Early Detection of Dementia using Risk Classification in MCI: Outcomes of Shanghai Mild Cognitive Impairment Cohort Study
CONCLUSION: A simple risk classification using the rt. HV and neuropsychological test scores, including those from the ADAS-Cog-C and PACC, could be a practicable and efficient approach to identifying individuals at risk of all-cause dementia.PMID:37711110 | DOI:10.2174/1567205020666230914161034 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - September 15, 2023 Category: Neurology Authors: Bin Zhou Qianhua Zhao Shinsuke Kojima Ding Ding Satoshi Higashide Masanori Fukushima Zhen Hong Source Type: research
MicroRNA-125a-3p modulate amyloid β-protein through the MAPK pathway in Alzheimer's disease
CONCLUSION: Our study indicates that targeting miR-125a-3p may be an applicable therapy for AD in the future. However, more in vitro and in vivo studies with more samples are needed to confirm these results.PMID:37711111 | DOI:10.2174/1567205020666230913105811 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - September 15, 2023 Category: Neurology Authors: Xi-Chen Zhu Meng-Zhuo Zhu Jing Lu Qing-Yu Yao Jia-Wei Hu Wen-Jun Long Sha-Sha Ruan Wen-Zhuo Dai Rong Li Source Type: research
Early Detection of Dementia using Risk Classification in MCI: Outcomes of Shanghai Mild Cognitive Impairment Cohort Study
CONCLUSION: A simple risk classification using the rt. HV and neuropsychological test scores, including those from the ADAS-Cog-C and PACC, could be a practicable and efficient approach to identifying individuals at risk of all-cause dementia.PMID:37711110 | DOI:10.2174/1567205020666230914161034 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - September 15, 2023 Category: Neurology Authors: Bin Zhou Qianhua Zhao Shinsuke Kojima Ding Ding Satoshi Higashide Masanori Fukushima Zhen Hong Source Type: research
MicroRNA-125a-3p modulate amyloid β-protein through the MAPK pathway in Alzheimer's disease
CONCLUSION: Our study indicates that targeting miR-125a-3p may be an applicable therapy for AD in the future. However, more in vitro and in vivo studies with more samples are needed to confirm these results.PMID:37711111 | DOI:10.2174/1567205020666230913105811 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - September 15, 2023 Category: Neurology Authors: Xi-Chen Zhu Meng-Zhuo Zhu Jing Lu Qing-Yu Yao Jia-Wei Hu Wen-Jun Long Sha-Sha Ruan Wen-Zhuo Dai Rong Li Source Type: research
Glial-derived neuroinflammation induced with amyloid-beta-peptide plus fibrinogen injection in rat hippocampus
CONCLUSION: The findings suggest the utility of combining peptide plus fibrinogen as a potent and understudied neuroinflammatory stimulus for the induction of glial-derived neurotoxic factors in BBB-compromised AD brain.PMID:37702232 | DOI:10.2174/1567205020666230912113501 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - September 13, 2023 Category: Neurology Authors: James G McLarnon Source Type: research
Glial-derived neuroinflammation induced with amyloid-beta-peptide plus fibrinogen injection in rat hippocampus
CONCLUSION: The findings suggest the utility of combining peptide plus fibrinogen as a potent and understudied neuroinflammatory stimulus for the induction of glial-derived neurotoxic factors in BBB-compromised AD brain.PMID:37702232 | DOI:10.2174/1567205020666230912113501 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - September 13, 2023 Category: Neurology Authors: James G McLarnon Source Type: research
Neuropsychiatric symptoms and trajectories of dependence and cognition in a sample of community-dwelling older adults with dementia
CONCLUSION: Our results confirm and extend prior results in clinic-based samples. The presence of NPS was associated with worse trajectories of dependence and cognition in this muti-ethnic sample of older adults with AD. Importantly, sex modified the association between depressed mood and dependence. Our results on NPS as predictors of differential AD progression in a community-dwelling, ethnically diverse sample serve to better inform the clinical care of patients and the future development of AD therapies.PMID:37694796 | DOI:10.2174/1567205020666230908163414 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - September 11, 2023 Category: Neurology Authors: Anton J Kociolek Kayri K Fernandez Michelle Hernandez Zhezhen Jin Stephanie Cosentino Carolyn W Zhu Yian Gu Davangere P Devanand Yaakov Stern Source Type: research
Innovative Discoveries in Neurosurgical Treatment of Neurodegenerative Diseases: A Narrative Review
Curr Alzheimer Res. 2023 Sep 11. doi: 10.2174/1567205020666230911125646. Online ahead of print.ABSTRACTNeurodegenerative diseases (NDDs) encapsulate conditions in which neural cell populations are perpetually degraded and nervous system function destroyed. Generally linked to increased age, the proportion of patients diagnosed with a NDD is growing as human life expectancies rise. Traditional NDD therapies and surgical interventions have been limited. However, recent breakthroughs in understanding disease pathophysiology, improved drug delivery systems, and targeted pharmacologic agents have allowed innovative treatment ap...
