Ampelopsin improves cognitive impairment in Alzheimer's disease and involvement of neuroinflammation and oxidative stress in the hippocampus.
CONCLUSION: We showed the significant role of AMP in improving the memory impairment in AD rats likely via inhibition of signal pathways of neuroinflammation and oxidative stress suggesting that AMP may present prospects in preventing and/or alleviating development of the impaired cognitive functions in AD as a complementary alternative intervention. PMID: 31797758 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - December 3, 2019 Category: Neurology Authors: Wang Y, Lv W, Li Y, Liu D, He X, Liu T Tags: Curr Alzheimer Res Source Type: research

Dual inhibition of DPP-4 and cholinesterase enzymes by phytoconstituents of an ethanolic extract of Prosopis cineraria pods: Therapeutic implications for the treatment of diabetes-associated neurological impairments.
CONCLUSION: It can be concluded that phytoconstituents of Prosopis cineraria pod extract may be significantly consider in neuropharmacology to resolve insulin resistance induced neurological complications as shown inhibition against DPP-4, AChE and BuChE targets enzymes. PMID: 31797759 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - December 3, 2019 Category: Neurology Authors: Ram H, Jaipal N, Kumar P, Deka P, Kumar S, Kashyap P, Kumar S, Singh BP, Alqarawi AA, Hashem A, Tabassum B, Abd Allah EF Tags: Curr Alzheimer Res Source Type: research

A Qualitative Analysis Based on Relative Expression Orderings Identifies Transcriptional Subgroups for Alzheimer's Disease.
CONCLUSION: AD transcriptional subgroups might help understand the underlying pathogenesis of AD, and lend support to a personalized approach to AD management. PMID: 31763973 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - November 22, 2019 Category: Neurology Authors: Hong G, Zeng P, Li N, Cai H, Guo Y, Li X, Li K, Li H Tags: Curr Alzheimer Res Source Type: research

Metabolic alterations in the outer membrane vesicles of patients with Alzheimer's disease: an LC-MS/MS -based metabolomics analysis.
CONCLUSION: Metabolic activity is significantly altered in the OMVs from AD patients. This data might be helpful for identifying novel biomarkers and their diagnostic roles in AD. Furthermore, OMVs metabolomics analysis combined with GWAS could enrich our understanding of the genetic spectrum of AD and lead to early predictions and diagnosis and clinical applications of better AD treatments. PMID: 31755388 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - November 21, 2019 Category: Neurology Authors: Wei SC, Wei W, Peng WJ, Liu Z, Cai ZY, Zhao B Tags: Curr Alzheimer Res Source Type: research

Genome-wide Network-assisted Association and Enrichment Study of Amyloid Imaging Phenotype in Alzheimer's Disease.
CONCLUSION: The identified genes, consensus modules and enriched pathways may provide important clues to future research on the neurobiology of Alzheimer's disease and suggest potential therapeutic targets. PMID: 31755389 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - November 21, 2019 Category: Neurology Authors: Li J, Chen F, Zhang Q, Meng X, Yao X, Risacher SL, Yan J, Saykin AJ, Liang H, Shen L Tags: Curr Alzheimer Res Source Type: research

Editorial: Multi Target - Directed Ligands in the Treatment of Alzheimer's Disease.
PMID: 31729288 [PubMed - in process] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - November 17, 2019 Category: Neurology Authors: Soukup O, Korabecny J Tags: Curr Alzheimer Res Source Type: research

Neuroprotective effect of β-secretase inhibitory peptide from Pacific hake (Merluccius productus) fish protein hydrolysate.
CONCLUSION: Therefore, the results of this study suggest that β-secretase inhibitory peptides derived from marine organisms could be potential candidates to develop nutraceuticals or pharmaceuticals as anti-dementia agents. PMID: 31724512 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - November 13, 2019 Category: Neurology Authors: Lee JK, Li-Chan ECY, Cheung IWY, Jeon YJ, Ko JY, Byun HG Tags: Curr Alzheimer Res Source Type: research

