Aging Clinical and Experimental Research 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Markers for the detection of Lewy body disease versus Alzheimer's disease in mild cognitive impairment: a systematic review and meta-analysis
CONCLUSIONS: Few studies have assessed the accuracy of biomarkers and clinical tools to distinguish DLB from AD at the MCI stage. While results are promising for CSF markers, FDG-PET and clinical symptoms scales, more studies, particularly with a prospective design, are needed to evaluate their accuracy and clinical usefulness.CLINICAL TRIAL REGISTRATION: Prospero (CRD42023422600).PMID:38451331 | PMC:PMC10920203 | DOI:10.1007/s40520-024-02704-y (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - March 7, 2024 Category: Geriatrics Authors: Marianna Ilarj Burgio Nicola Veronese Davide Sar à Carlo Saccaro Roberta Masnata Giusy Vassallo Angela Catania Giuseppina Catanese Christoph Mueller Lee Smith Ligia Juliana Dominguez Laura Vernuccio Mario Barbagallo Source Type: research
Relationship between hemoglobin and grip strength in older adults: the ActiFE study
CONCLUSIONS: Our data show an association between hemoglobin and grip strength only in women < 80 years old. For men < 80 years, the association was only significant with ferritin levels ≥ 300 µg/L. Considering the decreasing levels of hemoglobin and grip strength and the high prevalence of iron deficiency in older adults further analyses investigating this relationship with more iron specific parameters such as transferrin saturation are warranted.PMID:38451343 | PMC:PMC10920471 | DOI:10.1007/s40520-024-02698-7 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - March 7, 2024 Category: Geriatrics Authors: Theresa Hammer Ulrike Braisch Dietrich Rothenbacher Michael Denkinger Dhayana Dallmeier Source Type: research
Validity and reliability of a ruler drop test to measure dual-task reaction time, choice reaction time and discrimination reaction time
CONCLUSION: We conclude that the RDT is a suitable instrument for measuring dual-task, choice and discrimination reaction time. Future studies should explore the reliability of these measures in other populations.PMID:38451364 | PMC:PMC10920456 | DOI:10.1007/s40520-024-02726-6 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - March 7, 2024 Category: Geriatrics Authors: Soraia Ferreira Armando Raimundo Jesus Del Pozo-Cruz Nilton Leite Ana Pinto Jos é Marmeleira Source Type: research
Bile acid profile associated with CSF and PET biomarkers in Alzheimer's disease
CONCLUSION: The findings from our study suggest a correlation between altered profiles of BAs and CSF and imaging biomarkers associated with AD. These results provide supporting evidence for the link between the gut microbiome and the pathological features of AD.PMID:38451317 | DOI:10.1007/s40520-024-02729-3 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - March 7, 2024 Category: Geriatrics Authors: Fardin Nabizadeh Parya Valizadeh Mohammad Sadegh Fallahi Alzheimer ’s disease Neuroimaging Initiative Source Type: research
Markers for the detection of Lewy body disease versus Alzheimer's disease in mild cognitive impairment: a systematic review and meta-analysis
CONCLUSIONS: Few studies have assessed the accuracy of biomarkers and clinical tools to distinguish DLB from AD at the MCI stage. While results are promising for CSF markers, FDG-PET and clinical symptoms scales, more studies, particularly with a prospective design, are needed to evaluate their accuracy and clinical usefulness.CLINICAL TRIAL REGISTRATION: Prospero (CRD42023422600).PMID:38451331 | DOI:10.1007/s40520-024-02704-y (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - March 7, 2024 Category: Geriatrics Authors: Marianna Ilarj Burgio Nicola Veronese Davide Sar à Carlo Saccaro Roberta Masnata Giusy Vassallo Angela Catania Giuseppina Catanese Christoph Mueller Lee Smith Ligia Juliana Dominguez Laura Vernuccio Mario Barbagallo Source Type: research
Relationship between hemoglobin and grip strength in older adults: the ActiFE study
CONCLUSIONS: Our data show an association between hemoglobin and grip strength only in women < 80 years old. For men < 80 years, the association was only significant with ferritin levels ≥ 300 µg/L. Considering the decreasing levels of hemoglobin and grip strength and the high prevalence of iron deficiency in older adults further analyses investigating this relationship with more iron specific parameters such as transferrin saturation are warranted.PMID:38451343 | DOI:10.1007/s40520-024-02698-7 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - March 7, 2024 Category: Geriatrics Authors: Theresa Hammer Ulrike Braisch Dietrich Rothenbacher Michael Denkinger Dhayana Dallmeier Source Type: research
Validity and reliability of a ruler drop test to measure dual-task reaction time, choice reaction time and discrimination reaction time
CONCLUSION: We conclude that the RDT is a suitable instrument for measuring dual-task, choice and discrimination reaction time. Future studies should explore the reliability of these measures in other populations.PMID:38451364 | DOI:10.1007/s40520-024-02726-6 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - March 7, 2024 Category: Geriatrics Authors: Soraia Ferreira Armando Raimundo Jesus Del Pozo-Cruz Nilton Leite Ana Pinto Jos é Marmeleira Source Type: research
Bile acid profile associated with CSF and PET biomarkers in Alzheimer's disease
CONCLUSION: The findings from our study suggest a correlation between altered profiles of BAs and CSF and imaging biomarkers associated with AD. These results provide supporting evidence for the link between the gut microbiome and the pathological features of AD.PMID:38451317 | DOI:10.1007/s40520-024-02729-3 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - March 7, 2024 Category: Geriatrics Authors: Fardin Nabizadeh Parya Valizadeh Mohammad Sadegh Fallahi Alzheimer ’s disease Neuroimaging Initiative Source Type: research
