Trajectories of physical performance in nursing home residents with dementia.
CONCLUSIONS: To prevent excessive decline in physical performance in this population, NH clinicians should focus efforts specifically on assessment of physical performance at admission and on identification and management of musculoskeletal pain and neuropsychiatric symptoms. PMID: 32060802 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - February 14, 2020 Category: Geriatrics Authors: Sverdrup K, Bergh S, Selbæk G, Benth JŠ, Røen IM, Husebo B, Tangen GG Tags: Aging Clin Exp Res Source Type: research

Cost trajectories as a measure of functional resilience after hospitalization in older adults.
We examined whether trajectories of cost can be used as a marker of functional recovery after hospitalization. METHODS: Secondary analysis of the National Health and Aging Trends Study merged with Centers for Medicare and Medicaid Services data. Community-dwelling participants with a first hospitalization occurring after any annual survey were included (N = 937). Monthly total cost trajectories were constructed for the 3 months before and 3 months following hospitalization. Growth mixture models identified groups of patients with similar trajectories. The association of cost classes with five f...
Source: Aging Clinical and Experimental Research - February 14, 2020 Category: Geriatrics Authors: Colón-Emeric CS, Huang J, Pieper CF, Bettger JP, Roth DL, Sheehan OC Tags: Aging Clin Exp Res Source Type: research

Posterior single-stepping thresholds are prospectively related to falls in older women.
CONCLUSION: Posterior single-stepping thresholds held a significant relationship with future fall status. This relationship was independent of, and superior to that of, other measures of standing balance, gait, strength, and balance confidence. PMID: 32060804 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - February 14, 2020 Category: Geriatrics Authors: Crenshaw JR, Bernhardt KA, Atkinson EJ, Achenbach SJ, Khosla S, Amin S, Kaufman KR Tags: Aging Clin Exp Res Source Type: research

Updated incidence and costs of hip fractures in elderly Italian population.
CONCLUSION: The number of hip fractures and related hospitalizations costs in Italian elderly population is still increasing due to the absolute number of fractures occurring in people ≥ 65 years old and particularly over 75 years old. PMID: 32056151 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - February 13, 2020 Category: Geriatrics Authors: Piscitelli P, Neglia C, Feola M, Rizzo E, Argentiero A, Ascolese M, Rivezzi M, Rao C, Miani A, Distante A, Esposito S, Iolascon G, Tarantino U Tags: Aging Clin Exp Res Source Type: research

Patterns of benzodiazepine administration and prescribing to older adults in U.S. emergency departments.
In this study we examine the overall utilization of benzodiazepines in the older adult population in U.S. EDs. METHODS: Data were compiled from the National Hospital Ambulatory Medical Care Survey 2005-2015. Variables were created to identify all patients over 60 years of age who had and had not been administered benzodiazepines. Bivariate statistical tests were utilized to examine patient demographics, hospital course events and ED/hospital resource allocation and compare older adults administered (in the ED) and prescribed (from the ED) benzodiazepines to those not receiving these agents. RESULTS: Between ...
Source: Aging Clinical and Experimental Research - February 13, 2020 Category: Geriatrics Authors: Pourmand A, Lombardi KM, Roberson J, Mazer-Amirshahi M Tags: Aging Clin Exp Res Source Type: research

Role of motor function and lung function in pathways to ageing and decline.
CONCLUSION: Understanding the cascade of events that can lead to dependence can help in the development of interventions targeted early in the disablement process. PMID: 32056153 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - February 13, 2020 Category: Geriatrics Authors: Finkel D, Ernsth Bravell M, Pedersen NL Tags: Aging Clin Exp Res Source Type: research

Does self-report of multimorbidity in later life predict impaired physical functioning, and might this be useful in clinical practice?
Abstract BACKGROUND: Multimorbidity has been shown in several studies to relate to impaired physical function in later life. AIMS: To examine if self-report of multimorbidity predicts impaired physical functioning, as assessed by formal physical function testing, in community-dwelling older adults. METHODS: Non-communicable diseases (NCDs) were self-reported by 443 older community-dwelling UK adults via questionnaire, asking the question: 'Have you been told by a doctor that you have any of the following conditions?' Assessments of walking speed, chair stands and balance allowed us to create a composite ...
Source: Aging Clinical and Experimental Research - February 13, 2020 Category: Geriatrics Authors: Clynes MA, Bevilacqua G, Jameson KA, Cooper C, Dennison EM Tags: Aging Clin Exp Res Source Type: research

