Evaluating Responses to Gluten Challenge: A Randomized, Double-Blind, 2-Dose Gluten Challenge Trial
Gluten challenge is used to diagnose celiac disease (CeD) and for clinical research. Sustained gluten exposure reliably induces histological changes but is burdensome. We investigated the relative abilities of multiple biomarkers to assess disease activity induced by two gluten doses, and aimed to identify biomarkers to supplement or replace histology. (Source: Gastroenterology)
Source: Gastroenterology - October 29, 2020 Category: Gastroenterology Authors: Maureen M. Leonard, Jocelyn A. Silvester, Daniel Leffler, Alessio Fasano, Ciar án P. Kelly, Suzanne K. Lewis, Jeffrey D. Goldsmith, Elliot Greenblatt, William W. Kwok, William J. McAuliffe, Kevin Galinsky, Jenifer Siegelman, I-Ting Chow, John A. Wagner, Source Type: research
Intestinal Dysbiosis in, and Enteral Bacterial Therapies for, Systemic Autoimmune Diseases
Recent studies have shown that a number of common autoimmune diseases have perturbations of their intestinal microbiome (dysbiosis). These include: Celiac Disease (CeD), Multiple Sclerosis (MS), Rheumatoid Arthritis (RA), Sjogren’s Syndrome (SS), and Type 1 diabetes (T1D). All of these have intestinal microbiomes that are different from healthy controls. There have been numerous studies using animal models of single probiotics (monoclonal) or mixtures of probiotics (polyclonal) and even complete microbiota transfer (fecal microbial transfer-FMT) to inhibit or delay the onset of autoimmune diseases such as the aforeme...
Source: Frontiers in Immunology - October 28, 2020 Category: Allergy & Immunology Source Type: research
Gut Microbiota in Celiac Disease: Microbes, Metabolites, Pathways and Therapeutics.
Authors: Olshan KL, Leonard MM, Serena G, Zomorrodi AR, Fasano A Abstract INTRODUCTION: Current evidence supports a vital role of the microbiota on human health outcomes, with alterations in an otherwise healthy balance linked to chronic medical conditions such as celiac disease (CD). Recent advances in microbiome analysis allow for unparalleled profiling of the microbes and metabolites. With the growing volume of data available, trends are emerging that support a role for the gut microbiota in CD pathogenesis. AREAS COVERED: In this article, the authors review the relationship between factors such as genes and...
Source: Expert Review of Clinical Immunology - October 27, 2020 Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
ESPGHAN ‘biopsy-sparing’ guidelines for celiac disease in children with low antitransglutaminase during COVID-19
Objectives Recent guidelines for celiac disease have allowed a biopsy-free approach in endomysial antibodies (EMAs) positive children with high antitransglutaminase (TGA-IgA) titer [>10 time upper limit of normal (ULN)]. Esophagogastroduodenoscopy is still necessary for diagnosis in children with lower title. Because elective pediatric endoscopy has been substantially shouted down during coronavirus disease (COVID-19) pandemic, many children remained undiagnosed – and therefore untreated – for a long time. We aimed to analyze the feasibility and accuracy of a biopsy-free approach in suspected celiac diseas...
Source: European Journal of Gastroenterology and Hepatology - October 27, 2020 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research
Low Tenofovir Plasma Exposure in HIV Oral Pre-exposure Prophylaxis Recipients with Gastrointestinal Disorders.
rri G Abstract Four pre-exposure prophylaxis (PrEP) users with gastro-intestinal disorders (sleeve gastrectomy, terminal ileitis, celiac disease or chronic diarrhea) and receiving oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) were included. Despite a self-reported high adherence, trough plasma tenofovir concentrations (after a supervised intake) were significantly lower than those observed in PrEP recipients without gastrointestinal disorders [21 (±9.1) vs. 138 (±85) ng/mL]. PrEP users with gastrointestinal disorders may need increased TDF doses or alternative prophylactic measures. ...