Tau PET distributional pattern in AD patients with visuospatial dysfunction.
CONCLUSION: These findings suggested that occipitoparietal cortex, posterior cingulate cortex and precuneus, which were particularly affected by increased tau accumulation in VS-AD patients, may associate with visuospatial dysfunction of AD. PMID: 31724513 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - November 13, 2019 Category: Neurology Authors: Sun X, Nie B, Zhao S, Chen Q, Li P, Zhang T, Pan T, Feng T, Wang L, Yin X, Zhang W, Zhao S, Shan B, Liu H, Liang S, Ai L, Wang G Tags: Curr Alzheimer Res Source Type: research

Serum Vitamin D and Cingulate Cortex Thickness in Older Adults: Quantitative MRI of the Brain.
Abstract BACKGROUND: Vitamin D insufficiency is associated with brain changes, and cognitive and mobility declines in older adults. OBJECTIVE: Our objective was to investigate in older adults whether vitamin D insufficiency
Source: Current Alzheimer Research - November 13, 2019 Category: Neurology Authors: Foucault G, Duval GT, Simon R, Beauchet O, Dinomais M, Annweiler C Tags: Curr Alzheimer Res Source Type: research

Assessment of Memory Impairment in Early Diagnosis of Alzheimer's Disease.
eni R, Di Nuovo S Abstract Memory impairment has been considered as one of the earliest clinical hallmarks of Alzheimer's disease. This paper summarizes recent progress in the assessment of memory impairment in predementia stages. New promising approaches of memory assessment include evaluation of longitudinal cognitive changes, assessment of long-term memory loss, evaluation of subjective cognitive concerns and testing of other memory modalities, such as spatial memory. In addition, we describe new challenging memory tests based on memory binding paradigms that have been recently developed and are currently being...
Source: Current Alzheimer Research - November 13, 2019 Category: Neurology Authors: Vyhnálek M, Marková H, Laczó J, De Beni R, Di Nuovo S Tags: Curr Alzheimer Res Source Type: research

Common Pathological Mechanisms and Risk Factors for Alzheimer's Disease and Type-2 Diabetes: Focus on Inflammation.
CONCLUSION: We propose that it is now necessary to consider whether neuroinflammation in Alzheimer's disease affects inflammation in the pancreas related to diabetes. PMID: 31692443 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - November 5, 2019 Category: Neurology Authors: Moyse E, Haddad M, Benlabiod C, Ramassamy C, Krantic S Tags: Curr Alzheimer Res Source Type: research

Consideration of a Pharmacological Combinatorial Approach to Inhibit Chronic Inflammation in Alzheimer's Disease.
This article suggests a starting point using four compounds which present some differential in anti-inflammatory targets and actions but a commonality in showing a finite permeability through blood-brain barrier (BBB). A basis for first- choice compounds demonstrated neuroprotection in animal models (thalidomide and minocycline), clinical trial data showing some slowing in the progression of pathology in AD brain (ibuprofen) and indirect evidence for putative efficacy in blocking oxidative damage and chemotactic response mediated by activated microglia (dapsone). It is emphasized that a number of candidate compounds, other...
Source: Current Alzheimer Research - November 5, 2019 Category: Neurology Authors: McLarnon JG Tags: Curr Alzheimer Res Source Type: research

Strategies targeting soluble β-Amyloid oligomers and their application to early diagnosis of Alzheimer's Disease.
CONCLUSION: This review article covers three kinds of strategies that could be translated into clinic practice and lead to earlier diagnosis and therapeutic interventions of AD. PMID: 31670622 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - October 31, 2019 Category: Neurology Authors: Zenga F, Li Y, Xua Y, Yanga J, Liua Z, Lia X, Rena L Tags: Curr Alzheimer Res Source Type: research

Plasma Clusterin as a Potential Biomarker for Alzheimer's Disease-A Systematic Review and Meta-analysis.
CONCLUSION: Our meta-analysis suggested no relationship between plasma clusterin levels and the diagnosis, risk, and disease severity of AD and no difference in the CSF clusterin between AD and the control groups. Overall, there is no evidence to support plasma clusterin as a biomarker of AD based on the pooled results. PMID: 31647395 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - October 24, 2019 Category: Neurology Authors: Shi XR, Xie BJ, Xing Y, Tang Y Tags: Curr Alzheimer Res Source Type: research

