Functional recovery in hip fracture patients: the role of pharmacotherapy.
CONCLUSIONS: These findings can help the physician to better plan the rehabilitation of hip fracture patients who require polypharmacy. PMID: 30900212 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - March 21, 2019 Category: Geriatrics Authors: Gialanella B, Santoro R, Prometti P, Giordano A, Monguzzi V, Comini L, Olivares A, Grioni G Tags: Aging Clin Exp Res Source Type: research

Single-bed rooms in a geriatric ward prevent delirium in older patients.
Abstract BACKGROUND: Few studies have investigated treatment environment risk factors for delirium in geriatric patients. In March 2017, a geriatric department was moved from old hospital buildings with multiple-bed rooms (old wards) to a new hospital with single-bed rooms (new wards), with no changes regarding uptake area, staff and admission criteria. AIMS: The aim of this study was to investigate the risk of delirium among patients in single-bed rooms compared with multiple-bed rooms. METHODS: An observational prospective study included patients aged ≥ 75 years admitted between 1...
Source: Aging Clinical and Experimental Research - March 21, 2019 Category: Geriatrics Authors: Blandfort S, Gregersen M, Rahbek K, Juul S, Damsgaard EM Tags: Aging Clin Exp Res Source Type: research

Heavy metal intoxication and amyotrophic lateral sclerosis: causal or casual relationship?
e; RS PMID: 30900214 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - March 21, 2019 Category: Geriatrics Authors: Portaro S, Naro A, Giorgianni R, Mazzon E, Calabrò RS Tags: Aging Clin Exp Res Source Type: research

Cross-cultural adaptation and validation of the Groningen Frailty Indicator in Chinese nursing home residents.
CONCLUSIONS: The GFI was successfully adapted for Chinese nursing home residents and presented acceptable validity and reliability. PMID: 30900215 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - March 21, 2019 Category: Geriatrics Authors: Xiang W, Cheng Y, Li Z, Han J, Li K Tags: Aging Clin Exp Res Source Type: research

Untangling the relationship between fat distribution, nutritional status and Parkinson's disease severity.
no DL Abstract BACKGROUND: Parkinson's disease (PD) is responsible for significant changes in body composition. AIMS: We aimed to test the association between PD severity and fat distribution patterns, and to investigate the potential modifier effect of nutritional status in this association. METHODS: We enrolled 195 PD subjects consecutively admitted to a university geriatric day hospital. All participants underwent comprehensive clinical evaluation, including assessment of total and regional body composition (dual-energy X-ray absorptiometry, DXA), body mass index, nutritional status (Mini-Nutritional ...
Source: Aging Clinical and Experimental Research - March 15, 2019 Category: Geriatrics Authors: Pisciotta MS, Fusco D, Grande G, Brandi V, Lo Monaco MR, Laudisio A, Onder G, Bentivoglio AR, Ricciardi D, Bernabei R, Zuccalà G, Vetrano DL Tags: Aging Clin Exp Res Source Type: research

Factors associated with hospitalization for community-acquired pneumonia in home health care patients in Taiwan.
CONCLUSIONS: Our results revealed risk factors associated with hospitalization for CAP in HHC patients. In addition to chronic diseases, malnutrition is an important risk factor. Caregivers should make prompt assessments and take preventive measures for such patients. PMID: 30877643 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - March 14, 2019 Category: Geriatrics Authors: Lin CJ, Chang YC, Tsou MT, Chan HL, Chen YJ, Hwang LC Tags: Aging Clin Exp Res Source Type: research

Psychological markers of longevity in Sardinian centenarians: the impact of developmental factors and social desirability.
This study had two related aims. First, to fully characterize the psychological health of Sardinian elders in the very late adult span. Second, to determine the psychological health of long-lived individuals (i.e., centenarians) from this population. Three gender-matched age groups (octogenarian, nonagenarian, centenarian) of cognitively healthy, community dwelling adults were recruited in Sardinia, an Italian island characterized by higher levels of longevity. Comparisons of total and sub-scale levels of psychological well-being and depressive symptomatology were made while controlling for social desirability. There were ...
Source: Aging Clinical and Experimental Research - March 13, 2019 Category: Geriatrics Authors: Fastame MC, Penna MP, Hitchcott PK Tags: Aging Clin Exp Res Source Type: research

