COVID-19 and geriatric clinical trials research.
PMID: 32939681 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - September 16, 2020 Category: Geriatrics Authors: Rhodus EK, Bardach SH, Abner EL, Gibson A, Jicha GA Tags: Aging Clin Exp Res Source Type: research

Between-day repeatability of sensor-based in-home gait assessment among older adults: assessing the effect of frailty.
Abstract BACKGROUND: While sensor-based daily physical activity (DPA) gait assessment has been demonstrated to be an effective measure of physical frailty and fall-risk, the repeatability of DPA gait parameters between different days of measurement is not clear. AIMS: To evaluate test-retest reliability (repeatability) of DPA gait performance parameters, representing the quality of walking, and quantitative gait measures (e.g. number of steps) between two separate days of assessment among older adults. METHODS: DPA was acquired for 48-h from older adults (age ≥ 65 years) using a tri...
Source: Aging Clinical and Experimental Research - September 15, 2020 Category: Geriatrics Authors: Pradeep Kumar D, Wendel C, Mohler J, Laksari K, Toosizadeh N Tags: Aging Clin Exp Res Source Type: research

Comparison between drug therapy-based comorbidity indices and the Charlson Comorbidity Index for the detection of severe multimorbidity in older subjects.
CONCLUSION: CDS and MCI were better predictors of severe multimorbidity in older adults than DDCI, according to the CCI classification. A high CCI score was related to a high TBCI. However, the opposite is not necessarily true probably because of non-evidence-based prescriptions or physicians' prescribing attitudes. TBCIs did not appear selective for detecting of severe multimorbidity, though they could be used as a measure of disease burden, in the absence of other solutions. PMID: 32930989 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - September 15, 2020 Category: Geriatrics Authors: Novella A, Elli C, Tettamanti M, Nobili A, Ianes A, Mannucci PM, Pasina L, REPOSI* Investigators Tags: Aging Clin Exp Res Source Type: research

The effect of different test protocols and walking distances on gait speed in older persons.
CONCLUSIONS: Gait speed was faster, if the test protocol did not include a static start or stop. The differences were greater for a shorter walking distance. This aspect should be considered for the comparison of study results and is particularly relevant for systematic reviews and meta-analyses. PMID: 32930990 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - September 15, 2020 Category: Geriatrics Authors: Krumpoch S, Lindemann U, Rappl A, Becker C, Sieber CC, Freiberger E Tags: Aging Clin Exp Res Source Type: research

Physical performance measures and hospital outcomes among Italian older adults: results from the CRIME project.
mer K Abstract BACKGROUND: Older adults are a complex population, at risk of adverse events during and after hospital stay. AIM: To investigate the association of walking speed (WS) and grip strength (GS) with adverse outcomes, during and after hospitalization, among older individuals admitted to acute care wards. METHODS: Multicentre observational study including 1123 adults aged ≥ 65 years admitted to acute wards in Italy. WS and GS were measured at admission and discharge. Outcomes were length-of-stay, in-hospital mortality, 1-year mortality and rehospitalisation. Length-of-stay ...
Source: Aging Clinical and Experimental Research - September 14, 2020 Category: Geriatrics Authors: Villani ER, Vetrano DL, Franza L, Carfì A, Brandi V, Volpato S, Corsonello A, Lattanzio F, Ruggiero C, Onder G, Palmer K Tags: Aging Clin Exp Res Source Type: research

The impact of COVID-19 on health status of home-dwelling elderly patients  with dementia in East Lombardy, Italy: results from COVIDEM network.
The impact of COVID-19 on health status of home-dwelling elderly patients with dementia in East Lombardy, Italy: results from COVIDEM network. Aging Clin Exp Res. 2020 Sep 12;: Authors: Caratozzolo S, Zucchelli A, Turla M, Cotelli MS, Fascendini S, Zanni M, Bianchetti A, Psy MP, Rozzini R, Boffelli S, Cappuccio M, Psy FG, Psy CV, Bellandi D, Caminati C, Gentile S, Psy EL, Di Fazio I, Psy MZ, Vezzadini G, Psy CF, Psy MC, Psy RT, Psy SP, Scalvini A, Di Cesare M, Psy MG, Falanga L, Medici N, Palamini N, Psy EZ, Psy EG, Bellelli G, Marengoni A, Trabucchi M, Padovani A, COVIDEM Network Abstract BACKGR...
Source: Aging Clinical and Experimental Research - September 12, 2020 Category: Geriatrics Authors: Caratozzolo S, Zucchelli A, Turla M, Cotelli MS, Fascendini S, Zanni M, Bianchetti A, Psy MP, Rozzini R, Boffelli S, Cappuccio M, Psy FG, Psy CV, Bellandi D, Caminati C, Gentile S, Psy EL, Di Fazio I, Psy MZ, Vezzadini G, Psy CF, Psy MC, Psy RT, Psy SP, S Tags: Aging Clin Exp Res Source Type: research