Pain management and cognitive function among older adults: an exploratory study of the China Health and Retirement Longitudinal Study.
Abstract BACKGROUND: Chronic pain and cognitive decline are common age-related conditions affecting a large segment of older populations. Little is known about the pathway of cognitive functioning during the course of pain management in older adults. AIMS: The study aimed to examine the association between chronic body pain management and cognitive function over time among Chinese older adults. METHODS: A total of 792 respondents aged 60 and above from urban and rural households in 28 provinces, 150 counties/districts, and 450 communities were selected from the China Health and Retirement Longitudinal St...
Source: Aging Clinical and Experimental Research - February 13, 2020 Category: Geriatrics Authors: Pan X, Meng H Tags: Aging Clin Exp Res Source Type: research

A decade of FRAX: how has it changed the management of osteoporosis?
Abstract The fracture risk assessment tool, FRAX®, was released in 2008 and provides country-specific algorithms for estimating individualized 10-year probability of hip and major osteoporotic fracture (hip, clinical spine, distal forearm, and proximal humerus). Since its release, 71 models have been made available for 66 countries covering more than 80% of the world population. The website receives approximately 3 million visits annually. Following independent validation, FRAX has been incorporated into more than 80 guidelines worldwide. The application of FRAX in assessment guidelines has been heterogeneous ...
Source: Aging Clinical and Experimental Research - February 11, 2020 Category: Geriatrics Authors: Kanis JA, Harvey NC, Johansson H, Liu E, Vandenput L, Lorentzon M, Leslie WD, McCloskey EV Tags: Aging Clin Exp Res Source Type: research

Correction to: Pneumonia prevention in the elderly patients: the other sides.
Prendki V Abstract The article "Pneumonia prevention in the elderly patients: the other sides" written by Najla Chebib, Clémence Cuvelier, Astrid Malézieux-Picard. PMID: 32036577 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - February 8, 2020 Category: Geriatrics Authors: Chebib N, Cuvelier C, Malézieux-Picard A, Parent T, Roux X, Fassier T, Müller F, Prendki V Tags: Aging Clin Exp Res Source Type: research

The accuracy of the Geriatric Nutritional Risk Index in detecting frailty and sarcopenia in hospitalized older adults.
CONCLUSIONS: Sarcopenia, frailty, and malnutrition coexisted in 26% of our sample. GNRI Score at ≤ 86.73 was 71.9% sensitive and 65.6% specific for detecting frailty and its score at ≤ 89.04 was 64.42% sensitive and 63.53% specific for detecting sarcopenia. GNRI is a simple method, which could be used for sarcopenia, and frailty screening in all elders attending primary care settings where other tools for assessing muscle mass are unavailable. PMID: 32036578 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - February 8, 2020 Category: Geriatrics Authors: Rasheedy D, El-Kawaly WH Tags: Aging Clin Exp Res Source Type: research

Psychometric properties of the external Housing-Related Control Belief Questionnaire among people with Parkinson's disease.
CONCLUSIONS: Taken together, the psychometric results suggest a 14-item version of the external HCQ to be sufficiently reliable and valid for use in the PD population. The results pave the way for further studies, using the HCQ to analyse how perceptions of control of the home may be associated with health among people ageing with PD. PMID: 32034704 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - February 7, 2020 Category: Geriatrics Authors: Andersson N, Nilsson MH, Slaug B, Oswald F, Iwarsson S Tags: Aging Clin Exp Res Source Type: research

Incorporation of a patient navigator into a secondary fracture prevention program identifies barriers to patient care.
Abstract INTRODUCTION: Patient navigation improves outcomes in various clinical contexts, but has not been evaluated in secondary fracture prevention. METHODS: We retrospectively reviewed charts of patients, age 50 + from April to October, 2016 hospitalized with fragility fracture contacted by a patient navigator. Patients were identified using an electronic tool extracting data from electronic medical records which alerted the patient navigator to contact patients by phone post-discharge to schedule appointments to "High-Risk Osteoporosis Clinic" (HiROC) and Dual-energy X-ray Absorpti...
Source: Aging Clinical and Experimental Research - February 7, 2020 Category: Geriatrics Authors: Jia KQ, Southerland L, Phieffer L, Stephens JA, Ing SW Tags: Aging Clin Exp Res Source Type: research