A systematic review and meta-analysis of the associations of vitamin D receptor genetic variants with two types of most common neurodegenerative disorders.
Abstract BACKGROUND: Whether vitamin D receptor (VDR) genetic variants influence individual susceptibility to neurodegenerative disorders remains controversial. AIMS: This meta-analysis was conducted to analyze correlations of VDR genetic variants with two types of most common neurodegenerative disorders, Parkinson's disease (PD) and Alzheimer's disease (AD). METHODS: Systematic literature research of PubMed and Embase was performed to identify eligible articles. Q test and I2 statistic were employed to decide whether pooled analyses would be performed with random-effect models (REMs) or fixed-effect mod...
Source: Aging Clinical and Experimental Research - March 12, 2019 Category: Geriatrics Authors: Geng J, Zhang J, Yao F, Liu X, Liu J, Huang Y Tags: Aging Clin Exp Res Source Type: research

Latin American Adult Immunisation Advocacy Summit: Overcoming regional barriers to adult vaccination.
Abstract Older adults in Latin America are at an increased risk of hospitalisation, ill health, catastrophic disability and death due to vaccine-preventable diseases such as influenza, herpes zoster, and pneumonia. The Latin American Adult Immunisation Advocacy Summit, held in Mexico City, gathered 40 experts in health, ageing and immunisation from 12 Latin American countries to explore good practices of adult vaccination, key country and regional barriers, and strategies to overcome these barriers. The Summit comprised of introductory lectures, plenary panels and breakout sessions with the overarching goal of imp...
Source: Aging Clinical and Experimental Research - March 11, 2019 Category: Geriatrics Authors: Barratt J, Mishra V, Acton M Tags: Aging Clin Exp Res Source Type: research

The Mediterranean diet: a pathway to successful aging.
Abstract PMID: 30859461 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - March 11, 2019 Category: Geriatrics Authors: Capurso A, Crepaldi G, Capurso C Tags: Aging Clin Exp Res Source Type: research

Development of a German version of the Oral Health Assessment Tool.
r A Abstract BACKGROUND: Limited assessment tools for estimating the oral health of nursing home residents are available in the German language. AIMS: To develop a German version of the Oral Health Assessment Tool (OHAT) and to evaluate test-retest and inter-examiner reliability in use for the assessment of nursing home residents' oral health by caregivers before and after dental training. METHODS: The original English version of the OHAT was translated into German by a forward-backward translation process. Reliability assessments were conducted in a nursing home (n = 18) by independent app...
Source: Aging Clinical and Experimental Research - March 7, 2019 Category: Geriatrics Authors: Klotz AL, Zajac M, Ehret J, Hassel AJ, Rammelsberg P, Zenthöfer A Tags: Aging Clin Exp Res Source Type: research

Impact of frailty status on the cost of drugs and dietary supplements prescribed to nursing home residents: the SENIOR cohort.
CONCLUSIONS: Frailty status has an impact on the expenditures related to the consumption of drugs. PMID: 30847844 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - March 7, 2019 Category: Geriatrics Authors: Buckinx F, Charles A, Quabron A, Van Hees T, Petermans J, Reginster JY, Bruyère O Tags: Aging Clin Exp Res Source Type: research

Comparative effects of fentanyl versus sufentanil on cerebral oxygen saturation and postoperative cognitive function in elderly patients undergoing open surgery.
This study was aimed to systematically evaluate the effects of fentanyl and sufentanil on intraoperative cerebral oxygen saturation changes and postoperative cognitive function in elderly patients undergoing open surgery. Ninety-six elderly patients who had undergone open surgery under general anesthesia were randomly divided into fentanyl group (F group, anesthesia by fentanyl, 4 g/kg) and sufentanil group (S group, anesthesia by sufentanil, 0.4 µg/kg). There were no significant differences between the F group and S group in the general characteristics of patients. Compared to the F group, the S group had ...
Source: Aging Clinical and Experimental Research - March 7, 2019 Category: Geriatrics Authors: Zhang J, Chen L, Sun Y, He W Tags: Aging Clin Exp Res Source Type: research