Clinical and demographic parameters predict the progression from mild cognitive impairment to dementia in elderly patients.
Abstract OBJECTIVES: To evaluate the possibility of predicting the risk of progression from mild cognitive impairment (MCI) to dementia using a combination of clinical/demographic parameters. METHODS: A total of 462 MCI elderly patients (follow-up: 33 months). Variable measured included cognitive functions, age, gender, MCI type, education, comorbidities, clinical chemistry, and functional status. RESULTS: Amnestic type (aMCI) represented 63% of the sample, non-amnestic (naMCI) 37%; 190 subjects progressed to dementia, 49% among aMCI, and 28% among naMCI. At Cox multivariate regression analysis, onl...
Source: Aging Clinical and Experimental Research - September 12, 2020 Category: Geriatrics Authors: Zuliani G, Polastri M, Romagnoli T, Marabini L, Seripa D, Cervellati C, Zurlo A, Passaro A, Brombo G Tags: Aging Clin Exp Res Source Type: research

Birth cohort differences in cognitive performance in 75- and 80-year-olds: a comparison of two cohorts over 28  years.
CONCLUSIONS: The results of this study provide strong evidence that cognitive performance is better in more recent cohorts of older people compared to their counterparts measured 28 years earlier. PMID: 32918698 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - September 12, 2020 Category: Geriatrics Authors: Munukka M, Koivunen K, von Bonsdorff MB, Sipilä S, Portegijs E, Ruoppila I, Rantanen T Tags: Aging Clin Exp Res Source Type: research

Multidimensional prognostic index (MPI) predicts successful application for disability social benefits in older people.
CONCLUSION: MPI is an excellent predictor of social benefits' release by local and national agencies. PMID: 32915449 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - September 11, 2020 Category: Geriatrics Authors: Senesi B, Prete C, Siri G, Pinna A, Giorgeschi A, Veronese N, Sulpasso R, Sabbà C, Pilotto A Tags: Aging Clin Exp Res Source Type: research

Direct anterior approach versus direct lateral approach in total hip arthroplasty and bipolar hemiarthroplasty for femoral neck fractures: a retrospective comparative study.
CONCLUSIONS: The direct anterior approach in THA for FNFs provides significant benefits in the early post-operative period compared to the direct lateral approach in terms of functional recovery, residual pain, blood loss and mortality rate in the elderly active population. LEVEL OF EVIDENCE: Level IV, retrospective cohort study. PMID: 32910422 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - September 10, 2020 Category: Geriatrics Authors: Spina M, Luppi V, Chiappi J, Bagnis F, Balsano M Tags: Aging Clin Exp Res Source Type: research

Correction to: Perioperative Management of Elderly patients (PriME): recommendations from an Italian intersociety consensus.
), Società Italiana di Gerontologia e Geriatria (SIGG), Società Italiana di Chirurgia (SIC), Società Italiana di Chirurgia Geriatrica (SICG) and Associazione Italiana di Psicogeriatria (AIP) Abstract The article Perioperative Management of Elderly patients (PriME). PMID: 32910423 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - September 10, 2020 Category: Geriatrics Authors: Aceto P, Antonelli Incalzi R, Bettelli G, Carron M, Chiumiento F, Corcione A, Crucitti A, Maggi S, Montorsi M, Pace MC, Petrini F, Tommasino C, Trabucchi M, Volpato S, Società Italiana di Anestesia Analgesia Rianimazione e Terapia Intensiva (SIAARTI), So Tags: Aging Clin Exp Res Source Type: research