Anti-Alzheimer's Materials Isolated from Marine Bio-resources: A Review.
Abstract The most common type of dementia found in the elderly population is Alzheimer's disease. The disease not only impacts the patients and their families but also the society therefore, the main focus of researchers is to search new bioactive materials for treating AD. The marine environment is a rich source of functional ingredients and to date, we can find sufficient research relating to anti- Alzheimer's compounds isolated from marine environment. Therefore, this review focuses on the anti- Alzheimer's material from marine bio-resources and then expounds on the anti-Alzheimer's compounds from marine seawee...
Source: Current Alzheimer Research - October 24, 2019 Category: Neurology Authors: Rathnayake AU, Abuine R, Kim YJ, Byun HG Tags: Curr Alzheimer Res Source Type: research

Glycemic Control is Related to Cognitive Dysfunction in Elderly People with Type 2 Diabetes Mellitus in a Rural Chinese Population.
Abstract BACKGROUND: There is an increasing interest on cognitive impairment (CI) in patients with type 2 diabetes mellitus (T2DM), but evidence is conflicting regarding the association between CI and glycemic control. OBJECTIVE: The present study aimed to estimate the prevalence of CI in patients with T2DM from northern rural China in order to determine whether cognitive dysfunction is related to glycemic control. METHODS: First, we conducted a study with a cross-sectional design. We performed cluster random sampling of 1848 residents who were aged 60 years or older and lived in the countryside in China...
Source: Current Alzheimer Research - October 23, 2019 Category: Neurology Authors: Liu S, Lu Y, Cai X, Cong R, Li J, Jiang H, Li M Tags: Curr Alzheimer Res Source Type: research

Alzheimer's Disease And Retinal Degeneration: A Glimpse At Essential Trace Metals In Ocular Fluids And Tissues.
CONCLUSION: Hence, this review address current knowledge about some up-to-date investigated essential trace metals associated with AD and AMD. Changes in the levels of systemic and ocular fluid essential metals might reflect the early stages of AMD, possibly disclosing neurodegeneration pathways shared with AD, which might open to potential early detection. PMID: 31642780 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - October 23, 2019 Category: Neurology Authors: Micera A, Bruno L, Cacciamani A, Rongioletti M, Squitti R Tags: Curr Alzheimer Res Source Type: research

Receptor-Interacting Protein Kinase 1 (RIPK1) as a Potential Therapeutic Target: An Overview of Its Possible Role in the Pathogenesis of Alzheimer's Disease.
Abstract Alzheimer's disease (AD) is an age-dependent neurodegenerative disorder, the most common type of dementia that is clinically characterized by the presence of beta-amyloid (Aβ) extracellularly and intraneuronal tau protein tangles that eventually leads to the onset of memory and cognition impairment, development of psychiatric symptoms and behavioral disorders that affect basic daily activities. Current treatment approved by the U.S Food and Drug Administration (FDA) for AD is mainly focused on the symptoms but not on the pathogenesis of the disease. Recently, receptor-interacting protein kinase 1 (RI...
Source: Current Alzheimer Research - October 22, 2019 Category: Neurology Authors: Chan HH, Koh RY, Lim CL, Leong CO Tags: Curr Alzheimer Res Source Type: research

Amyloid- β Oligomers-induced Mitochondrial DNA Repair Impairment Contributes to Altered Human Neural Stem Cell Differentiation.
CONCLUSION: Aβ42O-induced mtDNA repair impairment may change cell fate thus shifting human NSC differentiation toward an astrocytic lineage. Repair stimulation counteracts Aβ42O neurotoxicity, suggesting mtDNA repair pathway as a potential target for the treatment of neurodegenerative disorders like AD. PMID: 31642778 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - October 22, 2019 Category: Neurology Authors: Lu J, Li Y, Mollinari C, Garaci E, Merlo D, Pei G Tags: Curr Alzheimer Res Source Type: research

