New Approaches to Develop Drug Treatment for Alzheimer's Disease: Targeting Calcium Dysregulation.
PMID: 32623998 [PubMed - in process] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - July 8, 2020 Category: Neurology Authors: Wei H Tags: Curr Alzheimer Res Source Type: research

Accuracy of Telephone-Based Cognitive Screening Tests: Systematic Re-view and Meta-Analysis.
Abstract BACKGROUND: Telephone-based cognitive assessments may be preferable to in-person testing in terms of test burden, economic and opportunity cost. OBJECTIVE: We sought to determine the accuracy of telephone-based screening for the identification of dementia or mild cognitive impairment (MCI). METHODS: Five multidisciplinary databases were searched. Two researchers independently screened articles and extracted data. Eligible studies compared any multi-domain telephone-based assessment of cognition to the face-to-face diagnostic evaluation. Where data allowed, we pooled test accuracy metrics using t...
Source: Current Alzheimer Research - June 26, 2020 Category: Neurology Authors: Elliott E, Green C, Llewellyn DJ, Quinn TJ Tags: Curr Alzheimer Res Source Type: research

The Relationship between Social Cognition and Executive Functions in Alzheimer's Disease: A Systematic Review.
CONCLUSION: SC impairment is associated with disease progression, mainly because of the decline in EF. Studies on SC components are unequal, contributing to a frequent generalization of Theory of Mind results, and often hampering the investigation of other components, mainly empathy. More precise knowledge about SC functioning in AD may contribute to a better understanding of the behavioral changes and interpersonal interactions. PMID: 32589558 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - June 26, 2020 Category: Neurology Authors: Dos Santos TTBA, de Carvalho RLS, Nogueira M, Baptista MAT, Kimura N, Lacerda IB, Dourado MCN Tags: Curr Alzheimer Res Source Type: research

Identification of a pathogenic PSEN1 mutation associated with early-onset Alzheimer's disease.
CONCLUSION: Together, the clinical characteristics and the effect of the mutation would facilitate our understanding of PSEN1 in AD pathogenesis for the disease diagnosis and treatment. Future in vivo study is needed to evaluate the role of PSEN1 p.Ala285Val mutation in AD disease progression. PMID: 32589559 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - June 26, 2020 Category: Neurology Authors: Giau VV, Pyun JM, Bagyinszky E, An SSA, Kim SY Tags: Curr Alzheimer Res Source Type: research

Presenilin 1 and APP Gene Mutations in Early-Onset AD Families from a Southeast Region of China.
CONCLUSION: The variant p. S290C (c.869-2>G) in PSEN1 in the Chinese EOAD family revealed different clinical phenotypes when compared with that of Europeans. PMID: 32579498 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - June 24, 2020 Category: Neurology Authors: Zhou J, Chen Y, Meng F, Zhang K, Liu X, Peng G Tags: Curr Alzheimer Res Source Type: research

Risk Reduction and Prevention of Alzheimer's Disease: Biological Mechanisms of Diet.
Abstract Alzheimer's disease (AD) incidence is increasing and with no disease modifying agents available, preventative measures through lifestyle factors are being investigated. Combined with the prevention of AD risk factors such as heart disease, diabetes, and with more recent evidence, microbiome dysfunction, there is a substantial foundation for diet as a modifiable risk factor and preventative measure for AD. Recent evidence suggests AD associated pathologies, such as oxidative stress and inflammation, can be modulated by the lipids, vitamins, and polyphenols obtained through nutritional intake. Furthermore, ...
Source: Current Alzheimer Research - June 24, 2020 Category: Neurology Authors: McGurran H, Glenn J, Madero E, Bott N Tags: Curr Alzheimer Res Source Type: research

Melatonin Prevents Neddylation Dysfunction in A β42-exposed SH-SY5Y Neuroblastoma Cells by Regulating the Amyloid Precursor ProteinBinding Protein 1 Pathway.
CONCLUSION: These findings indicate that melatonin regulates the interplay of molecular signaling associated with the APPBP1 pathway and might preclude the pathogenic mechanisms occurring during disease development, thus providing a propitious therapeutic strategy for preventing AD. PMID: 32579500 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - June 24, 2020 Category: Neurology Authors: Shukla M, Chinchalongporn V, Govitrapong P Tags: Curr Alzheimer Res Source Type: research

