Is it a refractory celiac disease?
(Source: Gastroenterology)
Source: Gastroenterology - September 7, 2018 Category: Gastroenterology Authors: Ming-Jun Ma, Zhen Li, Yan-Qing Li Source Type: research

Registries and care of neuromuscular disorders
The diagnosis and follow up of the hyperCKemia in almost all the cases remains a challenge because sometimes they need very invasive studies to finally get into it. To describe patients with hyperckemia and their difference diagnosis. Patients with CK level 1.5 times (at least 2 measurements). We follow up mean to two years. Patients with asymptomatics and oligosymptomatics clinical features. We excluded non neuromuscular disorders (thyroid, celiac disease and pharmacological or drugs). We studied all the patients with muscular dystrophy, electromyography, intermediate metabolism, acid alpha glucosidase, genetics test for ...
Source: Neuromuscular Disorders - September 6, 2018 Category: Neurology Authors: M. Garcia Erro, E. Cavassa, J. Muntadas, M. Pauni, G. Vazquez Source Type: research

Determinants of Follow-up Care for Patients With Celiac Disease
Conclusions: Gender had no impact on follow-up patterns despite prior studies demonstrating an impact on diagnosis rates. Future attention should focus on retaining young patients and those with atypical modes of presentation. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - September 6, 2018 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Analysis of IL17A and IL21 Expression in the Small Intestine of Celiac Disease Patients and Correlation with Circulating Thioredoxin Level
Genetic Testing and Molecular Biomarkers, Ahead of Print. (Source: Genetic Testing and Molecular Biomarkers)
Source: Genetic Testing and Molecular Biomarkers - September 5, 2018 Category: Genetics & Stem Cells Authors: Manizhe Faghih Mohammad Rostami-Nejad Davar Amani Amir Sadeghi Mohamad Amin Pourhoseingholi Andrea Masotti Mohammad Reza Zali Source Type: research

Bidirectional relationship between eating disorders and autoimmune diseases
ConclusionsThe interactions between EDs and autoimmune diseases support the previously reported associations. The bidirectional risk pattern observed in women suggests either a shared mechanism or a third mediating variable contributing to the association of these illnesses. (Source: Journal of Child Psychology and Psychiatry)
Source: Journal of Child Psychology and Psychiatry - September 3, 2018 Category: Psychiatry Authors: Anna Hedman, Lauren Breithaupt, Christopher H übel, Laura M. Thornton, Annika Tillander, Claes Norring, Andreas Birgegård, Henrik Larsson, Jonas F. Ludvigsson, Lars Sävendahl, Catarina Almqvist, Cynthia M. Bulik Tags: Original Article Source Type: research

Gastrointestinal Manifestations in Children with Primary Immunodeficiencies: Single Center: 12 Years Experience
Conclusions: PID may present with GI manifestations or develop during the course of the disease. Investigating immunodeficiency in patients with atypical GI symptoms can provide an appropriate therapeutic option, and an improved quality of life, particularly in populations with a high rate of consanguinity.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - September 2, 2018 Category: Gastroenterology Source Type: research

The Role of a Low Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyol Diet in Nonceliac Gluten Sensitivity.
Conclusions: A low FODMAP diet has potential for improvement of clinical symptoms in NCGS. In addition, some evidence suggests an additional benefit to simultaneous adherence to both low FODMAP diet and GFD. PMID: 30158962 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - September 1, 2018 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Physiolgic hypercortisolism at onset of celiac disease in a girl: A case report
Rationale: Celiac disease (CD) is an autoimmune disorder induced by dietary gluten in genetically predisposed subjects. Activation of the hypothalamic-pituitary-axis (HPA) can occur in patients with CD; however, this condition has never been described in overweight/obese CD children. Patient concerns: A 12-year-old girl with CD was admitted with mild acanthosis nigricans of the armpits, groin and neck. Recently, extra fat appeared around the neck, and moon face was observed. The abdomen was globular and meteoric, treatable and not aching. She weighed 64 kilos (75°–97° percentile) and was 146 centimeter...
Source: Medicine - September 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Use of an Educational Module to Improve Confidence and Knowledge of Celiac Disease Among Nurse Practitioners in Pennsylvania: A Quasi-Experimental Mixed-Methods Design
Accurate and prompt diagnosis of celiac disease has proven difficult due to the myriad of presenting symptoms and a lack of a clear diagnostic protocol. This pilot study investigated the use of an evidence-based multimedia educational module on nurse practitioner confidence and knowledge of celiac disease. Thirteen nurse practitioners in Pennsylvania completed all study activities, which involved the use of an online pretest, learning component, an immediate post-test, along with 2 follow-up surveys. Results revealed that nurse practitioner confidence (p ≤ .05) and knowledge (p ≤ .05) levels significantly improved af...
Source: Gastroenterology Nursing - September 1, 2018 Category: Nursing Tags: Features Source Type: research

