Alterations in Peripheral Metabolites as Key Actors in Alzheimer's Disease
Curr Alzheimer Res. 2023 Aug 25. doi: 10.2174/1567205020666230825091147. Online ahead of print.ABSTRACTGrowing evidence supports that Alzheimer's disease (AD) could be regarded as a metabolic disease, accompanying central and peripheral metabolic disturbance. Nowadays, exploring novel and potentially alternative hallmarks for AD is needed. Peripheral metabolites based on blood and gut may provide new biochemical insights about disease mechanisms. These metabolites can influence brain energy homeostasis, maintain gut mucosal integrity, and regulate the host immune system, which may further play a key role in modulating the ...
Source: Current Alzheimer Research - August 25, 2023 Category: Neurology Authors: Can Sheng Xu Chu Yan He Qingqing Ding Shulei Jia Qiguang Shi Ran Sun Li Song Wenying Du Yuan Liang Nian Chen Yan Yang Xiaoni Wang Source Type: research
Alterations in Peripheral Metabolites as Key Actors in Alzheimer's Disease
Curr Alzheimer Res. 2023 Aug 25. doi: 10.2174/1567205020666230825091147. Online ahead of print.ABSTRACTGrowing evidence supports that Alzheimer's disease (AD) could be regarded as a metabolic disease, accompanying central and peripheral metabolic disturbance. Nowadays, exploring novel and potentially alternative hallmarks for AD is needed. Peripheral metabolites based on blood and gut may provide new biochemical insights about disease mechanisms. These metabolites can influence brain energy homeostasis, maintain gut mucosal integrity, and regulate the host immune system, which may further play a key role in modulating the ...
Source: Current Alzheimer Research - August 25, 2023 Category: Neurology Authors: Can Sheng Xu Chu Yan He Qingqing Ding Shulei Jia Qiguang Shi Ran Sun Li Song Wenying Du Yuan Liang Nian Chen Yan Yang Xiaoni Wang Source Type: research
Integrative Theory of Alzheimer's Disease: Linking Molecular Mechanisms of Neurotoxicity, Beta-amyloid Biomarkers, and the Diagnosis
CONCLUSION: The resulting mathematical model interprets the positive correlation between the density of Aβ deposits and the probability of an AD diagnosis without assuming any cytotoxicity of the aggregated beta-amyloid. To the best of our knowledge, this model is the first to mechanistically explain the negative correlation between the concentration of Aβ42 in the CSF and the probability of an AD diagnosis. Finally, based on the amyloid degradation toxicity hypothesis and the insights provided by mathematical modeling, we propose new pathophysiology-relevant biomarkers to diagnose and predict AD.PMID:37605411 | DOI:10.2...
Source: Current Alzheimer Research - August 22, 2023 Category: Neurology Authors: Yaroslav I Molkov Maria V Zaretskaia Dmitry V Zaretsky Source Type: research
Integrative Theory of Alzheimer's Disease: Linking Molecular Mechanisms of Neurotoxicity, Beta-amyloid Biomarkers, and the Diagnosis
CONCLUSION: The resulting mathematical model interprets the positive correlation between the density of Aβ deposits and the probability of an AD diagnosis without assuming any cytotoxicity of the aggregated beta-amyloid. To the best of our knowledge, this model is the first to mechanistically explain the negative correlation between the concentration of Aβ42 in the CSF and the probability of an AD diagnosis. Finally, based on the amyloid degradation toxicity hypothesis and the insights provided by mathematical modeling, we propose new pathophysiology-relevant biomarkers to diagnose and predict AD.PMID:37605411 | DOI:10.2...
Source: Current Alzheimer Research - August 22, 2023 Category: Neurology Authors: Yaroslav I Molkov Maria V Zaretskaia Dmitry V Zaretsky Source Type: research
Integrative Theory of Alzheimer's Disease: Linking Molecular Mechanisms of Neurotoxicity, Beta-amyloid Biomarkers, and the Diagnosis
CONCLUSION: The resulting mathematical model interprets the positive correlation between the density of Aβ deposits and the probability of an AD diagnosis without assuming any cytotoxicity of the aggregated beta-amyloid. To the best of our knowledge, this model is the first to mechanistically explain the negative correlation between the concentration of Aβ42 in the CSF and the probability of an AD diagnosis. Finally, based on the amyloid degradation toxicity hypothesis and the insights provided by mathematical modeling, we propose new pathophysiology-relevant biomarkers to diagnose and predict AD.PMID:37605411 | DOI:10.2...