Source: Current Alzheimer Research - September 11, 2023 Category: Neurology Authors: Matthew C Findlay Majid Khan Mrinmoy Kundu Chase M Johansen Brandon Lucke-Wold Source Type: research
Neuropsychiatric symptoms and trajectories of dependence and cognition in a sample of community-dwelling older adults with dementia
CONCLUSION: Our results confirm and extend prior results in clinic-based samples. The presence of NPS was associated with worse trajectories of dependence and cognition in this muti-ethnic sample of older adults with AD. Importantly, sex modified the association between depressed mood and dependence. Our results on NPS as predictors of differential AD progression in a community-dwelling, ethnically diverse sample serve to better inform the clinical care of patients and the future development of AD therapies.PMID:37694796 | DOI:10.2174/1567205020666230908163414 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - September 11, 2023 Category: Neurology Authors: Anton J Kociolek Kayri K Fernandez Michelle Hernandez Zhezhen Jin Stephanie Cosentino Carolyn W Zhu Yian Gu Davangere P Devanand Yaakov Stern Source Type: research
Innovative Discoveries in Neurosurgical Treatment of Neurodegenerative Diseases: A Narrative Review
Curr Alzheimer Res. 2023 Sep 11. doi: 10.2174/1567205020666230911125646. Online ahead of print.ABSTRACTNeurodegenerative diseases (NDDs) encapsulate conditions in which neural cell populations are perpetually degraded and nervous system function destroyed. Generally linked to increased age, the proportion of patients diagnosed with a NDD is growing as human life expectancies rise. Traditional NDD therapies and surgical interventions have been limited. However, recent breakthroughs in understanding disease pathophysiology, improved drug delivery systems, and targeted pharmacologic agents have allowed innovative treatment ap...
Source: Current Alzheimer Research - September 11, 2023 Category: Neurology Authors: Matthew C Findlay Majid Khan Mrinmoy Kundu Chase M Johansen Brandon Lucke-Wold Source Type: research
T lymphocytes in the pathogenesis and progression of Alzheimer's disease: pursuing direct neuropathological evidence
Curr Alzheimer Res. 2023 Sep 4. doi: 10.2174/1567205020666230904151011. Online ahead of print.ABSTRACTMultiple studies have proposed important roles of T cells in the pathogenesis of Alzheimer's disease. Given the successful application of immune-based therapy for cancer and a variety of diseases, T cell-modifying therapy becomes an attractive way to develop new therapies for Alzheimer's disease and perhaps neurodegenerative diseases in general. However, most of these studies address peripheral T cell responses, while direct pathological evidence documenting T cell infiltration relative to Alzheimer's disease pathological ...
Source: Current Alzheimer Research - September 6, 2023 Category: Neurology Authors: Peng Cheng Han Eric D Hamlett Source Type: research
T lymphocytes in the pathogenesis and progression of Alzheimer's disease: pursuing direct neuropathological evidence
Curr Alzheimer Res. 2023 Sep 4. doi: 10.2174/1567205020666230904151011. Online ahead of print.ABSTRACTMultiple studies have proposed important roles of T cells in the pathogenesis of Alzheimer's disease. Given the successful application of immune-based therapy for cancer and a variety of diseases, T cell-modifying therapy becomes an attractive way to develop new therapies for Alzheimer's disease and perhaps neurodegenerative diseases in general. However, most of these studies address peripheral T cell responses, while direct pathological evidence documenting T cell infiltration relative to Alzheimer's disease pathological ...
Source: Current Alzheimer Research - September 6, 2023 Category: Neurology Authors: Peng Cheng Han Eric D Hamlett Source Type: research
T lymphocytes in the pathogenesis and progression of Alzheimer's disease: pursuing direct neuropathological evidence
Curr Alzheimer Res. 2023 Sep 4. doi: 10.2174/1567205020666230904151011. Online ahead of print.ABSTRACTMultiple studies have proposed important roles of T cells in the pathogenesis of Alzheimer's disease. Given the successful application of immune-based therapy for cancer and a variety of diseases, T cell-modifying therapy becomes an attractive way to develop new therapies for Alzheimer's disease and perhaps neurodegenerative diseases in general. However, most of these studies address peripheral T cell responses, while direct pathological evidence documenting T cell infiltration relative to Alzheimer's disease pathological ...
Source: Current Alzheimer Research - September 6, 2023 Category: Neurology Authors: Peng Cheng Han Eric D Hamlett Source Type: research
T lymphocytes in the pathogenesis and progression of Alzheimer's disease: pursuing direct neuropathological evidence
Curr Alzheimer Res. 2023 Sep 4. doi: 10.2174/1567205020666230904151011. Online ahead of print.ABSTRACTMultiple studies have proposed important roles of T cells in the pathogenesis of Alzheimer's disease. Given the successful application of immune-based therapy for cancer and a variety of diseases, T cell-modifying therapy becomes an attractive way to develop new therapies for Alzheimer's disease and perhaps neurodegenerative diseases in general. However, most of these studies address peripheral T cell responses, while direct pathological evidence documenting T cell infiltration relative to Alzheimer's disease pathological ...
Source: Current Alzheimer Research - September 6, 2023 Category: Neurology Authors: Peng Cheng Han Eric D Hamlett Source Type: research
A New Hope in Alzheimer's Disease Psychosis: Pimavanserin
Curr Alzheimer Res. 2023 Aug 25. doi: 10.2174/1567205020666230825124922. Online ahead of print.ABSTRACTAlzheimer's disease (AD) ranks first among the causes of dementia worldwide. AD can develop a psychotic manifest at a significant rate. AD prognosis worsens by added psychosis clinic. There is no treatment approved by the United States Food and Drug Administration (FDA) among antipsychotics for Alzheimer's disease Psychosis (ADP). However, pimavanserine, an atypical antipsychotic, has been approved by the FDA for Parkinson's psychosis. It is predicted that pimavanserin, a new antipsychotic, will fill an important gap in t...
Source: Current Alzheimer Research - August 29, 2023 Category: Neurology Authors: Faruk Kurhan Mustafa Ak ın Source Type: research