Markers for the detection of Lewy body disease versus Alzheimer's disease in mild cognitive impairment: a systematic review and meta-analysis
CONCLUSIONS: Few studies have assessed the accuracy of biomarkers and clinical tools to distinguish DLB from AD at the MCI stage. While results are promising for CSF markers, FDG-PET and clinical symptoms scales, more studies, particularly with a prospective design, are needed to evaluate their accuracy and clinical usefulness.CLINICAL TRIAL REGISTRATION: Prospero (CRD42023422600).PMID:38451331 | DOI:10.1007/s40520-024-02704-y (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - March 7, 2024 Category: Geriatrics Authors: Marianna Ilarj Burgio Nicola Veronese Davide Sar à Carlo Saccaro Roberta Masnata Giusy Vassallo Angela Catania Giuseppina Catanese Christoph Mueller Lee Smith Ligia Juliana Dominguez Laura Vernuccio Mario Barbagallo Source Type: research
Relationship between hemoglobin and grip strength in older adults: the ActiFE study
CONCLUSIONS: Our data show an association between hemoglobin and grip strength only in women < 80 years old. For men < 80 years, the association was only significant with ferritin levels ≥ 300 µg/L. Considering the decreasing levels of hemoglobin and grip strength and the high prevalence of iron deficiency in older adults further analyses investigating this relationship with more iron specific parameters such as transferrin saturation are warranted.PMID:38451343 | DOI:10.1007/s40520-024-02698-7 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - March 7, 2024 Category: Geriatrics Authors: Theresa Hammer Ulrike Braisch Dietrich Rothenbacher Michael Denkinger Dhayana Dallmeier Source Type: research
Validity and reliability of a ruler drop test to measure dual-task reaction time, choice reaction time and discrimination reaction time
CONCLUSION: We conclude that the RDT is a suitable instrument for measuring dual-task, choice and discrimination reaction time. Future studies should explore the reliability of these measures in other populations.PMID:38451364 | DOI:10.1007/s40520-024-02726-6 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - March 7, 2024 Category: Geriatrics Authors: Soraia Ferreira Armando Raimundo Jesus Del Pozo-Cruz Nilton Leite Ana Pinto Jos é Marmeleira Source Type: research
Association between natriuretic peptides and C-reactive protein with frailty in heart failure: a systematic review and meta-analysis
CONCLUSIONS: Frailty in HF is linked to increased concentrations of BNP, NT-proBNP, and CRP, which have been epidemiologically associated with adverse outcomes. The increased risk of NYHA III/IV classification further emphasizes the clinical impact of frailty in this population.PMID:38446241 | DOI:10.1007/s40520-024-02713-x (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - March 6, 2024 Category: Geriatrics Authors: Konstantinos Prokopidis Hironori Ishiguchi Cara Jordan Krzysztof Irlik Katarzyna Nabrdalik Francesc Formiga Rajiv Sankaranarayanan Gregory Y H Lip Masoud Isanejad Source Type: research
The interaction between Mediterranean diet and intestinal microbiome: relevance for preventive strategies against frailty in older individuals
Aging Clin Exp Res. 2024 Mar 6;36(1):58. doi: 10.1007/s40520-024-02707-9.ABSTRACTAge-related changes in intestinal microbiome composition and function are increasingly recognized as pivotal in the pathophysiology of aging and are associated with the aging phenotype. Diet is a major determinant of gut-microbiota composition throughout the entire lifespan, and several of the benefits of a healthy diet in aging could be mediated by the microbiome. Mediterranean diet (MD) is a traditional dietary pattern regarded as the healthy diet paradigm, and a large number of studies have demonstrated its benefits in promoting healthy agi...
Source: Aging Clinical and Experimental Research - March 6, 2024 Category: Geriatrics Authors: Andrea Ticinesi Antonio Nouvenne Nicoletta Cerundolo Alberto Parise Pedro Mena Tiziana Meschi Source Type: research
Association between natriuretic peptides and C-reactive protein with frailty in heart failure: a systematic review and meta-analysis
CONCLUSIONS: Frailty in HF is linked to increased concentrations of BNP, NT-proBNP, and CRP, which have been epidemiologically associated with adverse outcomes. The increased risk of NYHA III/IV classification further emphasizes the clinical impact of frailty in this population.PMID:38446241 | DOI:10.1007/s40520-024-02713-x (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - March 6, 2024 Category: Geriatrics Authors: Konstantinos Prokopidis Hironori Ishiguchi Cara Jordan Krzysztof Irlik Katarzyna Nabrdalik Francesc Formiga Rajiv Sankaranarayanan Gregory Y H Lip Masoud Isanejad Source Type: research
Progranulin and neuropathological features of Alzheimer's disease: longitudinal study
CONCLUSION: Our findings revealed that an increase in CSF progranulin over time is associated with faster formation of Aβ plaques in patients with only tau pathology based on the A/T/N classification (suspected non-Alzheimer's pathology). Together, our findings showed that the role of progranulin-related microglial activity on AD pathology can be stage-dependent, complicated, and more prominent in non-AD pathologic changes. Thus, there is a need for further studies to consider progranulin-based therapies for AD treatment.PMID:38441695 | DOI:10.1007/s40520-024-02715-9 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - March 5, 2024 Category: Geriatrics Authors: Fardin Nabizadeh Rasa Zafari Alzheimer ’s disease Neuroimaging Initiative (ADNI) Source Type: research