Counting deficits or diseases? The agreement between frailty and multimorbidity in subjects with cognitive disturbances.
Abstract In the present study, we explored the relationship between multimorbidity and frailty in a population of older individuals with cognitive disturbances attending a memory clinic. All subjects consecutively attending the Memory Clinic of the Department of Human Neuroscience, "Sapienza" University of Rome, between January 2017 and April 2018 for a first neurological evaluation were considered for the present analysis. Multimorbidity was defined as the simultaneous presence of two or more diseases in the same individual. A Frailty Index was computed by considering 44 age-related, multidimensional he...
Source: Aging Clinical and Experimental Research - March 6, 2019 Category: Geriatrics Authors: Canevelli M, Raganato R, Remiddi F, Quarata F, Valletta M, Bruno G, Cesari M Tags: Aging Clin Exp Res Source Type: research

Inflammatory biomarkers and frailty among older hospitalized patients.
Abstract PMID: 30840192 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - March 6, 2019 Category: Geriatrics Authors: Kawada T Tags: Aging Clin Exp Res Source Type: research

Characteristics of radiographic morphometries of the lower leg in subjects with progression of knee osteoarthritis in the TOEI cohort.
CONCLUSIONS: Higher age was the risk of osteoarthritis progression of the knee in female subjects but not significant risk in male subjects. Hip morphometries such as height of the hip center and femoral neck length in which showed a sex difference might be associated with the progression of knee osteoarthritis. PMID: 30840205 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - March 6, 2019 Category: Geriatrics Authors: Tran DH, Hoshino H, Togawa D, Matsuyama Y Tags: Aging Clin Exp Res Source Type: research

Long-term strength and balance training in prevention of decline in muscle strength and mobility in older adults.
kinen A Abstract BACKGROUND: Reductions in muscle strength and poor balance may lead to mobility limitations in older age. AIMS: We assessed the effects of long-term once-weekly strength and balance training (SBT) on muscle strength and physical functioning in a community-based sample of older adults. METHODS: 182 individuals [130 women and 52 men, mean age 80 (SD ± 3.9) years] underwent supervised SBT as part of the Geriatric Multidisciplinary Strategy for the Good Care of the Elderly study. Training was offered once a week for 2.3 years. Isometric knee extension and flexion st...
Source: Aging Clinical and Experimental Research - March 4, 2019 Category: Geriatrics Authors: Aartolahti E, Lönnroos E, Hartikainen S, Häkkinen A Tags: Aging Clin Exp Res Source Type: research

Comparing absolute handgrip strength and handgrip strength normalized to body weight in aging adults.
Abstract PMID: 30806906 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - February 26, 2019 Category: Geriatrics Authors: McGrath R Tags: Aging Clin Exp Res Source Type: research

Muscle adaptation in response to a high-intensity interval training in obese older adults: effect of daily protein intake distribution.
Abstract BACKGROUND: Aging is associated with declines in muscle mass, strength and quality, leading to physical impairments. An even protein distribution in daily meals has recently been proposed along with adequate total protein intake as important modulators of muscle mass. In addition, due to its short duration, high-intensity interval training (HIIT) has been highlighted as a promising intervention to prevent physical deterioration. However, the interaction between daily protein intake distribution and HIIT intervention in elderlies remain unknown. OBJECTIVE: To investigate muscle adaptation following HI...
Source: Aging Clinical and Experimental Research - February 26, 2019 Category: Geriatrics Authors: Buckinx F, Gaudreau P, Marcangeli V, Boutros GEH, Dulac MC, Morais JA, Aubertin-Leheudre M Tags: Aging Clin Exp Res Source Type: research

Adult vaccination as the cornerstone of successful ageing: the case of herpes zoster vaccination. A European Interdisciplinary Council on Ageing (EICA) expert focus group.
This report proposes strategies to increase awareness of HZ and its vaccine, enhance vaccine uptake, and educate regarding the role of prevention, including immunization, as a means to "age well". A key strategy that could rapidly and easily be implemented at low cost is co-administration of HZ vaccine with other vaccines scheduled in the target age group. The scientific evidence surrounding the safety and efficacy of co-administration is discussed. Other strategies, such as active calls, publicity campaigns and national vaccine registries are also outlined. There is a compelling need for a full consensus documen...
Source: Aging Clinical and Experimental Research - February 25, 2019 Category: Geriatrics Authors: Ecarnot F, Bernabei R, Gabutti G, Giuffrida S, Michel JP, Rezza G, Maggi S Tags: Aging Clin Exp Res Source Type: research

