Behavioural Variant Frontotemporal Dementia due to < em > CCNF < /em > Gene Mutation: A Case Report
CONCLUSION: The early clinical manifestations of bvFTD are complex and variable, and the condition is easily misdiagnosed, thus delaying treatment. Therefore, for patients with a high clinical suspicion of FTD, in addition to a detailed understanding of their medical history and family history and improvement of relevant examinations, genetic testing should be performed as early as possible to help confirm the diagnosis. For diseases closely related to genes, genetic testing of other family members should be optimised as much as possible to allow early diagnosis and intervention and guide fertility in the next generation.P...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Feng-Ling You Gao-Fu Xia Jing Cai Source Type: research
Common Neuropsychiatric Symptoms in Alzheimer's Disease, Mild Cognitive Impairment, and Subjective Memory Complaints: A Unified Framework
Curr Alzheimer Res. 2023 Oct 23. doi: 10.2174/0115672050255489231012072014. Online ahead of print.ABSTRACTThe Alzheimer's disease (AD) continuum is a unique spectrum of cognitive impairment that typically involves the stages of subjective memory complaints (SMC), mild cognitive impairment (MCI), and AD dementia. Neuropsychiatric symptoms (NPS), such as apathy, anxiety, stress, and depression, are highly common throughout the AD continuum. However, there is a dearth of research on how these NPS vary across the AD continuum, especially SMC. There is also disagreement on the effects of specific NPS on each stage of the AD con...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Samuel L Warren Eid Abo Hamza Richard Tindle Edwina Reid Paige Whitfield Adam Doumit Ahmed A Moustafa Source Type: research
Early Chronic Stress Induced Changes within the Locus Coeruleus in Sporadic Alzheimer's Disease
Curr Alzheimer Res. 2023;20(5):301-317. doi: 10.2174/1567205020666230811092956.ABSTRACTChronic exposure to stress throughout the lifespan has been the focus of many studies on Alzheimer's disease (AD) because of the similarities between the biological mechanisms involved in chronic stress and the pathophysiology of AD. In fact, the earliest abnormality associated with the disease is the presence of phosphorylated tau protein in locus coeruleus neurons, a brain structure highly responsive to stress and perceived threat. Here, we introduce allostatic load as a useful concept for understanding many of the complex, interacting...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Donn é Minné Jeanine L Marnewick Penelope Engel-Hills Source Type: research
Behavioural Variant Frontotemporal Dementia due to < em > CCNF < /em > Gene Mutation: A Case Report
CONCLUSION: The early clinical manifestations of bvFTD are complex and variable, and the condition is easily misdiagnosed, thus delaying treatment. Therefore, for patients with a high clinical suspicion of FTD, in addition to a detailed understanding of their medical history and family history and improvement of relevant examinations, genetic testing should be performed as early as possible to help confirm the diagnosis. For diseases closely related to genes, genetic testing of other family members should be optimised as much as possible to allow early diagnosis and intervention and guide fertility in the next generation.P...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Feng-Ling You Gao-Fu Xia Jing Cai Source Type: research
Common Neuropsychiatric Symptoms in Alzheimer's Disease, Mild Cognitive Impairment, and Subjective Memory Complaints: A Unified Framework
Curr Alzheimer Res. 2023 Oct 23. doi: 10.2174/0115672050255489231012072014. Online ahead of print.ABSTRACTThe Alzheimer's disease (AD) continuum is a unique spectrum of cognitive impairment that typically involves the stages of subjective memory complaints (SMC), mild cognitive impairment (MCI), and AD dementia. Neuropsychiatric symptoms (NPS), such as apathy, anxiety, stress, and depression, are highly common throughout the AD continuum. However, there is a dearth of research on how these NPS vary across the AD continuum, especially SMC. There is also disagreement on the effects of specific NPS on each stage of the AD con...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Samuel L Warren Eid Abo Hamza Richard Tindle Edwina Reid Paige Whitfield Adam Doumit Ahmed A Moustafa Source Type: research
