The Celiac-Disease Superantigen Oligomerizes and Increases Permeability in an Enterocyte Cell Model
Angew Chem Int Ed Engl. 2024 Mar 18:e202317552. doi: 10.1002/anie.202317552. Online ahead of print.ABSTRACTCeliac disease (CeD) is an autoimmune disorder triggered by gluten proteins, affecting approximately 1% of the global population. The 33-mer deamidated gliadin peptide (DGP) is a metabolically modified wheat-gluten superantigen for CeD. Here, we demonstrate that the 33-mer DGP spontaneously assembles into oligomers with a diameter of approximately 24 nm. The 33-mer DGP oligomers present two main secondary structural motifs-a major polyproline II helix and a minor β-sheet structure. Importantly, in the presence of 33-...
Source: Angewandte Chemie - March 18, 2024 Category: Chemistry Authors: Maria Georgina Herrera Maria Julia Amundarain Philipp W D örfler Veronica I Dodero Source Type: research

Immunomodulatory and Anti-Inflammatory Effects of Vitamin A and Tryptophan on Monocyte-Derived Dendritic Cells Stimulated with Gliadin in Celiac Disease Patients
AbstractCeliac Disease (CeD) is an autoimmune disorder with various symptoms upon gluten exposure. Dendritic cells (DCs) play a crucial role in gliadin-induced inflammation. Vitamin A (retinol; Ret) and its metabolite, retinoic acid (RA), along with tryptophan (Trp) and its metabolite, kynurenic acid (KYNA), are known to influence the immune function of DCs and enhance their tolerogenicity. This research aims to assess the impact of gliadin on DC maturation and the potential of vitamin A and tryptophan to induce immune tolerance in DCs. The monocyte cells obtained from peripheral blood mononuclear cells (PBMCs) of celiac d...
Source: Inflammation - March 16, 2024 Category: Allergy & Immunology Source Type: research

Italian guidelines for the management of irritable bowel syndrome in children and adolescents
AbstractThe irritable bowel syndrome (IBS) is a functional gastrointestinal disorder (FGID), whose prevalence has widely increased in pediatric population during the past two decades. The exact pathophysiological mechanism underlying IBS is still uncertain, thus resulting in challenging diagnosis and management. Experts from 4 Italian Societies participated in a Delphi consensus, searching medical literature and voting process on 22 statements on both diagnosis and management of IBS in children. Recommendations and levels of evidence were evaluated according to the grading of recommendations, assessment, development, and e...
Source: Italian Journal of Pediatrics - March 14, 2024 Category: Pediatrics Source Type: research

Shared and distinct genetics of pure type 1 diabetes and type 1 diabetes with celiac disease, homology in their auto-antigens and immune dysregulation states: a study from North India
ConclusionSame HLA genes provide susceptibility for both T1D and CD. Non-HLA genes CTLA4, PTPN22 and INS provide further susceptibility while different polymorphisms in PTPN22 and INS can discriminate between T1D and T1D  + CD. Epitope homology between autoantigens of two diseases further encourages the two diseases to occur together. The T1D + CD being more common in females along with co-existence of thyroid autoimmunity, and have more immune dysregulated state than T1D alone. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 14, 2024 Category: Endocrinology Source Type: research

The role of antral histopathology in diagnosing paediatric celiac disease
Pol J Pathol. 2023;74(4):256-264. doi: 10.5114/pjp.2023.134290.ABSTRACTThe aim of this study was to evaluate the diagnostic potential of gastric antrum histology in children suspected of having celiac disease (CD). The present retrospective study was performed on 224 patients who were suspected of having CD and had several duodenal and one gastric antrum biopsies. They were divided into 2 groups based on the definite diagnosis of CD. The statistical analysis was performed using SPSS version 22 software. Receiver operating characteristic (ROC) curves were drown and the area under the curves (AUCs) was calculated. Article au...
Source: Polish Journal of Pathology - March 13, 2024 Category: Pathology Authors: Zahra Heidari Manijeh Khalili Hamidreza Mahmoudzadeh Sagheb Mahdi Afshari Fateme Parooie Iraj Shahramian Fateme Sargazi Alireza Aminisefat Mahdi Shirdel Kahkha Zhale Ali Mansuri Source Type: research