Effects of positive personal and non-personal autobiographical stimuli on emotional regulation in older adults.
te JJ Abstract People can regulate negative emotional states using personal episodic information stored in memory. However, amongst older adults, assistance in retrieving personal memories might be needed. As such, positive personal images might better facilitate the retrieval of positive personal memories, relative to generic positive images. The present study induced older adults (N = 40; Mage = 76.28) into a negative mood state using a validated film clip ("Dead Man Walking"; Robbins et al. in Dead Man Walking [Cinta Cinematográfica]. PolyGram Filmed Entertainment, Working Title F...
Source: Aging Clinical and Experimental Research - February 25, 2019 Category: Geriatrics Authors: Carretero LM, Latorre JM, Fernández D, Barry TJ, Ricarte JJ Tags: Aging Clin Exp Res Source Type: research

The nutritional risk and short-, medium- and long-term mortality of hospitalized patients with atrial fibrillation.
CONCLUSIONS: Nutritional risk is associated with the short-, medium- and long-term mortality of hospitalized patients with atrial fibrillation. PMID: 30790240 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - February 21, 2019 Category: Geriatrics Authors: Díez-Manglano J, Clemente-Sarasa C Tags: Aging Clin Exp Res Source Type: research

Usefulness of systolic blood pressure combined with heart rate measured on admission to identify 1-year all-cause mortality risk in elderly patients firstly hospitalized due to acute heart failure.
Corbella X Abstract BACKGROUND: Systolic blood pressure (SBP) and heart rate (HR) are well-known prognostic factors in heart failure (HF). AIMS: Our objective was to assess the value of the combination of admission SBP and HR to estimate 1-year mortality risks in elderly patients admitted due to a first episode of acute HF (AHF). METHODS: During a 36-month period, we retrospectively reviewed 901 consecutive patients aged ≥ 75 admitted because of a first episode of AHF. According to admission SBP-HR combinations, three groups were defined: "low-risk" (HR 
Source: Aging Clinical and Experimental Research - February 21, 2019 Category: Geriatrics Authors: Moreno-González R, Formiga F, Mora Lujan JM, Chivite D, Ariza-Solé A, Corbella X Tags: Aging Clin Exp Res Source Type: research

The role of omega-3 in the prevention and treatment of sarcopenia.
Abstract Sarcopenia is a geriatric syndrome with increasing importance due to the aging of the population. It is known to impose a major burden in terms of morbidity, mortality and socio-economic costs. Therefore, adequate preventive and treatment strategies are required. Progressive resistance training and protein supplementation are currently recommended for the prevention and treatment of sarcopenia. Omega-3 polyunsaturated fatty acids (PUFAs) might be an alternative therapeutic agent for sarcopenia due to their anti-inflammatory properties, which target the 'inflammaging', the age-related chronic low-grade inf...
Source: Aging Clinical and Experimental Research - February 19, 2019 Category: Geriatrics Authors: Dupont J, Dedeyne L, Dalle S, Koppo K, Gielen E Tags: Aging Clin Exp Res Source Type: research

A randomized double-blinded placebo controlled trial of ergocalciferol 40,000 versus 100,000  IU per week for vitamin D inadequacy in institutionalized postmenopausal women.
A randomized double-blinded placebo controlled trial of ergocalciferol 40,000 versus 100,000 IU per week for vitamin D inadequacy in institutionalized postmenopausal women. Aging Clin Exp Res. 2019 Feb 19;: Authors: Mueangpaisarn P, Chaiamnuay S Abstract BACKGROUND: Vitamin D inadequacy is common in institutionalized post-menopausal women who are at the highest risk for osteoporotic fracture. AIM: To evaluate efficacy and safety of ergocalciferol 40,000 versus 100,000 IU per week for 12 weeks for vitamin D inadequacy in institutionalized postmenopausal women. METHOD: A randomi...
Source: Aging Clinical and Experimental Research - February 19, 2019 Category: Geriatrics Authors: Mueangpaisarn P, Chaiamnuay S Tags: Aging Clin Exp Res Source Type: research

Is sitting time leading to mobility decline in long-term care residents?
CONCLUSION: People living in LTC are highly sedentary. Sitting time differs amongst the mobility statues, but is unable to predict upcoming changes in mobility status. PMID: 30778873 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - February 18, 2019 Category: Geriatrics Authors: Lee AM, Sénéchal M, Hrubeniuk TJ, Bouchard DR Tags: Aging Clin Exp Res Source Type: research