Source: Antimicrobial Agents and Chemotherapy - October 26, 2020 Category: Microbiology Authors: Calcagno A, Dal Conte I, Cattaneo D, Testi R, Mistrangelo M, Gervasoni C, de Nicolò A, Bonora S, D'Avolio A, Di Perri G Tags: Antimicrob Agents Chemother Source Type: research
Recent advances on dietary polyphenol's potential roles in Celiac Disease
Publication date: Available online 24 October 2020Source: Trends in Food Science & TechnologyAuthor(s): Ricardo Dias, Catarina Bessa Pereira, Rosa Pérez-Gregorio, Nuno Mateus, Victor Freitas (Source: Trends in Food Science and Technology)
Source: Trends in Food Science and Technology - October 25, 2020 Category: Food Science Source Type: research
Endocannabinoid System and Bone Loss in Celiac Disease: Towards a Demanding Research Agenda
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - October 24, 2020 Category: Gastroenterology Tags: Invited Commentaries Source Type: research
The Role of Cannabinoid Receptor Type 2 in the Bone Loss Associated With Pediatric Celiac Disease
Conclusions: CB2 could be a molecular marker to predict the risk of bone alterations in CD and a pharmacological target to reduce bone mass loss in patients who need a direct intervention on bone metabolism, in addition to the GFD. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - October 24, 2020 Category: Gastroenterology Tags: Original Article: Gastroenterology: Celiac Disease Source Type: research
Prevalence of elevated alanine aminotransferase levels in adult participants from a community-based study from northern part of India
AbstractAlanine aminotransferase (ALT) is a cytosolic enzyme specific to hepatocytes, and its elevated level in the peripheral blood denotes liver cell injury. Detection of persistently elevated ALT levels during routine health check-up in asymptomatic or symptomatic individuals provides a window of opportunity to explore the causes of liver cell damage and for the timely institution of appropriate treatment. This was a retrospective study using a subset of the data from a previous community-based prospective study done for the estimation of the prevalence of celiac disease (CD) in India, during which estimatio...
Source: Indian Journal of Gastroenterology - October 24, 2020 Category: Gastroenterology Source Type: research
Association between atopic dermatitis and autoimmune diseases: a population-based case-control study.
CONCLUSION: This large population-based study indicates a significant autoimmune comorbidity of adults with AD, especially between AD and autoimmune dermatologic, gastrointestinal and rheumatologic diseases. Having multiple autoimmune diseases had a stronger association with AD than having only one autoimmune disease. PMID: 33091150 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 22, 2020 Category: Dermatology Authors: Ivert LU, Wahlgren CF, Lindelöf B, Dal H, Bradley M, Johansson EK Tags: Br J Dermatol Source Type: research
[Research Articles] Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation
Metabolism of tryptophan by the gut microbiota into derivatives that activate the aryl hydrocarbon receptor (AhR) contributes to intestinal homeostasis. Many chronic inflammatory conditions, including celiac disease involving a loss of tolerance to dietary gluten, are influenced by cues from the gut microbiota. We investigated whether AhR ligand production by the gut microbiota could influence gluten immunopathology in nonobese diabetic (NOD) mice expressing DQ8, a celiac disease susceptibility gene. NOD/DQ8 mice, exposed or not exposed to gluten, were subjected to three interventions directed at enhancing AhR pathway acti...
