Examining pain, function, behavioral symptoms and associations with engagement in meaningful activity for residents with dementia in assisted living
CONCLUSION: Findings from this study show that pain is a significant factor that is negatively associated with residents' engagement in meaningful activity. Ongoing research is needed to help improve pain management for residents with dementia in assisted living and support their engagement in meaningful activity.PMID:38651198 | DOI:10.1080/13607863.2024.2342963 (Source: Aging and Mental Health)
Source: Aging and Mental Health - April 23, 2024 Category: Geriatrics Authors: Sarah D Holmes Barbara Resnick Elizabeth Galik Sorah Levy Susan Scherr Erin O'Brien Source Type: research
Dipeptidyl peptidase 4 inhibitors vs. metformin for new-onset dementia: a propensity score-matched cohort study
CONCLUSION: In this real-world study, we found that DPP4 inhibitors presented an association with a lower risk of dementia in individuals with type 2 diabetes than metformin, particularly in older people and those without diabetes-related comorbidities.PMID:38652239 | DOI:10.1210/clinem/dgae281 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 23, 2024 Category: Endocrinology Authors: Siyang Liu Heng Wan Sheng Nie Huanyi Cao Lan Liu Hua Liang Hong Xu Bicheng Liu Chunbo Chen Huafeng Liu Qiongqiong Yang Hua Li Yaozhong Kong Guisen Li Qijun Wan Yan Zha Ying Hu Gang Xu Yongjun Shi Yilun Zhou Guobin Su Ying Tang Mengchun Gong Aixin Guo Jian Source Type: research
Commentary on: physical activity and exercise for mild cognitive impairment and dementia: a collaborative international guideline
In conclusion, there is limited evidence on the beneficial role of physical activity and exercise in preserving cognitive functions in subjects with normal cognition, MCI or dementia. The guidelines support the promotion of physical activity based on the beneficial effects on almost all facets of health.PMID:38652380 | DOI:10.1007/s40520-024-02747-1 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - April 23, 2024 Category: Geriatrics Authors: Nicola Veronese Pinar Soysal Mario Barbagallo Susan D Shenkin Terence J Quinn Source Type: research
Factors influencing the commissioning and implementation of health and social care interventions for people with dementia: commissioner and stakeholder perspectives
ConclusionSeveral barriers and facilitators for commissioning and implementing health and social care interventions for people with dementia were identified which need to be addressed. Recommended actions to facilitate the commissioning and implementation of dementia friendly services are: 1) map out local needs, 2) evidence the intervention including effectiveness and cost-effectiveness, 3) create/utilise networks with stakeholders, and 4) plan required resources. (Source: Archives of Public Health)
Source: Archives of Public Health - April 23, 2024 Category: International Medicine & Public Health Source Type: research
Radiographers' experiences in working with patients living with dementia in Norway – A qualitative study
This study explored radiographers' experiences during imaging examinations for PWD. (Source: Radiography)
Source: Radiography - April 23, 2024 Category: Radiology Authors: E. Kjelle, C. Eikefet, C.C. Chilanga Source Type: research
Neuronal cell cycle reentry events in the aging brain are more prevalent in neurodegeneration and lead to cellular senescence
by Deng Wu, Jacquelyne Ka-Li Sun, Kim Hei-Man Chow
Increasing evidence indicates that terminally differentiated neurons in the brain may recommit to a cell cycle-like process during neuronal aging and under disease conditions. Because of the rare existence and random localization of these cells in the brain, their molecular profiles and disease-specific heterogeneities remain unclear. Through a bioinformatics approach that allows integrated analyses of multiple single-nucleus transcriptome datasets from human brain samples, these rare cell populations were identified and selected for further characterization. Our analyses...
Source: PLoS Biology: Archived Table of Contents - April 23, 2024 Category: Biology Authors: Deng Wu Source Type: research
Structural insights into the potential binding sites of Cathepsin D using molecular modelling techniques
Amino Acids. 2024 Apr 22;56(1):33. doi: 10.1007/s00726-023-03367-1.ABSTRACTAlzheimer's disease (AD) is the most prevalent type of dementia caused by the accumulation of amyloid beta (Aβ) peptides. The extracellular deposition of Aβ peptides in human AD brain causes neuronal death. Therefore, it has been found that Aβ peptide degradation is a possible therapeutic target for AD. CathD has been known to breakdown amyloid beta peptides. However, the structural role of CathD is not yet clear. Hence, for the purpose of gaining a deeper comprehension of the structure of CathD, the present computational investigation was perfor...
