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A dynamic computational model of the parallel circuit on the basal ganglia-cortex associated with Parkinson's disease dementia
Biol Cybern. 2024 Apr 21. doi: 10.1007/s00422-024-00988-x. Online ahead of print.ABSTRACTThe cognitive impairment will gradually appear over time in Parkinson's patients, which is closely related to the basal ganglia-cortex network. This network contains two parallel circuits mediated by putamen and caudate nucleus, respectively. Based on the biophysical mean-field model, we construct a dynamic computational model of the parallel circuit in the basal ganglia-cortex network associated with Parkinson's disease dementia. The simulated results show that the decrease of power ratio in the prefrontal cortex is mainly caused by d...
Source: Biological Cybernetics - April 21, 2024 Category: Science Authors: Hao Yang XiaoLi Yang SiLu Yan Source Type: research

Molecular mechanisms linking type 2 diabetes mellitus and late-onset Alzheimer's disease: A systematic review and qualitative meta-analysis
Neurobiol Dis. 2024 Apr 19:106485. doi: 10.1016/j.nbd.2024.106485. Online ahead of print.ABSTRACTResearch evidence indicating common metabolic mechanisms through which type 2 diabetes mellitus (T2DM) increases risk of late-onset Alzheimer's dementia (LOAD) has accumulated over recent decades. The aim of this systematic review is to provide a comprehensive review of common mechanisms, which have hitherto been discussed in separate perspectives, and to assemble and evaluate candidate loci and epigenetic modifications contributing to polygenic risk linkages between T2DM and LOAD. For the systematic review on pathophysiologica...
Source: Neurobiology of Disease - April 21, 2024 Category: Neurology Authors: Erwin Lemche Richard Killick Jackie Mitchell Paul W Caton Pratik Choudhary Jane K Howard Source Type: research

Age-specific prevalence of the different clinical presentations of AD and FTD in young-onset dementia
ConclusionsAmnestic AD is the clinical presentation that increases the most with advancing age, followed by bvFTD, suggesting that there is a differential vulnerability to the effect of ageing within the same neurodegenerative disease. (Source: Journal of Neurology)
Source: Journal of Neurology - April 21, 2024 Category: Neurology Source Type: research

Beyond the stethoscope: Reflections from a dementia unit
Australas J Ageing. 2024 Apr 19. doi: 10.1111/ajag.13319. Online ahead of print.NO ABSTRACTPMID:38641891 | DOI:10.1111/ajag.13319 (Source: Australasian Journal on Ageing)
Source: Australasian Journal on Ageing - April 20, 2024 Category: Geriatrics Authors: Eleanor Tkh Dunn Source Type: research

Characterization and quantification of epilepsy patients with hospital episodes in Portugal: A multicenter retrospective study from Liga Portuguesa Contra a Epilepsia
CONCLUSION: This study showed similar results to other European countries. However, due to methodological limitations, a prospective epidemiological study is needed to support this observation. Furthermore, the present study provides a comprehensive picture of hospitalized epilepsy patients in Portugal, their comorbidities, mortality, and hospital procedures.PMID:38642529 | DOI:10.1016/j.yebeh.2024.109771 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - April 20, 2024 Category: Neurology Authors: Carla Bentes Nuno Canas Hugo Pedrosa Jo ão Completo F ábio Pereira Magda Carrilho Jos é Lopes Lima Cristina Pereira Ricardo Rego Helena Rocha Francisca S á Francisco Sales Manuela Santos Rute Teot ónio Source Type: research

Glucose Color Index: Development and Validation of a Novel Measure of the Shape of Glycemic Variability
CONCLUSION: We developed and validated the GCI, a novel CGM metric that captures the shape of glucose variability using the periodogram signal decomposition. Glucose Color Index was reliable within participants over a three-month period and associated with diabetes comorbidities. The GCI suggests a promising avenue toward the development of CGM metrics which more fully incorporate time series information.PMID:38641966 | DOI:10.1177/19322968241245654 (Source: Atherosclerosis)
Source: Atherosclerosis - April 20, 2024 Category: Cardiology Authors: Joseph Sartini Michael Fang Mary R Rooney Elizabeth Selvin Josef Coresh Scott Zeger Source Type: research

Clinical impact of an individualised clinical pharmacy programme into the memory care pathway of older people: an observational study
ConclusionThe integration of clinical pharmacist secured the Memory care pathway of older patients with a cognitive complaint by identifying an important number of DRPs and PIMs with potential cognitive iatrogenic risk. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 20, 2024 Category: Drugs & Pharmacology Source Type: research