Source: Science Translational Medicine - October 21, 2020 Category: Biomedical Science Authors: Lamas, B., Hernandez-Galan, L., Galipeau, H. J., Constante, M., Clarizio, A., Jury, J., Breyner, N. M., Caminero, A., Rueda, G., Hayes, C. L., McCarville, J. L., Bermudez Brito, M., Planchais, J., Rolhion, N., Murray, J. A., Langella, P., Loonen, L. M. P. Tags: Research Articles Source Type: research
Effect of Gluten Ingestion and FODMAP Restriction on Intestinal Epithelial Integrity in Patients with Irritable Bowel Syndrome and Self ‐Reported Non‐Coeliac Gluten Sensitivity
Circulating syndecan ‐1 concentrations are elevated in patients with irritable bowel syndrome and self‐reported sensitivity to gluten on a gluten‐free diet. When fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) are restricted, syndecan‐1 levels normalize (33–35% reduction). B linded gluten challenges have no effect, suggesting an association of FODMAPs, but not gluten, with epithelial injury. ScopeSince epithelial barrier dysfunction has been associated with gluten and fermentable oligosaccharide, disaccharide, monosaccharide, and polyols (FODMAPs), the effect of alterations...
Source: Molecular Nutrition and Food Research - October 21, 2020 Category: Food Science Authors: Mary Ajamian, Gennaro Rosella, Evan D. Newnham, Jessica R. Biesiekierski, Jane G. Muir, Peter R. Gibson Tags: Research Article Source Type: research
IL-10 gene promoter region polymorphisms and their association with celiac disease.
Authors: López MS, Tiscornia MM, Dicarlos MB, Zapata PD Abstract INTRODUCTION: in celiac disease (CD), immune response activation results in local cytokine network impairment. Interleukin 10 (IL-10) is a key anti-inflammatory cytokine in the prevention of inflammatory conditions. OBJECTIVE: to analyze the association of single nucleotide polymorphisms in the IL-10 gene promoter region with CD in a population of Misiones Province, Argentina. PATIENTS AND METHODS: DNA from whole blood was extracted from 40 patients with CD and 80 controls and the IL-10 gene promoter region containing polymorphisms rs18...
Source: Revista Espanola de Enfermedades Digestivas - October 20, 2020 Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
Medical Care of Adults With Down Syndrome —A Clinical Guideline
This combination evidence-based and consensus clinical guideline presents recommendations and statements of good practice for the medical care of adults with Down syndrome, including screening, diagnosis, and treatment of behavioral health conditions, dementia, diabetes, cardiovascular disease, obesity, osteoporosis, atlantoaxial instability, hypothyroidism, and celiac disease. (Source: JAMA)
Source: JAMA - October 20, 2020 Category: General Medicine Source Type: research
Imaging findings of en bloc simultaneous liver-kidney transplantation
AbstractSimultaneous liver-kidney transplantations (SLKTs) are increasing in incidence, and the en bloc surgical approach is associated with a unique spectrum of vascular complications. En bloc SLKTs have a common arterial supply from the celiac axis and post-operative assessment with Doppler ultrasound can help to localize vascular lesions as either proximal in the shared arterial supply or distal in the organ-specific arteries. Venous complications predominantly include thrombosis or stenosis of the portal vein, hepatic veins, renal vein, or IVC, but have a much lower incidence. Radiologists familiar with the ...
Source: Abdominal Imaging - October 20, 2020 Category: Radiology Source Type: research
Value of biopsy in a cohort of children with high-titer celiac serologies: observation of dynamic policy differences between Europe and North America
Healthcare systems implement change at different rates because of differences in incentives, organizational processes, key influencers, and management styles. A comparable set of forces may play out at the nat... (Source: BMC Health Services Research)
Source: BMC Health Services Research - October 20, 2020 Category: General Medicine Authors: Kamran Badizadegan, David M. Vanlandingham, Wesley Hampton and Kimberly M. Thompson Tags: Research article Source Type: research
Duodenal Histological Findings and Risk of Coeliac Disease in Subjects with Autoimmune Atrophic Gastritis: A Retrospective Evaluation
Conclusions: We support the screening of all AAG patients with CeD autoantibodies. Findings of isolated IEL or villous atrophy are not exclusively related to CeD.Digestion (Source: Digestion)
Source: Digestion - October 19, 2020 Category: Gastroenterology Source Type: research
NOMI after cardiac arrest. Could refined diagnostics improve outcome?