Source: Amino Acids - April 22, 2024 Category: Biochemistry Authors: Subodh A Kamble Sagar S Barale Ali Abdulmawjood Mohammed Sneha B Paymal Nitin M Naik Kailas D Sonawane Source Type: research
Structural insights into the potential binding sites of Cathepsin D using molecular modelling techniques
Amino Acids. 2024 Apr 22;56(1):33. doi: 10.1007/s00726-023-03367-1.ABSTRACTAlzheimer's disease (AD) is the most prevalent type of dementia caused by the accumulation of amyloid beta (Aβ) peptides. The extracellular deposition of Aβ peptides in human AD brain causes neuronal death. Therefore, it has been found that Aβ peptide degradation is a possible therapeutic target for AD. CathD has been known to breakdown amyloid beta peptides. However, the structural role of CathD is not yet clear. Hence, for the purpose of gaining a deeper comprehension of the structure of CathD, the present computational investigation was perfor...
Source: Amino Acids - April 22, 2024 Category: Biochemistry Authors: Subodh A Kamble Sagar S Barale Ali Abdulmawjood Mohammed Sneha B Paymal Nitin M Naik Kailas D Sonawane Source Type: research
Structural insights into the potential binding sites of Cathepsin D using molecular modelling techniques
Amino Acids. 2024 Apr 22;56(1):33. doi: 10.1007/s00726-023-03367-1.ABSTRACTAlzheimer's disease (AD) is the most prevalent type of dementia caused by the accumulation of amyloid beta (Aβ) peptides. The extracellular deposition of Aβ peptides in human AD brain causes neuronal death. Therefore, it has been found that Aβ peptide degradation is a possible therapeutic target for AD. CathD has been known to breakdown amyloid beta peptides. However, the structural role of CathD is not yet clear. Hence, for the purpose of gaining a deeper comprehension of the structure of CathD, the present computational investigation was perfor...
Source: Amino Acids - April 22, 2024 Category: Biochemistry Authors: Subodh A Kamble Sagar S Barale Ali Abdulmawjood Mohammed Sneha B Paymal Nitin M Naik Kailas D Sonawane Source Type: research
Structural insights into the potential binding sites of Cathepsin D using molecular modelling techniques
Amino Acids. 2024 Apr 22;56(1):33. doi: 10.1007/s00726-023-03367-1.ABSTRACTAlzheimer's disease (AD) is the most prevalent type of dementia caused by the accumulation of amyloid beta (Aβ) peptides. The extracellular deposition of Aβ peptides in human AD brain causes neuronal death. Therefore, it has been found that Aβ peptide degradation is a possible therapeutic target for AD. CathD has been known to breakdown amyloid beta peptides. However, the structural role of CathD is not yet clear. Hence, for the purpose of gaining a deeper comprehension of the structure of CathD, the present computational investigation was perfor...
Source: Amino Acids - April 22, 2024 Category: Biochemistry Authors: Subodh A Kamble Sagar S Barale Ali Abdulmawjood Mohammed Sneha B Paymal Nitin M Naik Kailas D Sonawane Source Type: research
Pathologic and cognitive correlates of plasma biomarkers in neurodegenerative disease
DISCUSSION: Combining plasma biomarkers can optimize detection of Alzheimer's disease (AD) pathology across cognitively normal and clinically diverse neurodegenerative disease.HIGHLIGHTS: Participants were clinically heterogeneous, with autopsy- or biomarker-confirmed Aβ. Combining plasma p-tau181, GFAP, and NfL improved diagnostic accuracy for Aβ status. Diagnosis by plasma biomarkers is more accurate in amnestic AD than nonamnestic AD. Plasma analytes show independent associations with tau PET and post mortem Aβ/tau. Plasma NfL predicted longitudinal cognitive decline in both Aβ+ and Aβ- individuals.PMID:38644682 | ...
Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Katheryn A Q Cousins Jeffrey S Phillips Sandhitsu R Das Kyra O'Brien Thomas F Tropea Alice Chen-Plotkin Leslie M Shaw Ilya M Nasrallah Dawn Mechanic-Hamilton Corey T McMillan David J Irwin Edward B Lee David A Wolk Source Type: research
Japan-Multimodal Intervention Trial for the Prevention of Dementia: A randomized controlled trial
We examined the efficacy of a multidomain intervention in preventing cognitive decline among Japanese older adults with mild cognitive impairment (MCI).METHODS: Participants aged 65-85 years with MCI were randomized into intervention (management of vascular risk factors, exercise, nutritional counseling, and cognitive training) and control groups. The primary outcome was changes in the cognitive composite score over a period of 18 months.RESULTS: Of 531 participants, 406 completed the trial. The between-group difference in composite score changes was 0.047 (95% CI: -0.029 to 0.124). Secondary analyses indicated positive im...
Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Takashi Sakurai Taiki Sugimoto Hiroyasu Akatsu Takehiko Doi Yoshinori Fujiwara Akihiro Hirakawa Fumie Kinoshita Masafumi Kuzuya Sangyoon Lee Nanae Matsumoto Koichiro Matsuo Makoto Michikawa Akinori Nakamura Susumu Ogawa Rei Otsuka Kenji Sato Hiroyuki Shim Source Type: research
Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial
DISCUSSION: AD-GRS and APOE4 may have different impacts on potential intervention effects on amyloid, that is, less accumulation in the higher-risk group (AD-GRS) versus lower-risk group (APOE).HIGHLIGHTS: First study of neuroimaging and AD genetics in a multidomain lifestyle intervention. Possible intervention effect on brain amyloid deposition may rely on genetic risk. AD-GRS and APOE4 allele may have different impacts on amyloid during intervention.PMID:38647197 | DOI:10.1002/alz.13843 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 22, 2024 Category: Psychiatry Authors: Gazi Saadmaan Maria Carolina Dalmasso Alfredo Ramirez Mikko Hiltunen Nina Kemppainen Jenni Lehtisalo Francesca Mangialasche Tiia Ngandu Juha Rinne Hilkka Soininen Ruth Stephen Miia Kivipelto Alina Solomon Source Type: research
Structural insights into the potential binding sites of Cathepsin D using molecular modelling techniques
Amino Acids. 2024 Apr 22;56(1):33. doi: 10.1007/s00726-023-03367-1.ABSTRACTAlzheimer's disease (AD) is the most prevalent type of dementia caused by the accumulation of amyloid beta (Aβ) peptides. The extracellular deposition of Aβ peptides in human AD brain causes neuronal death. Therefore, it has been found that Aβ peptide degradation is a possible therapeutic target for AD. CathD has been known to breakdown amyloid beta peptides. However, the structural role of CathD is not yet clear. Hence, for the purpose of gaining a deeper comprehension of the structure of CathD, the present computational investigation was perfor...
Source: Amino Acids - April 22, 2024 Category: Biochemistry Authors: Subodh A Kamble Sagar S Barale Ali Abdulmawjood Mohammed Sneha B Paymal Nitin M Naik Kailas D Sonawane Source Type: research
Effectiveness of the online-based comprehensive cognitive training application, Smart Brain, for community-dwelling older adults with dementia: a randomized controlled trial
CONCLUSIONS: Smart Brain significantly improved cognitive function, reduced depression, and enhanced physical and nutritional status in older adults with dementia. This demonstrates its potential as an effective non-pharmacological intervention in community-based dementia care.CLINICAL REHABILITATION IMPACT: Smart Brain's personalized approach, which integrates user-specific preferences and expert guidance, enhances engagement and goal achievement in dementia care. This enhances self-esteem and clinical outcomes, demonstrates the application's potential to innovate rehabilitation practices.PMID:38647533 | DOI:10.23736/S197...
Source: European Journal of Physical and Rehabilitation Medicine - April 22, 2024 Category: Rehabilitation Authors: Hee-Jae Chae Seon-Heui Lee Source Type: research
