Neuropsychiatric symptoms and trajectories of dependence and cognition in a sample of community-dwelling older adults with dementia

CONCLUSION: Our results confirm and extend prior results in clinic-based samples. The presence of NPS was associated with worse trajectories of dependence and cognition in this muti-ethnic sample of older adults with AD. Importantly, sex modified the association between depressed mood and dependence. Our results on NPS as predictors of differential AD progression in a community-dwelling, ethnically diverse sample serve to better inform the clinical care of patients and the future development of AD therapies.PMID:37694796 | DOI:10.2174/1567205020666230908163414

Source: Current Alzheimer Research - September 11, 2023 Category: Neurology Authors: Anton J Kociolek Kayri K Fernandez Michelle Hernandez Zhezhen Jin Stephanie Cosentino Carolyn W Zhu Yian Gu Davangere P Devanand Yaakov Stern Source Type: research