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Acetyl-cholinesterase-inhibitors reconsidered. A narrative review of post-marketing studies on Alzheimer's disease
Aging Clin Exp Res. 2024 Feb 7;36(1):23. doi: 10.1007/s40520-023-02675-6.ABSTRACTThe real efficacy of Acetyl-cholinesterase-inhibitors (AChEI) has been questioned. In this narrative review we evaluated their effect on cognitive decline, measured by Mini Mental State Examination (MMSE), and on total mortality rates in patients with Alzheimer's disease (AD) recruited into post-marketing open/non-randomized/retrospective studies. In AD patients treated with AChEI, the mean MMSE loss ranged from 0.2 to 1.37 points/years, compared with 1.07-3.4 points/years in non-treated patients. Six studies also reported data about survival;...
Source: Aging Clinical and Experimental Research - February 6, 2024 Category: Geriatrics Authors: Giovanni Zuliani Marco Zuin Tommaso Romagnoli Michele Polastri Carlo Cervellati Gloria Brombo Source Type: research

Predictors of hospital readmission rate in geriatric patients
CONCLUSIONS: This study highlights the importance of performing an accurate CGA, since defined domains and variables contained in the CGA (i.e., LOS, lower albumin and systolic blood pressure, poor renal function, and greater comorbidity burden), when combined altogether, may offer a valid tool to identify the most fragile patients with clinical and functional impairment enhancing their risk of unplanned early and late readmission.PMID:38321332 | PMC:PMC10847193 | DOI:10.1007/s40520-023-02664-9 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - February 6, 2024 Category: Geriatrics Authors: Arianna Bortolani Francesco Fantin Anna Giani Alessandra Zivelonghi Bruno Pernice Elena Bortolazzi Silvia Urbani Elena Zoico Rocco Micciolo Mauro Zamboni Source Type: research

Knowledge mapping of trends and hotspots in the field of exercise and cognition research over the past decade
This study aims to address this gap and map the research landscape regarding the role of exercise in cognitive function enhancement. Firstly, the frequencies and co-occurrence of keywords were analysed to identify six main clusters: aging, cognitive impairment, rehabilitation, obesity, fatigue, and hippocampus. Secondly, reference timeline co-citation analysis revealed that hippocampus and aging were the major bursts with high intensity and long attention span while children had recently emerged as a topical subject. Finally, the evolution of themes from 2012 to 2022 was analysed, and found that older adults had been the l...
Source: Aging Clinical and Experimental Research - February 3, 2024 Category: Geriatrics Authors: Ying-Hai Zhu Peng Hu Ya-Xi Luo Xiu-Qing Yao Source Type: research

General self-efficacy, not musculoskeletal health, was associated with social isolation and loneliness in older adults during the COVID-19 pandemic: findings from the Hertfordshire Cohort Study
CONCLUSIONS: No musculoskeletal condition was associated with increased social isolation or loneliness, but longitudinal studies in larger samples are required. Greater self-efficacy was associated with reduced social isolation and reduced loneliness. Interventions promoting self-efficacy in older adults may reduce isolation and loneliness in this age group.PMID:38308733 | PMC:PMC10838234 | DOI:10.1007/s40520-023-02676-5 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - February 3, 2024 Category: Geriatrics Authors: Gregorio Bevilacqua Leo D Westbury Ilse Bloom Jean Zhang Wendy T Lawrence Mary E Barker Kate A Ward Elaine M Dennison Source Type: research

Telecoaching as a new training method for elderly people: a systematic review
CONCLUSION: TC seems to be a safe, effective, and injury-free training method, despite its limited application in elderly population. Future studies should better investigate this training method in elderly people in order to evaluate the effectiveness in a wider range of diseases.PMID:38305822 | PMC:PMC10837264 | DOI:10.1007/s40520-023-02648-9 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - February 2, 2024 Category: Geriatrics Authors: Ignazio Leale Flavia Figlioli Valerio Giustino Jessica Brusa Matteo Barcellona Valerio Nocera Alberto Canzone Antonino Patti Giuseppe Messina Mario Barbagallo Antonio Palma Ligia J Dominguez Giuseppe Battaglia Source Type: research

Association of preoperative frailty with the risk of postoperative delirium in older patients undergoing hip fracture surgery: a prospective cohort study
CONCLUSION: Preoperative frailty increased the risk of POD in older patients undergoing hip fracture surgery.DISCUSSION: Preoperative assessment of frailty in geriatric hip surgery can timely identify potential risks and provide interventions targeting frailty factors to reduce the incidence of POD in older patients undergoing hip fracture surgery. The findings suggested that preoperative frailty could increase the risk of POD in older patients undergoing hip fracture surgery. Further research is necessary to determine whether perioperative interventions aimed at enhancing frailty can mitigate the risk of POD and improve p...
Source: Aging Clinical and Experimental Research - January 31, 2024 Category: Geriatrics Authors: Chunyu Feng Haotian Wu Ziheng Qi Yuzhi Wei Bo Yang Haolin Yin Siyi Yan Lu Wang Yangyang Yu Juanjuan Xie Xueyan Xing Shumin Tu Huan Zhang Source Type: research

