Disruptions of Gut Microbiota are Associated with Cognitive Deficit of Preclinical Alzheimer's Disease: A Cross-Sectional Study
CONCLUSION: The gut microbiota in patients with preclinical AD has significantly changed in terms of composition and richness. Correlations have been discovered between changes in characteristic species and cognitive performances. Gut microbiota alterations have shown promise in affecting AD pathology and cognitive deficit.PMID:38529601 | DOI:10.2174/0115672050303878240319054149 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 26, 2024 Category: Neurology Authors: Binbin Yu Guomeng Wan Shupeng Cheng Pengcheng Wen Xi Yang Jiahuan Li Huifang Tian Yaxin Gao Qian Zhong Jin Liu Jianan Li Yi Zhu Source Type: research
Current Progress on Central Cholinergic Receptors as Therapeutic Targets for Alzheimer's Disease
Curr Alzheimer Res. 2024 Mar 25. doi: 10.2174/0115672050306008240321034006. Online ahead of print.ABSTRACTAcetylcholine (ACh) is ubiquitously present in the nervous system and has been involved in the regulation of various brain functions. By modulating synaptic transmission and promoting synaptic plasticity, particularly in the hippocampus and cortex, ACh plays a pivotal role in the regulation of learning and memory. These procognitive actions of ACh are mediated by the neuronal muscarinic and nicotinic cholinergic receptors. The impairment of cholinergic transmission leads to cognitive decline associated with aging and d...
Source: Current Alzheimer Research - March 26, 2024 Category: Neurology Authors: Kushagra Nagori Madhulika Pradhan Mukesh Sharma None Ajazuddin Hemant R Badwaik Kartik T Nakhate Source Type: research
Disruptions of Gut Microbiota are Associated with Cognitive Deficit of Preclinical Alzheimer's Disease: A Cross-Sectional Study
CONCLUSION: The gut microbiota in patients with preclinical AD has significantly changed in terms of composition and richness. Correlations have been discovered between changes in characteristic species and cognitive performances. Gut microbiota alterations have shown promise in affecting AD pathology and cognitive deficit.PMID:38529601 | DOI:10.2174/0115672050303878240319054149 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 26, 2024 Category: Neurology Authors: Binbin Yu Guomeng Wan Shupeng Cheng Pengcheng Wen Xi Yang Jiahuan Li Huifang Tian Yaxin Gao Qian Zhong Jin Liu Jianan Li Yi Zhu Source Type: research
Current Progress on Central Cholinergic Receptors as Therapeutic Targets for Alzheimer's Disease
Curr Alzheimer Res. 2024 Mar 25. doi: 10.2174/0115672050306008240321034006. Online ahead of print.ABSTRACTAcetylcholine (ACh) is ubiquitously present in the nervous system and has been involved in the regulation of various brain functions. By modulating synaptic transmission and promoting synaptic plasticity, particularly in the hippocampus and cortex, ACh plays a pivotal role in the regulation of learning and memory. These procognitive actions of ACh are mediated by the neuronal muscarinic and nicotinic cholinergic receptors. The impairment of cholinergic transmission leads to cognitive decline associated with aging and d...