Neuroimaging Outcomes in Studies of Cognitive Training in Mild Cognitive Impairment and Early Alzheimer's Disease: A Systematic Review.
CONCLUSIONS: CT resulted in variable functional and structural changes in dementia, and conclusions are limited by heterogeneity and study quality. Larger, more robust studies are required to correlate these findings with clinical benefits from CT. PMID: 32579501 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - June 24, 2020 Category: Neurology Authors: Beishon L, Intharakham K, Swienton D, Panerai RB, Robinson TG, Haunton VJ Tags: Curr Alzheimer Res Source Type: research

Evaluation and Prediction of Early Alzheimer's Disease Using a Machine Learning-based Optimized Combination-Feature Set on Gray Matter Volume and Quantitative Susceptibility Mapping.
CONCLUSION: The purposed OCF based ML approach with GMV and QSM was shown the effective performance of the subject group classification and prediction for aMCI stage. Therefore, it can be used as personalized analysis or diagnostic aid program for diagnosis. PMID: 32579502 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - June 24, 2020 Category: Neurology Authors: Kim HG, Park S, Rhee HY, Lee KM, Ryu CW, Lee SY, Kim EJ, Wang Y, Jahng GH Tags: Curr Alzheimer Res Source Type: research

Reversal of calcium dysregulation as potential approach for treating Alzheimer's Disease.
Abstract Despite decades of research and effort, there is still no effective disease-modifying treatment for Alzheimer's Disease (AD). Most of the recent AD clinical trials were targeting amyloid pathway, but all these trials failed. Although amyloid pathology is a hallmark and defining feature of AD, targeting the amyloid pathway has been very challenging due to low efficacy and serious side effects. Alternative approaches or mechanisms for our understanding of the major cause of memory loss in AD need to be considered as potential therapeutic targets. Increasing studies suggest that Ca2+ dysregulation in AD play...
Source: Current Alzheimer Research - May 28, 2020 Category: Neurology Authors: Popugaeva E, Chernyuk D, Bezprozvanny I Tags: Curr Alzheimer Res Source Type: research

Diversity of Molecular Factors in Alzheimer's Disease.
PMID: 32442077 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - May 24, 2020 Category: Neurology Authors: Dorszewska J, Lahiri DK Tags: Curr Alzheimer Res Source Type: research

Associations of Plasma BACE1 level and BACE1 C786G Gene Polymorphism with Cognitive Functions in Patients with type 2 Diabetes: a Crosssectional study.
Abstract BACKGROUND: β-Site APP-cleaving enzyme 1 (BACE1) is a key enzyme involved in the pathophysiology of Type 2 diabetes mellitus (T2DM) and mild cognitive impairment (MCI). We aimed to investigate the potential associations of plasma BACE1 levels and BACE1 gene polymorphism with different cognitive performances in T2DM patients with MCI. METHODS: The recruited 186 T2DM subjects were divided into 92 MCI group and 94 healthy-cognition controls, according to the Montreal Cognitive Assessment (MoCA) scores. Sociodemographic characteristics, clinical parameters and neuropsychological tests were assessed....
Source: Current Alzheimer Research - May 22, 2020 Category: Neurology Authors: Tian S, Huang R, Guo D, Lin H, Wang J, An K, Wang S Tags: Curr Alzheimer Res Source Type: research

Approaches To Optimizing Dantrolene Neuroprotection For The Treatment Of Alzheimer's Disease.
Abstract Alzheimer's Disease (AD), a neurodegenerative disorder with high incidence and mortality, is leading its way to the top of the list of the deadliest diseases [1], without an effective disease-modifying drug. Ca2+ dysregulation, specifically abnormal release of Ca2+ by over activated ryanodine receptor (RyR), has been increasingly considered as an alternative upstream mechanism in AD pathology. Consequently, dantrolene, a RyR antagonist and FDA approved drug to treat malignant hyperthermia and chronic muscle spasms, has been shown to ameliorate memory loss in AD transgenic mice. However, the inefficiency o...
Source: Current Alzheimer Research - May 22, 2020 Category: Neurology Authors: Abou MB, Sun L, Wei H Tags: Curr Alzheimer Res Source Type: research