Source: Current Alzheimer Research - August 22, 2023 Category: Neurology Authors: Yaroslav I Molkov Maria V Zaretskaia Dmitry V Zaretsky Source Type: research
Multiple Sensory Impairments in Relation to Cognitive Function: Two Nationwide Cross-sectional Studies
CONCLUSION: A larger number of SI was related to worse cognitive function and higher odds of SCC.PMID:37587821 | DOI:10.2174/1567205020666230816090903 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - August 17, 2023 Category: Neurology Authors: Binghan Wang Hui Chen Jie Shen Wansi Zhong Yan Zheng Min Lou Lusha Tong Changzheng Yuan Source Type: research
Predicting Dementia Due to Alzheimer's Disease and Behavioral Variant Frontotemporal Dementia Using Algorithms with the Addenbrooke's Cognitive Examination-Revised Subscores Combined with Sociodemographic Factors
CONCLUSION: The combination of ACE-R scores with sociodemographic data allowed good differentiation between AD and bvFTD in the study sample.PMID:37587822 | DOI:10.2174/1567205020666230816160700 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - August 17, 2023 Category: Neurology Authors: Viviane Amaral-Carvalho Thais Bento Lima-Silva Luciano In ácio Mariano Leonardo Cruz de Souza Henrique Cerqueira Guimar ães Valeria Santoro Bahia Ricardo Nitrini Maira Tonidandel Barbosa M ônica Sanches Yassuda Paulo Caramelli Source Type: research
Multiple Sensory Impairments in Relation to Cognitive Function: Two Nationwide Cross-sectional Studies
CONCLUSION: A larger number of SI was related to worse cognitive function and higher odds of SCC.PMID:37587821 | DOI:10.2174/1567205020666230816090903 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - August 17, 2023 Category: Neurology Authors: Binghan Wang Hui Chen Jie Shen Wansi Zhong Yan Zheng Min Lou Lusha Tong Changzheng Yuan Source Type: research
Predicting Dementia Due to Alzheimer's Disease and Behavioral Variant Frontotemporal Dementia Using Algorithms with the Addenbrooke's Cognitive Examination-Revised Subscores Combined with Sociodemographic Factors
CONCLUSION: The combination of ACE-R scores with sociodemographic data allowed good differentiation between AD and bvFTD in the study sample.PMID:37587822 | DOI:10.2174/1567205020666230816160700 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - August 17, 2023 Category: Neurology Authors: Viviane Amaral-Carvalho Thais Bento Lima-Silva Luciano In ácio Mariano Leonardo Cruz de Souza Henrique Cerqueira Guimar ães Valeria Santoro Bahia Ricardo Nitrini Maira Tonidandel Barbosa M ônica Sanches Yassuda Paulo Caramelli Source Type: research
Multiple Sensory Impairments in Relation to Cognitive Function: Two Nationwide Cross-sectional Studies
CONCLUSION: A larger number of SI was related to worse cognitive function and higher odds of SCC.PMID:37587821 | DOI:10.2174/1567205020666230816090903 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - August 17, 2023 Category: Neurology Authors: Binghan Wang Hui Chen Jie Shen Wansi Zhong Yan Zheng Min Lou Lusha Tong Changzheng Yuan Source Type: research
Predicting Dementia Due to Alzheimer's Disease and Behavioral Variant Frontotemporal Dementia Using Algorithms with the Addenbrooke's Cognitive Examination-Revised Subscores Combined with Sociodemographic Factors
CONCLUSION: The combination of ACE-R scores with sociodemographic data allowed good differentiation between AD and bvFTD in the study sample.PMID:37587822 | DOI:10.2174/1567205020666230816160700 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - August 17, 2023 Category: Neurology Authors: Viviane Amaral-Carvalho Thais Bento Lima-Silva Luciano In ácio Mariano Leonardo Cruz de Souza Henrique Cerqueira Guimar ães Valeria Santoro Bahia Ricardo Nitrini Maira Tonidandel Barbosa M ônica Sanches Yassuda Paulo Caramelli Source Type: research
Multiple Sensory Impairments in Relation to Cognitive Function: Two Nationwide Cross-sectional Studies
CONCLUSION: A larger number of SI was related to worse cognitive function and higher odds of SCC.PMID:37587821 | DOI:10.2174/1567205020666230816090903 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - August 17, 2023 Category: Neurology Authors: Binghan Wang Hui Chen Jie Shen Wansi Zhong Yan Zheng Min Lou Lusha Tong Changzheng Yuan Source Type: research
Predicting Dementia Due to Alzheimer's Disease and Behavioral Variant Frontotemporal Dementia Using Algorithms with the Addenbrooke's Cognitive Examination-Revised Subscores Combined with Sociodemographic Factors
CONCLUSION: The combination of ACE-R scores with sociodemographic data allowed good differentiation between AD and bvFTD in the study sample.PMID:37587822 | DOI:10.2174/1567205020666230816160700 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - August 17, 2023 Category: Neurology Authors: Viviane Amaral-Carvalho Thais Bento Lima-Silva Luciano In ácio Mariano Leonardo Cruz de Souza Henrique Cerqueira Guimar ães Valeria Santoro Bahia Ricardo Nitrini Maira Tonidandel Barbosa M ônica Sanches Yassuda Paulo Caramelli Source Type: research
Neuroprotection of Thioredoxin1 in the brain
Curr Alzheimer Res. 2023 Aug 9. doi: 10.2174/1567205020666230809145041. Online ahead of print.ABSTRACTThioredoxin1 (Trx1) is a ubiquitous antioxidant protein that regulates the cell's redox status. Trx1's thiol redox activity protects neurons from various physiological processes that cause neuronal damage and neurodegeneration, including oxidative stress, apoptosis, and inflammation. Several studies have found that direct or indirect Trx1 regulation has neuroprotective effects in the brain, protecting against, preventing, or delaying neurodegenerative processes or brain traumas. This review focuses on the term neuroprotect...
Source: Current Alzheimer Research - August 10, 2023 Category: Neurology Authors: Roxana Noriega-Navarro Ricardo J Mart ínez-Tapia Juan L Osornio-Hern ández Lucia Landa-Navarro Luis O Xinastle-Castillo Abraham Landa Luz Navarro Source Type: research
Neural Oscillation Disorder in the Hippocampal CA1 Region of Different Alzheimer's Disease Mice
CONCLUSION: This study revealed neural network activity differences in oscillation power and cross-frequency coupling in the early stage of AD, providing a new perspective for developing biomarkers for early AD diagnosis.PMID:37559542 | DOI:10.2174/1567205020666230808122643 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - August 10, 2023 Category: Neurology Authors: Weiming Yuan Weijia Zhi Lizhen Ma Xiangjun Hu Qian Wang Yong Zou Lifeng Wang Source Type: research