Source: Current Alzheimer Research - March 26, 2024 Category: Neurology Authors: Kushagra Nagori Madhulika Pradhan Mukesh Sharma None Ajazuddin Hemant R Badwaik Kartik T Nakhate Source Type: research
Disruptions of Gut Microbiota are Associated with Cognitive Deficit of Preclinical Alzheimer's Disease: A Cross-Sectional Study
CONCLUSION: The gut microbiota in patients with preclinical AD has significantly changed in terms of composition and richness. Correlations have been discovered between changes in characteristic species and cognitive performances. Gut microbiota alterations have shown promise in affecting AD pathology and cognitive deficit.PMID:38529601 | DOI:10.2174/0115672050303878240319054149 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 26, 2024 Category: Neurology Authors: Binbin Yu Guomeng Wan Shupeng Cheng Pengcheng Wen Xi Yang Jiahuan Li Huifang Tian Yaxin Gao Qian Zhong Jin Liu Jianan Li Yi Zhu Source Type: research
Current Progress on Central Cholinergic Receptors as Therapeutic Targets for Alzheimer's Disease
Curr Alzheimer Res. 2024 Mar 25. doi: 10.2174/0115672050306008240321034006. Online ahead of print.ABSTRACTAcetylcholine (ACh) is ubiquitously present in the nervous system and has been involved in the regulation of various brain functions. By modulating synaptic transmission and promoting synaptic plasticity, particularly in the hippocampus and cortex, ACh plays a pivotal role in the regulation of learning and memory. These procognitive actions of ACh are mediated by the neuronal muscarinic and nicotinic cholinergic receptors. The impairment of cholinergic transmission leads to cognitive decline associated with aging and d...
Source: Current Alzheimer Research - March 26, 2024 Category: Neurology Authors: Kushagra Nagori Madhulika Pradhan Mukesh Sharma None Ajazuddin Hemant R Badwaik Kartik T Nakhate Source Type: research
Disruptions of Gut Microbiota are Associated with Cognitive Deficit of Preclinical Alzheimer's Disease: A Cross-Sectional Study
CONCLUSION: The gut microbiota in patients with preclinical AD has significantly changed in terms of composition and richness. Correlations have been discovered between changes in characteristic species and cognitive performances. Gut microbiota alterations have shown promise in affecting AD pathology and cognitive deficit.PMID:38529601 | DOI:10.2174/0115672050303878240319054149 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 26, 2024 Category: Neurology Authors: Binbin Yu Guomeng Wan Shupeng Cheng Pengcheng Wen Xi Yang Jiahuan Li Huifang Tian Yaxin Gao Qian Zhong Jin Liu Jianan Li Yi Zhu Source Type: research
Current Progress on Central Cholinergic Receptors as Therapeutic Targets for Alzheimer's Disease
Curr Alzheimer Res. 2024 Mar 25. doi: 10.2174/0115672050306008240321034006. Online ahead of print.ABSTRACTAcetylcholine (ACh) is ubiquitously present in the nervous system and has been involved in the regulation of various brain functions. By modulating synaptic transmission and promoting synaptic plasticity, particularly in the hippocampus and cortex, ACh plays a pivotal role in the regulation of learning and memory. These procognitive actions of ACh are mediated by the neuronal muscarinic and nicotinic cholinergic receptors. The impairment of cholinergic transmission leads to cognitive decline associated with aging and d...
Source: Current Alzheimer Research - March 26, 2024 Category: Neurology Authors: Kushagra Nagori Madhulika Pradhan Mukesh Sharma None Ajazuddin Hemant R Badwaik Kartik T Nakhate Source Type: research
Disruptions of Gut Microbiota are Associated with Cognitive Deficit of Preclinical Alzheimer's Disease: A Cross-Sectional Study
CONCLUSION: The gut microbiota in patients with preclinical AD has significantly changed in terms of composition and richness. Correlations have been discovered between changes in characteristic species and cognitive performances. Gut microbiota alterations have shown promise in affecting AD pathology and cognitive deficit.PMID:38529601 | DOI:10.2174/0115672050303878240319054149 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 26, 2024 Category: Neurology Authors: Binbin Yu Guomeng Wan Shupeng Cheng Pengcheng Wen Xi Yang Jiahuan Li Huifang Tian Yaxin Gao Qian Zhong Jin Liu Jianan Li Yi Zhu Source Type: research
Current Progress on Central Cholinergic Receptors as Therapeutic Targets for Alzheimer's Disease
Curr Alzheimer Res. 2024 Mar 25. doi: 10.2174/0115672050306008240321034006. Online ahead of print.ABSTRACTAcetylcholine (ACh) is ubiquitously present in the nervous system and has been involved in the regulation of various brain functions. By modulating synaptic transmission and promoting synaptic plasticity, particularly in the hippocampus and cortex, ACh plays a pivotal role in the regulation of learning and memory. These procognitive actions of ACh are mediated by the neuronal muscarinic and nicotinic cholinergic receptors. The impairment of cholinergic transmission leads to cognitive decline associated with aging and d...