Physical inactivity is liable to the increased cardiovascular risk and impaired cognitive profile.
A, Lima LM Abstract A sedentary life-style is a significant public health issue. It increases the incidence of type-2 diabetes mellitus (DM2) and systemic arterial hypertension (SAH), which in turn may impair physical and mental health. In fact, disrupted glucose metabolism is one of the characteristics of Alzheimer's dementia, and it is often dubbed as type-3 diabetes. The purpose of this crosssectional study was to assess the level of activity, body composition, cardio-vascular risk and cognitive profile of patients with DM2 and/or SAH. Various parameters were evaluated, such as anthropo-metric variables, pedo-...
Source: Current Alzheimer Research - May 22, 2020 Category: Neurology Authors: Teixeira RB, Dos Santos Amorim PR, Marins JCB, de Lucas Xavier Martins Y, de Souza Magalhães Marques S, Aguiar VPR, Palotás A, Lima LM Tags: Curr Alzheimer Res Source Type: research

Dangerous Liaisons: Tau Interaction with Muscarinic Receptors.
Abstract The molecular processes underlying neurodegenerative diseases (such as Alzheimer's Disease - AD) remain poorly understood. There is also an imperative need for disease-modifying therapies in AD since the present treatments, acetylcholinesterase inhibitors and NMDA antagonists, do not halt its progression. AD and other dementias present unique pathological features such as that of microtubule associated protein tau metabolic regulation. Tau has numerous binding partners, including signaling molecules, cytoskeletal elements and lipids, which suggests that it is a multifunctional protein. AD has also been as...
Source: Current Alzheimer Research - April 24, 2020 Category: Neurology Authors: Wysocka A, Palasz E, Steczkowska M, Niewiadomska G Tags: Curr Alzheimer Res Source Type: research

Anticholinesterase and Antioxidant Activities of Natural Abietane Diterpenoids with Molecular Docking Studies.
CONCLUSION: Abietane diterpenoids are promising molecules for the treatment of mild-moderate AD. PMID: 32329687 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - April 24, 2020 Category: Neurology Authors: Topçu G, Akdemir A, Kolak U, Öztürk M, Boğa M, Bahadori F, Çakmar SDH Tags: Curr Alzheimer Res Source Type: research

L1CAM Beneficially Inhibits Histone Deacetylase 2 Expression under Conditions of Alzheimer's Disease.
CONCLUSION: Our results suggest that some functionally interdependent activities of L1 and HDAC2 contribute to ameliorating the phenotype of AD by GR1 dephosphorylation, which leads to reduced HDAC2 expression. The combined findings encourage further investigations on the beneficial effects of L1 in the treatment of AD. PMID: 32321402 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - April 22, 2020 Category: Neurology Authors: Hu C, Hu J, Meng X, Zhang H, Shen H, Huang P, Schachner M, Zhao W Tags: Curr Alzheimer Res Source Type: research

Genetic Editing and Pharmacogenetics in Current And Future Therapy Of Neurocognitive Disorders.
In conclusion, the pharmacogenetic studies on dementia diseases may improve the efficacy of pharmacotherapy in some patients with beneficial genetic variants, at the same time, identifying the carriers of unfavorable alleles, the potential group of novel approaches to the treatment and prevention of dementia. PMID: 32321403 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - April 22, 2020 Category: Neurology Authors: Prendecki M, Kowalska M, Toton E, Kozubski W Tags: Curr Alzheimer Res Source Type: research

There is no Failure, Only Discovery-the Year Ahead for CARving New Paths.
PMID: 32209035 [PubMed - in process] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 28, 2020 Category: Neurology Authors: Lahiri DK Tags: Curr Alzheimer Res Source Type: research

Dehydroepiandrosterone (DHEA) and its Sulphate (DHEAS) in Alzheimer's Disease.
CONCLUSION: Despite mixed results, the findings of various preclinical studies are generally supportive of the involvement of DHEA and DHEAS in the pathophysiology of Alzheimer's disease, showing some promise for potential benefits of these neurosteroids in the prevention and treatment. However, so far small clinical trials brought little evidence to support their therapy in AD. Therefore, large-scale human studies are needed to elucidate the specific effects of DHEA and DHEAS and their mechanisms of action, prior to their applications in clinical practice. PMID: 32183671 [PubMed - as supplied by publisher] (Source: C...
Source: Current Alzheimer Research - March 16, 2020 Category: Neurology Authors: Strac DS, Konjevod M, Perkovic MN, Tudor L, Erjavec GN, Pivac N Tags: Curr Alzheimer Res Source Type: research

