Multimodal Gamma Stimulation Improves Activity but not Memory in Aged Tgf344-AD Rats
CONCLUSION: Multimodal gamma stimulation did not enhance memory performance in the object location task or the spontaneous alternation task. However, in both tasks, the treatment group had improved measures of exploratory activity relative to the untreated group. We conclude that several limitations could have contributed to this mixed effect, including aging complications, different animal models, or light cycle effects.PMID:38445702 | DOI:10.2174/0115672050281956240228075849 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 6, 2024 Category: Neurology Authors: J H Bentley J I Broussard Source Type: research
Nanostructured Lipid Carriers of Donepezil Hydrochloride for the Treatment of Alzheimer's Disease
CONCLUSION: The DNZ-loaded NLCs, when administered via nasal route, showed markedly improved drug availability in the brain, suggesting an efficient drug delivery strategy to treat Alzheimer's disease.PMID:38445703 | DOI:10.2174/0115672050288659240229080535 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 6, 2024 Category: Neurology Authors: Avinash Tekade Ram Susar Gajanan Kulkarni Samiksha Surwade Anil Gaikwad Source Type: research
Estimating Dementia Onset: AT(N) Profiles and Predictive Modeling in Mild Cognitive Impairment Patients
CONCLUSION: Based on proposed natural histories and cross-sectional and longitudinal analysis of AD markers, the results indicated that only a single cerebrospinal fluid sample is necessary during the prodromal phase of AD. Prediction from MCI into dementia and its timeline can be achieved exclusively through neuropsychological measures.PMID:38425106 | DOI:10.2174/0115672050295317240223162312 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 1, 2024 Category: Neurology Authors: Carlos Platero Jussi Tohka Bryan Strange Source Type: research
Exploring Potential of Nano-formulations in the Treatment of Alzheimer's Disease through Nasal Route
CONCLUSION: Delivering drugs to the brain through the nasal route for treating Alzheimer's disease is crucial due to the limited efficacy of existing treatments and the profound impact of the disease on patients and their families. Thus, by exploring innovative approaches such as nose-to-brain drug delivery, it is possible to improve the quality of life for individuals living with Alzheimer's and alleviate its societal burden.PMID:38425107 | DOI:10.2174/0115672050290462240222092303 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 1, 2024 Category: Neurology Authors: Avinash Tekade Prasad Kadam Sachin Jagdale Samiksha Surwade Anil Gaikwad Parth Pawar Rushikesh Shinde Source Type: research
Estimating Dementia Onset: AT(N) Profiles and Predictive Modeling in Mild Cognitive Impairment Patients
CONCLUSION: Based on proposed natural histories and cross-sectional and longitudinal analysis of AD markers, the results indicated that only a single cerebrospinal fluid sample is necessary during the prodromal phase of AD. Prediction from MCI into dementia and its timeline can be achieved exclusively through neuropsychological measures.PMID:38425106 | DOI:10.2174/0115672050295317240223162312 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 1, 2024 Category: Neurology Authors: Carlos Platero Jussi Tohka Bryan Strange Source Type: research
Exploring Potential of Nano-formulations in the Treatment of Alzheimer's Disease through Nasal Route
CONCLUSION: Delivering drugs to the brain through the nasal route for treating Alzheimer's disease is crucial due to the limited efficacy of existing treatments and the profound impact of the disease on patients and their families. Thus, by exploring innovative approaches such as nose-to-brain drug delivery, it is possible to improve the quality of life for individuals living with Alzheimer's and alleviate its societal burden.PMID:38425107 | DOI:10.2174/0115672050290462240222092303 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 1, 2024 Category: Neurology Authors: Avinash Tekade Prasad Kadam Sachin Jagdale Samiksha Surwade Anil Gaikwad Parth Pawar Rushikesh Shinde Source Type: research
Estimating Dementia Onset: AT(N) Profiles and Predictive Modeling in Mild Cognitive Impairment Patients
CONCLUSION: Based on proposed natural histories and cross-sectional and longitudinal analysis of AD markers, the results indicated that only a single cerebrospinal fluid sample is necessary during the prodromal phase of AD. Prediction from MCI into dementia and its timeline can be achieved exclusively through neuropsychological measures.PMID:38425106 | DOI:10.2174/0115672050295317240223162312 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 1, 2024 Category: Neurology Authors: Carlos Platero Jussi Tohka Bryan Strange Source Type: research
Exploring Potential of Nano-formulations in the Treatment of Alzheimer's Disease through Nasal Route
CONCLUSION: Delivering drugs to the brain through the nasal route for treating Alzheimer's disease is crucial due to the limited efficacy of existing treatments and the profound impact of the disease on patients and their families. Thus, by exploring innovative approaches such as nose-to-brain drug delivery, it is possible to improve the quality of life for individuals living with Alzheimer's and alleviate its societal burden.PMID:38425107 | DOI:10.2174/0115672050290462240222092303 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 1, 2024 Category: Neurology Authors: Avinash Tekade Prasad Kadam Sachin Jagdale Samiksha Surwade Anil Gaikwad Parth Pawar Rushikesh Shinde Source Type: research