The contribution of CNVs to the most common aging-related neurodegenerative diseases.
Abstract Alzheimer and Parkinson's diseases are neurodegenerative aging-related pathological conditions, mainly caused by the interplay of genetic and non-genetic factors and whose incidence rate is going to drastically increase given the growing life expectancy. To address these complex multifactorial traits, a systems biology strategy is needed to highlight genotype-phenotype correlations as well as overlapping gene signatures. Copy number variants (CNVs) are structural chromosomal imbalances that can have pathogenic nature causing or contributing to the disease onset or progression. Moreover, neurons affected b...
Source: Aging Clinical and Experimental Research - February 6, 2020 Category: Geriatrics Authors: Gentile G, La Cognata V, Cavallaro S Tags: Aging Clin Exp Res Source Type: research

Differences between muscle from osteoporotic and osteoarthritic subjects: in vitro study by diffusion-tensor MRI and histological findings.
CONCLUSION: This work highlights differences between muscles of osteoporotic and osteoarthritic subjects that can be quantified by NMR DTI investigations. PMID: 32026431 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - February 6, 2020 Category: Geriatrics Authors: Di Pietro G, Scimeca M, Iundusi R, Celi M, Gasbarra E, Tarantino U, Capuani S Tags: Aging Clin Exp Res Source Type: research

Sedentary behaviours, cognitive function, and possible mechanisms in older adults: a systematic review.
CONCLUSION: There is a lack of clarity about the overall and independent association between sedentary behaviour and cognition in older age. Underlying mechanisms are similar to physical activity and probably multi-modal. More studies with robust designs and methodology are needed to confirm effect of sedentary behaviour on cognition. PMID: 32026419 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - February 5, 2020 Category: Geriatrics Authors: Olanrewaju O, Stockwell S, Stubbs B, Smith L Tags: Aging Clin Exp Res Source Type: research

Three-year National report from the Gruppo Italiano di Ortogeriatria (GIOG) in the management of hip-fractured patients.
CONCLUSIONS: The study results suggest high inter-center variability in the key-performance indicators, and different approaches in providing care to our HF patients in comparison to other countries. A National debate on the topic is required in Italy to harmonize practices of orthogeriatric care. PMID: 32026420 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - February 5, 2020 Category: Geriatrics Authors: Ferrara MC, Andreano A, Tassistro E, Rapazzini P, Zurlo A, Volpato S, Mussi C, Corsi M, Lunardelli ML, Martini E, Castoldi G, De Filippi F, Pizzonia M, Monacelli F, Barone A, Pilotto A, March A, Ungar A, Capelli R, Galmarini V, Franzoni S, Terragnoli F, B Tags: Aging Clin Exp Res Source Type: research

Effects of rural community-based integrated exercise and health education programs on the mobility function of older adults with knee osteoarthritis.
Abstract AIM: To examine the effects of a rural community-based program integrating health education and self-directed home-based resistance training on the mobility function of older women with knee osteoarthritis (OA). METHODS: Participants were assigned to the control (CON) or intervention (INT) group. Participants completed a mobility function assessment and questionnaire evaluation. The CON group received only the health education program and the INT group also participated in resistance training for 5 months. Primary outcomes were mobility function measured using a timed chair stand (TCS), timed up...
Source: Aging Clinical and Experimental Research - February 4, 2020 Category: Geriatrics Authors: Oh SL, Kim DY, Bae JH, Lim JY Tags: Aging Clin Exp Res Source Type: research

Association between periodontal disease and tooth loss and mortality in an elderly Chinese population.
CONCLUSION: Periodontal diseases and tooth loss were the potential predictors of total mortality even after adjustment for confounding factors. However, these were not independent indicators for CVD mortality. PMID: 32020486 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - February 4, 2020 Category: Geriatrics Authors: Qi L, Qian Y, Zhu F, Cao N, Lu H, Zhang L Tags: Aging Clin Exp Res Source Type: research

Potential herb-drug interactions in community-dwelling older adults in China: the Shanghai Aging Study.
CONCLUSION: 43.3% of community-dwelling older adults who used any combination of drug-herb or herb-herb was exposed to pHDIs, and more than half of pHDIs were related to herbs with anticoagulant/antiplatelet properties. Awareness of the patterns and high-risk groups of these pHDIs may contribute to increased patient safety. PMID: 32008224 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - February 1, 2020 Category: Geriatrics Authors: Chi D, Ding D, Zhao Q, Liang X, Wu W, Luo J, Wang B Tags: Aging Clin Exp Res Source Type: research

