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Association Between Caregivers' Pain Severity and Relationship Stress Among Persons Living with Dementia and Their Caregivers During COVID-19
The COVID-19 pandemic placed economic and social strains on the population globally, and particularly on family caregivers for persons living with dementia who were tasked with keeping persons living with dementia safe and cared for while physically distancing at home. Pandemic caregiving duties may have been particularly stressful for caregivers self-reporting pain, as pain is known to interfere with daily function and well-being. Unknown is whether pain influenced the care dynamics between the caregiver and persons living with dementia during a stressful pandemic period. (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - February 18, 2024 Category: Geriatrics Authors: Johanna Keller, Brandon C. Yarns, Mark A. Lumley, Amanda Leggett Tags: Poster # EI5 Source Type: research

Examining the Plasma Ab42/40 Ratio in the Context of Memory Disorder Clinics
This study aimed to assess plasma Aβ's utility in a real-world memory clinic setting with an emphasis on patient heterogeneity. (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - February 18, 2024 Category: Geriatrics Authors: Margaret Gunter, Ram Bishnoi Tags: Poster # EI6 Source Type: research

Alzheimer's Disease-Related Psychosis is Positively Correlated with Preserved Hippocampal Volume
Psychosis presents as delusions and/or hallucinations, and occurs in approximately 41% of Alzheimer's disease (AD) patients, leading to accelerated decline in cognitive function. Alzheimer's disease is characterized by the presence of overall brain cortical atrophy, which is most notable in association areas and the limbic system, including the hippocampus. However, associations between neuroanatomical changes in AD and AD-related psychosis are not well studied, in particular as they relate to APOE4, which may play a stronger modulatory role in females when compared to males. (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - February 18, 2024 Category: Geriatrics Authors: Jonathan Fan, Luis Fornazzari, Nathan Churchill, David Munoz, Tom Schweizer, Ayad Fadhel, Corinne E. Fischer Tags: Poster # EI7 Source Type: research

Is There Evidence for Using Ketamine Among Individuals with Dementia?
Multiple studies have found positive effects of ketamine for potential use in several acute and chronic psychiatric conditions, including its use in treatment resistant depression, bipolar disorder, posttraumatic stress disorder, obsessive compulsive disorder, substance use disorder, eating disorders, delirium prevention and pain. Its use has been proposed in persons with dementia, based on its effect on neuroinflammation and stimulation of neurotrophic factors.The aim of this review is to evaluate the existing literature on the clinical use of ketamine among individuals with dementia especially among those individuals wit...
Source: The American Journal of Geriatric Psychiatry - February 18, 2024 Category: Geriatrics Authors: Arushi Kapoor, Tanya Peguero Estevez, Natsuko Yamagata, Carol Chan, Kyra Doumlele, Rajesh R. Tampi Tags: Poster # EI8 Source Type: research

Increased Suicide Risk after Diagnosis of Dementia/MNCD: Clinical Recommendations for Outpatient Transitions
The psychological impact on a patient after being diagnosed with dementia/major neurocognitive disorder (MNCD) is varied, but studies report that patients may have feelings of anxiety and depression1-2 and increased suicide risk.3-6 Long term hospital stays increased during the COVID-19 pandemic.7 On geropsychiatric units, this allowed older adult patients to stabilize from acute psychiatric conditions so they could be evaluated for MNCD. The transition of care from inpatient to outpatient settings poses a risk for such patients newly diagnosed with MNCD, since continuity of care can be lost during this process. (Source: T...
Source: The American Journal of Geriatric Psychiatry - February 18, 2024 Category: Geriatrics Authors: Hannah Lynch, Helen Kyomen Tags: Poster # EI9 Source Type: research

Late Onset Suicide and Dementia
Rates of completed suicide are overrepresented among people over the age of 65. Older adults have been identified as having the highest suicide rate in almost every country, reaching 48.7/100,000 in the US for white men (more than four times that nation's age-adjusted rate of 11.1/100,000) and 140/100,000 in rural China for men. The factors strongly associated with suicide includes physical illnesses, such as cancer, stroke, dementia and pain. A common complaint in the elderly is cognitive impairment. (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - February 18, 2024 Category: Geriatrics Authors: Heba Ekladios, Nicholas Flugrad, Rehan Aziz, Robert Stern Tags: Poster # EI10 Source Type: research