Common combinations of medications used among oldest-old women: a population-based study over 15  years.
CONCLUSION: Identification of combinations of medication use may provide opportunities to develop multimorbidity guidelines and target medication reviews, and may help reduce medication load for older individuals. PMID: 32909246 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - September 9, 2020 Category: Geriatrics Authors: Thiruchelvam K, Byles J, Hasan SS, Egan N, Cavenagh D, Kairuz T Tags: Aging Clin Exp Res Source Type: research

Correction to: COVID-19 and the elderly patients: insights into pathogenesis and clinical decision-making.
Abstract In the published article, the title was published incorrectly as COVID-19. PMID: 32902821 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - September 9, 2020 Category: Geriatrics Authors: Perrotta F, Corbi G, Mazzeo G, Boccia M, Aronne L, D'Agnano V, Komici K, Mazzarella G, Parrella R, Bianco A Tags: Aging Clin Exp Res Source Type: research

Cognitive and vascular function in older adults with and without CKD.
CONCLUSIONS: The findings of this study support the assessment of cognitive and vascular function in older adults with and without CKD with preclinical cognitive impairment. PMID: 32902822 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - September 9, 2020 Category: Geriatrics Authors: Hannan M, Collins EG, Phillips SA, Quinn L, Steffen A, Bronas UG Tags: Aging Clin Exp Res Source Type: research

Internal fixation of acetabular quadrilateral plate fractures in elderly  patients: Could the fracture reduction quality affect their functional recovery?
CONCLUSIONS: In this study, the functional recovery at 24 months follow-up showed no significant differences in elderly patients with QP fracture undergoing anatomical reconstruction (displacement 0-1 mm) compared to patients receiving a good QP fracture reconstruction (displacement ≤ 3 mm). PMID: 32902823 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - September 9, 2020 Category: Geriatrics Authors: Panella A, Solarino G, Vicenti G, Bizzoca D, Baglioni M, Fortunato F, Maruccia F, Notarnicola A, Piazzolla A, Pascarella R, Belluati A, Moretti B Tags: Aging Clin Exp Res Source Type: research

Why should you stay one night? Prospective observational study of enhanced recovery in elderly patients.
CONCLUSION: The data from this study support an enhanced recovery approach for elderly patients, in which after a minor surgical procedure with anaesthesia, a recovery period of one night in the hospital can contribute to normalizing the CAM4 score and reducing the incidence of delirium. PMID: 32901431 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - September 8, 2020 Category: Geriatrics Authors: Melegari G, Albertini G, Romani A, Malaguti S, Traccitto F, Giuliani E, Cavallini GM, Bertellini E, Barbieri A Tags: Aging Clin Exp Res Source Type: research

A double-blind randomized controlled trial of the efficacy of cognitive training delivered using two different methods in mild cognitive impairment in Parkinson's disease: preliminary report of benefits associated with the use of a computerized tool.
CONCLUSION: CCT proved effective in PD-MCI patients when compared with traditional PCT. Further follow-up assessments are being conducted to verify the retention of the gains and the potential ability of the tool to delay conversion to PD-dementia. Trial registration number (ClinicalTrials.gov): NCT04111640 (30th September 2019). PMID: 32895890 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - September 8, 2020 Category: Geriatrics Authors: Bernini S, Panzarasa S, Barbieri M, Sinforiani E, Quaglini S, Tassorelli C, Bottiroli S Tags: Aging Clin Exp Res Source Type: research

Lipopolysaccharide binding protein is associated with CVD risk in older adults.
Abstract BACKGROUND: Intestinal (i.e., "gut") permeability may be related to cardiovascular disease (CVD) risk, but biomarkers for gut permeability are limited and associations with CVD risk are unknown-particularly among older adults. AIMS: This cross-sectional study aimed to determine if serum biomarkers related to gut permeability [intestinal fatty acid-binding protein (iFABP)] and bacterial toxin clearing [cluster of differentiation 14 (CD14), lipopolysaccharide binding protein (LBP)] are associated with CVD risk among older adults. METHODS: Older adults (n = 74, 69.6 &...
Source: Aging Clinical and Experimental Research - September 8, 2020 Category: Geriatrics Authors: Roberts LM, Buford TW Tags: Aging Clin Exp Res Source Type: research