Estimating Dementia Onset: AT(N) Profiles and Predictive Modeling in Mild Cognitive Impairment Patients
CONCLUSION: Based on proposed natural histories and cross-sectional and longitudinal analysis of AD markers, the results indicated that only a single cerebrospinal fluid sample is necessary during the prodromal phase of AD. Prediction from MCI into dementia and its timeline can be achieved exclusively through neuropsychological measures.PMID:38425106 | DOI:10.2174/0115672050295317240223162312 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 1, 2024 Category: Neurology Authors: Carlos Platero Jussi Tohka Bryan Strange Source Type: research
Exploring Potential of Nano-formulations in the Treatment of Alzheimer's Disease through Nasal Route
CONCLUSION: Delivering drugs to the brain through the nasal route for treating Alzheimer's disease is crucial due to the limited efficacy of existing treatments and the profound impact of the disease on patients and their families. Thus, by exploring innovative approaches such as nose-to-brain drug delivery, it is possible to improve the quality of life for individuals living with Alzheimer's and alleviate its societal burden.PMID:38425107 | DOI:10.2174/0115672050290462240222092303 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - March 1, 2024 Category: Neurology Authors: Avinash Tekade Prasad Kadam Sachin Jagdale Samiksha Surwade Anil Gaikwad Parth Pawar Rushikesh Shinde Source Type: research
Proton Pump Inhibitors and Cognitive Health: Review on Unraveling the Dementia Connection and Co-morbid Risks
Curr Alzheimer Res. 2024 Feb 28. doi: 10.2174/0115672050289946240223050737. Online ahead of print.ABSTRACTDementia, an international health issue distinguished by the impairment of daily functioning due to cognitive decline, currently affects more than 55 million people worldwide, with the majority residing in low-income and middle-income countries. Globally, dementia entails significant economic burdens in 2019, amounting to a cost of 1.3 trillion US dollars. Informal caregivers devote considerable hours to providing care for those affected. Dementia imposes a greater caregiving and disability-adjusted life-year burden on...
Source: Current Alzheimer Research - February 29, 2024 Category: Neurology Authors: Zuber Khan Sidharth Mehan Mohd Anas Saifi Ghanshyam Das Gupta Acharan S Narula Reni Kalfin Source Type: research
Handwriting Markers for the Onset of Alzheimer's Disease
CONCLUSION: The handwriting marker of AD could be an effective supplement instrument for earlier screening. It is also useful when traditional biomarkers and neurological tests could not be applied. AD-HS can accompany therapy as an indication of its effect on a person.PMID:38424434 | DOI:10.2174/0115672050299338240222051023 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - February 29, 2024 Category: Neurology Authors: Yury Chernov Source Type: research
The Association of Allergy-Related and Non-Allergy-Related Olfactory Impairment with Cognitive Function in Older Adults: Two Cross-Sectional Studies
CONCLUSION: OI, particularly non-allergy-related OI, was related to poorer cognitive function in older adults. Although the current cross-sectional study is subject to several limitations, such as reverse causality and residual confounding, the findings will provide insights into the OI-cognition association and enlighten future attention to non-allergy-related OI for the prevention of potential cognitive impairment.PMID:38409711 | DOI:10.2174/0115672050284179240215052257 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - February 27, 2024 Category: Neurology Authors: Hui Chen Yihong Ding Liyan Huang Wansi Zhong Xiaojun Lin Baoyue Zhang Yan Zheng Xin Xu Min Lou Changzheng Yuan Source Type: research
Alzheimer's Disease and Suicide: An Integrative Literature Review
CONCLUSION: Adequately delineating which elderly people are vulnerable to suicide is important so that new treatments for Alzheimer's disease can be successful. This review showed a need for new studies to investigate the interface between Alzheimer's disease and suicide.PMID:38409712 | DOI:10.2174/0115672050292472240216052614 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - February 27, 2024 Category: Neurology Authors: Juliano Fl ávio Rubatino Rodrigues Livia Peregrino Rodrigues Gerardo Gerardo Maria de Ara újo Filho Source Type: research
Antipsychotics in Alzheimer's Disease: Current Status and Therapeutic Alternatives
Curr Alzheimer Res. 2024 Feb 22. doi: 10.2174/0115672050287534240215052417. Online ahead of print.ABSTRACTPsychosis and hyperactive behaviors, such as agitation and wandering, affect a significant proportion of patients with Alzheimer's disease (AD). These symptoms are often treated with antipsychotics, usually in an off-label approach. This mini-review provides an updated perspective on the pharmacological approach for the neuropsychiatric symptoms (NPS) in AD. The results of new studies have provided a better understanding of AD-related NPS management, but high-quality evidence still needs to be obtained. Herein, we argu...
Source: Current Alzheimer Research - February 27, 2024 Category: Neurology Authors: Maria Paula Maziero Natalia P Rocha Antonio L Teixeira Source Type: research