Actigraphy for Assessing Light Effects on Sleep and Circadian Activity Rhythm in Alzheimer's Dementia: A Narrative Review.
CONCLUSION: Fusing knowledge across complementary research disciplines has the potential to critically advance our understanding of the biological input of light on health and may contribute to architectural lighting designs in hospitals, as well as our homes and work environments. PMID: 31608835 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - October 10, 2019 Category: Neurology Authors: Canazei M, Turiaux J, Huber SE, Marksteiner J, Papousek I, Weiss EM Tags: Curr Alzheimer Res Source Type: research

Neuroinflammation in Alzheimer's Disease: Microglia, Molecular Participants and Therapeutic Choices.
Abstract Alzheimer's disease is the world's most common dementing illness. It is pathologically characterized by β-amyloid accumulation, extracellular senile plaques and intracellular neurofibrillary tangles formation, and neuronal necrosis and apoptosis. Neuroinflammation has been widely recognized as a crucial process that participates in AD pathogenesis. In this review, we briefly summarized the involvement of microglia in the neuroinflammatory process of Alzheimer's disease. Its roles in the AD onset and progression are also discussed. Numerous molecules, including interleukins, tumor necrosis factor alph...
Source: Current Alzheimer Research - October 5, 2019 Category: Neurology Authors: Wang H, Shen Y, Chuang H, Chiu C, Ye Y, Zhao L Tags: Curr Alzheimer Res Source Type: research

A pilot study of exenatide actions in Alzheimer's disease.
CONCLUSION: The positive finding of lower EV Aβ42 supports emerging evidence that plasma neuronal EVs provide an effective platform for demonstrating biomarker responses in clinical trials in AD. The study was underpowered due to early termination and therefore we cannot draw any firm conclusions. However, the analysis of secondary outcomes shows no trends in support of the hypothesis that exenatide is disease- modifying in clinical AD, and lowering EV Aβ42 in and of itself may not improve cognitive outcomes in AD. PMID: 31518224 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - September 13, 2019 Category: Neurology Authors: Mullins RJ, Mustapic M, Chia CW, Carlson O, Gulyani S, Tran J, Li Y, Mattson MP, Resnick S, Egan JM, Greig NH, Kapogiannis D Tags: Curr Alzheimer Res Source Type: research

Role of TREM2 in Alzheimer's disease and its consequences on β-amyloid, Tau and neurofibrillary tangles.
Role of TREM2 in Alzheimer's disease and its consequences on β-amyloid, Tau and neurofibrillary tangles. Curr Alzheimer Res. 2019 Sep 02;: Authors: Singh AK, Mishra G, Maurya A, Awasthi R, Kumari K, Thakur A, Rai A, Rai GK, Sharma B, Kulkarni GT, Singh SK Abstract Alzheimer's disease (AD) is age-related neurodegenerative disorder recognized by a steadily gradual cognitive decline that has devastating personal and socioeconomic implications. Recently, some genetic factors for AD have been identified which attracted wide attention of researchers in different areas of AD...
Source: Current Alzheimer Research - September 2, 2019 Category: Neurology Authors: Singh AK, Mishra G, Maurya A, Awasthi R, Kumari K, Thakur A, Rai A, Rai GK, Sharma B, Kulkarni GT, Singh SK Tags: Curr Alzheimer Res Source Type: research

Erratum to: Inhibition of the PERK-dependent Unfolded Protein Response Signaling Pathway Involved in the Pathogenesis of Alzheimer's Disease.
Authors: Abstract This work was supported by grant PRELUDIUM no. 2015/19/N/NZ3/00055 from the Polish National Science Centre, grant of Medical University of Lodz no. 502-03/5-108-05/502-54-194, grant OPUS no. 2016/21/B/NZ5/01411 from the Polish National Science Centre, grant HARMONIA no. 2013/10/M/NZ1/00280 and grant of Medical University of Lodz, Poland no. 502- 03/5-108-05/502-54-224-18. PMID: 31456511 [PubMed - in process] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - August 30, 2019 Category: Neurology Tags: Curr Alzheimer Res Source Type: research