Brain-derived neurotrophic factor Val66Met polymorphism is associated with mild cognitive impairment in elderly patients with type 2 diabetes: a case-controlled study.
This study was performed to investigate the association between BDNF Val66Met polymorphism and mild cognitive impairment (MCI) in elderly patients with T2DM. METHODS: In total, 105 MCI and 105 normal cognition controls of T2DM patients were enrolled; all of the patients underwent neuropsychological assessments. BDNF Val66Met polymorphism was genotyped via TaqMan SNP genotyping assay. Data from clinical and laboratory-based examinations were collected. RESULTS: The frequency of the BDNF Met allele was significantly higher in the MCI group than in the controls. Multiple regression analysis indicated an association ...
Source: Aging Clinical and Experimental Research - September 6, 2020 Category: Geriatrics Authors: Liu J, Yang W, Luo H, Ma Y, Zhao H, Dan X Tags: Aging Clin Exp Res Source Type: research

Are we maximizing the utility of handgrip strength assessments for evaluating muscle function?
PMID: 32892298 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - September 5, 2020 Category: Geriatrics Authors: McGrath R Tags: Aging Clin Exp Res Source Type: research

Looking for a needle in a haystack: an older diabetic man with cheiroarthropathy loses an insulin pen needle in subcutaneous tissue.
PMID: 32889662 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - September 5, 2020 Category: Geriatrics Authors: Iacomelli I, Giulietti C, Di Bari M Tags: Aging Clin Exp Res Source Type: research

Evidence for possible association of vitamin D status with cytokine storm and unregulated inflammation in COVID-19 patients.
CONCLUSION: We conclude that future studies on VitD's role in reducing cytokine storm and COVID-19 mortality are warranted. PMID: 32876941 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - September 2, 2020 Category: Geriatrics Authors: Daneshkhah A, Agrawal V, Eshein A, Subramanian H, Roy HK, Backman V Tags: Aging Clin Exp Res Source Type: research

Cytokine storm in aged people with CoV-2: possible role of vitamins as therapy or preventive strategy.
CONCLUSIONS: Vitamins may shift the proinflammatory Th17-mediated immune response arising in autoimmune diseases towards a T-cell regulatory phenotype. This review discusses the possible activity of vitamins A, D, E, and C in restoring normal antiviral immune system function and the potential therapeutic role of these micronutrients as part of a therapeutic strategy against SARS-CoV-2 infection. PMID: 32865757 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - August 31, 2020 Category: Geriatrics Authors: Fiorino S, Gallo C, Zippi M, Sabbatani S, Manfredi R, Moretti R, Fogacci E, Maggioli C, Travasoni Loffredo F, Giampieri E, Corazza I, Dickmans C, Denitto C, Cammarosano M, Battilana M, Orlandi PE, Del Forno F, Miceli F, Visani M, Acquaviva G, De Leo A, Le Tags: Aging Clin Exp Res Source Type: research

Functional outcome in intensive care older survivors.
CONCLUSIONS: Comorbidity burden and infections acquired within 3 months after discharge are important determinants of long-term functional level after ICU admission. PMID: 32865758 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - August 31, 2020 Category: Geriatrics Authors: Ali SH, Nasr RA, Abou-Hashem RM Tags: Aging Clin Exp Res Source Type: research

Remote assessment for identifying COVID-19 post-acute care needs.
PMID: 32864709 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - August 30, 2020 Category: Geriatrics Authors: Sivan M Tags: Aging Clin Exp Res Source Type: research

What does hand motor function tell us about our aging brain in association with WMH?
CONCLUSIONS: Complex hand movements in the non-dominant hand are mediated by WMH. Subtle loss of motor movements of non-dominant hand might predict future excessive white matter atrophy. PMID: 32860625 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - August 29, 2020 Category: Geriatrics Authors: Riaz M, Vangberg TR, Vasylenko O, Castro-Chavira S, Gorecka MM, Waterloo K, Rodríguez-Aranda C Tags: Aging Clin Exp Res Source Type: research