The Effects of Exposure to Recent Autobiographical Events on Declarative Memory in Amnestic Mild Cognitive Impairment: A preliminary pilot study.
CONCLUSION: The present study provides preliminary evidence that aMCI patients may benefit from a cognitive intervention program based on re-experiencing recent autobiographical events. However, future studies incorporating a control group will be needed to confirm these preliminary findings. PMID: 32183672 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 16, 2020 Category: Neurology Authors: Gelonch O, Cano N, Vancells M, Bolaños M, Farràs-Permanyer L, Garolera M Tags: Curr Alzheimer Res Source Type: research

Joint Effect of ABCA7 rs4147929 and Body Mass Index on Progression from Mild Cognitive Impairment to Alzheimer's Disease: the Shanghai Aging Study.
CONCLUSION: ABCA7 rs4147929 and BMI jointly affect MCI-AD progression. MCI participants with the rs4147929 risk genotype may benefit from maintaining an overweight BMI level with regard to their risk for incident AD. PMID: 32183673 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 16, 2020 Category: Neurology Authors: Xi J, Ding D, Zhao Q, Liang X, Zheng L, Guo Q, Hong Z, Fu H, Xu J, Xiao Q Tags: Curr Alzheimer Res Source Type: research

Detection of Mild Cognitive Impairment Based on Virtual Reality: A Scoping Review.
CONCLUSION: VR applications are promising in the detection of MCI, but further research is needed for clinical use. PMID: 32183674 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 16, 2020 Category: Neurology Authors: Wang S, Yin H, Li G, Jia Y, Leng M, Meng Q, Wang C, Chen L Tags: Curr Alzheimer Res Source Type: research

Association between Anemia and Dementia-A Nationwide, Population-Based Cohort Study in Taiwan.
Abstract BACKGROUND: In addition to the traditional risk predictors, whether anemia is an early biomarker of dementia, needs to be confirmed. OBJECTIVE: This population-based cohort study aimed to investigate the dementia risk in patients with newly diagnosed anemia using data from the Taiwan National Health Insurance Research Database. METHODS: All newly diagnosed anemia patients (n = 26,343) with no history of stroke hospitalization, central nervous disease other than dementia, psychiatric disorders, traumatic brain injury, major operations, or blood loss diseases, were enrolled. A group of non-anemic ...
Source: Current Alzheimer Research - March 16, 2020 Category: Neurology Authors: Hong CT, Hsieh YC, Liu HY, Chiou HY, Chien LN Tags: Curr Alzheimer Res Source Type: research

Association between ALDH2 Gene Polymorphism and Late-onset Alzheimer Disease: An Up-to-date Meta-analysis.
CONCLUSIONS: This study comprehends only five existing case-control studies, and the result is negative. The positive trend might appear when the sample size is enlarged. In the future, more large-scale casecontrol or cohort studies should be done to enhance the association between ALDH2 polymorphism and AD or other neurodegenerative diseases. PMID: 32183676 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 16, 2020 Category: Neurology Authors: Liu H, Ge W, Chen W, Kong X, Jian W, Wang A Tags: Curr Alzheimer Res Source Type: research

Tactile Angle Discrimination Decreases due to Subjective Cognitive Decline in Alzheimer's Disease.
CONCLUSION: These findings emphasize the importance of tactile working memory dysfunction in explaining the cognitive decline in angle discrimination that occurs in SCD to AD patients and offer further insight into the very early detection of subjects with AD. PMID: 32148194 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 8, 2020 Category: Neurology Authors: Zhang Z, Chen G, Zhang J, Yan T, Go R, Fukuyama H, Wu J, Han Y, Li C Tags: Curr Alzheimer Res Source Type: research

