Nanostructured Lipid Carriers of Donepezil Hydrochloride for the Treatment of Alzheimer's Disease
CONCLUSION: The DNZ-loaded NLCs, when administered via nasal route, showed markedly improved drug availability in the brain, suggesting an efficient drug delivery strategy to treat Alzheimer's disease.PMID:38445703 | DOI:10.2174/0115672050288659240229080535 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 6, 2024 Category: Neurology Authors: Avinash Tekade Ram Susar Gajanan Kulkarni Samiksha Surwade Anil Gaikwad Source Type: research
Multimodal Gamma Stimulation Improves Activity but not Memory in Aged Tgf344-AD Rats
CONCLUSION: Multimodal gamma stimulation did not enhance memory performance in the object location task or the spontaneous alternation task. However, in both tasks, the treatment group had improved measures of exploratory activity relative to the untreated group. We conclude that several limitations could have contributed to this mixed effect, including aging complications, different animal models, or light cycle effects.PMID:38445702 | DOI:10.2174/0115672050281956240228075849 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 6, 2024 Category: Neurology Authors: J H Bentley J I Broussard Source Type: research
Nanostructured Lipid Carriers of Donepezil Hydrochloride for the Treatment of Alzheimer's Disease
CONCLUSION: The DNZ-loaded NLCs, when administered via nasal route, showed markedly improved drug availability in the brain, suggesting an efficient drug delivery strategy to treat Alzheimer's disease.PMID:38445703 | DOI:10.2174/0115672050288659240229080535 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 6, 2024 Category: Neurology Authors: Avinash Tekade Ram Susar Gajanan Kulkarni Samiksha Surwade Anil Gaikwad Source Type: research
Multimodal Gamma Stimulation Improves Activity but not Memory in Aged Tgf344-AD Rats
CONCLUSION: Multimodal gamma stimulation did not enhance memory performance in the object location task or the spontaneous alternation task. However, in both tasks, the treatment group had improved measures of exploratory activity relative to the untreated group. We conclude that several limitations could have contributed to this mixed effect, including aging complications, different animal models, or light cycle effects.PMID:38445702 | DOI:10.2174/0115672050281956240228075849 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 6, 2024 Category: Neurology Authors: J H Bentley J I Broussard Source Type: research
Nanostructured Lipid Carriers of Donepezil Hydrochloride for the Treatment of Alzheimer's Disease
CONCLUSION: The DNZ-loaded NLCs, when administered via nasal route, showed markedly improved drug availability in the brain, suggesting an efficient drug delivery strategy to treat Alzheimer's disease.PMID:38445703 | DOI:10.2174/0115672050288659240229080535 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 6, 2024 Category: Neurology Authors: Avinash Tekade Ram Susar Gajanan Kulkarni Samiksha Surwade Anil Gaikwad Source Type: research
Multimodal Gamma Stimulation Improves Activity but not Memory in Aged Tgf344-AD Rats
CONCLUSION: Multimodal gamma stimulation did not enhance memory performance in the object location task or the spontaneous alternation task. However, in both tasks, the treatment group had improved measures of exploratory activity relative to the untreated group. We conclude that several limitations could have contributed to this mixed effect, including aging complications, different animal models, or light cycle effects.PMID:38445702 | DOI:10.2174/0115672050281956240228075849 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 6, 2024 Category: Neurology Authors: J H Bentley J I Broussard Source Type: research
Nanostructured Lipid Carriers of Donepezil Hydrochloride for the Treatment of Alzheimer's Disease
CONCLUSION: The DNZ-loaded NLCs, when administered via nasal route, showed markedly improved drug availability in the brain, suggesting an efficient drug delivery strategy to treat Alzheimer's disease.PMID:38445703 | DOI:10.2174/0115672050288659240229080535 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 6, 2024 Category: Neurology Authors: Avinash Tekade Ram Susar Gajanan Kulkarni Samiksha Surwade Anil Gaikwad Source Type: research
Estimating Dementia Onset: AT(N) Profiles and Predictive Modeling in Mild Cognitive Impairment Patients
CONCLUSION: Based on proposed natural histories and cross-sectional and longitudinal analysis of AD markers, the results indicated that only a single cerebrospinal fluid sample is necessary during the prodromal phase of AD. Prediction from MCI into dementia and its timeline can be achieved exclusively through neuropsychological measures.PMID:38425106 | DOI:10.2174/0115672050295317240223162312 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 1, 2024 Category: Neurology Authors: Carlos Platero Jussi Tohka Bryan Strange Source Type: research
Exploring Potential of Nano-formulations in the Treatment of Alzheimer's Disease through Nasal Route