Vitamin D supplementation: upper limit for safety revisited?
Abstract Vitamin D overdosing includes hypercalcemia, hypercalciuria, and mineral deposits in soft tissues. A safety upper limit of 4000 IU/day, which is consistently accepted, has been challenged, since the risk of adverse events in other systems than calcium-phosphate homeostasis may depend not only on the dose, but on the outcome, the treatment regimen, and possibly the age, sex and vitamin D status. The therapeutic window of vitamin D supplementation may be narrower than hitherto recognized. The prevention and/or correction of vitamin D deficiency/insufficiency with 800-1000 IU/daily of vitamin D or ...
Source: Aging Clinical and Experimental Research - August 28, 2020 Category: Geriatrics Authors: Rizzoli R Tags: Aging Clin Exp Res Source Type: research

Does trail making test predict long-term prognosis in older patients with COPD?
Abstract Executive abilities are frequently impaired in patients with chronic obstructive pulmonary disease (COPD). We aimed at investigating the association between trail making test (TMT) and survival. Our series consisted of 68 stable COPD outpatients followed-up every 6 months for 52.6 ± 27.6 months. Enrolled patients underwent a baseline comprehensive neuropsychological assessment, including mini-mental state exam, attentional matrices, digit span, Rey auditory verbal learning, Rey-Osterrieth complex figure, copy drawing, tokens test, verbal fluency, category fluency, frontal as...
Source: Aging Clinical and Experimental Research - August 17, 2020 Category: Geriatrics Authors: Fumagalli A, Misuraca C, Riva S, Soraci L, Fabbietti P, Di Rosa M, Corsonello A, Lattanzio F, Colombo D Tags: Aging Clin Exp Res Source Type: research

Revisiting the role of vitamin D levels in the prevention of COVID-19 infection and mortality in European countries post infections peak.
Abstract Various studies are underway to identify protective variables for the COVID-19 pandemic. We hypothesized that if indeed the vitamin D levels would be protective in the European population, as recently proposed, the correlation would become more robust when the countries had passed the infection peak as on May 12 2020, compared to April 8 2020, when the majority had not. Comparative analysis of data from the mentioned stages indicated a significant increase in negative correlation of vitamin D levels with COVID-19 cases per million population in later stage (r(20): -0.5504; R2 = 0.3029; p val...
Source: Aging Clinical and Experimental Research - August 14, 2020 Category: Geriatrics Authors: Singh S, Kaur R, Singh RK Tags: Aging Clin Exp Res Source Type: research

Effects of participatory art-based painting workshops in geriatric inpatients: results of a non-randomized open label trial.
CONCLUSION: The participation in painting workshops reduced the number of medications taken daily and incident inhospital mortality in geriatric inpatients admitted to a geriatric acute care ward, suggested a positive effect on health condition of this participatory art-based activity. PMID: 32794100 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - August 13, 2020 Category: Geriatrics Authors: Beauchet O, Lafleur L, Remondière S, Galery K, Vilcocq C, Launay CP Tags: Aging Clin Exp Res Source Type: research

Incidence and associated factors of delirium after orthopedic surgery in elderly patients: a systematic review and meta-analysis.
CONCLUSIONS: Related prophylaxis strategies should be implemented in the elderly involved with above-mentioned risk factors to prevent delirium after orthopedic surgery. PMID: 32772312 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - August 9, 2020 Category: Geriatrics Authors: Yang Y, Zhao X, Gao L, Wang Y, Wang J Tags: Aging Clin Exp Res Source Type: research

Problem-solving therapy for major depressive disorders in older adults: an updated systematic review and meta-analysis of randomized controlled trials.
Abstract BACKGROUND: Major depressive disorder is a global public health problem among older adults. Many studies show that problem-solving therapy (PST) is a cognitive behavioral approach that can effectively treat late-life depression. AIM: To summarize and assess the effects of PST on major depressive disorders in older adults. METHODS: We searched the PubMed, Web of Science, Cochrane Library, EMBASE, MEDLINE, UpToDate, and PsycINFO databases and three Chinese databases (CNKI, CBM, and Wan Fang Data) to identify articles written in English or Chinese that were published until Feb 1, 2020. Randomized c...
Source: Aging Clinical and Experimental Research - August 7, 2020 Category: Geriatrics Authors: Shang P, Cao X, You S, Feng X, Li N, Jia Y Tags: Aging Clin Exp Res Source Type: research