Effects of aerobic fitness on cognitive motor interference during self-paced treadmill walking in older adults.
This study aims to investigate the effects of aerobic fitness on CMI during self-paced treadmill walking in older adults. METHODS: Thirty participants (67.6 ± 10.34 years, 21 females) were included in a 2-day cross-sectional design study. Aerobic fitness was assessed with the Rockport 1-mile test. The dual-task paradigm consisted of walking only, and dual-task standing and dual-task walking (i.e., standing/walking while performing the Modified Stroop color word test) on a treadmill. To assess CMI, gait speed and accuracy rate were measured to later calculate the dual-task cost for each parame...
Source: Aging Clinical and Experimental Research - February 1, 2020 Category: Geriatrics Authors: Chaparro GN, Sosnoff JJ, Hernandez ME Tags: Aging Clin Exp Res Source Type: research

Prognostic value of non-alcoholic fatty liver disease in the elderly patients.
CONCLUSION: The data obtained in our study show that NAFLD is not associated to overall mortality in the elderly population. PMID: 32008226 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - February 1, 2020 Category: Geriatrics Authors: Tallarico V, Recinella G, Magalotti D, Muscari A, Zoli M, Bianchi G Tags: Aging Clin Exp Res Source Type: research

Relationship between tongue pressure and back muscle strength in healthy elderly individuals.
CONCLUSIONS: TP was correlated more with BMS than aging and occlusal support in healthy elderly individuals. This study indicated that the clinical evaluation of the whole body is important when assessing oral and swallowing function. PMID: 32006384 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 31, 2020 Category: Geriatrics Authors: Yoshimi K, Nakagawa K, Hara K, Yamaguchi K, Nakane A, Kubota K, Furuya J, Tohara H Tags: Aging Clin Exp Res Source Type: research

Operationalization of a frailty index among older adults in the InCHIANTI study: predictive ability for all-cause and cardiovascular disease mortality.
Abstract BACKGROUND: The frailty index (FI) is a sensitive instrument to measure the degree of frailty in older adults, and is increasingly used in cohort studies on aging. AIMS: To operationalize an FI among older adults in the "Invecchiare in Chianti" (InCHIANTI) study, and to validate its predictive capacity for mortality. METHODS: Longitudinal data were used from 1129 InCHIANTI participants aged ≥ 65 years. A 42-item FI was operationalized following a standard procedure using baseline data (1998/2000). Associations of the FI with 3- and 6-year all-cause and cardiovascu...
Source: Aging Clinical and Experimental Research - January 31, 2020 Category: Geriatrics Authors: Hoogendijk EO, Stenholm S, Ferrucci L, Bandinelli S, Inzitari M, Cesari M Tags: Aging Clin Exp Res Source Type: research

Working memory training format in older adults: individual versus group sessions.
This study was conducted in two waves. In the first wave, participants were randomized into individual training (n = 11) and individual control conditions (n = 15). In the second wave, participants were randomized into group training (n = 16) and group control conditions (n = 17). Training consisted of three sessions of WM exercises and participants in the active control condition responded to questionnaires during the same time. There was significant improvement for both training conditions at post-test and maintenance at follow-up for the target task, other WM tasks...
Source: Aging Clinical and Experimental Research - January 31, 2020 Category: Geriatrics Authors: Brum PS, Borella E, Carretti B, Yassuda MS Tags: Aging Clin Exp Res Source Type: research

Driving status and health-related quality of life among the oldest old: a population-based examination using data from the AgeCoDe-AgeQualiDe prospective cohort study.
, König HH Abstract BACKGROUND: It is almost unknown whether the driving status is associated with HRQOL among individuals in highest age. AIMS: Based on a multicenter prospective cohort study, the objective of this study was to examine whether the driving status is associated with health-related quality of life (HRQOL) among the oldest old in Germany. METHODS: Cross-sectional data from follow-up wave 9 (n = 544) were derived from the "Study on Needs, health service use, costs and health-related quality of life in a large sample of oldest-old primary care patients (85+)" (Age...
Source: Aging Clinical and Experimental Research - January 31, 2020 Category: Geriatrics Authors: Hajek A, Brettschneider C, Lühmann D, van den Bussche H, Wiese B, Mamone S, Weyerer S, Werle J, Leve V, Fuchs A, Röhr S, Stein J, Bickel H, Mösch E, Heser K, Wagner M, Scherer M, Maier W, Riedel-Heller SG, Pentzek M, König HH Tags: Aging Clin Exp Res Source Type: research