Early Chronic Stress Induced Changes within the Locus Coeruleus in Sporadic Alzheimer's Disease
Curr Alzheimer Res. 2023;20(5):301-317. doi: 10.2174/1567205020666230811092956.ABSTRACTChronic exposure to stress throughout the lifespan has been the focus of many studies on Alzheimer's disease (AD) because of the similarities between the biological mechanisms involved in chronic stress and the pathophysiology of AD. In fact, the earliest abnormality associated with the disease is the presence of phosphorylated tau protein in locus coeruleus neurons, a brain structure highly responsive to stress and perceived threat. Here, we introduce allostatic load as a useful concept for understanding many of the complex, interacting...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Donn é Minné Jeanine L Marnewick Penelope Engel-Hills Source Type: research
Behavioural Variant Frontotemporal Dementia due to < em > CCNF < /em > Gene Mutation: A Case Report
CONCLUSION: The early clinical manifestations of bvFTD are complex and variable, and the condition is easily misdiagnosed, thus delaying treatment. Therefore, for patients with a high clinical suspicion of FTD, in addition to a detailed understanding of their medical history and family history and improvement of relevant examinations, genetic testing should be performed as early as possible to help confirm the diagnosis. For diseases closely related to genes, genetic testing of other family members should be optimised as much as possible to allow early diagnosis and intervention and guide fertility in the next generation.P...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Feng-Ling You Gao-Fu Xia Jing Cai Source Type: research
Common Neuropsychiatric Symptoms in Alzheimer's Disease, Mild Cognitive Impairment, and Subjective Memory Complaints: A Unified Framework
Curr Alzheimer Res. 2023 Oct 23. doi: 10.2174/0115672050255489231012072014. Online ahead of print.ABSTRACTThe Alzheimer's disease (AD) continuum is a unique spectrum of cognitive impairment that typically involves the stages of subjective memory complaints (SMC), mild cognitive impairment (MCI), and AD dementia. Neuropsychiatric symptoms (NPS), such as apathy, anxiety, stress, and depression, are highly common throughout the AD continuum. However, there is a dearth of research on how these NPS vary across the AD continuum, especially SMC. There is also disagreement on the effects of specific NPS on each stage of the AD con...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Samuel L Warren Eid Abo Hamza Richard Tindle Edwina Reid Paige Whitfield Adam Doumit Ahmed A Moustafa Source Type: research
Early Chronic Stress Induced Changes within the Locus Coeruleus in Sporadic Alzheimer's Disease
Curr Alzheimer Res. 2023;20(5):301-317. doi: 10.2174/1567205020666230811092956.ABSTRACTChronic exposure to stress throughout the lifespan has been the focus of many studies on Alzheimer's disease (AD) because of the similarities between the biological mechanisms involved in chronic stress and the pathophysiology of AD. In fact, the earliest abnormality associated with the disease is the presence of phosphorylated tau protein in locus coeruleus neurons, a brain structure highly responsive to stress and perceived threat. Here, we introduce allostatic load as a useful concept for understanding many of the complex, interacting...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Donn é Minné Jeanine L Marnewick Penelope Engel-Hills Source Type: research
Behavioural Variant Frontotemporal Dementia due to < em > CCNF < /em > Gene Mutation: A Case Report
CONCLUSION: The early clinical manifestations of bvFTD are complex and variable, and the condition is easily misdiagnosed, thus delaying treatment. Therefore, for patients with a high clinical suspicion of FTD, in addition to a detailed understanding of their medical history and family history and improvement of relevant examinations, genetic testing should be performed as early as possible to help confirm the diagnosis. For diseases closely related to genes, genetic testing of other family members should be optimised as much as possible to allow early diagnosis and intervention and guide fertility in the next generation.P...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Feng-Ling You Gao-Fu Xia Jing Cai Source Type: research