EWHETA (Eat Well for a HEalthy Third Age) Project: novel foods to improve the nutrition in the elderly  people.
EWHETA (Eat Well for a HEalthy Third Age) Project: novel foods to improve the nutrition in the elderly people. Aging Clin Exp Res. 2020 Aug 07;: Authors: Volpe R, Predieri S, Cianciabella M, Daniele GM, Gatti E, Magli M, Rodinò P, Schiavetto E, Sotis G, Urbinati S Abstract Cardiovascular diseases (CVD) are the leading cause of mortality. However, by treating modifiable cardiovascular risk factors and following a healthy diet as the Mediterranean diet, we have opportunity to prevent CVD. In the EWHETA (Eat Well for a HEalthy Third Age) Project, our goal has been to develop novel foods (&quo...
Source: Aging Clinical and Experimental Research - August 7, 2020 Category: Geriatrics Authors: Volpe R, Predieri S, Cianciabella M, Daniele GM, Gatti E, Magli M, Rodinò P, Schiavetto E, Sotis G, Urbinati S Tags: Aging Clin Exp Res Source Type: research

Prognostic value of geriatric nutritional risk index in elderly patients with heart failure: a meta-analysis.
CONCLUSION: Lower GNRI independently predicts all-cause mortality and major cardiovascular events in elderly patients with heart failure. Determination of nutritional status using GNRI may improve risk stratification in elderly patients with heart failure. PMID: 32766928 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - August 6, 2020 Category: Geriatrics Authors: Li H, Cen K, Sun W, Feng B Tags: Aging Clin Exp Res Source Type: research

Determinants of dental treatment avoidance: findings from a nationally representative study.
CONCLUSIONS: The present study highlights the association between dental treatment avoidance and different socioeconomic and health-related factors. These results suggest that it is necessary to promote the importance of dental visits. PMID: 32754887 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - August 4, 2020 Category: Geriatrics Authors: Spinler K, Aarabi G, Walther C, Valdez R, Heydecke G, Buczak-Stec E, König HH, Hajek A Tags: Aging Clin Exp Res Source Type: research

Role of the community pharmacist in detecting frailty and spatio-temporal disorientation among community-dwelling older people in France.
ier M Abstract BACKGROUND: Many older community-dwelling subjects may be frail and/or disoriented, putting them at risk of adverse outcomes. We investigated the prevalence of frailty and spatiotemporal disorientation among patients aged > 65 years collecting regular medication at a community pharmacy. METHODS: Prospective, cross-sectional study of geriatric evaluation in 218 community pharmacies in France. Regular customers aged > 65 years attending the pharmacy to receive ≥ 1 prescription drug were eligible. Spatio-temporal disorientation was asses...
Source: Aging Clinical and Experimental Research - August 4, 2020 Category: Geriatrics Authors: Rhalimi M, Housieaux E, Mary A, Detuncq C, Muller A, Georgin F, Comby F, Wehrlé C, Davoust N, Brazier M Tags: Aging Clin Exp Res Source Type: research

No impact of a prescription booklet on medication consumption in nursing home residents from 2011 to 2014: a controlled before-after study.
CONCLUSION: We observed an overall decrease in medication consumption in both the control and intervention groups. Our analysis did not provide any evidence that this reduction was related to the use of the booklet. Other factors, such as national policy or increased physician awareness, may have contributed to our findings. PMID: 32748114 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - August 3, 2020 Category: Geriatrics Authors: Sanchez S, Payet C, Herr M, Ecarnot F, Blochet C, Armaingaud D, Chrusciel J, Novella JL, Mahmoudi R Tags: Aging Clin Exp Res Source Type: research

Effects of the intermediate care unit on the oldest-old general surgical patients: a retrospective, pre- and postintervention study.
CONCLUSIONS: The allocation of the oldest-old surgical patients who do not need organ support therapy in the ICU to IMCU rather than in the standard wards was associated with a significant decrease in postoperative life-threatening complications and treatment fee. TRIAL REGISTRATION: This study was registered at https://www.chictr.org.cn (ChiCTR2000030639). PMID: 32737843 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - July 31, 2020 Category: Geriatrics Authors: Wang L, Qing J, Zhang X, Chen L, Li Z, Xu W, Yao L Tags: Aging Clin Exp Res Source Type: research