Parkinson's disease and the non-motor symptoms: hyposmia, weight loss, osteosarcopenia.
Abstract Non-motor symptoms (NMSs) are common in Parkinson's disease (PD) and can precede, sometimes for several years. NMSs include, other than gastrointestinal symptoms like constipation and dysphagia, also hyposmia, weight loss and osteosarcopenia. These three NMSs seem to be inter-related and affect patients' health and quality of life. Unfortunately, patients with these symptoms usually are not initially seen by a neurologist, and by the time they are consulted, nearly ~ 80% of the dopaminergic neurons in the substantia nigra have died. To date, no guidelines exist for screening, assessment and ...
Source: Aging Clinical and Experimental Research - January 27, 2020 Category: Geriatrics Authors: De Rui M, Inelmen EM, Trevisan C, Pigozzo S, Manzato E, Sergi G Tags: Aging Clin Exp Res Source Type: research

Safinamide as an adjunct therapy in older patients with Parkinson's disease: a retrospective study.
CONCLUSIONS: Safinamide as an adjunct therapy in patients aged ≥ 60 years with advanced PD was found to be safe and well-tolerated in older patients. There were no specific demographic or clinical characteristics associated with suspension. PMID: 31981101 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 24, 2020 Category: Geriatrics Authors: Lo Monaco MR, Petracca M, Vetrano DL, Di Stasio E, Fusco D, Ricciardi D, Laudisio A, Zuccalà G, Onder G, Bentivoglio AR Tags: Aging Clin Exp Res Source Type: research

The Frailty Index in older women with gynecological cancer.
Abstract INTRODUCTION: Frailty is a key condition to be screened among elderly oncological patients. Aim of our work is to measure the functional and prognostic value for 1-year mortality of the Frailty Index (FI) in a cohort of older women with gynecological cancer. METHODS: The prognostic value of FI was tested in 200 older women with gynaecological cancer (mean age = 73.5 years). FI was retrospectively calculated following the Rockwood model. Spearman's rho test was used for correlations with other oncological scales: Eastern Cooperative Oncology Group Performance Status (ECOG); Karnofsky Performance Statu...
Source: Aging Clinical and Experimental Research - January 24, 2020 Category: Geriatrics Authors: Orlandini L, Nestola T, Colloca GF, Ferrini A, Cesari M Tags: Aging Clin Exp Res Source Type: research

Oldest old hip fracture patients: centenarians as the lowest complexity patients.
A, Pablos-Hernández C Abstract BACKGROUND: Hip fracture leads to an increase in mortality and deterioration in the quality of life. The increase in life expectancy results in an increase in the number of oldest old patients. AIMS: To analyze the characteristics of centenarian hip fracture patients and compare them with younger hip fracture patients. METHODS: Retrospective study, including 176 patients (48 centenarians, 65 nonagenarians and 63 octogenarians) undergoing surgery after hip from 2009 to 2018 and followed for 1-year survival. Qualitative variables were compared by Chi-square test and q...
Source: Aging Clinical and Experimental Research - January 23, 2020 Category: Geriatrics Authors: Blanco JF, da Casa C, Sánchez de Vega R, Hierro-Estévez MA, González-Ramírez A, Pablos-Hernández C Tags: Aging Clin Exp Res Source Type: research

A novel behavioural INTErvention to REduce Sitting Time in older adults undergoing orthopaedic surgery (INTEREST): results of a randomised-controlled feasibility study.
CONCLUSION: In this older surgical population, it is feasible to use behavioural techniques to displace sedentary time to activity and to conduct a trial spanning the period of surgical intervention. This may improve physical function and surgical outcomes. The INTEREST intervention is now ready for evaluation in a full-scale randomised-controlled trial. REGISTRATION: This trial was registered on Clinicaltrials.gov on 13/11/2018. ID: NCT03740412. PMID: 31975288 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 23, 2020 Category: Geriatrics Authors: Aunger JA, Greaves CJ, Davis ET, Asamane EA, Whittaker AC, Greig CA Tags: Aging Clin Exp Res Source Type: research

