggregates in the cytoplasm of neurons is the neuropathological hallmark of amyotrophic lateral sclerosis (ALS) and a group of neurodegenerative diseases collectively referred to as TDP-43 proteinopathies that includes frontotemporal dementia, Alzheimer's disease, and limbic onset age-related TDP-43 encephalopathy. The mechanism of TDP-43 phosphorylation is poorly understood. Previously we reported casein kinase 1 epsilon gene (CSNK1E gene encoding CK1ε protein) as be...
Source: Neurobiology of Disease - April 27, 2024 Category: Neurology Authors: Vivian I Ko Kailee Ong Don W Cleveland Haiyang Yu John M Ravits Source Type: research
Relationship between Depressive Symptoms, Caregiver Strain, and Social Support with Dementia Grief in Family Caregivers
Conclusions: In family caregivers, depressive symptoms, caregiver strain, and social support are related to the intensity of dementia grief, with a greater influence of depressive symptoms. Moreover, being female, having a low level of education, and caring for a care recipient at an advanced stage of dementia are factors associated with increased dementia grief. Concerning study limitations, the sample was restricted, belonging to a specific region of Spain and to a Provincial Federation of associations. It is necessary to exercise caution in generalizing results due to the sociodemographic and geographical characteristic...
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Miriam S ánchez-Alcón Almudena Garrido-Fern ández Jos é María Cano-Rojas Jos é Luis Sánchez-Ramos Juan Diego Ramos-Pichardo Source Type: research
Lifestyle and incident dementia: A COSMIC individual participant data meta ‐analysis
DISCUSSION: Modifiable risk and protective factors appear relevant for dementia risk reduction across diverse geographical and sociodemographic groups.HIGHLIGHTS: A two-step individual participant data meta-analysis was conducted. This was done at a global scale using data from 21 ethno-regionally diverse cohorts. The association between a modifiable dementia risk score and dementia was examined. The association was modified by geographical region and age at baseline. Yet, modifiable dementia risk and protective factors appear relevant in all investigated groups and regions.PMID:38676366 | DOI:10.1002/alz.13846 (Source: Th...
Source: The Journal of Alzheimers Association - April 27, 2024 Category: Psychiatry Authors: Stephanie Van Asbroeck Sebastian K öhler Martin P J van Boxtel Darren M Lipnicki John D Crawford Erico Castro-Costa Maria Fernanda Lima-Costa Sergio Luis Blay Xiao Shifu Tao Wang Ling Yue Richard B Lipton Mindy J Katz Carol A Derby Ma ëlenn Guerchet Pie Source Type: research
Failure of the glymphatic system as possible link between lumbar spinal stenosis and dementia
Alzheimers Dement. 2024 Apr 27. doi: 10.1002/alz.13812. Online ahead of print.NO ABSTRACTPMID:38676574 | DOI:10.1002/alz.13812 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 27, 2024 Category: Psychiatry Authors: Pasquale Gallina Francesco Lolli Berardino Porfirio Source Type: research
Metabolomics profiling reveals distinct, sex-specific signatures in serum and brain metabolomes in mouse models of Alzheimer's disease
DISCUSSION: Several of our findings were consistent with results in humans, showing glycerophospholipids reduction in serum of apolipoprotein E (apoE) ε4 carriers and replicating the serum metabolic imprint of the APOE ε4 genotype. Our work thus represents a significant step toward translating metabolic dysregulation from model organisms to human AD.HIGHLIGHTS: This was a metabolomic assessment of two mouse models relevant to Alzheimer's disease. Mouse models exhibit broad sex-specific metabolic differences, similar to human study cohorts. The early-onset 5XFAD mouse model primarily alters brain metabolites while the lat...
Source: The Journal of Alzheimers Association - April 27, 2024 Category: Psychiatry Authors: Ravi S Pandey Mattias Arnold Richa Batra Jan Krumsiek Kevin P Kotredes Dylan Garceau Harriet Williams Michael Sasner Gareth R Howell Rima Kaddurah-Daouk Gregory W Carter Source Type: research
Elevated blood homocysteine increases the risk of incident Motoric Cognitive Risk syndrome: A two cohort study
CONCLUSIONS: Higher blood homocysteine levels are associated with increased risk of developing MCR in older adults, particularly in men with vascular disease or vascular risk factors.PMID:38671552 | DOI:10.1093/gerona/glae114 (Source: Molecular Medicine)
Source: Molecular Medicine - April 27, 2024 Category: Molecular Biology Authors: Kelly Cotton Emmeline Ayers Ying Jin Olivier Beauchet Carol A Derby Richard B Lipton Mindy Katz Kevin Galery Pierrette Gaudreau Joe Verghese Source Type: research
Relationship between Depressive Symptoms, Caregiver Strain, and Social Support with Dementia Grief in Family Caregivers
Conclusions: In family caregivers, depressive symptoms, caregiver strain, and social support are related to the intensity of dementia grief, with a greater influence of depressive symptoms. Moreover, being female, having a low level of education, and caring for a care recipient at an advanced stage of dementia are factors associated with increased dementia grief. Concerning study limitations, the sample was restricted, belonging to a specific region of Spain and to a Provincial Federation of associations. It is necessary to exercise caution in generalizing results due to the sociodemographic and geographical characteristic...
