Strengths and weaknesses of the vascular apathy hypothesis: a narrative review
As a clinical syndrome, apathy is characterized by diminished motivation, leading to a reduction in emotions, thoughts and initiative to perform activities 1 . Cerebral small vessel disease (CSVD), an atherosclerotic disease of the brain causing ischemic changes in the surrounding brain tissue, is suspected to be a cause of this frequent and disabling syndrome 2 3. Neuroimaging markers of CSVD include white matter hyperintensities (WMH), cerebral microbleeds, lacunar infarcts and visible perivascular spaces. (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - September 30, 2022 Category: Geriatrics Authors: Lonneke Wouts, Radboud M. Marijnissen, Richard C. Oude Voshaar, Aartjan T.F. Beekman Tags: Clinical Review Article Source Type: research

Inflammatory Markers of Geriatric Depression Response to Tai Chi or Health Education Adjunct Interventions
CONCLUSION: Changes in certain cytokines/chemokines may accompany improvement in depressive symptoms in older adults. Future studies will need to explore the role of these molecules in remission of late-life depression.PMID:36175271 | DOI:10.1016/j.jagp.2022.08.004 (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - September 29, 2022 Category: Psychiatry Authors: Prabha Siddarth Matthew Abikenari Adrienne Grzenda Monica Cappelletti Hanadi Oughli Claire Liu Michaela M Millillo Helen Lavretsky Source Type: research

“My work is done. Why wait?” Lessons learned from older adults who died by suicide
On March 14, 1932 George Eastman, founder of Kodak, industrialist, entrepreneur, and fabulously wealthy philanthropist wrote these words: “To my friends – my work is done, why wait?” He then pulled a handgun from his bedside table and shot himself to death. Eastman's words convey the gritty self-determination that marked his life. However, they mask other truths that made Eastman at such high risk for suicide – chronic and pro gressive illness, pain, inability to care for himself, social isolation, loss of identity and purpose, hopelessness, and demoralization. (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - September 29, 2022 Category: Geriatrics Authors: Yeates Conwell Tags: COMMENTARY Source Type: research

Corrigendum to ‘Slowed Processing Speed Disrupts Patient Expectancy in Late Life Depression’ [The American Journal of Geriatric Psychiatry 29 (2021) 619-630]
The authors regret an omission from the published study methodology. As described in the published manuscript, current treatment with antidepressant medication was an exclusion criterion for the clinical trial whose data were analyzed. We wish to clarify that while current treatment with antidepressant medication was an exclusion criterion, otherwise eligible individuals who were taking ineffective antidepressant medication were allowed to sign consent and participate in the study so long as they completed a study-supervised taper and discontinuation of the medication prior to beginning the study medication. (Source: The A...
Source: The American Journal of Geriatric Psychiatry - September 28, 2022 Category: Geriatrics Authors: Bret R Rutherford, C. Jean Choi, Jongwoo Choi, Ben Maas, Xiaofu He, Kaleigh O'Boyle, Joel Sneed, Patrick J. Brown, Adam Brickman, Melanie M. Wall, Steven P. Roose Source Type: research

Telehealth Support for Dementia Caregivers During the COVID-19 Pandemic: Lessons Learned From the NYU Family Support Program
CONCLUSIONS: While video telehealth is frequently cited as beneficial for those in rural communities, socioeconomically disadvantaged groups, or homebound individuals, our findings suggest that video telehealth is also advantageous for dementia caregivers, given their unique barriers, including lack of time due to caregiving responsibilities, lack of respite care for the person with dementia, and the additional burdens of travel time to access in-person services.PMID:36167652 | PMC:PMC9424119 | DOI:10.1016/j.jagp.2022.08.005 (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - September 27, 2022 Category: Psychiatry Authors: Maureen K O'Connor Roscoe Nicholson Cynthia Epstein Tiffany Donley Rebecca Salant Andrew H Nguyen Steven Shirk Elizabeth Stevenson Mary S Mittelman Source Type: research

Telehealth Support for Dementia Caregivers During the COVID-19 Pandemic: Lessons Learned From the NYU Family Support Program
CONCLUSIONS: While video telehealth is frequently cited as beneficial for those in rural communities, socioeconomically disadvantaged groups, or homebound individuals, our findings suggest that video telehealth is also advantageous for dementia caregivers, given their unique barriers, including lack of time due to caregiving responsibilities, lack of respite care for the person with dementia, and the additional burdens of travel time to access in-person services.PMID:36167652 | DOI:10.1016/j.jagp.2022.08.005 (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - September 27, 2022 Category: Psychiatry Authors: Maureen K O'Connor Roscoe Nicholson Cynthia Epstein Tiffany Donley Rebecca Salant Andrew H Nguyen Steven Shirk Elizabeth Stevenson Mary S Mittelman Source Type: research

