Neuroinflammation induced by amyloid-forming pancreatic amylin: Rationale for a mechanistic hypothesis
Biophys Chem. 2024 Apr 22;310:107252. doi: 10.1016/j.bpc.2024.107252. Online ahead of print.ABSTRACTAmylin is a systemic neuroendocrine hormone co-expressed and co-secreted with insulin by pancreatic β-cells. In persons with thype-2 diabetes, amylin forms pancreatic amyloid triggering inflammasome and interleukin-1β signaling and inducing β-cell apoptosis. Here, we summarize recent progress in understanding the potential link between amyloid-forming pancreatic amylin and Alzheimer's disease (AD). Clinical data describing amylin pathology in AD alongside mechanistic studies in animals are reviewed. Data from multiple res...
Source: Biophysical Chemistry - April 25, 2024 Category: Chemistry Authors: Noah S Leibold Florin Despa Source Type: research
RNA sequencing of olfactory bulb in Parkinson's disease reveals gene alterations associated with olfactory dysfunction
In conclusion, this study reveals gene alterations associated with neuroinflammation, neurotransmitter dysfunction, and disruptions of factors involved in the initiation of olfactory transduction signaling that may be involved in PD-related olfactory dysfunction.PMID:38663633 | DOI:10.1016/j.nbd.2024.106514 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - April 25, 2024 Category: Neurology Authors: C écilia Tremblay Sidra Aslam Jessica E Walker Ileana Lorenzini Anthony J Intorcia Richard A Arce Parichita Choudhury Charles H Adler Holly A Shill Erika Driver-Dunckley Shyamal Mehta Ignazio S Piras Christine M Belden Alireza Atri Thomas G Beach Geidy E Source Type: research
Research Progress of Eye Movement Analyses and its Detection Algorithms in Alzheimer's Disease
Curr Alzheimer Res. 2024 Apr 24. doi: 10.2174/0115672050300564240416074025. Online ahead of print.ABSTRACTAlzheimer's disease (AD) has been considered one of the most challenging forms of dementia. The earlier the people are diagnosed with AD, the easier it is for doctors to find a treatment. Based on the previous literature summarizing the research results on the relationship between eye movement and AD before 2013, this paper reviewed 34 original eye movements research papers only closely related to AD published in the past ten years and pointed out that the prosaccade (4 papers) and antisaccade (5 papers) tasks, reading...
Source: Current Alzheimer Research - April 25, 2024 Category: Neurology Authors: Xueying He Ivan Selesnick Ming Zhu Source Type: research
Adult-Onset Attention-Deficit/Hyperactivity Disorder and the Risk of Lewy Body Dementia: An Invited Commentary
Am J Geriatr Psychiatry. 2024 Apr 10:S1064-7481(24)00302-6. doi: 10.1016/j.jagp.2024.04.004. Online ahead of print.NO ABSTRACTPMID:38664081 | DOI:10.1016/j.jagp.2024.04.004 (Source: Am J Geriatr Psychia...)
Source: Am J Geriatr Psychia... - April 25, 2024 Category: Geriatrics Authors: Anat Rotstein Source Type: research
The association of neighborhood socioeconomic status with executive function and processing speed in cognitively normal Mexican Americans elders from the Health and Aging Brains Study - Health Disparities cohort
CONCLUSION: Our study revealed that living in an area of higher deprivation was associated with lower cognitive function in MA but not in NHW, which is important to consider in future interventions to slow cognitive decline.PMID:38663362 | DOI:10.1159/000539035 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 25, 2024 Category: Psychiatry Authors: Raul Vintimilla Abigail Benton Roya Morakabian James R Hall Leigh A Johnson Sid E O'Bryant HABS-HD Study Team Source Type: research
Adult-Onset Attention-Deficit/Hyperactivity Disorder and the Risk of Lewy Body Dementia: An Invited Commentary
Am J Geriatr Psychiatry. 2024 Apr 10:S1064-7481(24)00302-6. doi: 10.1016/j.jagp.2024.04.004. Online ahead of print.NO ABSTRACTPMID:38664081 | DOI:10.1016/j.jagp.2024.04.004 (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - April 25, 2024 Category: Psychiatry Authors: Anat Rotstein Source Type: research
Dementia Care in Rural Appalachia: Multilevel Analysis of Individual and County-level Factors
DISCUSSION AND IMPLICATIONS: Findings suggest that informal support in caring for the person living with dementia enables HCBS use in rural Appalachia. In contrast, limited geographic accessibility and service availability can impede HCBS use in rural regions. Policymakers are urged to allocate direct public funding to service providers to expand service availability in under-resourced rural regions.PMID:38661552 | DOI:10.1093/geront/gnae037 (Source: The Gerontologist)
Source: The Gerontologist - April 25, 2024 Category: Geriatrics Authors: Suyoung Nah Jyoti Savla Karen A Roberto Source Type: research
Neuroinflammation induced by amyloid-forming pancreatic amylin: Rationale for a mechanistic hypothesis
Biophys Chem. 2024 Apr 22;310:107252. doi: 10.1016/j.bpc.2024.107252. Online ahead of print.ABSTRACTAmylin is a systemic neuroendocrine hormone co-expressed and co-secreted with insulin by pancreatic β-cells. In persons with thype-2 diabetes, amylin forms pancreatic amyloid triggering inflammasome and interleukin-1β signaling and inducing β-cell apoptosis. Here, we summarize recent progress in understanding the potential link between amyloid-forming pancreatic amylin and Alzheimer's disease (AD). Clinical data describing amylin pathology in AD alongside mechanistic studies in animals are reviewed. Data from multiple res...