Intestinal ischaemia is usually classified into acute mesenteric ischaemia (AMI), chronic mesenteric ischaemia and colonic ischaemia. Coeliac, inferior and superior mesenteric arterial/venous emboli/thrombi and non-occlusive mesenteric ischaemia (NOMI) can cause AMI. NOMI pathophysiology involves hypoperfusion, aggravated by bacterial translocation, reperfusion injury, apoptosis and decreased proliferation of enterocytes. NOMI was first reported in 1958 by Ende in three heart failure patients.1 NOMI is the most lethal form of AMI due to initial mild and nonspecific symptoms that delay diagnosis and treatment. (Source: Resuscitation)
Source: Resuscitation - October 19, 2020 Category: Emergency Medicine Authors: Ulf Sch ött, Thomas Kander Tags: Editorial Source Type: research
Celiac disease serology and gut microbiome following protein pump inhibitor treatment: Erratum
No abstract available (Source: Medicine)
Source: Medicine - October 16, 2020 Category: Internal Medicine Tags: Erratum Source Type: research
GSE159495 Immune and Metabolic Pathogenesis of Environmental Enteric Dysfunction in Childhood Undernutrition: A Birth Inception Cohort
Contributors : Yael Haberman ; Najeeha T Iqbal ; Sudhir Ghandikota ; Indika Mallawaarachchi ; Tzipi Braun ; Phillip J Dexheimer ; Najeeb Rahman ; Rotem Hadar ; Kamran Sadiq ; Zubair Ahmad ; Romana Idress ; Junaid Iqbal ; Sheraz Ahmed ; Aneeta Hotwani ; Fayyaz Umrani ; Lubaina Ehsan ; Greg Medlock ; Chris Moskaluk ; Sana Syed ; Jennie Z Ma ; Anil G Jegga ; Sean R Moore ; Syed A Ali ; Lee A DensonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Environmental enteric dysfunction (EED) is a major impediment to the Sustainable Development Goals of improved childhood survival and...
Source: GEO: Gene Expression Omnibus - October 15, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Analysis of gluten immunogenic peptides in feces to assess adherence to the gluten-free diet in pediatric celiac patients
AbstractPurposeIn celiac disease (CD) there is a need for precise and non-invasive tools to assess dietary compliance to the gluten-free diet (GFD). Our aim is to evaluate the efficacy of the detection of gluten immunogenic peptides (GIP) in feces, to monitor in real life, the adherence to GFD in pediatric patients with CD.MethodsA cross-sectional, prospective study was conducted. Fecal samples from CD children were analyzed by a rapid immunochromatographic (IC) test and by an ELISA method, both based on the antigliadin 33-mer monoclonal antibody.ResultsGroup 1 comprises 43 children on a GFD. According to the food records ...
Source: European Journal of Nutrition - October 15, 2020 Category: Nutrition Source Type: research
Correction to: Unexpected high frequency of neurofibroma in the celiac ganglion of German cattle
An amendment to this paper has been published and can be accessed via the original article. (Source: Veterinary Research)
Source: Veterinary Research - October 15, 2020 Category: Veterinary Research Source Type: research
Unusual Presentation of Polyautoimmunity and Renal Tubular Acidosis in an Adolescent With Hashimoto's Thyroiditis and Central Pontine Myelinolysis
Conclusions: This is the rare case of polyautoimmunity including autoimmune thyroiditis, Sjögren's syndrome, vitiligo and celiac disease in an adolescent with few disease-specific symptoms. The diagnoses were made via a complicating nephritis causing dRTA and proteinuria. Delay in diagnosis lead to permanent neurological damage. This case highlights the need for pediatricians to be aware of rare accompanying diseases and their complications in “common” pediatric autoimmune diseases like Hashimoto's thyroiditis and celiac disease. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - October 14, 2020 Category: Endocrinology Source Type: research
Innate and adaptive immunity in celiac disease
Purpose of review The current review is prompted by recent studies indicating that adaptive immunity could be sufficient to explain rapid onset symptoms as well as many chronic effects of gluten in celiac disease. Recent findings Gluten re-exposure in treated celiac disease drives a coordinated systemic cytokine release response implicating T-cell activation within 2 h. Instead of direct effects of gluten on innate immunity, long lasting memory CD4+ T cells activated within 2 h of ingesting gluten or injecting purified gluten peptides now appear to be responsible for acute digestive symptoms. In addition, memory B...