Apathy Endorsement in Late Life Depression is Associated with Executive Dysfunction
Executive function deficits are prevalent in late life depression (LLD) and linked to poorer outcomes. Little is known about the underlying factors that contribute to greater executive dysfunction in LLD, yet understanding these factors is critical for identifying new intervention targets to reduce the public health burden associated with depression and cognitive impairment in late life. Although negative affect has traditionally been the focus of scientific inquiry related to depressive symptomatology, emerging work is highlighting associations of Positive Valence System (PVS) dysfunction with depression. (Source: The Ame...
Source: The American Journal of Geriatric Psychiatry - February 18, 2024 Category: Geriatrics Authors: Maria Kryza-Lacombe, Michelle Kassel, Susanna Fryer, Philip S. Insel, Branwen Vang, Meryl A. Butters, Paul Aisen, Rema Raman, Susan Landau, Andrew J. Saykin, Arthur W. Toga, Clifford R. Jack, Michael W. Weiner, Craig Nelson, Duygu Tosun, R. Scott Mackin Tags: Poster # EI11 Source Type: research

Cerebral Blood Flow Changes and Neuroticism in Late-Life Depression
The neuroticism personality trait plays an important role in the etiology of major depressive disorder. Our previous study suggested that different neural mechanisms drive unique brain morphology changes in individuals with late-life depression and high neuroticism (LLD_HN) compared with those with LLD and low neuroticism (LLD_LN). We found that LLD_HN had smaller volume in the frontal pole than LLD_LN and never-depressed control subjects, whereas LLD_LN had higher volumes of non-white matter hypo-intensities in the cingulate and basal ganglia area, which suggests differences in pathology of LLD with and without neuroticis...
Source: The American Journal of Geriatric Psychiatry - February 18, 2024 Category: Geriatrics Authors: Thea Anderson, David Steffens, Lihong Wang, Godfrey D. Pearlson Tags: Poster # EI12 Source Type: research

Unique Time-Series Patterns of Behavioral and Psychological Factors in Late-Life Depression: A Computational Psychiatry Approach with Hidden Markov Models
Traditional approaches for characterizing changes in psychopathological constructs (e.g., depression) often focus on elucidating how the individual construct changes within the time-series data, while statistically accounting for other related constructs (e.g., anxiety, loneliness) that may a have shared/common variance. While these methods are useful for exploring associations among the isolated signals of those constructs, these classical frameworks fall short in providing insights into the comprehensive system-level dynamics underlying changes of observable psychological/behavioral constructs. (Source: The American Jour...
Source: The American Journal of Geriatric Psychiatry - February 18, 2024 Category: Geriatrics Authors: Saurab Faruque, Akiko Mizuno, Linghai Wang, Minjie Wu, Noah Schweitzer, Sarah Stahl, Howard Aizenstein Tags: Poster # EI13 Source Type: research

Suicidal Ideation and Treatment Response Among Depressed Elder Abuse Victims
Elder abuse (EA) afflicts up to 10% of adults 60 years and older in the US (Acierno et al., 2010; Rosay& Mulford, 2017) and 1 in 6 worldwide (Yon et al. 2017). Depression is prevalent among elder abuse victims (Mouton et al., 2010; Sirey et al., 2015; Li, Liang& Dong, 2019) and is associated with higher mortality rates among victims (Lachs et al., 1998; Dong et al., 2009; Olofsson et al. 2012). Furthermore, studies suggest that older adults who experience mistreatment are at a higher risk of reporting/experiencing suicidal ideation (Dong et al. (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - February 18, 2024 Category: Geriatrics Authors: Isabel Rollandi, Nili Solomonov, Clare Culver, Fiallo Olivia, Emily Carter, Samprit Banerjee, Jo Anne Sirey Tags: Poster # EI14 Source Type: research