Update on the ESCEO recommendation for the conduct of clinical trials for drugs aiming at the treatment of sarcopenia in older adults.
CONCLUSION: The working group has formulated consensus recommendations on specific aspects of trial design, and in doing so hopes to contribute to an improvement of the methodological robustness and comparability of clinical trials. Standardization of designs and outcomes would advance the field by allowing better comparison across studies, including performing individual patient-data meta-analyses, and different pro-myogenic therapies. PMID: 32737844 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - July 31, 2020 Category: Geriatrics Authors: Reginster JY, Beaudart C, Al-Daghri N, Avouac B, Bauer J, Bere N, Bruyère O, Cerreta F, Cesari M, Rosa MM, Cooper C, Cruz Jentoft AJ, Dennison E, Geerinck A, Gielen E, Landi F, Laslop A, Maggi S, Prieto Yerro MC, Rizzoli R, Sundseth H, Sieber C, Trombett Tags: Aging Clin Exp Res Source Type: research

Neuroimaging markers of chronic fatigue in older people: a narrative review.
CONCLUSION: This review suggests that hippocampus damage and potentially loss of function in basal ganglia networks could play a role on chronic fatigue during aging. Further studies are needed to assess the associations of fatigue with white matter alterations. PMID: 32734575 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - July 30, 2020 Category: Geriatrics Authors: Angioni D, Virecoulon Giudici K, Montoya Martinez M, Rolland Y, Vellas B, de Souto Barreto P Tags: Aging Clin Exp Res Source Type: research

Clinical characteristics, laboratory outcome characteristics, comorbidities, and complications of related COVID-19 deceased: a systematic review and meta-analysis.
CONCLUSION: Most of the COVID-19 deceased were elderly males. Fever, dyspnea, dry cough, fatigue, hypertension, chronic cardiovascular and cerebrovascular disease, diabetes, and laboratory examinations showed low levels of platelet content, increased CRP and LDH were associated with the risk of dying. ARDS and shock were risk factors for death in COVID-19 patients. PMID: 32734576 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - July 30, 2020 Category: Geriatrics Authors: Qiu P, Zhou Y, Wang F, Wang H, Zhang M, Pan X, Zhao Q, Liu J Tags: Aging Clin Exp Res Source Type: research

Frailty prevalence according to the Survey of Health, Ageing and Retirement in Europe-Frailty Instrument (SHARE-FI) definition, and its variables associated, in patients with symptomatic knee osteoarthritis: findings from a cross-sectional study.
CONCLUSIONS: SHARE-FI can represent an useful tool to define frailty in symptomatic KOA. PMID: 32734577 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - July 30, 2020 Category: Geriatrics Authors: Salaffi F, Di Carlo M, Carotti M, Farah S, Giovagnoni A Tags: Aging Clin Exp Res Source Type: research

TOMM40 and APOE variants synergistically increase the risk of Alzheimer's disease in a Chinese population.
Abstract BACKGROUND: The apolipoprotein E (APOE) ε4 allele is a strong risk factor for Alzheimer's disease (AD) in Caucasian and African American populations. It suggests that other genetic factors may modulate AD pathogenesis in Chinese populations, among which the frequency of this allele is reduced but the AD prevalence is maintained. The translocase of outer mitochondrial membrane 40 (TOMM40), which is located adjacent to APOE, may play an APOE-dependent role in modulating AD pathogenesis. AIMS: This work aimed to investigate whether TOMM40 polymorphisms modulate AD risk independently of, or in co...
Source: Aging Clinical and Experimental Research - July 28, 2020 Category: Geriatrics Authors: Zhu Z, Yang Y, Xiao Z, Zhao Q, Wu W, Liang X, Luo J, Cao Y, Shao M, Guo Q, Ding D Tags: Aging Clin Exp Res Source Type: research