Intracranial Atherosclerotic Stenosis is Associated With the Cognitive Decline in Patients With NondisablingIschemic Stroke: a Cross-sectional Study of Post-stroke Cognitive Impairment.
Abstract BACKGROUND: Intracranial atherosclerotic stenosis (ICAS) is an important risk factor for cognitive impairment. However, it is unclear whether patients with ICAS are more likely to develop cognitive impairment after an acute, non-disabling ischemic stroke (minor stroke). OBJECTIVE: We aimed to investigate the association between ICAS and post-stroke cognitive impairment. METHODS: In this cross-sectional study, patients with acute, non-disabling ischemic stroke underwent two cognitive tests and imaging evaluation for ICAS, within two weeks after the stroke. To determine the association between ICA...
Source: Current Alzheimer Research - March 3, 2020 Category: Neurology Authors: Gong L, Wang H, Dong Q, Zhu X, Zheng X, Gu Y, Cai W, Zhao YX, Liu X Tags: Curr Alzheimer Res Source Type: research

Learning from the Past: a Review of Clinical Trials Targeting Amyloid, Tau and Neuroinflammation in Alzheimer's Disease.
er BB Abstract Alzheimer's disease (AD) is the most common neurodegenerative disease and cause of dementia. Characterized by amyloid plaques and neurofibrillary tangles of hyperphosphorylated Tau, AD pathology has been intensively studied during the last century. After a long series of failed trials of drugs targeting amyloid or Tau deposits, currently hope lies in the positive results of one Phase III trial, highly debated, and on other ongoing trials. In parallel, some approaches target neuroinflammation, another central feature of AD. Therapeutic strategies are initially evaluated on animal models, in which the...
Source: Current Alzheimer Research - March 3, 2020 Category: Neurology Authors: Ceyzériat K, Zilli T, Millet P, Frisoni GB, Garibotto V, Tournier BB Tags: Curr Alzheimer Res Source Type: research

MRI Radiomics Classification and Prediction in Alzheimer's Disease and Mild Cognitive Impairment: A Review.
CONCLUSION: Although radiomics analysis are already applied to AD and MCI diagnosis and classification, there still is a long way to go from these computer-aided diagnostic methods to the clinical application. PMID: 32124697 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 2, 2020 Category: Neurology Authors: Feng Q, Ding Z Tags: Curr Alzheimer Res Source Type: research

Mechanistic Modeling of Soluble A β Dynamics and Target Engagement in the Brain by Anti-Aβ mAbs in Alzheimer's Disease.
CONCLUSION: This model is useful for comparing target engagement profiles of different anti-Aβ therapies and demonstrates that 60 mg/kg crenezumab yields a significant increase in Aβ engagement compared with lower doses of solanezumab, supporting the selection of 60 mg/kg crenezumab for phase 3 studies. The model also provides evidence that delivery of sufficient quantities of mAb to brain interstitial fluid is a limiting step with respect to the magnitude of soluble Aβ oligomer neutralization. PMID: 32116192 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 2, 2020 Category: Neurology Authors: Ferl GZ, Fuji RN, Atwal JK, Sun T, Ramanujan S, Quartino AL Tags: Curr Alzheimer Res Source Type: research

Targeting Post-Translational Remodeling of Ryanodine Receptor: a New Track for Alzheimer's Disease Therapy?
We describe RyR macromolecular complex structure and discuss the molecular mechanisms and signaling cascade underlying neuronal RyR2 remodeling in AD. We provide evidences linking RyR2 dysfunction with β-adrenergic signaling cascade that is altered in AD. RyR2 remodeling in AD leads to histopathological lesions, alteration of synaptic plasticity, learning and memory deficits. Targeting RyR macromolecular complex remodeling should be considered as a new therapeutic window to treat/or prevent AD setting and/or progression. PMID: 32096743 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - February 24, 2020 Category: Neurology Authors: Chami M, Checler F Tags: Curr Alzheimer Res Source Type: research

Mechanisms of Anticholinesterase Interference with Tau Aggregation Inhibitor Activity in a Tau-Transgenic Mouse Model.
CONCLUSION: The interference with the pharmacological activity of LMTM by a cholinesterase inhibitor can be reproduced in a tau transgenic mouse model and, to a lesser extent, in wild-type mice. Long-term pretreatment with a symptomatic drug alters a broad range of brain responses to LMTM across different transmitter systems and cellular compartments at multiple levels of brain function. There is, therefore, no single locus for the negative interaction. Rather, the chronic neuronal activation induced by reducing cholinesterase function produces compensatory homeostatic downregulation in multiple neuronal systems. This redu...
Source: Current Alzheimer Research - February 24, 2020 Category: Neurology Authors: Riedel G, Klein J, Niewiadomska G, Kondak C, Schwab K, Lauer D, Magbagbeolu M, Steczkowska M, Zadrozny M, Wydrych M, Cranston A, Melis V, Santos RX, Theuring F, Harrington CR, Wischik CM Tags: Curr Alzheimer Res Source Type: research