European Collaborative and Interprofessional Capability Framework for Prevention and Management of Frailty-a consensus process supported by the Joint Action for Frailty Prevention (ADVANTAGE) and the European Geriatric Medicine Society (EuGMS).
CONCLUSIONS: The multi-professional capability framework for frailty prevention and management incorporated interprofessional collaborative practice, consistent with current recommendations by the World Health Organization, Science Advice for Policy by European Academies and the European Commission. PMID: 31970670 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 22, 2020 Category: Geriatrics Authors: Roller-Wirnsberger R, Lindner S, Liew A, O'Caoimh R, Koula ML, Moody D, Espinosa JM, van Durme T, Dimitrov P, Benjak T, Nicolaidou E, Hammar T, Vanhecke E, Junius-Walker U, Csizmadia P, Galluzzo L, Macijauskienė J, Salem M, Rietman L, Ranhoff AH, Targows Tags: Aging Clin Exp Res Source Type: research

Prevalence, clinical correlates, and burden of undiagnosed aortic stenosis in older patients: a prospective study in a non-cardiologic acute hospital ward.
CONCLUSIONS: Among older patients admitted to non-cardiologic acute hospital wards, AS was common and frequently underdiagnosed. The severity of AS was not associated with increased 6-month mortality, whereas frailty was the most important predictor. PMID: 31970672 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 22, 2020 Category: Geriatrics Authors: Perego S, Zambon A, Nistri S, Bruni A, Motta S, Cavalieri D'Oro L, Rossi E, Annoni G, Bellelli G Tags: Aging Clin Exp Res Source Type: research

Molecular mechanisms underlying copper function and toxicity in neurons and their possible therapeutic exploitation for Alzheimer's disease.
PMID: 31965480 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 21, 2020 Category: Geriatrics Authors: Malosio ML, Tecchio F, Squitti R Tags: Aging Clin Exp Res Source Type: research

Neural substrate of a cognitive intervention program using Go game: a positron emission tomography study.
Abstract BACKGROUND: Influence of cognitive intervention programs on brain activity has not been enough explored. AIMS: The aims of the present study were to clarify changes in brain activity from a cognitive intervention program utilizing the board game "Go" and to examine the relationship between brain activity and the acquisition of Go skills. METHODS: Eighteen community-dwelling older adults were randomly assigned either to an intervention group (IG), in which members attended 12 Go lessons either in groups or individually using tablet computers, or a control group (CG), in which members at...
Source: Aging Clinical and Experimental Research - January 17, 2020 Category: Geriatrics Authors: Iizuka A, Ishii K, Wagatsuma K, Ishibashi K, Onishi A, Tanaka M, Suzuki H, Awata S, Fujiwara Y Tags: Aging Clin Exp Res Source Type: research

The demographic and clinical characteristics of an Italian population of adult outpatients with chronic cough.
CONCLUSIONS: There seem to be clinical indicators that help in assessing the level of cough-related discomfort. PMID: 31950437 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 16, 2020 Category: Geriatrics Authors: Campi G, Noale M, Fabbrizzi A, Lavorini F, Maggi S, Fontana G Tags: Aging Clin Exp Res Source Type: research

Frailty and prediction of recurrent falls over 10  years in a community cohort of 75-year-old women.
CONCLUSIONS: This suggests that frailty should be an integral part of falls-risk assessment to improve identification of those at risk of becoming fallers. PMID: 31939201 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 14, 2020 Category: Geriatrics Authors: Bartosch PS, Kristensson J, McGuigan FE, Akesson KE Tags: Aging Clin Exp Res Source Type: research

Impact of the backward chaining method on physical and psychological outcome measures in older adults at risk of falling: a systematic review.
CONCLUSIONS: BCM provides a promising intervention in fall-related recovery strategies for older adults and is most effective when offered to older adults at risk of falling. Considering the small number of included studies and the varying methodological quality, these findings should be evaluated accordingly. The growing evidence regarding the benefits of BCM, yet the lack of adoption into standard care, highlights the need for further research and clinical application of this intervention approach. PMID: 31939202 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 14, 2020 Category: Geriatrics Authors: Leonhardt R, Becker C, Groß M, Mikolaizak AS Tags: Aging Clin Exp Res Source Type: research