Source: Current Opinion in Gastroenterology - October 13, 2020 Category: Gastroenterology Tags: IMMUNOLOGY: Edited by Jocelyn A. Silvester Source Type: research
Host immune interactions in chronic inflammatory gastrointestinal conditions
Purpose of review We performed a literature review of the latest studies on the interactions between the host immune system and microbes in chronic intestinal inflammatory conditions. Recent findings The mechanisms leading to celiac disease (CeD) and inflammatory bowel disease (IBD), the most common chronic inflammatory gastrointestinal conditions, are complex. The intestinal homeostasis depends on the interactions between the microbiota, the intestinal mucosa and the host immune system. Failure to achieve or maintain equilibrium between a host and its microbiota has the potential to induce chronic conditions with an ...
Source: Current Opinion in Gastroenterology - October 13, 2020 Category: Gastroenterology Tags: IMMUNOLOGY: Edited by Jocelyn A. Silvester Source Type: research
The risk of contracting covid-19 is not increased in patients with celiac disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 11, 2020 Category: Gastroenterology Authors: J. Zhen, J.P. Stefanolo, M.P. Temprano, S. Tedesco, C. Seiler, A. Caminero, E. de-Madaria, M. Montoro Huguet, S. Vivas, S. Niveloni, P. Bercik, E. Smecuol, L. Uscanga, E. Trucco, V. Lopez, C. Olano, P. Mansueto, A. Caroccio, P.H. Green, A.S. Day, J.A. Tye Source Type: research
Digestive involvement in primary Sj ögren's syndrome: analysis from the Sjögrenser registry.
CONCLUSIONS: DI is frequent in Sjögrenser patients, mainly in the form of autoimmune disorders, and seem to be associated with a more severe phenotype. Our results suggest that DI should be evaluated in pSS patients, especially those with more severe disease. PMID: 33025900 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 9, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Effect of Bifidobacterium infantis NLS super strain in symptomatic coeliac disease patients on long-term gluten-free diet – an exploratory study
Beneficial Microbes, Ahead of Print. (Source: Beneficial Microbes)
Source: Beneficial Microbes - October 9, 2020 Category: Gastroenterology Authors: E. Smecuol M. Constante M.P. Temprano A.F. Costa M.L. Moreno M.I. Pinto-Sanchez H. V ázquez J.P. Stefanolo A.F. Gonzalez C.R. D ’Adamo S.I. Niveloni E. Mauri ño E.F. Verdu J.C. Bai Source Type: research
The skin doesn't lie: a case of dermatitis herpetiformis in the setting of refractory coeliac disease.
Authors: Quintarelli L, Corrá A, Maglie R, Antiga E, Caproni M PMID: 33016667 [PubMed - as supplied by publisher] (Source: Giornale Italiano di Dermatologia e Venereologia)
Source: Giornale Italiano di Dermatologia e Venereologia - October 7, 2020 Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
Fatal food-induced anaphylaxis: Determination of tryptase and specific IgE on cadaveric blood samples. What else for a better methodological standard?
We describe the case of a 16-year-old boy with a medical history of allergic asthma, celiac disease, and known food-induced allergy for fish, fresh milk, peanuts, hazelnuts, walnuts, apples, kiwis, and peaches. Acute onset of dyspnea followed by cyanosis of the lips and respiratory failure was described immediately after having an ice cream sandwich. Unsuccessful rescues were immediately attempted with oral administration of betamethasone, intramuscular injection of adrenaline, and cardiopulmonary resuscitation. A complete post-mortem examination was performed. Serum dosage of mast cell beta-tryptase from femoral blood det...