Inhibition of microRNA-155 Alleviates Cognitive Impairment in Alzheimer's Disease and Involvement of Neuroinflammation.
CONCLUSION: We showed the critical role of miR-155 in regulating the memory impairment in AD rats likely via engagement of neuroinflammatory mechanisms, suggesting that miR-155 and its signaling molecules may present prospects in preventing and/or improving the development of the impaired cognitive functions in AD. PMID: 31456514 [PubMed - in process] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - August 30, 2019 Category: Neurology Authors: Liu D, Zhao D, Zhao Y, Wang Y, Zhao Y, Wen C Tags: Curr Alzheimer Res Source Type: research

Neuropeptides in Alzheimer's Disease: An Update.
Abstract Neuropeptides are small proteins broadly expressed throughout the central nervous system, which act as neurotransmitters, neuromodulators and neuroregulators. Growing evidence has demonstrated the involvement of many neuropeptides in both neurophysiological functions and neuropathological conditions, among which is Alzheimer's disease (AD). The role exerted by neuropeptides in AD is endorsed by the evidence that they are mainly neuroprotective and widely distributed in brain areas responsible for learning and memory processes. Confirming this point, it has been demonstrated that numerous neuropeptide-cont...
Source: Current Alzheimer Research - August 30, 2019 Category: Neurology Authors: Petrella C, Di Certo MG, Barbato C, Gabanella F, Ralli M, Greco A, Possenti R, Severini C Tags: Curr Alzheimer Res Source Type: research

Strong association of serum GSK-3 β/BDNF ratio with mild cognitive impairment in elderly type 2 diabetic patients.
Strong association of serum GSK-3β/BDNF ratio with mild cognitive impairment in elderly type 2 diabetic patients. Curr Alzheimer Res. 2019 Aug 27;: Authors: Du B, Lian Y, Chen C, Zhang H, Bi Y, Fan C, Bi X Abstract BACKGROUND: Glycogen synthase kinase (GSK)-3β and brain-derived neurotrophic factor (BDNF) play vital roles in both mild cognitive impairment (MCI) and type 2 diabetes mellitus (T2DM). The underlying mechanisms may involve inflammation and oxidative stress. OBJECTIVES: To investigate the association of the GSK-3β/BDNF ratio with MCI in elderly patients with T2DM, and whe...
Source: Current Alzheimer Research - August 27, 2019 Category: Neurology Authors: Du B, Lian Y, Chen C, Zhang H, Bi Y, Fan C, Bi X Tags: Curr Alzheimer Res Source Type: research

HMPAO-SPECT can discriminate between Patients with Subjective Cognitive Complaints with and without Cognitive Deficits and those with Mild Cognitive Impairment.
CONCLUSIONS: Automated analysis of HMPAO-SPECT data of MCI and SCC+ patients showed significant perfusion differences in medial temporal region and impaired verbal memory, both of which are known features of Alzheimer's dementia. Perfusion patterns and verbal memory performance in SCC+ are more similar to MCI than SCC-. Thus, SPECT analysis could distinguish those subjects whose perfusion pattern resembles that of an MCI from those who don't. In our opinion, this could identify two populations with a different risk of progression to AD, with SCC+ subjects needing further diagnostic examination and repeated follow-up. ...
Source: Current Alzheimer Research - August 27, 2019 Category: Neurology Authors: Rossini F, Zauner H, Bergmann J, Kronbichler M, Spindler I, Golaszewski S, Trinka E, Staffen W Tags: Curr Alzheimer Res Source Type: research

Alzheimer's Disease: Erythrocyte 2,3-diphosphoglycerate content and circulating erythropoietin.
CONCLUSION: We have studied (i) 2,3-DPG in red cells, and (ii) circulating EPO in AD, and both markers are unaffected by dementia. Disturbances of these oxygen-regulatory pathways do not appear to participate in brain hypoxia in AD. PMID: 31453787 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - August 27, 2019 Category: Neurology Authors: Järemo P, Jejcic A, Jelic V, Shahnaz T, Behbahani H, Oweling M, Winblad B Tags: Curr Alzheimer Res Source Type: research