A meta-analysis on the levels of VILIP-1 in the CSF of Alzheimer's disease compared to normal controls and other neurodegenerative conditions.
Abstract Alzheimer's disease (AD) is a progressing neurodegenerative disorder and the main cause of serious irreversible cognitive decline in elderly people. Visinin-like protein 1 (VILIP-1) is a member of the family of calcium-binding proteins and plays a crucial role in AD pathophysiology. Multiple studies have shown that CSF levels of VILIP-1 are increased in AD patients compared to normal controls, or other neurodegenerative conditions. We searched online databases for studies on the levels of VILIP-1 in the CSF of AD patients in comparison to normal controls, mild cognitive impairment (MCI) patients and Demen...
Source: Aging Clinical and Experimental Research - January 14, 2020 Category: Geriatrics Authors: Mavroudis IA, Petridis F, Chatzikonstantinou S, Karantali E, Kazis D Tags: Aging Clin Exp Res Source Type: research

Physical fitness in institutionalized older adults with dementia: association with cognition, functional capacity and quality of life.
Abstract This cross-sectional study investigated the association of physical fitness with cognitive function, functional capacity and quality of life among institutionalized older adults with dementia. One hundred and two older adults aged 78.0 ± 8.4 years, predominantly female (67.6%), with neurocognitive disorder due to Alzheimer's disease (AD) (49.2%), vascular dementia (14.7%), Parkinson's disease (2%), dementia with Lewy bodies (2%) or unspecified dementia (32.1%) participated in the present study. Regression analyses were used to examine associations between physical fitness compone...
Source: Aging Clinical and Experimental Research - January 11, 2020 Category: Geriatrics Authors: Sampaio A, Marques-Aleixo I, Seabra A, Mota J, Marques E, Carvalho J Tags: Aging Clin Exp Res Source Type: research

The association between sociodemographic characteristics and dementia in patients with atrial fibrillation.
CONCLUSIONS: Some results were expected, i.e. association between lower educational level and dementia. The higher risk of dementia in low deprivation NSES-areas could be due to a higher awareness about dementia, and subsequent earlier diagnosis and treatment of dementia. PMID: 31927710 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 11, 2020 Category: Geriatrics Authors: Wändell P, Carlsson AC, Li X, Gasevic D, Sundquist J, Sundquist K Tags: Aging Clin Exp Res Source Type: research

The association between light intensity physical activity with gait speed in older adults ( ≥ 50 years). A longitudinal analysis using the English Longitudinal Study of Ageing (ELSA).
CONCLUSION: Therefore, future fall prevention interventions should also include recommendations for LPA for old-older adults (≥ 70 years). PMID: 31925725 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 10, 2020 Category: Geriatrics Authors: McMullan II, Bunting BP, McDonough SM, Tully MA, Casson K Tags: Aging Clin Exp Res Source Type: research

Mitochondrial communication in the context of aging.
Abstract Mitochondria constantly contribute to the cell homeostasis and this, during the lifespan of a cell, takes its toll. Indeed, the functional decline of mitochondria appears correlated to the aging of the cell. The initial idea was that excessive production of reactive oxygen species (ROS) by functionally compromised mitochondria was the causal link between the decline of the organelle functions and cellular aging. However, in recent years accumulating evidence suggests that the contribution of mitochondria to cellular aging goes beyond ROS production. In this short review, we discuss how intracellular signa...
Source: Aging Clinical and Experimental Research - January 10, 2020 Category: Geriatrics Authors: Lefkimmiatis K, Grisan F, Iannucci LF, Surdo NC, Pozzan T, Di Benedetto G Tags: Aging Clin Exp Res Source Type: research

Delirium in patients with hip fracture is associated with increased heart rate variability.
CONCLUSION: HRV measurements in patients with hip fractures provide additional information beyond heart rate and might be used to identify relevant pathophysiological factors in delirium. PMID: 31916197 [PubMed - as supplied by publisher] (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 8, 2020 Category: Geriatrics Authors: Ernst G, Watne LO, Rostrup M, Neerland BE Tags: Aging Clin Exp Res Source Type: research

Where are the keys to improve vaccine uptake in adults and elders in European countries?
Abstract Improving vaccination of the elderly is one of the most important challenges in the coming years, as it was for infant's decades ago. Insufficient vaccine uptake in the elderly can be considered a concern with regard to the burden of vaccine preventable diseases in this growing population. The purpose of this paper is to have an overview on the different steps involved in decision policy making from the regulatory agencies until people are vaccinated. Examples of different policies within European countries will be compared for influenza, streptococcal and zoster infections. For each step, key improvement...
Source: Aging Clinical and Experimental Research - January 3, 2020 Category: Geriatrics Authors: Gaillat J Tags: Aging Clin Exp Res Source Type: research