Do older patients ( >  80 years) also benefit from ERAS after colorectal resection? A safety and feasibility study.
Do older patients (> 80 years) also benefit from ERAS after colorectal resection? A safety and feasibility study. Aging Clin Exp Res. 2020 Jul 27;: Authors: Boon K, Bislenghi G, D'Hoore A, Boon N, Wolthuis AM Abstract BACKGROUND AND AIMS: The aim of this study was to evaluate the safety and feasibility of a standard Enhanced Recovery After Surgery (ERAS) program following colorectal resection in a geriatric population, aged 80 years and older. METHODS: In this single-center before-after cohort study all patients aged 80 years and older were included after colorectal resec...
Source: Aging Clinical and Experimental Research - July 27, 2020 Category: Geriatrics Authors: Boon K, Bislenghi G, D'Hoore A, Boon N, Wolthuis AM Tags: Aging Clin Exp Res Source Type: research

Impact of self-assessed health status and physical and functional limitations on healthcare utilization and mortality among older cancer survivors in US.
This study included 17,715 cancer patients with a mean age of 75 years and 57% females. Cancer survivors with poor self-assessed health had a higher rate of hospitalizations (adjusted Odds Ratio: aOR: 1.60, 95% Confidence Interval: CI: 1.47-1.72, p 
Source: Aging Clinical and Experimental Research - July 24, 2020 Category: Geriatrics Authors: Chavan PP, Kedia SK, Mzayek F, Ahn S, Yu X Tags: Aging Clin Exp Res Source Type: research

Primary hemiarthroplasty for the elderly patient with cognitive dysfunction and a displaced femoral neck fracture: a prospective, observational cohort study.
CONCLUSIONS: Hemiarthroplasty is an acceptable option for elderly patients with a displaced femoral neck fracture and cognitive dysfunction. A lack of structured rehabilitation is associated with a significant deterioration in walking ability despite a well-functioning hip. However, the causality of this could be due to selection bias of healthier patients being sent to geriatric rehabilitation. PMID: 32705584 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - July 23, 2020 Category: Geriatrics Authors: Chammout G, Kelly-Pettersson P, Hedbeck CJ, Bodén H, Stark A, Mukka S, Sköldenberg O Tags: Aging Clin Exp Res Source Type: research

Associations between hypovitaminosis D and COVID-19: a narrative review.
Abstract In the search for factors affecting incidence and lethality of the current COVID-19 pandemic, recent association studies explored the possible role of vitamin D deficiency. Altogether, these studies, in most cases based on cross-sectional analyses, could not yet provide a convincing demonstration of a cause-effect relationship. In this editorial, the authors describe the scientific evidence underlying a possible role of vitamin D in the prevention and development of the pandemic, considering its immunomodulatory role and antiviral effects. They conclude that further studies are needed to (1) better explor...
Source: Aging Clinical and Experimental Research - July 23, 2020 Category: Geriatrics Authors: Isaia G, Medico E Tags: Aging Clin Exp Res Source Type: research

Psychometric properties of the German version of the Fear of Falling Questionnaire-revised (FFQ-R) in a sample of older adults after hip or pelvic fracture.
CONCLUSIONS: Results demonstrated moderate to good psychometric properties similar to the original English version in a comparable sample of fracture patients. PMID: 32705586 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - July 23, 2020 Category: Geriatrics Authors: Dautel A, Gross M, Abel B, Pomiersky R, Eckert T, Hauer K, Schäufele M, Büchele G, Becker C, Pfeiffer K Tags: Aging Clin Exp Res Source Type: research

COVID-19 and associations with frailty and multimorbidity: a prospective analysis of UK Biobank participants.
CONCLUSIONS: Frailty and multimorbidity do not appear to aid risk stratification, in terms of positive versus negative results of COVID-19 testing. Investigation of the prognostic value of these markers for adverse clinical sequelae following COVID-19 disease is urgently needed. PMID: 32705587 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - July 23, 2020 Category: Geriatrics Authors: Woolford SJ, D'Angelo S, Curtis EM, Parsons CM, Ward KA, Dennison EM, Patel HP, Cooper C, Harvey NC Tags: Aging Clin Exp Res Source Type: research

Physical and mental health in the oldest-old: a mixed-methods study on a southern Italy sample.
CONCLUSIONS: Wellbeing in the oldest-old appeared to be promoted by the sense of belonging and life purpose. PMID: 32705588 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - July 23, 2020 Category: Geriatrics Authors: Fabio RA, Gallo R, Colombo B Tags: Aging Clin Exp Res Source Type: research