Active Amyloid- β Vaccination Results in Epigenetic Changes in the Hippocampus of an Alzheimer's Disease-Like Mouse Model.
CONCLUSION: Our results indicate that active Aβ vaccination has significant effects on the epigenome in the hippocampus of APP swe /PS1dE9 mice, and suggest that DNA methylation and hydroxymethylation may be involved in cognitive functioning. PMID: 31453788 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - August 27, 2019 Category: Neurology Authors: Lardenoije R, van den Hove DLA, Jung SE, Havermans M, Blackburn P, Liu B, Rutten BPF, Lemere CA Tags: Curr Alzheimer Res Source Type: research

Amyloid- β Aggregation Inhibitory and Neuroprotective Effects of Xanthohumol and its Derivatives for Alzheimer's Diseases.
CONCLUSION: Two derivatives have been identified to be biocompatible, non-toxic, neuroprotective against A β -induced toxicities and blood-brain barrier permeable highlighting their promising potential as AD drug candidates for future clinical use. PMID: 31453789 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - August 27, 2019 Category: Neurology Authors: Wang X, Ho SL, Poon CY, Yan T, Li HW, Wong MS Tags: Curr Alzheimer Res Source Type: research

Integrated genomic analysis revealed associated genes for Alzheimer's disease in APOE4 non-carriers.
CONCLUSION: The study provides new insight into the mechanism of distinct pathogenesis of LOAD not carrying APOE4 and prompts the functional exploration of identified genes based on APOE genotypes. PMID: 31441725 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - August 23, 2019 Category: Neurology Authors: Jiang S, Zhang CY, Tang L, Zhao LX, Chen HZ, Qiu Y Tags: Curr Alzheimer Res Source Type: research

ACAT1 as a therapeutic target and its genetic relationship with Alzheimer's disease.
CONCLUSION: Although there are several lines of evidence from cell-based and animal studies that suggest that ACAT inhibition is an effective way of reducing cerebral Aβ, there is still an information gap in terms of mechanisms and concerns to cover before passing to the next level. Additionally, an area of interest that may be useful in understanding AD to subsequently propose new therapeutic approaches is pharmacogenetics; however, there is still a lot of missing information in this area. PMID: 31441726 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - August 23, 2019 Category: Neurology Authors: Rubio JSA, Cedillo TJ Tags: Curr Alzheimer Res Source Type: research

Synthesis of a novel curcumin derivative as potential imaging probe in Alzheimer's disease imaging.
In conclusion we successfully produced a novel curcumin derivative which could easily be coupled to other imaging or therapeutic molecules as a sensor for amyloid plaques. PMID: 31418660 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - August 16, 2019 Category: Neurology Authors: Sturzu A, Sheikh S, Kalbacher H, Nägele T, Weidenmaier C, Wegenast-Braun BM, Schilling N, Ernemann U, Heckl S Tags: Curr Alzheimer Res Source Type: research

Increased prevalence of vestibular loss in mild cognitive impairment and Alzheimer's disease.
Conclusion: These findings suggest a dose-response relationship between vestibular loss and cognitive status, and support the hypothesis that vestibular loss contributes to cognitive decline. PMID: 31418661 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - August 16, 2019 Category: Neurology Authors: Wei EX, Oh ES, Harun A, Ehrenburg M, Xue QL, Simonsick E, Agrawal Y Tags: Curr Alzheimer Res Source Type: research

Probable novel PSEN1 Gln222Leu mutation in a Chinese family with early-onset Alzheimer's disease.
Conclusion:We reported a probably novel mutation in exon 5 of the presenilin 1 gene (Gln222Leu) in a Chinese family with early-onset Alzheimer's disease , besides,we predicted that the missense mutation was probably a novel pathogenic mutation that was reported for the first time in Chinese family with early-onset Alzheimer's disease. PMID: 31385772 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - August 6, 2019 Category: Neurology Authors: Wang H, Sun R, Shi Y, Xia M, Zhao J, Yang M, Ma L, Sun Y, Li G, Zhang H, Qin W, Zhang J Tags: Curr Alzheimer Res Source Type: research