The association between sedentary behavior and cognitive ability in older adults.
Abstract Executive functions (EF) are a grouping of cognitive abilities essential for daily life. Previous research has shown that physical activity (PA) may in fact preserve EF in older adults, but the link between sedentary behavior (SB) and cognitive ability has been less explored. The purpose of this study was to examine the relationship between SB and cognition (executive function and memory) in older adults. Seventy five older adults (74.6 ± 9 years) self-reported their sedentary time (ST) and PA, as well as EF ability (paper-based measure of EF). Participants also completed several...
Source: Aging Clinical and Experimental Research - January 2, 2020 Category: Geriatrics Authors: Coelho L, Hauck K, McKenzie K, Copeland JL, Kan IP, Gibb RL, Gonzalez CLR Tags: Aging Clin Exp Res Source Type: research

Compensatory adjustments in motor unit behavior during fatigue differ for younger versus older men.
Abstract BACKGROUND: The ability to maintain a submaximal force as a muscle fatigues is supplemented by compensatory adjustments in the nervous system's control of motor units. AIM: We sought to compare vastus lateralis motor unit recruitment and firing rate data for younger versus older men during isometric fatigue. METHODS: Twelve younger (age = 25 ± 3 years) and 12 older (75 ± 8 years) men performed contractions of the knee extensors at 50% of maximal voluntary contraction force until exhaustion. Surface electromyographic (sEMG) signals...
Source: Aging Clinical and Experimental Research - January 2, 2020 Category: Geriatrics Authors: Mota JA, Kwon DP, Kennedy M, Sobolewski EJ, Kim Y, Gonzales JU, Stock MS Tags: Aging Clin Exp Res Source Type: research

Validation of population-based cutoffs for low muscle mass and strength in a population of Turkish elderly adults.
Abstract BACKGROUND: Despite differences between the studies regarding methods for estimating low muscle mass, the European Working Group on Sarcopenia in Older People (EWGSOP) recommends use of two standard deviations (SDs) below the reference sex-specific means of healthy young adults. AIMS: The aim of this study was to determine the cutoff points of skeletal muscle mass index (SMI) and handgrip strength (HS) in Turkish population and to compare the power of different cutoff points to predict comprehensive geriatric assessment (CGA) parameters. METHODS: Two hundred and eight young healthy voluntee...
Source: Aging Clinical and Experimental Research - January 2, 2020 Category: Geriatrics Authors: Ates Bulut E, Soysal P, Dokuzlar O, Kocyigit SE, Aydin AE, Yavuz I, Isik AT Tags: Aging Clin Exp Res Source Type: research

Assessing the strengths and weaknesses of the Clinical Frailty Scale through correlation with a frailty index.
liva Morera JC, Comet R Abstract BACKGROUND: Care for the elderly patient is a challenge that geriatricians now share with other medical specialties. Frailty has emerged as a key concept. Due to its simplicity and applicability, the Clinical Frailty Scale (CFS) is gaining increasing acceptance. AIM: Compare the CFS with the Frail-VIG index (IF-VIG), an index based on the accumulation of deficits and developed on the basis of comprehensive geriatric assessment. METHODS: Cross-sectional and single-center study carried out at the Acute Geriatric Unit of a University Hospital. Patients consecutively recruite...
Source: Aging Clinical and Experimental Research - January 2, 2020 Category: Geriatrics Authors: Moreno-Ariño M, Torrente Jiménez I, Cartanyà Gutiérrez A, Oliva Morera JC, Comet R Tags: Aging Clin Exp Res Source Type: research

Type 2 myocardial infarction: is it a geriatric syndrome?
Abstract Type 2 myocardial infarctions (T2-MI) is a type of necrosis that results from reduced oxygen supply and/or increased demand secondary to other causes unrelated to acute coronary atherothrombosis. The development and implementation of sensitive and high-sensitivity cardiac necrosis marker and the age-related increase of comorbidity lead to a boost of the frequency of T2-MI. T2-MI is often a complication of a high degree of clinical frailty in older adults, emerging as a "geriatric syndrome". Age-related non-cardiovascular causes may be the triggering factors and are strongly associated with the d...
Source: Aging Clinical and Experimental Research - January 2, 2020 Category: Geriatrics Authors: Curcio F, Gerundo G, Sasso G, Panicara V, Liguori I, Testa G, Della-Morte D, Gargiulo G, Galizia G, Ungar A, Cacciatore F, Bonaduce D, Abete P Tags: Aging Clin Exp Res Source Type: research