Genetic variants and oxidative stress in Alzheimer's disease.
Abstract In an aging society, the number of people suffering from Alzheimer's disease (AD) is still growing. Currently, intensive research is being carried out on the pathogenesis of AD. The results of these studies indicated that oxidative stress plays an important role in the onset and development of this disease. Moreover, in AD, oxidative stress is generated by both genetic and biochemical factors as well as the functioning of the systems responsible for their formation and removal. The genetic factors associated with the regulation of the redox system include TOMM40, APOE, LPR, MAPT, APP, PSEN1 and PSEN2 gene...
Source: Current Alzheimer Research - February 24, 2020 Category: Neurology Authors: Kowalska M, Wize K, Prendecki M, Lianeri M, Kozubski W, Dorszewska J Tags: Curr Alzheimer Res Source Type: research

Synaptic Correlates of Anterograde Amnesia and Intact Retrograde Memory in a Mouse Model of Alzheimer's Disease.
CONCLUSION: Our data suggest that in the early AD stages synaptic plasticity of CA1 synapses, crucial to form new memories, is lost, while plasticity of aCC synapses is intact and contributes to the persistence of long-term memories. PMID: 32091333 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - February 24, 2020 Category: Neurology Authors: Rizzello E, Middei S, Marchetti C Tags: Curr Alzheimer Res Source Type: research

A Protective Role of Translocator Protein in Alzheimer's Disease Brain.
Abstract Translocator protein (18 kDa) (TSPO) is a mitochondrial protein that locates cytosol cholesterol to mitochondrial membranes to begin the synthesis of steroids including neurotrophic neurosteroids. TSPO is abundantly present in glial cells that support neurons and respond to neuroinflammation. Located at the outer membrane of mitochondria, TSPO regulates the opening of mitochondrial permeability transition pore (mPTP) that controls the entry of molecules necessary for mitochondrial function. TSPO is linked to neurodegenerative Alzheimer's disease (AD) such that TSPO is upregulated in the brain of AD patien...
Source: Current Alzheimer Research - February 16, 2020 Category: Neurology Authors: Jung ME Tags: Curr Alzheimer Res Source Type: research

Depression in Dementia or Dementia in Depression? Systematic Review of Studies and Hypotheses.
ski J Abstract The majority of research works to date suggest that major depressive disorder (MDD) is a risk factor for dementia and may predispose to cognitive decline in both early and late onset variants. The presence of depression may not, however, reflect the cause, rather, an effect: it may be a response to cognitive impairment or alters the threshold at which cognitive impairment might manifest or be detected. An alternative hypothesis is that depression may be part of a prodrome to Alzheimer's disease (AD), suggesting a neurobiological association rather than one of psychological response alone. Genetic po...
Source: Current Alzheimer Research - February 16, 2020 Category: Neurology Authors: Brzezińska A, Bourke J, Rivera-Hernández R, Tsolaki M, Woźniak J, Kaźmierski J Tags: Curr Alzheimer Res Source Type: research

Elevated Testosterone Level and Urine Scent Marking in Male 5xFAD Alzheimer Model Mice.
CONCLUSION: We suggest that overexpression of A®PP which mostly is used to mimic AD in model mice also affects male sexual behavior as assessed by the urine scent marking (USM) test. The elevated testosterone levels additionally might have an impact on central nervous system androgen receptors and also have to be considered when assessing learning and memory capabilities. PMID: 32065104 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - February 16, 2020 Category: Neurology Authors: Gadomsky L, Santos Guilherme MD, Winkler J, der Kooij MV, Hartmann T, Grimm M, Endres K Tags: Curr Alzheimer Res Source Type: research

Microglia in Alzheimer's Disease.
tzki JCM Abstract Alzheimer's Disease (AD) is the most frequent neurodegenerative disorder. Although proteinaceous aggregates of extracellular amyloid-β (Aβ) and intracellular hyperphosphorylated microtubuleassociated tau have long been identified as characteristic neuropathological hallmarks of AD, a diseasemodifying therapy against these targets has not been successful. An emerging concept is that microglia, the innate immune cells of the brain, are major players in AD pathogenesis. Microglia are long-lived tissue-resident professional phagocytes that survey and rapidly respond to changes in their micr...
Source: Current Alzheimer Research - February 12, 2020 Category: Neurology Authors: Süß P, Schlachetzki JCM Tags: Curr Alzheimer Res Source Type: research