Polypharmacy and sarcopenia in hospitalized older patients: results of the GLISTEN study.
CONCLUSIONS: Present findings demonstrate that the association of polypharmacy with sarcopenia, observed in the BASE-II study, is not evident in the GLISTEN sample, being our patients significantly older, more multi-morbid, with high prevalence of sarcopenia and polypharmacy, suggesting that this association might vary according to the heterogeneous health, functional, and nutritional characteristics of older people. PMID: 30778874 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - February 18, 2019 Category: Geriatrics Authors: Agosta L, Bo M, Bianchi L, Abete P, Belelli G, Cherubini A, Corica F, Di Bari M, Maggio M, Manca GM, Rizzo MR, Rossi A, Landi F, Volpato S, GLISTEN Group Investigators Tags: Aging Clin Exp Res Source Type: research

The effect of ageing on shear wave elastography muscle stiffness in adults.
Abstract BACKGROUND: Skeletal muscle undergoes structural changes with ageing which may alter its biomechanical properties. Shear wave elastography (SWE) may detect these changes by measuring muscle stiffness. AIMS: To investigate muscle stiffness in healthy young, middle-aged and elderly cohorts using SWE and correlate it with muscle strength and mass. METHODS: Shear wave velocity (SWV) was measured in the quadriceps, hamstrings and biceps brachii of 26 young (range 20-35 years), 21 middle-aged (40-55) and 30 elderly (77-94) volunteers. The participants performed several muscle tests to evaluate th...
Source: Aging Clinical and Experimental Research - February 14, 2019 Category: Geriatrics Authors: Alfuraih AM, Tan AL, O'Connor P, Emery P, Wakefield RJ Tags: Aging Clin Exp Res Source Type: research

Waist circumference or sarcopenic obesity: which is more predictive?
l MG, Cankurtaran M Abstract PMID: 30756251 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - February 13, 2019 Category: Geriatrics Authors: Koca M, Şengül Ayçiçek G, Ünsal P, Deniz O, Şendur A, Eşme M, Yavuz BB, Halil MG, Cankurtaran M Tags: Aging Clin Exp Res Source Type: research

Cost-effectiveness evaluation of glucosamine for osteoarthritis based on simulation of individual patient data obtained from aggregated data in published studies.
CONCLUSION: Using a new model to simulate individual health utility scores of patients included in ten published trials, ICER analysis showed that the use of crystalline glucosamine sulfate is cost-effective, while other formulations were not. The results confirm the importance of the formulation of glucosamine products. PMID: 30746645 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - February 12, 2019 Category: Geriatrics Authors: Bruyère O, Reginster JY, Honvo G, Detilleux J Tags: Aging Clin Exp Res Source Type: research

Efficacy of different types of exercises on global cognition in adults with mild cognitive impairment: a network meta-analysis.
CONCLUSIONS: High-intensity and frequent resistance exercises may be the most effective exercise type to improve global cognition in adults with mild cognitive impairment. More multi-arm designs and randomized controlled trials examining the efficacy of exergames are needed. PMID: 30739298 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - February 9, 2019 Category: Geriatrics Authors: Wang S, Yin H, Wang X, Jia Y, Wang C, Wang L, Chen L Tags: Aging Clin Exp Res Source Type: research

Calabria: a successful experience implementing Herpes Zoster vaccination strategies.
Abstract Recently, the National Immunization Plan (NIP) in Italy has highlighted the importance of immunization practices also for adults, including vaccinations against influenza, Pneumococcus (PNO) and HZ. In response to the NIP, the Calabria region decided to offer HZ vaccination to the two cohorts of 65- and 70-year-old subjects. We at the Reggio Calabria Local Health Services, concentrated our efforts on addressing all the above-mentioned shortcomings and, as a first measure, we addressed the convenience problem by scheduling the HZ vaccine administration during the same visit as the pneumococcal vaccination ...
Source: Aging Clinical and Experimental Research - February 8, 2019 Category: Geriatrics Authors: Giuffrida S Tags: Aging Clin Exp Res Source Type: research

Biochemical markers of inflammation are associated with increased mortality in hip fracture patients: the Bispebjerg Hip Fracture Biobank.
CONCLUSION: This study shows that 30-day mortality after a hip fracture is associated with elevated levels of suPAR, CRP and ferritin as well as with lower levels of transferrin. This excess inflammatory response is likely caused by muscle damage associated with the hip fracture. However, this needs to be further clarified. PMID: 30707355 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - February 1, 2019 Category: Geriatrics Authors: Norring-Agerskov D, Bathum L, Pedersen OB, Abrahamsen B, Lauritzen JB, Jørgensen NR, Jørgensen HL Tags: Aging Clin Exp Res Source Type: research