Common Neuropsychiatric Symptoms in Alzheimer's Disease, Mild Cognitive Impairment, and Subjective Memory Complaints: A Unified Framework
Curr Alzheimer Res. 2023 Oct 23. doi: 10.2174/0115672050255489231012072014. Online ahead of print.ABSTRACTThe Alzheimer's disease (AD) continuum is a unique spectrum of cognitive impairment that typically involves the stages of subjective memory complaints (SMC), mild cognitive impairment (MCI), and AD dementia. Neuropsychiatric symptoms (NPS), such as apathy, anxiety, stress, and depression, are highly common throughout the AD continuum. However, there is a dearth of research on how these NPS vary across the AD continuum, especially SMC. There is also disagreement on the effects of specific NPS on each stage of the AD con...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Samuel L Warren Eid Abo Hamza Richard Tindle Edwina Reid Paige Whitfield Adam Doumit Ahmed A Moustafa Source Type: research
Early Chronic Stress Induced Changes within the Locus Coeruleus in Sporadic Alzheimer's Disease
Curr Alzheimer Res. 2023;20(5):301-317. doi: 10.2174/1567205020666230811092956.ABSTRACTChronic exposure to stress throughout the lifespan has been the focus of many studies on Alzheimer's disease (AD) because of the similarities between the biological mechanisms involved in chronic stress and the pathophysiology of AD. In fact, the earliest abnormality associated with the disease is the presence of phosphorylated tau protein in locus coeruleus neurons, a brain structure highly responsive to stress and perceived threat. Here, we introduce allostatic load as a useful concept for understanding many of the complex, interacting...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Donn é Minné Jeanine L Marnewick Penelope Engel-Hills Source Type: research
Behavioural Variant Frontotemporal Dementia due to < em > CCNF < /em > Gene Mutation: A Case Report
CONCLUSION: The early clinical manifestations of bvFTD are complex and variable, and the condition is easily misdiagnosed, thus delaying treatment. Therefore, for patients with a high clinical suspicion of FTD, in addition to a detailed understanding of their medical history and family history and improvement of relevant examinations, genetic testing should be performed as early as possible to help confirm the diagnosis. For diseases closely related to genes, genetic testing of other family members should be optimised as much as possible to allow early diagnosis and intervention and guide fertility in the next generation.P...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Feng-Ling You Gao-Fu Xia Jing Cai Source Type: research
Common Neuropsychiatric Symptoms in Alzheimer's Disease, Mild Cognitive Impairment, and Subjective Memory Complaints: A Unified Framework
Curr Alzheimer Res. 2023 Oct 23. doi: 10.2174/0115672050255489231012072014. Online ahead of print.ABSTRACTThe Alzheimer's disease (AD) continuum is a unique spectrum of cognitive impairment that typically involves the stages of subjective memory complaints (SMC), mild cognitive impairment (MCI), and AD dementia. Neuropsychiatric symptoms (NPS), such as apathy, anxiety, stress, and depression, are highly common throughout the AD continuum. However, there is a dearth of research on how these NPS vary across the AD continuum, especially SMC. There is also disagreement on the effects of specific NPS on each stage of the AD con...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Samuel L Warren Eid Abo Hamza Richard Tindle Edwina Reid Paige Whitfield Adam Doumit Ahmed A Moustafa Source Type: research
Early Chronic Stress Induced Changes within the Locus Coeruleus in Sporadic Alzheimer's Disease
Curr Alzheimer Res. 2023;20(5):301-317. doi: 10.2174/1567205020666230811092956.ABSTRACTChronic exposure to stress throughout the lifespan has been the focus of many studies on Alzheimer's disease (AD) because of the similarities between the biological mechanisms involved in chronic stress and the pathophysiology of AD. In fact, the earliest abnormality associated with the disease is the presence of phosphorylated tau protein in locus coeruleus neurons, a brain structure highly responsive to stress and perceived threat. Here, we introduce allostatic load as a useful concept for understanding many of the complex, interacting...
Source: Current Alzheimer Research - October 24, 2023 Category: Neurology Authors: Donn é Minné Jeanine L Marnewick Penelope Engel-Hills Source Type: research