Amyloid β-induced Mesenteric Inflammation in an Alzheimer's Disease Transgenic Mouse Model.
CONCLUSION: The present study showed that pro-inflammatory mDC and T cells were induced in MLNs and PPs of 5×FAD mice. PMID: 32048974 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - February 12, 2020 Category: Neurology Authors: Ano Y, Ikado K, Uchida K, Nakayama H Tags: Curr Alzheimer Res Source Type: research

Automatic Detection of Cognitive Impairments through Acoustic Analysis of Speech.
CONCLUSION: Our machine learning model revealed that individuals' acoustic features can be employed to discriminate between healthy controls and those with mild cognitive impairment with global cognitive impairment, which is a more severe form of cognitive impairment compared with mild cognitive impairment or global cognitive impairment alone. It is suggested that language impairment increases in severity with cognitive impairment. PMID: 32053074 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - February 12, 2020 Category: Neurology Authors: Nagumo R, Zhang Y, Ogawa Y, Hosokawa M, Abe K, Ukeda T, Sumi S, Kurita S, Nakakubo S, Lee S, Doi T, Shimada H Tags: Curr Alzheimer Res Source Type: research

Fluoxetine Protects against Dendritic Spine Loss in Middle-aged APPswe/PSEN1dE9 Double Transgenic Alzheimer's Disease Mice.
Abstract Studies have suggested that cognitive impairment in Alzheimer's disease (AD) is associated with dendritic spine loss, especially in the hippocampus. Fluoxetine (FLX) has been shown to improve cognition in the early stage of AD and to be associated with diminishing synapse degeneration in the hippocampus. However, little is known about whether FLX affects the pathogenesis of AD in the middle- to-late stage and whether its effects are correlated with the amelioration of hippocampal dendritic dysfunction. Previously, it has been observed that FLX improves the spatial learning ability of middleaged APP/PS1 mi...
Source: Current Alzheimer Research - February 12, 2020 Category: Neurology Authors: Ma J, Gao Y, Tang W, Huang W, Tang Y Tags: Curr Alzheimer Res Source Type: research

Disrupted Time-Dependent and Functional Connectivity Brain Network in Alzheimer's Disease: A Resting-State fMRI Study Based on Visibility Graph.
CONCLUSION: These results would be helpful in revealing the underlying pathological mechanism of the disease. PMID: 32053076 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - February 12, 2020 Category: Neurology Authors: Gao Z, Feng Y, Ma C, Ma K, Cai Q Tags: Curr Alzheimer Res Source Type: research

Association of Neutrophil-Lymphocyte Ratio with Mild Cognitive Impairment in Elderly Chinese Adults: a Case-control Study.
Abstract BACKGROUND/AIM: Inflammation plays a significant role in the pathophysiology of cognitive impairment in previous studies. Neutrophil-lymphocyte ratio (NLR) is a reliable measure of systemic inflammation. The aim of this study was to investigate the association between NLR and mild cognitive impairment (MCI), and further to explore the diagnostic potential of the inflammatory markers NLR for the diagnosis of MCI in elderly Chinese individuals. METHODS: 186 MCI subjects and 153 subjects with normal cognitive function were evaluated consecutively in this study. Neutrophil (NEUT) count and lymphocyte (LY...
Source: Current Alzheimer Research - January 2, 2020 Category: Neurology Authors: An P, Zhou X, Du Y, Zhao J, Song A, Liu H, Ma F, Huang G Tags: Curr Alzheimer Res Source Type: research

Cornel iridoid glycoside suppresses tau hyperphosphorylation and aggregation in a mouse model of tauopathy through increasing activity of PP2A.
CONCLUSION: CIG might have the potential to treat tauopathy such as AD via activating PP2A. PMID: 31902362 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - January 2, 2020 Category: Neurology Authors: Ma D, Luo Y, Huang R, Zhao Z, Wang Q, Li L, Zhang L Tags: Curr Alzheimer Res Source Type: research