Relationship between blood pressure variability and cognitive function in geriatric hypertensive patients with well-controlled blood pressure.
Abstract BACKGROUND: Hypertension is an important risk factor for cardiovascular diseases and cognitive function. Blood pressure (BP) variability has been associated with cognitive dysfunction, but data are sparse regarding the relationship between BP variability and cognitive function in geriatric patients with well-controlled BP. AIM: The aim of this study was to demonstrate the relationship between blood pressure variability and cognitive functions in geriatric hypertensive patients with well-controlled BP. METHOD: We analyzed 435 hypertensive patients (167 male, 74.9 ± 8.3; 268 f...
Source: Aging Clinical and Experimental Research - February 1, 2019 Category: Geriatrics Authors: Yıldırım E, Ermis E, Allahverdiyev S, Ucar H, Yavuzer S, Yavuzer H, Cengiz M Tags: Aging Clin Exp Res Source Type: research

Nutritional influence on bone: role of gut microbiota.
Abstract Gut microbiota (GM) located within the intestinal tract lumen comprises the largest number of cells (10E14) in the human body. The gut microbiome refers to the collection of genomes and genes present in gut microbiota. GM can vary according to age, sex, genetic background, immune status, geography, diet, prebiotics, which are non-digestible fibers metabolized in the distal part of the gastrointestinal tract, probiotics, which are micro-organisms conferring a health benefit on the host when administered in adequate amounts, living conditions, diseases and drugs. A source of probiotics is fortified fermente...
Source: Aging Clinical and Experimental Research - February 1, 2019 Category: Geriatrics Authors: Rizzoli R Tags: Aging Clin Exp Res Source Type: research

Individual and cumulative association of commonly used biomarkers on frailty: a cross-sectional analysis of the Mexican Health and Aging Study.
Carrillo-Vega MF Abstract Frailty has been recognized as a common condition in older adults, however, there is scarce information on the association between frailty and commonly used biomarkers. The aim of this study was to assess the individual and cumulative association of biomarkers with frailty status. This is a cross-sectional analysis of the 2012 wave of the Mexican Health and Aging Study. A sub-sample of 60-year or older adults with anthropometric measurements was analyzed. Frailty was defined with a 31-item frailty index and those considered frail had a score ≥ 0.21. Biomarkers were furth...
Source: Aging Clinical and Experimental Research - January 31, 2019 Category: Geriatrics Authors: Pérez-Zepeda MU, García-Peña C, Carrillo-Vega MF Tags: Aging Clin Exp Res Source Type: research

The role of parathyroid hormone (PTH) and vitamin D in falls and hip fracture type.
CONCLUSION: Elevated PTH levels predispose both to falls and trochanteric fractures, while vitamin D-deficient patients with normal PTH levels are mostly related to subcapital fractures. It is thereby indicated that different pathophysiological processes lie behind subcapital and trochanteric fractures. A better understanding of these mechanisms may assist in the development of prevention strategies for individuals recognized at risk for falls and either type of hip fracture. PMID: 30701437 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 30, 2019 Category: Geriatrics Authors: Dretakis K, Igoumenou VG Tags: Aging Clin Exp Res Source Type: research

Efficacy and safety of endoscopic submucosal dissection for gastric epithelial neoplasia in elderly patients aged 80  years and older.
Efficacy and safety of endoscopic submucosal dissection for gastric epithelial neoplasia in elderly patients aged 80 years and older. Aging Clin Exp Res. 2019 Jan 29;: Authors: Son YW, Kim A, Jeon HH Abstract BACKGROUND: Endoscopic submucosal dissection (ESD) has been widely used in gastric tumor as a minimally invasive treatment. The efficacy and safety of ESD is still unclear in the elderly who have high frequency comorbidities. The aim of this study is to evaluate the efficacy and safety of ESD for gastric epithelial neoplasia in patients aged 80 years and older. METHODS: Between Mar...
Source: Aging Clinical and Experimental Research - January 29, 2019 Category: Geriatrics Authors: Son YW, Kim A, Jeon HH Tags: Aging Clin Exp Res Source Type: research