Source: Biophysical Chemistry - April 25, 2024 Category: Chemistry Authors: Noah S Leibold Florin Despa Source Type: research
RNA sequencing of olfactory bulb in Parkinson's disease reveals gene alterations associated with olfactory dysfunction
In conclusion, this study reveals gene alterations associated with neuroinflammation, neurotransmitter dysfunction, and disruptions of factors involved in the initiation of olfactory transduction signaling that may be involved in PD-related olfactory dysfunction.PMID:38663633 | DOI:10.1016/j.nbd.2024.106514 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - April 25, 2024 Category: Neurology Authors: C écilia Tremblay Sidra Aslam Jessica E Walker Ileana Lorenzini Anthony J Intorcia Richard A Arce Parichita Choudhury Charles H Adler Holly A Shill Erika Driver-Dunckley Shyamal Mehta Ignazio S Piras Christine M Belden Alireza Atri Thomas G Beach Geidy E Source Type: research
Research Progress of Eye Movement Analyses and its Detection Algorithms in Alzheimer's Disease
Curr Alzheimer Res. 2024 Apr 24. doi: 10.2174/0115672050300564240416074025. Online ahead of print.ABSTRACTAlzheimer's disease (AD) has been considered one of the most challenging forms of dementia. The earlier the people are diagnosed with AD, the easier it is for doctors to find a treatment. Based on the previous literature summarizing the research results on the relationship between eye movement and AD before 2013, this paper reviewed 34 original eye movements research papers only closely related to AD published in the past ten years and pointed out that the prosaccade (4 papers) and antisaccade (5 papers) tasks, reading...
Source: Current Alzheimer Research - April 25, 2024 Category: Neurology Authors: Xueying He Ivan Selesnick Ming Zhu Source Type: research
Adult-Onset Attention-Deficit/Hyperactivity Disorder and the Risk of Lewy Body Dementia: An Invited Commentary
Am J Geriatr Psychiatry. 2024 Apr 10:S1064-7481(24)00302-6. doi: 10.1016/j.jagp.2024.04.004. Online ahead of print.NO ABSTRACTPMID:38664081 | DOI:10.1016/j.jagp.2024.04.004 (Source: Am J Geriatr Psychia...)
Source: Am J Geriatr Psychia... - April 25, 2024 Category: Geriatrics Authors: Anat Rotstein Source Type: research
The association of neighborhood socioeconomic status with executive function and processing speed in cognitively normal Mexican Americans elders from the Health and Aging Brains Study - Health Disparities cohort
CONCLUSION: Our study revealed that living in an area of higher deprivation was associated with lower cognitive function in MA but not in NHW, which is important to consider in future interventions to slow cognitive decline.PMID:38663362 | DOI:10.1159/000539035 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 25, 2024 Category: Psychiatry Authors: Raul Vintimilla Abigail Benton Roya Morakabian James R Hall Leigh A Johnson Sid E O'Bryant HABS-HD Study Team Source Type: research
Adult-Onset Attention-Deficit/Hyperactivity Disorder and the Risk of Lewy Body Dementia: An Invited Commentary
Am J Geriatr Psychiatry. 2024 Apr 10:S1064-7481(24)00302-6. doi: 10.1016/j.jagp.2024.04.004. Online ahead of print.NO ABSTRACTPMID:38664081 | DOI:10.1016/j.jagp.2024.04.004 (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - April 25, 2024 Category: Psychiatry Authors: Anat Rotstein Source Type: research
Dementia Care in Rural Appalachia: Multilevel Analysis of Individual and County-level Factors
DISCUSSION AND IMPLICATIONS: Findings suggest that informal support in caring for the person living with dementia enables HCBS use in rural Appalachia. In contrast, limited geographic accessibility and service availability can impede HCBS use in rural regions. Policymakers are urged to allocate direct public funding to service providers to expand service availability in under-resourced rural regions.PMID:38661552 | DOI:10.1093/geront/gnae037 (Source: The Gerontologist)
Source: The Gerontologist - April 25, 2024 Category: Geriatrics Authors: Suyoung Nah Jyoti Savla Karen A Roberto Source Type: research
Research Progress of Eye Movement Analyses and its Detection Algorithms in Alzheimer's Disease
Curr Alzheimer Res. 2024 Apr 24. doi: 10.2174/0115672050300564240416074025. Online ahead of print.ABSTRACTAlzheimer's disease (AD) has been considered one of the most challenging forms of dementia. The earlier the people are diagnosed with AD, the easier it is for doctors to find a treatment. Based on the previous literature summarizing the research results on the relationship between eye movement and AD before 2013, this paper reviewed 34 original eye movements research papers only closely related to AD published in the past ten years and pointed out that the prosaccade (4 papers) and antisaccade (5 papers) tasks, reading...
Source: Current Alzheimer Research - April 25, 2024 Category: Neurology Authors: Xueying He Ivan Selesnick Ming Zhu Source Type: research