Relationship Between the Japanese Version of the Montreal Cognitive Assessment and PET Imaging in Subjects with Mild Cognitive Impairment.
CONCLUSION: The total MoCA-J score correlated with amyloid deposition and frontal and parietal glucose metabolism in subjects with mild cognitive impairment. Our findings support the usefulness of the MoCA-J test for screening subjects at high risk for Alzheimer's disease. PMID: 31385770 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - August 5, 2019 Category: Neurology Authors: Eguchi A, Kimura N, Aso Y, Yabuuchi K, Ishibashi M, Hori D, Sasaki Y, Nakamichi A, Uesugi S, Jikumaru M, Sumi K, Shimomura T, Matsubara E Tags: Curr Alzheimer Res Source Type: research

Association of PICALM gene  polymorphisms with Alzheimer's disease: Evidence from an updated meta-analysis.
CONCLUSION: rs3851179 and rs541458 appear to be associated with decreased AD risk. The null associations for rs592297 with AD risk need further confirmation with a larger number of participants. PMID: 31385771 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - August 5, 2019 Category: Neurology Authors: Zeng FF, Liu J, He H, Gao XP, Liao MQ, Yu XX, Liu YH, Zhu S, Jing CX Tags: Curr Alzheimer Res Source Type: research

Resveratrol rescues tau-induced cognitive deficits and neuropathology in a mouse model of tauopathy.
CONCLUSION: These findings suggest that RSV has promising therapeutic potential for AD and other tauopathies. PMID: 31368873 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - August 1, 2019 Category: Neurology Authors: Sun XY, Dong QX, Zhu J, Sun X, Zhang LF, Qiu M, Yu XL, Liu RT Tags: Curr Alzheimer Res Source Type: research

Proteomics Analysis of CA1 Region of the Hippocampus in PRE-, Progression and Pathological Stages in a Mouse Model of the Alzheimer's Disease.
CONCLUSION: We conclude that CA1 region-specific proteomic analysis of hippocampal degeneration may be useful in identifying the earliest as well as progressional changes that are associated with Alzheimer's disease. PMID: 31362689 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - July 30, 2019 Category: Neurology Authors: Gurel B, Cansev M, Koc C, Ocalan B, Cakir A, Aydin S, Kahveci N, Ulus IH, Sahin B, Basar MK, Baykal AT Tags: Curr Alzheimer Res Source Type: research

Mild Parkinsonian Signs in a Hospital-based Cohort of Mild Cognitive Impairment Types: A Cross-sectional Study.
CONCLUSION: MPS are present in both amnestic and nonamnestic MCI types, particularly in those multiple domain, and carrying the APOE ε4 allele. Cortical and subcortical vascular and atrophic processes contribute to MPS. Long prospective studies are needed to disentangle the contribution of MPS to the conversion from MCI to dementia. PMID: 31362655 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - July 25, 2019 Category: Neurology Authors: Camarda C, Torelli P, Pipia C, Battaglini I, Azzarello D, Rosano R, Ventimiglia CC, Sottile G, Cilluffo G, Camarda R Tags: Curr Alzheimer Res Source Type: research

Level of knowledge about Alzheimer's Disease among nursing staff in Suzhou and its influencing factors.
CONCLUSION: Mastery of AD knowledge among the nursing staff in Suzhou is not satisfactory. It is urgent to change the nursing staff's negative attitude towards AD and put into effect AD-related health education and training courses so that nursing staff can upgrade their level of AD knowledge and provide better care in order to improve the quality of life for AD patients. PMID: 31362656 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - July 25, 2019 Category: Neurology Authors: Lin L, Lv S, Liang J, Li H, Xu Y Tags: Curr Alzheimer Res Source Type: research

Effects Of Folic Acid And Vitamin B 12 , Alone and in Combination on Cognitive Function and inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-Blind Experimental Design.
CONCLUSIONS: The combination of oral folic acid plus vitamin B 12 in MCI elderly for six months can significantly improve cognitive performance and reduce the levels of inflammatory cytokines in human peripheral blood. The combination of folic acid and vitamin B 12 was significantly superior to either folic acid or vitamin B 12 alone. PMID: 31345146 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - July 25, 2019 Category: Neurology Authors: Ma F, Zhou X, Li Q, Zhao J, Song A, An P, Du Y, Xu W, Huang G Tags: Curr Alzheimer Res Source Type: research

