Antipsychotics in Alzheimer's Disease: Current Status and Therapeutic Alternatives

Curr Alzheimer Res. 2024 Feb 22. doi: 10.2174/0115672050287534240215052417. Online ahead of print.ABSTRACTPsychosis and hyperactive behaviors, such as agitation and wandering, affect a significant proportion of patients with Alzheimer's disease (AD). These symptoms are often treated with antipsychotics, usually in an off-label approach. This mini-review provides an updated perspective on the pharmacological approach for the neuropsychiatric symptoms (NPS) in AD. The results of new studies have provided a better understanding of AD-related NPS management, but high-quality evidence still needs to be obtained. Herein, we argue for a more cautious approach to the use of antipsychotics in AD and highlight the importance of exploring alternative treatments for NPS. By doing so, we can ensure that patients with AD receive optimal care that is both effective and safe.PMID:38409713 | DOI:10.2174/0115672050287534240215052417

Source: Current Alzheimer Research - February 27, 2024 Category: Neurology Authors: Maria Paula Maziero Natalia P Rocha Antonio L Teixeira Source Type: research