Corrigendum to ‘Association of White Matter Integrity with Executive Function and Antidepressant Treatment Outcome in Patients with Late-Life Depression’ [The American Journal of Geriatric Psychiatry 29 (2021) 1188-1198]
The authors regret an omission from the published study methodology. As described in the published manuscript, current treatment with antidepressant medication was an exclusion criterion for the clinical trial whose data were analyzed. We wish to clarify that while current treatment with antidepressant medication was an exclusion criterion, otherwise eligible individuals who were taking ineffective antidepressant medication were allowed to sign consent and participate in the study so long as they completed a study-supervised taper and discontinuation of the medication prior to beginning the study medication. (Source: The A...
Source: The American Journal of Geriatric Psychiatry - September 27, 2022 Category: Geriatrics Authors: Xiaofu He, Elena Pueraro, Yoojean Kim, Carolina Montes Garcia, Ben Maas, Jongwoo Choi, Dakota A. Egglefield, Sophie Schiff, Joel Sneed, Patrick J. Brown, Adam Brickman, Steven P. Roose, Bret R Rutherford Tags: Corrigendum Source Type: research

Did the COVID-19 Pandemic Affect the Use of Antipsychotics among Nursing Home Residents with ADRD?
The COVID-19 pandemic has disproportionately affected nursing home (NH) residents, whose deaths have accounted for 17 percent of all COVID-related deaths in the US.1,2 The pandemic has created challenges in caring for NH residents, and in particular for those most vulnerable, such as the residents with Alzheimer's disease and related dementias (ADRD), who represent almost half of the NH population.3 The pandemic also impacted NH staff, with more than one million infected by COVID-19,2 and many leaving the industry due to stress, burnout, and increasing workloads. (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - September 27, 2022 Category: Geriatrics Authors: Di Yan, Helena Temkin-Greener, Shubing Cai Tags: Regular Research Article Source Type: research

A Qualitative Analysis of Suicide Notes to Understand Suicidality in Older Adults
CONCLUSIONS: Suicide notes enrich our understanding of the thoughts and emotions of those at highest risk of suicide, and they inform potential interventions for reducing suicide risk in older adults.PMID:36163122 | DOI:10.1016/j.jagp.2022.08.006 (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - September 26, 2022 Category: Psychiatry Authors: Ari B Cuperfain Zainab Furqan Mark Sinyor Benoit H Mulsant Kenneth Shulman Paul Kurdyak Juveria Zaheer Source Type: research

Late-Life Depression is Associated With Increased Levels of GDF-15, a Pro-Aging Mitokine
CONCLUSION: Our results suggest that depression in late life is associated with GDF-15, a marker of amplified age-related biological changes. GDF-15 is a novel and potentially targetable biological pathway between depression and accelerated aging, including cognitive aging.PMID:36153290 | DOI:10.1016/j.jagp.2022.08.003 (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - September 24, 2022 Category: Psychiatry Authors: Emma Mastrobattista Eric J Lenze Charles F Reynolds Benoit H Mulsant Julie Wetherell Gregory F Wu Daniel M Blumberger Jordan F Karp Meryl A Butters Ana Paula Mendes-Silva Erica L Vieira George Tseng Breno S Diniz Source Type: research

In pre-clinical AD small vessel disease is associated with altered hippocampal connectivity and atrophy
Cerebral small vessel disease (SVD) refers to injury to small arteries, arterioles, veins, venules, and capillaries in the brain. White matter lesions (WMLs), identified as hyperintensities (WMH) on T2-weighted FLAIR MR brain images, are an important radiologic marker of SVD. SVD is very common in both non-demented elderly and late-onset Alzheimer's disease (AD) patients. Amyloid-beta (A β) plaques in the brain are one of the key pathological hallmarks of AD and the accumulation of Aβ starts approximately 10 to 20 years prior to the onset of clinical dementia (1-3). (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - September 24, 2022 Category: Geriatrics Authors: Minjie Wu, Noah Schweitzer, Bistra E. Iordanova, Edythe Halligan-Eddy, Dana L. Tudorascu, Chester A. Mathis, Brian J. Lopresti, M. Ilyas Kamboh, Ann D. Cohen, Beth E. Snitz, William E. Klunk, Howard J. Aizenstein Source Type: research