Source: International Journal of Immunopathology and Pharmacology - October 6, 2020 Category: Allergy & Immunology Tags: Int J Immunopathol Pharmacol Source Type: research
Low prevalence of upper endoscopic gastrointestinal findings despite high frequency of alarm symptoms at the time of diagnosis in adult coeliac disease
Conclusions Despite the high prevalence of alarm symptoms at diagnosis, coincident major UGI endoscopic findings are rare in adult coeliac disease. These results may be relevant for future developments in coeliac disease diagnosis in adults. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - October 6, 2020 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research
Serological exclusion of coeliac disease: an audit of anti-tissue transglutaminase and immunoglobulin A testing
No abstract available (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - October 6, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Concurrent cerebral arterial and venous sinus thrombosis revealing celiac disease- a case report and literature review
Celiac disease is an autoimmune condition characterized by an inappropriate immune reaction against gluten. It classically presents as chronic diarrhea, bloating, and nausea in addition to malabsorption sympto... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - October 6, 2020 Category: Gastroenterology Authors: Dalia Alhosain and Lamia Kouba Tags: Case report Source Type: research
Autoimmune thyroid diseases, autoimmune hepatitis, celiac disease and type 1 diabetes mellitus in pediatric systemic lupus erythematosus: Results from the CARRA Legacy Registry.
CONCLUSION: In cSLE, PA is associated with more hospitalizations and aggressive immunotherapy use. Although lupus disease activity improved over time, patients' QoL neither improved over time nor differed by having other autoimmune disease. Prospective, case-control, long-term follow-up studies on cSLE are needed to validate our results. MESH KEY INDEXING TERMS: Pediatric systemic lupus erythematosus; Autoimmune diseases; Outcome assessment. PMID: 33016198 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - October 3, 2020 Category: Rheumatology Authors: AlAhmed O, Sivaraman V, Moore-Clingenpeel M, Ardoin SP, Bout-Tabaku S, CARRA registry investigators Tags: Lupus Source Type: research
Distal Pancreatectomy with Celiac Axis Resection (DP-CAR): Optimal Perioperative Outcome in a Patient with Locally Advanced Pancreas Adenocarcinoma
Publication date: Available online 2 October 2020Source: International Journal of Surgery Case ReportsAuthor(s): Gregory G. Tsiotos, Nikiforos Ballian, Fotios Milas, Panoraia Ziogou, Ilias Athanasiadis (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - October 3, 2020 Category: Surgery Source Type: research
Towards the Probabilistic Analysis of Small Bowel Capsule Endoscopy Features to Predict Severity of Duodenal Histology in Patients with Villous Atrophy
AbstractSmall bowel capsule endoscopy (SBCE) can be complementary to histological assessment of celiac disease (CD) and serology negative villous atrophy (SNVA). Determining the severity of disease on SBCE using statistical machine learning methods can be useful in the follow up of patients. SBCE can play an additional role in differentiating between CD and SNVA. De-identified SBCEs of patients with CD and SNVA were included. Probabilistic analysis of features on SBCE were used to predict severity of duodenal histology and to distinguish between CD and SNVA. Patients with higher Marsh scores were more likely to have a posi...
Source: Journal of Medical Systems - October 1, 2020 Category: Information Technology Source Type: research
P2Y12 shRNA normalizes inflammatory dysfunctional hepatic glucokinase activity in type 2 diabetic rats.