Needs of persons with dementia and their family caregivers in dementia caf és.
CONCLUSIONS: Dementia cafés should create programmes and comfortable environments answering to the differences of their needs. PMID: 30694511 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 29, 2019 Category: Geriatrics Authors: Fukui C, Fujisaki-Sueda-Sakai M, Yokouchi N, Sumikawa Y, Horinuki F, Baba A, Suto M, Okada H, Ogino R, Park H, Okata J Tags: Aging Clin Exp Res Source Type: research

Association between serum uric acid levels and coronary artery disease in different age and gender: a cross-sectional study.
Abstract BACKGROUND: The association between uric acid (UA) and coronary artery disease (CAD) was controversial. It was still unclear how the UA level changes with age and gender. AIMS: To confirm the relationship between the change of UA with age and gender and CAD, especially in elderly people. METHODS: 8285 individuals were investigated. The changes of UA and hyperuricemia in female and male with age were analyzed. The associations of UA, and hyperuricemia with CAD in different age and sex were assessed. RESULTS: Individuals were stratified into four groups according to their age: ≤ 39&nb...
Source: Aging Clinical and Experimental Research - January 29, 2019 Category: Geriatrics Authors: Sun Y, Zhang H, Tian W, Shi L, Chen L, Li J, Zhao S, Qi G Tags: Aging Clin Exp Res Source Type: research

Vitamin B12-fortified toothpaste improves vitamin status in elderly people: a randomized, double-blind, placebo-controlled study.
Abstract BACKGROUND: Elderly people are at risk for vitamin B12 deficiency. AIMS: We studied the ability of vitamin B12-enriched toothpaste vs. placebo to increase vitamin B12 status in elderly subjects. METHODS: We conducted a randomized double-blind placebo-controlled intervention in 103 elderly subjects. Serum concentrations of vitamin B12, holotranscobalamin (holoTC), methylmalonic acid (MMA), and plasma total homocysteine (tHcy) were measured at baseline and after 3 months. RESULTS: 92 subjects met the inclusion criteria, completed the 3 months study, and were included in the data ana...
Source: Aging Clinical and Experimental Research - January 24, 2019 Category: Geriatrics Authors: Zant A, Awwad HM, Geisel J, Keller M, Obeid R Tags: Aging Clin Exp Res Source Type: research

Dietary strategies for mitigating osteosarcopenia in older adults: a narrative review.
Abstract The synchronic loss of bone mineral density and decrease in muscle mass, strength, and function defines the scenario of osteosarcopenia, which is associated with an increased risk of falls and fractures in older adults. An important role in preventing muscle and bone loss is played by nutritional factors, in particular the intake of proteins, calcium, magnesium and vitamin D. This review summarizes the available literature concerning the influence of protein intake and supplementation (vitamin D, Ca, Mg, branched-chain amino acids) on the decline of musculoskeletal integrity in healthy older adults. Furth...
Source: Aging Clinical and Experimental Research - January 23, 2019 Category: Geriatrics Authors: De Rui M, Inelmen EM, Pigozzo S, Trevisan C, Manzato E, Sergi G Tags: Aging Clin Exp Res Source Type: research

Sarcopenia and swallowing disorders in older people.
Abstract Aging is accompanied by several changes which may affect swallowing function. The beginning of these changes, termed presbyphagia, still captures a preserved swallowing function, although burdened by the consequences of the physiological aging process. Several stressors (including diseases and medications) can easily trigger the disruption of this (increasingly weak) equilibrium and lead to overt dysphagia. It is noteworthy that the swallowing dysfunction may be aggravated by the sarcopenic process, characterizing the so-called "sarcopenic dysphagia", potentially responsible for several health-r...
Source: Aging Clinical and Experimental Research - January 22, 2019 Category: Geriatrics Authors: Azzolino D, Damanti S, Bertagnoli L, Lucchi T, Cesari M Tags: Aging Clin Exp Res Source Type: research

Diabetes mellitus, frailty and prognosis in very elderly patients with acute coronary syndromes.
CONCLUSIONS: About 40% of elderly patients with ACS had previous known DM diagnosis. The association between DM and outcomes was different according to frailty status. PMID: 30671867 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 22, 2019 Category: Geriatrics Authors: Gual M, Formiga F, Ariza-Solé A, López-Palop R, Sanchís J, Marín F, Vidán MT, Martínez-Sellés M, Sionis A, Sánchez-Salado JC, Lorente V, Díez-Villanueva P, Vives-Borrás M, Cordero A, Bueno H, Alegre O, Abu-Assi E, Cequier À, LONGEVO-SCA registr Tags: Aging Clin Exp Res Source Type: research