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Miriam S ánchez-Alcón Almudena Garrido-Fern ández Jos é María Cano-Rojas Jos é Luis Sánchez-Ramos Juan Diego Ramos-Pichardo Source Type: research
CK1 δ/ε kinases regulate TDP-43 phosphorylation and are therapeutic targets for ALS-related TDP-43 hyperphosphorylation
Neurobiol Dis. 2024 Apr 25:106516. doi: 10.1016/j.nbd.2024.106516. Online ahead of print.ABSTRACTHyperphosphorylated TAR DNA-binding protein 43 (TDP-43) aggregates in the cytoplasm of neurons is the neuropathological hallmark of amyotrophic lateral sclerosis (ALS) and a group of neurodegenerative diseases collectively referred to as TDP-43 proteinopathies that includes frontotemporal dementia, Alzheimer's disease, and limbic onset age-related TDP-43 encephalopathy. The mechanism of TDP-43 phosphorylation is poorly understood. Previously we reported casein kinase 1 epsilon gene (CSNK1E gene encoding CK1ε protein) as being ...
Source: Neurobiology of Disease - April 27, 2024 Category: Neurology Authors: Vivian I Ko Kailee Ong Don W Cleveland Haiyang Yu John M Ravits Source Type: research
Delusions of love and passion in the behavioral variant of frontotemporal dementia
We present the unique case of a 59-year-old woman with a strong family history of early-onset dementia in whom erotomania was the initial manifestation that led to a diagnosis of definite Behavioral Variant of Frontotemporal Dementia with a pathogenic missense mutation in the MAPT gene. Based on this case, we propose a hypothetical model for developing erotomania in patients with FTD.PMID:38678305 | DOI:10.1080/13554794.2024.2345110 (Source: Neurocase)
Source: Neurocase - April 27, 2024 Category: Neurology Authors: Miguel Restrepo-Mart ínez Jesus Ramirez-Bermudez Isis So Kristy Coleman Elizabeth Finger Source Type: research
Exploring the Link between Anticoagulation, Cognitive Impairment and Dementia in Atrial Fibrillation: A Systematic Review
Conclusions: The use of oral anticoagulants has the potential to prevent cognitive impairment and dementia in patients with AF. Since most of the published research on this subject is observational in nature, more randomized controlled trials are needed to fully understand the effect of anticoagulants on cognitive function.PMID:38673694 | DOI:10.3390/jcm13082418 (Source: Cancer Control)
Source: Cancer Control - April 27, 2024 Category: Cancer & Oncology Authors: Abhimanyu Agarwal Mohamed A Mostafa Muhammad Imtiaz Ahmad Elsayed Z Soliman Source Type: research
Lifestyle and incident dementia: A COSMIC individual participant data meta ‐analysis
DISCUSSION: Modifiable risk and protective factors appear relevant for dementia risk reduction across diverse geographical and sociodemographic groups.HIGHLIGHTS: A two-step individual participant data meta-analysis was conducted. This was done at a global scale using data from 21 ethno-regionally diverse cohorts. The association between a modifiable dementia risk score and dementia was examined. The association was modified by geographical region and age at baseline. Yet, modifiable dementia risk and protective factors appear relevant in all investigated groups and regions.PMID:38676366 | DOI:10.1002/alz.13846 (Source: Th...
Source: The Journal of Alzheimers Association - April 27, 2024 Category: Psychiatry Authors: Stephanie Van Asbroeck Sebastian K öhler Martin P J van Boxtel Darren M Lipnicki John D Crawford Erico Castro-Costa Maria Fernanda Lima-Costa Sergio Luis Blay Xiao Shifu Tao Wang Ling Yue Richard B Lipton Mindy J Katz Carol A Derby Ma ëlenn Guerchet Pie Source Type: research
Elevated blood homocysteine increases the risk of incident Motoric Cognitive Risk syndrome: A two cohort study
CONCLUSIONS: Higher blood homocysteine levels are associated with increased risk of developing MCR in older adults, particularly in men with vascular disease or vascular risk factors.PMID:38671552 | DOI:10.1093/gerona/glae114 (Source: Molecular Medicine)
Source: Molecular Medicine - April 27, 2024 Category: Molecular Biology Authors: Kelly Cotton Emmeline Ayers Ying Jin Olivier Beauchet Carol A Derby Richard B Lipton Mindy Katz Kevin Galery Pierrette Gaudreau Joe Verghese Source Type: research
A useful map with some blind spots still: neurofilament light protein differentiating behavioural variant frontotemporal dementia from psychiatric disorders
Many of us work in a setting where differentiation between psychiatric disorders and neurological conditions is an everyday conundrum. Frontotemporal dementia, and particularly its behavioral variant (bvFTD) is one of the conditions contributing to this problem since its characteristic symptoms overlap with those of common psychiatric disorders. Not only does this lead to challenges for diagnosis by the medical team, but more importantly causes delay in diagnosis and access to appropriate care. Imaging biomarkers (i.e. (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - April 27, 2024 Category: Geriatrics Authors: Dhamidhu Eratne, Alexander F Santillo Tags: Editorial Source Type: research
Mechanical ventilation in older adults with dementia: opportunities to promote goal-concordant care
: Recent studies show increasing use of mechanical ventilation among people living with dementia. There are concerns that this trend may not be driven by patient preferences. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 27, 2024 Category: Palliative Care Authors: Lauren R. Pollack, Jamie T. Nomitch, Lois Downey, Sudiptho R. Paul, May J. Reed, Alison M. Uyeda, Whitney A. Kiker, Danae G. Dotolo, Elizabeth Dzeng, Robert Y. Lee, Ruth A. Engelberg, Erin K. Kross Tags: Original Article Source Type: research