Default Mode Network Connectivity is Altered in Remitted Late-Life Depression
Late-life depression (LLD) is associated with cardiovascular disease, cognitive decline, and increased risk of suicide. One of the major challenges of LLD is its refractory nature, with reported relapse rates between of 43% in 2 years and 57% in 4 years. While much effort has been devoted to understanding the neurobiological basis of depression and its treatment, the pathophysiology of relapse remains vastly understudied. Brain-based investigations of LLD have consistently revealed alterations in limbic regions and higher order associative networks like the default mode (DMN), executive control (ECN), salience (SN), and do...
Source: The American Journal of Geriatric Psychiatry - February 18, 2024 Category: Geriatrics Authors: Andrew Gerlach, Helmet Karim, Robert Krafty, Warren Taylor, Olusola Ajilore, Carmen Andreescu Tags: Poster # EI15 Source Type: research

Heterogeneity Of Cognition in Older Adults with Remitted Major Depressive Disorder: A Latent Profile Analysis
Remitted major depressive disorder (rMDD) is a known risk factor for developing Alzheimer's dementia (AD). Nearly half of older patients with rMDD have cognitive impairment, and a third meet diagnostic criteria for mild cognitive impairment (MCI), a known prodrome to AD. However, there is a large degree of heterogeneity in the cognitive profiles of older patients with rMDD and rMDD+MCI. (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - February 18, 2024 Category: Geriatrics Authors: Tulip Marawi, Peter Zhukovsky, Heather Brooks, Christopher Bowie, Meryl Butters, Corinne Fischer, Alastair Flint, Nathan Herrmann, Krista Lanct ôt, Linda Mah, Bruce Pollock, Tarek Rajji, Aristotle Voineskos, Benoit Mulsant Tags: Poster # EI16 Source Type: research

Prevalence of Residual and Subsyndromal Symptoms in Older Age Bipolar Disorder (OABD) Compared with Younger Adults
This study explored the prevalence and associated factors of residual symptoms and subsyndromal symptoms in patients with OABD who are euthymic and compared older to younger adults. (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - February 18, 2024 Category: Geriatrics Authors: Sirinapa Aphisitphinyo, Maria Lapid, Brandon Coombes, Jacob Frank, Melanie T Gentry, Mark Frye Tags: Poster # EI17 Source Type: research

Stress and Coping Among Community-Dwelling Black Older Adults with Depression
In the U.S., there are disparities between the well-being of Black and white older adults. Black older adults are more likely to develop chronic illnesses such as hypertension, heart disease, and diabetes, which can diminish their quality of life. The prevalence of chronic illness is compounded by the stressors common in aging, such as decreased income, changes in physical function, and the loss of spouses and friends. Psychological well-being contributes to an individual's overall health, along with their environment and quality of life. (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - February 18, 2024 Category: Geriatrics Authors: Camryn Dixon, Jin Joo, Melissa Davey-Rothwell, Namkee Choi, Joseph Gallo, Ryan A. Mace, Alice Xie Tags: Poster # EI18 Source Type: research

Distanced by Design: Acknowledging Transportation Barriers to Psychiatric Care for Racially Minoritized Older Adults
Many geriatric psychiatry services treat disproportionately low numbers of racially minoritized populations (RMP) in their practices despite the disproportionately higher rates of dementia and mental illness in RMP. This holds true for the Geriatrics Division at McLean Hospital (Belmont, MA), the #1 ranked psychiatric hospital in the country. In 2020-2021, racial demographics of patients in the geriatric psychiatry outpatient clinic at McLean versus the Boston metro area, respectively, were 88% vs 50.1% White, 1% vs 23.5% Black, 2% vs 9.7% Asian, and McLean was 1% “other” and 8% unknown compared to the remainder of Bos...
Source: The American Journal of Geriatric Psychiatry - February 18, 2024 Category: Geriatrics Authors: Marie Clouqueur, Amaal Mahamed, Alison McCostis, Julia Merrill, Rosain Ozonsi, Carmen Black, Ipsit Vahia Tags: Poster # EI19 Source Type: research