Abstract The celiac ganglion projects its postganglionic (including purinergic) fibers to the liver. P2Y12 receptor is one of the P2Y family members. We found that the expression levels of P2Y12 receptor in both celiac ganglia and liver were increased in type 2 diabetes mellitus (T2DM) rats which also displayed an enhanced activity of celiac sympathetic nerve discharge (SND). In addition, a marked decrease of hepatic glucokinase (GK) expression was accompanied by reduced hepatic glycogen synthesis in T2DM rats, whereas meanwhile the levels of NLRP3, active caspase-1, NF-κB, and interleukin-1β were eleva...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 1, 2020 Category: Drugs & Pharmacology Authors: Li L, Yang J, Liu B, Zou Y, Sun M, Li Z, Yang R, Xu X, Zou L, Li G, Liu S, Li G, Liang S Tags: Biomed Pharmacother Source Type: research
Acute Pancreatitis in Celiac Disease: Has the Inpatient Prevalence Changed and Is It Associated With Worse Outcomes?
Objectives Studies suggest that adults diagnosed with celiac disease (CD) are at higher risk of developing acute pancreatitis (AP). The aim of this study is to explore the relationship between CD and AP in terms of inpatient prevalence, mortality, morbidity, and resource utilization in the past decade. Methods Retrospective cohort study using the Nationwide Inpatient Sample (2007–2016). The primary outcome was the occurrence of AP in CD patients. Secondary outcomes were the trend in AP cases in CD patients, and mortality, morbidity, length of stay, and total hospital charges and costs. Results Of 337,201 CD p...
Source: Pancreas - October 1, 2020 Category: Gastroenterology Tags: Original Articles Source Type: research
Free perforation of primary small bowel lymphoma in a patient with celiac sprue and dermatitis herpetiformis.
Abstract Small bowel lymphomas are rare and constitute approximately 1% of the malignant gastrointestinal tumors. However, the risk of malignant disease in adult celiac disease is about 8-10%, and non-Hodgkin lymphoma is the most common. In the literature, cases with celiac disease and small bowel lymphoma have been reported, but the emphasis on emergency surgery is extremely rare. We herein present a case of primary small intestinal lymphoma diagnosed after surgery in a 55-year-old male patient who presented to our emergency department with findings of gastrointestinal perforation and had a history of celiac dise...
Source: Turkish Journal of Trauma and Emergency Surgery : TJTES - October 1, 2020 Category: Emergency Medicine Authors: Bolat H, Teke Z Tags: Ulus Travma Acil Cerrahi Derg Source Type: research
Chemo-Resistant Locally Advanced Left-Sided Pancreatic Cancer Encasing Portal Venous Confluence, Celiac and Superior Mesenteric Arteries: Management Strategy
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 30, 2020 Category: Cancer & Oncology Source Type: research
AGA Clinical Practice Update on the Evaluation and Management of Seronegative Enteropathies
We aim to provide a consensus statement for the best approaches for diagnosis and management of patients with suspected enteropathy but negative results from serologic tests for celiac disease (seronegative enteropathy). (Source: Gastroenterology)
Source: Gastroenterology - September 29, 2020 Category: Gastroenterology Authors: Maureen M. Leonard, Benjamin Lebwohl, Alberto Rubio-Tapia, Federico Biagi Source Type: research
[Infections in early life as risk factor for coeliac disease].
CONCLUSIONS: Infections in the first 6 months of life increase the risk of developing CD, especially for respiratory infections and, to a greater extent, if 3 or more episodes occur. The use of antibiotics in this period of life has not been related to an increased risk of CD. PMID: 33011112 [PubMed - as supplied by publisher] (Source: Anales de Pediatria)
Source: Anales de Pediatria - September 29, 2020 Category: Pediatrics Authors: Llorente Pelayo S, Palacios Sánchez M, Docio Pérez P, Gutiérrez Buendía D, Peña Sainz-Pardo E, Vega Santa-Cruz B, García Calatayud S Tags: An Pediatr (Barc) Source Type: research
Latitude and Celiac Disease Prevalence: A Meta-analysis and Meta-regression
Latitudinal gradient effect is described for several autoimmune diseases including celiac disease in the United States. However, the association between latitude and global celiac disease prevalence is unknown. We aimed to explore the association between latitude and serology-based celiac disease prevalence through meta-analysis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 28, 2020 Category: Gastroenterology Authors: Melis G. Celdir, Claire L. Jansson-Knodell, Isabel A. Hujoel, Larry J. Prokop, Zhen Wang, M. Hassan Murad, Joseph A. Murray Source Type: research
[Immune disorders associated with juvenile recurrent chronic parotitis].