The Impact of Angiotensin-Converting Enzyme Gene on Behavioral and Psychological Symptoms of Dementia in Alzheimer's Disease.
CONCLUSION: ACE gene is involved in aggravating BPSD among AD patients. PMID: 31902363 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - January 2, 2020 Category: Neurology Authors: Hsieh SW, Liu MW, Huang LC, Wu MN, Yang YH Tags: Curr Alzheimer Res Source Type: research

Midlife Modifiable Risk Factors for Dementia: A Systematic Review and Meta-analysis of 34 Prospective Cohort Studies.
CONCLUSIONS: Middle-aged people with obesity, diabetes, hypertension, or hypercholesterolemia, and current smokers in midlife are at higher risk of developing dementia later in life. PMID: 31902364 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - January 2, 2020 Category: Neurology Authors: Li XY, Zhang M, Xu W, Li JQ, Cao XP, Yu JT, Tan L Tags: Curr Alzheimer Res Source Type: research

Long-Term Exposure to Ambient Hydrocarbons Increases Dementia Risk in People Aged 50 years and above in Taiwan.
Abstract BACKGROUND: Alzheimer's disease, the most common cause of dementia among the elderly, is a progressive and irreversible neurodegenerative disease. Exposure to air pollutants is known to have adverse effects on human health, however, little is known about hydrocarbons in the air that can trigger a dementia event. OBJECTIVE: We aimed to investigate whether long-term exposure to airborne hydrocarbons increases the risk of developing dementia. METHOD: The present cohort study included 178,085 people aged 50 years and older in Taiwan. Cox proportional hazards regression analysis was used to fit the m...
Source: Current Alzheimer Research - January 2, 2020 Category: Neurology Authors: Zhang HW, Kok VC, Chuang SC, Tseng CH, Lin CT, Li TC, Sung FC, Wen CP, Hsiung CA, Hsu CY Tags: Curr Alzheimer Res Source Type: research

Levosimendan Prevents Memory Impairment Induced by Diabetes in Rats: Role of Oxidative Stress.
Abstract BACKGROUND: Levosimendan is a calcium sensitizer and phosphodiesterase inhibitor that has potent antioxidant and anti-inflammatory activities. OBJECTIVES: The aim of the current study is to investigate the potential protective effect of levosimendan on learning and memory impairment induced by diabetes. METHODS: Adult Wister rats were randomly divided into four groups (n=15 rats/group): control, levosimendan, streptozotocin (STZ) induced diabetes, and levosimendan-STZ diabetes. Upon confirmation of the success of the STZ diabetic model, intraperitoneal levosimendan (100µg/kg/week) was admi...
Source: Current Alzheimer Research - January 2, 2020 Category: Neurology Authors: Rababa'h AM, Alzoubi KH, Baydoun S, Khabour OF Tags: Curr Alzheimer Res Source Type: research

Effect of different A β Aggregates as Antigen on the Measure of Naturally Occurring Autoantibodies against Amyloid-β40/42 in IVIG.
CONCLUSION: The nAbs-Aβ40/42 content in the same IVIG is significantly different when measured with Aβ40/42 aggregated under different conditions. The nAbs-Aβ40/42 content in IVIG by antigen-dependent measures, like ELISA, is uncertain. PMID: 31894747 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - January 2, 2020 Category: Neurology Authors: Cao H, Du X, Zeng R, Lv Z, Ye S, Jiang P, Wang Z, Ma L, Huang Y, Li C, Zhang R, Liu F Tags: Curr Alzheimer Res Source Type: research

Cost of Treatment and Care for People with Alzheimer 's disease: A Meta-Analysis.
H, Bryan LK Abstract There is now a general attempt in developed countries to implement strategic plans to fight against Alzheimer's disease, for which treatment represents an increasing economic burden for the ageing society. At present, the costs of treatment and care for Alzheimer's disease (AD) patients are not consistently tracked and logged, therefore, the economic burden is calculated based on the records kept by individual countries. The aim of this paper is to conduct a meta-analysis of the available data on the total costs of treatment and care for elderly AD patients with respect to the stage of the dis...
Source: Current Alzheimer Research - January 2, 2020 Category: Neurology Authors: Marešová P, Dolejs J, Mohelska H, Bryan LK Tags: Curr Alzheimer Res Source Type: research