Source: Current Alzheimer Research - March 26, 2024 Category: Neurology Authors: Kushagra Nagori Madhulika Pradhan Mukesh Sharma None Ajazuddin Hemant R Badwaik Kartik T Nakhate Source Type: research
Disruptions of Gut Microbiota are Associated with Cognitive Deficit of Preclinical Alzheimer's Disease: A Cross-Sectional Study
CONCLUSION: The gut microbiota in patients with preclinical AD has significantly changed in terms of composition and richness. Correlations have been discovered between changes in characteristic species and cognitive performances. Gut microbiota alterations have shown promise in affecting AD pathology and cognitive deficit.PMID:38529601 | DOI:10.2174/0115672050303878240319054149 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 26, 2024 Category: Neurology Authors: Binbin Yu Guomeng Wan Shupeng Cheng Pengcheng Wen Xi Yang Jiahuan Li Huifang Tian Yaxin Gao Qian Zhong Jin Liu Jianan Li Yi Zhu Source Type: research
Plant Soup Formulations Show Cholinesterase Inhibition Potential in the Prevention of Alzheimer's Disease
CONCLUSION: The outcomes of our study should serve as a catalyst for further exploration of this important research domain. Our current research focuses on deeper insights into the potential of comprehensive meal options. Furthermore, the synergy/antagonism/non-interaction between respective soup ingredients as well as elements of individual soups' chemical composition is a very interesting topic currently under our intensive scientific investigation.PMID:38523524 | DOI:10.2174/0115672050306101240321050146 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 25, 2024 Category: Neurology Authors: Dorota Gajowniczek-A łasa Dominik Szwajgier Ewa Baranowska-W ójcik Source Type: research
Beyond Conventional Therapies: Molecular Dynamics of Alzheimer's Treatment through CLOCK/BMAL1 Interactions
Conclusion: A novel therapeutic approach emerges, suggesting the combination of melatonin with Lecanemab as a monoclonal antibody therapy. Importantly, prior research has not explored the effects of FDA-approved drugs on Bmal1 expression or their potential for synergistic effects.PMID:38509675 | DOI:10.2174/0115672050301014240315065235 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 21, 2024 Category: Neurology Authors: Ismail Celil Haskologlu Emine Erdag Ahmet Ozer Sehirli Orhan Uludag Nurettin Abacioglu Source Type: research
Beyond Conventional Therapies: Molecular Dynamics of Alzheimer's Treatment through CLOCK/BMAL1 Interactions
Conclusion: A novel therapeutic approach emerges, suggesting the combination of melatonin with Lecanemab as a monoclonal antibody therapy. Importantly, prior research has not explored the effects of FDA-approved drugs on Bmal1 expression or their potential for synergistic effects.PMID:38509675 | DOI:10.2174/0115672050301014240315065235 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 21, 2024 Category: Neurology Authors: Ismail Celil Haskologlu Emine Erdag Ahmet Ozer Sehirli Orhan Uludag Nurettin Abacioglu Source Type: research
Beyond Conventional Therapies: Molecular Dynamics of Alzheimer's Treatment through CLOCK/BMAL1 Interactions
Conclusion: A novel therapeutic approach emerges, suggesting the combination of melatonin with Lecanemab as a monoclonal antibody therapy. Importantly, prior research has not explored the effects of FDA-approved drugs on Bmal1 expression or their potential for synergistic effects.PMID:38509675 | DOI:10.2174/0115672050301014240315065235 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 21, 2024 Category: Neurology Authors: Ismail Celil Haskologlu Emine Erdag Ahmet Ozer Sehirli Orhan Uludag Nurettin Abacioglu Source Type: research