CONCLUSION: Juvenile recurrent chronic parotitis can be considered a sentinel sign of other diseases of immunological/autoimmune aetiology for which the diagnosis, monitoring and early treatment can improve its prognosis. Viral infectious aetiology, with the exception of HIV, is not a priority in the study of recurrences. PMID: 33008791 [PubMed - as supplied by publisher] (Source: Anales de Pediatria)
Source: Anales de Pediatria - September 28, 2020 Category: Pediatrics Authors: Hidalgo-Santos AD, Gastón-Téllez R, Ferrer-Lorente B, Pina-Pérez R, Oltra-Benavent M Tags: An Pediatr (Barc) Source Type: research
Early Gluten Introduction and Celiac Disease in the EAT Study
This prespecified analysis of a randomized clinical trial compares the development of celiac disease in infants with gluten introduced to their diet before vs after age 6 months. (Source: JAMA Pediatrics)
Source: JAMA Pediatrics - September 28, 2020 Category: Pediatrics Source Type: research
Disease- and gender-related characteristics of coeliac disease influence diagnostic delay.
PMID: 33004263 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - September 27, 2020 Category: Internal Medicine Authors: Lenti MV, Di Sabatino A Tags: Eur J Intern Med Source Type: research
The aggression of the endothelium could be responsible for the visceral lesions observed after clamping of the coeliac aorta
Complex aortic surgeries may be complicated by various visceral lesions. Our assumption was that these damages could be in relation with visceral ischemia/reperfusion caused by the operation. Glycocalyx, a component of the endothelial membrane, is implied in severe pathological situations. The aim of our work was to explore the glycocalyx pathway as a causal link between visceral ischemia/reperfusion related to aortic clamping and the damages of remote organs. (Source: Annals of Vascular Surgery)
Source: Annals of Vascular Surgery - September 27, 2020 Category: Surgery Authors: Mickael Palmier, Nicolas Perzo, Anais Dumesnil, Emlyn Cornet, Quentin Cohen, Vincent Richard, Didier Plissonnier Source Type: research
Old and modern wheat (Triticum aestivum L.) cultivars and their potential to elicit celiac disease
Publication date: 1 March 2021Source: Food Chemistry, Volume 339Author(s): Darina Pronin, Andreas Börner, Katharina Anne Scherf (Source: Food Chemistry)
Source: Food Chemistry - September 27, 2020 Category: Food Science Source Type: research
Optic Nerve Infiltration in Systemic Metastatic Retinal Lymphoma (SMRL): Multimodal Imaging and Challenges in Diagnosis.
CONCLUSION: Optic nerve infiltration in systemic metastatic retinal lymphoma may have initial occult signs but with profound visual loss. Ocular infections like CMV retinitis and tuberculosis may mask and delay the diagnosis in immunocompromised patients. PMID: 32967510 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 26, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
IJERPH, Vol. 17, Pages 7051: Evaluation of Quality of Life of Adult Patients with Celiac Disease in Argentina: From Questionnaire Validation to Assessment
This study highlights the importance of maintaining current public health regulations that support chronic disease patients, such as celiac patients. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - September 25, 2020 Category: Environmental Health Authors: Nicole Selleski Renata Puppin Zandonadi Laura B. Milde Lenora Gandolfi Riccardo Pratesi Winfred H äuser Rosa Harumi Uenishi Eduardo Yoshio Nakano Claudia B. Pratesi Tags: Article Source Type: research