CONCLUSION: Delivering drugs to the brain through the nasal route for treating Alzheimer's disease is crucial due to the limited efficacy of existing treatments and the profound impact of the disease on patients and their families. Thus, by exploring innovative approaches such as nose-to-brain drug delivery, it is possible to improve the quality of life for individuals living with Alzheimer's and alleviate its societal burden.PMID:38425107 | DOI:10.2174/0115672050290462240222092303 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 1, 2024 Category: Neurology Authors: Avinash Tekade Prasad Kadam Sachin Jagdale Samiksha Surwade Anil Gaikwad Parth Pawar Rushikesh Shinde Source Type: research
Estimating Dementia Onset: AT(N) Profiles and Predictive Modeling in Mild Cognitive Impairment Patients
CONCLUSION: Based on proposed natural histories and cross-sectional and longitudinal analysis of AD markers, the results indicated that only a single cerebrospinal fluid sample is necessary during the prodromal phase of AD. Prediction from MCI into dementia and its timeline can be achieved exclusively through neuropsychological measures.PMID:38425106 | DOI:10.2174/0115672050295317240223162312 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 1, 2024 Category: Neurology Authors: Carlos Platero Jussi Tohka Bryan Strange Source Type: research
Exploring Potential of Nano-formulations in the Treatment of Alzheimer's Disease through Nasal Route
CONCLUSION: Delivering drugs to the brain through the nasal route for treating Alzheimer's disease is crucial due to the limited efficacy of existing treatments and the profound impact of the disease on patients and their families. Thus, by exploring innovative approaches such as nose-to-brain drug delivery, it is possible to improve the quality of life for individuals living with Alzheimer's and alleviate its societal burden.PMID:38425107 | DOI:10.2174/0115672050290462240222092303 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 1, 2024 Category: Neurology Authors: Avinash Tekade Prasad Kadam Sachin Jagdale Samiksha Surwade Anil Gaikwad Parth Pawar Rushikesh Shinde Source Type: research
Estimating Dementia Onset: AT(N) Profiles and Predictive Modeling in Mild Cognitive Impairment Patients
CONCLUSION: Based on proposed natural histories and cross-sectional and longitudinal analysis of AD markers, the results indicated that only a single cerebrospinal fluid sample is necessary during the prodromal phase of AD. Prediction from MCI into dementia and its timeline can be achieved exclusively through neuropsychological measures.PMID:38425106 | DOI:10.2174/0115672050295317240223162312 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 1, 2024 Category: Neurology Authors: Carlos Platero Jussi Tohka Bryan Strange Source Type: research
Exploring Potential of Nano-formulations in the Treatment of Alzheimer's Disease through Nasal Route
CONCLUSION: Delivering drugs to the brain through the nasal route for treating Alzheimer's disease is crucial due to the limited efficacy of existing treatments and the profound impact of the disease on patients and their families. Thus, by exploring innovative approaches such as nose-to-brain drug delivery, it is possible to improve the quality of life for individuals living with Alzheimer's and alleviate its societal burden.PMID:38425107 | DOI:10.2174/0115672050290462240222092303 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 1, 2024 Category: Neurology Authors: Avinash Tekade Prasad Kadam Sachin Jagdale Samiksha Surwade Anil Gaikwad Parth Pawar Rushikesh Shinde Source Type: research
Estimating Dementia Onset: AT(N) Profiles and Predictive Modeling in Mild Cognitive Impairment Patients
CONCLUSION: Based on proposed natural histories and cross-sectional and longitudinal analysis of AD markers, the results indicated that only a single cerebrospinal fluid sample is necessary during the prodromal phase of AD. Prediction from MCI into dementia and its timeline can be achieved exclusively through neuropsychological measures.PMID:38425106 | DOI:10.2174/0115672050295317240223162312 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 1, 2024 Category: Neurology Authors: Carlos Platero Jussi Tohka Bryan Strange Source Type: research
Exploring Potential of Nano-formulations in the Treatment of Alzheimer's Disease through Nasal Route
CONCLUSION: Delivering drugs to the brain through the nasal route for treating Alzheimer's disease is crucial due to the limited efficacy of existing treatments and the profound impact of the disease on patients and their families. Thus, by exploring innovative approaches such as nose-to-brain drug delivery, it is possible to improve the quality of life for individuals living with Alzheimer's and alleviate its societal burden.PMID:38425107 | DOI:10.2174/0115672050290462240222092303 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 1, 2024 Category: Neurology Authors: Avinash Tekade Prasad Kadam Sachin Jagdale Samiksha Surwade Anil Gaikwad Parth Pawar Rushikesh Shinde Source Type: research