The gut microbiota and celiac disease: Pathophysiology, current perspective and new therapeutic approaches
(Source: Critical Reviews in Food Science and Nutrition)
Source: Critical Reviews in Food Science and Nutrition - March 13, 2024 Category: Nutrition Authors: Zoghi, Sevda Abbasi, Amin Heravi, Fatemah Sadeghpour Somi, Mohammad Hossein Nikniaz, Zeinab Moaddab, Seyed Yaghoub Ebrahimzadeh Leylabadlo, Hamed Source Type: research

Developing International Classification of Disease code definitions for the study of enteric infection sequelae in Canada
CONCLUSION: The multi-step design to derive ICD code definitions provided flexibility to identify existing definitions, to improve their sensitivity and PPV and adapt them to the Canadian context.PMID:38455876 | PMC:PMC10917133 | DOI:10.14745/ccdr.v49i78a01 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - March 8, 2024 Category: Infectious Diseases Authors: Eleni Galanis Azita Goshtasebi Yuen Wai Hung Jonathan Chan Douglas Matsell Kristine Chapman Gilaad Kaplan David Patrick Bei Yuan Zhang Marsha Taylor Dimitra Panagiotoglou Shannon Majowicz Source Type: research

Developing International Classification of Disease code definitions for the study of enteric infection sequelae in Canada
CONCLUSION: The multi-step design to derive ICD code definitions provided flexibility to identify existing definitions, to improve their sensitivity and PPV and adapt them to the Canadian context.PMID:38455876 | PMC:PMC10917133 | DOI:10.14745/ccdr.v49i78a01 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - March 8, 2024 Category: Infectious Diseases Authors: Eleni Galanis Azita Goshtasebi Yuen Wai Hung Jonathan Chan Douglas Matsell Kristine Chapman Gilaad Kaplan David Patrick Bei Yuan Zhang Marsha Taylor Dimitra Panagiotoglou Shannon Majowicz Source Type: research

Developing International Classification of Disease code definitions for the study of enteric infection sequelae in Canada
CONCLUSION: The multi-step design to derive ICD code definitions provided flexibility to identify existing definitions, to improve their sensitivity and PPV and adapt them to the Canadian context.PMID:38455876 | PMC:PMC10917133 | DOI:10.14745/ccdr.v49i78a01 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - March 8, 2024 Category: Infectious Diseases Authors: Eleni Galanis Azita Goshtasebi Yuen Wai Hung Jonathan Chan Douglas Matsell Kristine Chapman Gilaad Kaplan David Patrick Bei Yuan Zhang Marsha Taylor Dimitra Panagiotoglou Shannon Majowicz Source Type: research

Biopsy proteome scoring to determine mucosal remodeling in celiac disease
Histological evaluation of gut biopsies is a cornerstone for diagnosis and management of celiac disease (CeD). Despite its wide use, the method depends on proper biopsy orientation, and it suffers from inter-observer variability. Biopsy proteome measurement reporting on tissue state can be obtained by mass spectrometry (MS) analysis of formalin-fixed paraffin embedded (FFPE) tissue. Here we aimed to transform biopsy proteome data into numerical scores that give observer-independent measures of mucosal remodeling in CeD. (Source: Gastroenterology)
Source: Gastroenterology - March 8, 2024 Category: Gastroenterology Authors: Anette Johansen, Geir Kjetil F. Sandve, Jostein Holen Ibsen, Knut E.A. Lundin, Ludvig M. Sollid, Jorunn Stamnaes Tags: Clinical - Alimentary Tract Source Type: research

Prevalence and Predictors of Celiac Disease in Children With Constipation
CONCLUSION: Children with constipation and associated growth failure have a high prevalence of celiac disease.PMID:38449276 (Source: Indian Pediatrics)
Source: Indian Pediatrics - March 7, 2024 Category: Pediatrics Authors: Monika Meena Manish Narang Rajesh Kumar Meena Anju Aggarwal Source Type: research