Long non-coding RNA MALAT1 Inhibits Neuron Apoptosis and Neuroinflammation while Stimulates Neurite Outgrowth and its Correlation with MiR-125b Mediated PTGS2, CDK5 and FOXQ1 in Alzheimer's Disease.
CONCLUSION: Lnc-MALAT1 might be interacted with miR-125b to inhibit neuron apoptosis and inflammation while promote neurite outgrowth in AD. PMID: 31345147 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - July 25, 2019 Category: Neurology Authors: Ma P, Li Y, Zhang W, Fang F, Sun J, Liu M, Li K, Dong L Tags: Curr Alzheimer Res Source Type: research

The CSF p-tau181/A β42 Ratio Offers a Good Accuracy "in Vivo" in the Differential Diagnosis of Alzheimer's Dementia.
CONCLUSIONS: The p-tau181/Aβ42 ratio alone might reliably detect AD pathology in heterogeneous samples of patients suffering from different types of dementia. It might constitute a simple, cost- effective and reproducible in vivo proxy of AD suitable to be adopted worldwide not only in daily clinical practice but also in future experimental trials, to avoid enrolment of misdiagnosed AD patients. PMID: 31345148 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - July 25, 2019 Category: Neurology Authors: Santangelo R, Dell Edera A, Sala A, Cecchetti G, Masserini F, Caso F, Pinto P, Leocani L, Falautano M, Passerini G, Martinelli V, Comi G, Perani D, Magnani G Tags: Curr Alzheimer Res Source Type: research

Dance for People with Alzheimer's Disease: A mini-Review.
CONCLUSION: Most of studies implementing dance as part of the therapeutic treatment has shown to improve or slow the worsening in the quality of life of patients with Alzheimer's disease and their caregivers. Future research focused on these patients should use a more exhaustive methodology and make a more detailed description of this kind of interventions. PMID: 31345149 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - July 25, 2019 Category: Neurology Authors: Ruiz-Muelle A Tags: Curr Alzheimer Res Source Type: research

#10 High contrast and resolution labeling of amyloid plaques in tissue sections from APP-PS1 mice and humans with Alzheimer's Disease with the zinc chelator HQ-O: Practical and theoretical considerations.
CONCLUSION: Zinc is intimately bound to all amyloid plaques, which was demonstrated by its histological localization using a novel fluorescent zinc chelator, HQ-O. Additionally, the tracer is also capable of labeling intravascular leucocytes due to their high zinc content. PMID: 31345150 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - July 25, 2019 Category: Neurology Authors: Schmued L, Raymick J Tags: Curr Alzheimer Res Source Type: research

Social Network Analysis of Dementia Wards in Psychiatric Hospitals to Explore the Advancement of Personhood in Patients with Alzheimer's Disease.
CONCLUSION: All professional roles were deemed to promote PWA personhood in dementia wards, although some limitation exists according to the context of the assessment. PMID: 31195945 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - June 12, 2019 Category: Neurology Authors: Lazzari C, Kotera Y, Thomas H Tags: Curr Alzheimer Res Source Type: research

Heterogeneity in cost-effectiveness analysis of vaccination for mild and moderate Alzheimer's disease.
CONCLUSION: There were considerable heterogeneities observed in the CEA of vaccination for AD. As with the development of personalized medicine, the CEA results assessed by health decision-maker should not only be considered by population-average level but also specific sub-group levels. PMID: 31195946 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - June 12, 2019 Category: Neurology Authors: Lin CH, Fann JC, Chen SL, Chen HH, Yang KC Tags: Curr Alzheimer Res Source Type: research

Lessons from Alzheimer's Disease (AD) Clinical Trials: Instead of "A-Drug", AD-D prevention to Avert AD.
Lessons from Alzheimer's Disease (AD) Clinical Trials: Instead of "A-Drug", AD-D prevention to Avert AD. Curr Alzheimer Res. 2019;16(4):279-280 Authors: Lahiri DK Abstract PMID: 31104627 [PubMed - in process] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - May 22, 2019 Category: Neurology Authors: Lahiri DK Tags: Curr Alzheimer Res Source Type: research