Optimal assessment of the glomerular filtration rate in older chinese patients using the equations of the Berlin Initiative Study
CONCLUSIONS: Although no equation was fully accurate in the mGFR < 60 mL/min/1.73 m2 subgroup, the BIScr-cys (of the eight equations) assessed the eGFRs of the entire population best. A new equation is urgently required for older Chinese and even East Asians, especially those with moderate-to-severe renal insufficiency.PMID:38294586 | PMC:PMC10830815 | DOI:10.1007/s40520-023-02657-8 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 31, 2024 Category: Geriatrics Authors: Yue Yang Yuan-Yuan Jiao Zheng Zhang Ding-Xin Di Dan-Yang Zhang Shi-Min Jiang Jia-Hui Zhou Wen-Ge Li Source Type: research

Comparison of the cost-effectiveness of sequential treatment with abaloparatide in US men and women at very high risk of fractures
CONCLUSIONS: Sequential therapy with ABL/ALN was cost-effective in US men and women at very high risk of fractures.PMID:38289413 | PMC:PMC10827834 | DOI:10.1007/s40520-023-02682-7 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 30, 2024 Category: Geriatrics Authors: Mickael Hiligsmann Stuart L Silverman Andrea J Singer Leny Pearman Yamei Wang John Caminis Jean-Yves Reginster Source Type: research

Physical activity trajectories and their associations with health outcomes in older adults with mild cognitive impairment or dementia: a national cohort study
This study adhered to the STROBE checklist for reporting.RESULTS: Three distinct PA trajectories were identified: high-decreasing and rebound class (9.34%), moderate-decreasing class (10.31%), and low-increasing class (80.34%). The logistic regression showed that age, sex, education level, body mass index, residence, depressive symptoms, mobility activities of daily life score, frequency of social activities score were PA predictors. Adjusting for sociodemographic variables, only the high-decreasing and rebound class remained significantly associated with worse self-rated health.DISCUSSION: This study revealed three PA tra...
Source: Aging Clinical and Experimental Research - January 30, 2024 Category: Geriatrics Authors: Yiping Chen Yao Li Wei Li Yuling Tian Hui Yang Source Type: research

Normalized stability time analysis within the boundaries between adults with and without fear of falling
CONCLUSION: The study highlights the need to account for both COP boundaries and visual conditions in adults with FOF. When assessing postural control during unilateral stances, clinicians must also give attention to non-visual cues.PMID:38281190 | PMC:PMC10822799 | DOI:10.1007/s40520-023-02651-0 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 28, 2024 Category: Geriatrics Authors: Dongchul Lee Paul S Sung Source Type: research

The relationship between circulating metabolites and prostate hyperplasia: a Mendelian randomization study
CONCLUSION: Bidirectional MR analysis furnishes genetic insight into the interplay between CM and BPH. The prominence of lipids and triglycerides emerges as significant factors intricately linked to BPH risk.PMID:38281223 | PMC:PMC10822814 | DOI:10.1007/s40520-023-02669-4 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 28, 2024 Category: Geriatrics Authors: Ze-Chao Zhang Shu-Ping Huang Ze-Sen Lin Yu Chen Peng Jiang Yu-Wei Yang Chang-Jie Shang Min Zhu Hong-Jun Gao Source Type: research

Development and validation of prediction model for older adults with cognitive frailty
CONCLUSION: The study could provide a practical tool to identify older adults with a high risk of CF early. Furthermore, targeting modifiable factors could prevent about half of the new-onset CF during a 6-year follow-up.PMID:38281238 | PMC:PMC10822804 | DOI:10.1007/s40520-023-02647-w (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 28, 2024 Category: Geriatrics Authors: Jundan Huang Xianmei Zeng Hongting Ning Ruotong Peng Yongzhen Guo Mingyue Hu Hui Feng Source Type: research

Association between low values of mean arterial pressure and impaired cognitive performance in older patients with mild cognitive impairment: cross-sectional preliminary findings from the STRENGTH Project
CONCLUSIONS: Routine assessment of MAP could aid clinicians in adjusting antihypertensive treatment and closely monitoring cognitive function in MCI patients.PMID:38281243 | PMC:PMC10822812 | DOI:10.1007/s40520-023-02668-5 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 28, 2024 Category: Geriatrics Authors: Elpidio Santillo Marta Balietti Paolo Fabbietti Maria Sole Antolini Cristina Paoloni Francesco Piacenza Cinzia Giuli Source Type: research

Prevalence of sarcopenia in Africa: a systematic review and meta-analysis of observational studies
CONCLUSION: Sarcopenia is a prevalent condition in Africa and thus research regarding this topic is a public health priority. Future studies that cover African countries for which data are not available and using standardized criteria are needed.PMID:38281246 | PMC:PMC10822818 | DOI:10.1007/s40520-023-02671-w (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 28, 2024 Category: Geriatrics Authors: Nicola Veronese Lee Smith Ai Koyanagi Jaco Hoffman Mouna Snoussi Konstantinos Prokopidis Ligia J Dominguez Mario Barbagallo Source Type: research

Association between accelerometry measured patterns of sedentary behaviors and functional status in older adults
CONCLUSIONS: Greater fragmentation of SB was associated with better function, and increasing SBF may be a useful strategy for mitigating the effects of SB in older adults, but prospective research is needed to support this approach.PMID:38281264 | PMC:PMC10822805 | DOI:10.1007/s40520-023-02644-z (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - January 28, 2024 Category: Geriatrics Authors: Jung Yoen Son Weijiao Zhou Katelyn E Webster-Dekker Deanna J Marriott Janet L Larson Source Type: research