Perception of parks and trails as mobility facilitators and transportation walking in older adults: a study using digital geographical maps.
CONCLUSIONS: Our findings suggest that the perception of environmental characteristics in the neighbourhood has an influence on older people's transportation choices. Taking environmental measures or informing older adults on their options in the neighbourhood might be possible ways to increase older adults' transportation walking on a population level. PMID: 30666515 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 21, 2019 Category: Geriatrics Authors: Hinrichs T, Keskinen KE, Pavelka B, Eronen J, Schmidt-Trucksäss A, Rantanen T, Portegijs E Tags: Aging Clin Exp Res Source Type: research

The effects of same-session combined exercise training on cardiorespiratory and functional fitness in older adults: a systematic review and meta-analysis.
Abstract Endurance and strength training are effective strategies for counteracting age-associated reductions in physical performance in older adults, with a combination of both exercise modes recommended to maximise potential fitness benefits. This meta-analysis sought to quantify the effects of same-session combined endurance and strength training on fitness in adults aged over 50 years. Five electronic databases were searched with studies required to include one of the following outcome measures: VO2peak, 6-min walk test (6MWT), 8-ft timed up-and-go (TUG), and 30-s chair stand. Separate random-effects meta...
Source: Aging Clinical and Experimental Research - January 19, 2019 Category: Geriatrics Authors: Hurst C, Weston KL, McLaren SJ, Weston M Tags: Aging Clin Exp Res Source Type: research

Behavioral and cognitive markers of mild cognitive impairment: diagnostic value of saccadic eye movements and Simon task.
CONCLUSION: The present results enable us to suggest eye tracking along with behavioral data as a possible sensitive tools to detect a-MCI in preclinical stage. PMID: 30659514 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 18, 2019 Category: Geriatrics Authors: Chehrehnegar N, Nejati V, Shati M, Esmaeili M, Rezvani Z, Haghi M, Foroughan M Tags: Aging Clin Exp Res Source Type: research

Differential impact of endurance, strength, or combined training on quality of life and plasma serotonin in healthy older women.
r N Abstract Aging is associated with a progressive decline in physical and neurophysiological functions, and some studies suggest that cerebral serotonin is decreased in older adults. These factors contribute to reduced ability to perform daily activities, influencing quality of life (QoL). Regular physical activity has demonstrated important benefits in reversing ageing effects; however, little is known whether different training protocols might induce differential effects on QoL. The aim of this study was to verify the effects of different types of training on QoL and its relation with plasma serotonin in healt...
Source: Aging Clinical and Experimental Research - January 18, 2019 Category: Geriatrics Authors: Pietta-Dias C, Bello MD, da Silva R, Vargas C, Machado GDB, Roncada C, Tiggemann CL, Schröder N Tags: Aging Clin Exp Res Source Type: research

Consistency and test-retest reliability of stepping tests designed to measure self-perceived and actual physical stepping ability in older adults.
s M Abstract BACKGROUND: Older adults with an incorrect perception of their physical abilities may fall more often, suggesting a need for tests to quantify self-perceived and actual abilities. AIMS: To determine between-test consistency and test-retest reliability of three tests that measure self-perceived and actual stepping ability in older adults. METHODS: Older adults performed three stepping tests, covering high (bar test) and far steps (river and step tests). We studied between-test consistency in the perceived ability and actual ability of 269 participants at each task and in the difference betwee...
Source: Aging Clinical and Experimental Research - January 16, 2019 Category: Geriatrics Authors: Weijer RHA, Hoozemans MJM, van Dieën JH, Pijnappels M Tags: Aging Clin Exp Res Source Type: research

Nursing home staff members' knowledge, experience and attitudes regarding advance care planning: a cross-sectional study involving 12 Italian nursing homes.
CONCLUSIONS: A multifaceted strategy including educational and training programmes and the increase of public awareness is needed to implement advance care planning in Italian nursing homes. PMID: 30637596 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 14, 2019 Category: Geriatrics Authors: Ottoboni G, Chattat R, Camedda C, Galletti M, Macripò S, Mariani E, Ingravallo F Tags: Aging Clin Exp Res Source Type: research