The Gut-Renal Connection in IgA Nephropathy
Summary: The connection between a dysregulated gut-associated lymphoid tissue and IgA nephropathy (IgAN) was supposed decades ago after the observation of increased association of IgAN with celiac disease. Pivotal studies have shown a role for alimentary antigens, particularly gliadin in developing IgAN in BALB/c mice, and a reduction in IgA antigliadin antibodies and proteinuria was reported after gluten free-diet in patients with IgAN. Recently a genome-wide association study showed that most loci associated with IgAN also are associated with immune-mediated inflammatory bowel diseases, maintenance of the intestinal barr...
Source: Seminars in Nephrology - September 1, 2018 Category: Urology & Nephrology Authors: Rosanna Coppo Source Type: research

Prevalence of celiac disease among school-age children in Çorum, Turkey.
CONCLUSION: Various studies in Turkey have reported a prevalence of CD between 0.6% and 0.9%, with 0.47% reported in a multicenter study. The present study identified CD prevalence as 0.46% (1 in 216) among children in Çorum, Turkey. PMID: 30260783 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - September 1, 2018 Category: Gastroenterology Authors: Comba A, Eren NB, Demir E Tags: Turk J Gastroenterol Source Type: research

The hidden danger: Silent celiac disease.
epe G PMID: 30260773 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - September 1, 2018 Category: Gastroenterology Authors: Çaltepe G Tags: Turk J Gastroenterol Source Type: research

Nutritional Approach in Tropical Sprue Patients
The objective of the present review is to determine whether if there is new evidence for a specific nutritional approach for TS, since the management remains the same from several years ago and the treatment can also be confounded by other conditions such as celiac disease, tropical enteropathy, and parasitic infections.Recent FindingsTropical sprue accounts for a large proportion of cases of malabsorption in South Asia. Since tropical sprue requires a specific test for its diagnosis, it could have been mistaken with other conditions. However, epidemics of tropical sprue have not been reported.SummaryTS has been thought to...
Source: Current Tropical Medicine Reports - September 1, 2018 Category: Tropical Medicine Source Type: research

Small Bowel Adenocarcinoma in Celiac Disease: a Case Report
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 1, 2018 Category: Cancer & Oncology Source Type: research

Clinical, endoscopic, and histological differentiation between celiac disease and tropical sprue: A systematic review
Journal of Gastroenterology and Hepatology, EarlyView. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - August 31, 2018 Category: Gastroenterology Authors: PragyaSharma , VandanaBaloda , Gaurav PSGahlot , AlkaSingh , RituMehta , SreenivasVishnubathla , KulwantKapoor , VineetAhuja , Siddhartha DattaGupta , Govind KMakharia , PrasenjitDas Source Type: research

Non-Celiac Gluten Sensitivity in Patients with Severe Abdominal Pain and Bloating:The Accuracy of ALCAT 5
Non-Celiac Gluten Sensitivity (NCGS) is a recently proposed clinical condition causing both intestinal and extra-intestinal symptoms, without gastrointestinal lesions, which improve on avoiding gluten intake, in the absence of celiac disease and wheat allergy. The prevalence of this condition is still a matter of debate, in part due to the very recent introduction of an accepted diagnostic test, a double-blind, placebo controlled gluten challenge. However, this is a lengthy and cumbersome procedure, theoretically burdened by a significant reduction of patient compliance. (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - August 29, 2018 Category: Nutrition Authors: Michele Di Stefano, Eugenia Vittoria Pesatori, Giulia Francesca Manfredi, Mara De Amici, Giacomo Grandi, Alessandro Gabriele, Davide Iozzi, Giuseppe di Fede Tags: Original article Source Type: research

Non-Celiac Gluten Sensitivity in patients with severe abdominal pain and bloating: The accuracy of ALCAT 5
Non-Celiac Gluten Sensitivity (NCGS) is a recently proposed clinical condition causing both intestinal and extra-intestinal symptoms, without gastrointestinal lesions, which improve on avoiding gluten intake, in the absence of celiac disease and wheat allergy. The prevalence of this condition is still a matter of debate, in part due to the very recent introduction of an accepted diagnostic test, a double-blind, placebo controlled gluten challenge. However, this is a lengthy and cumbersome procedure, theoretically burdened by a significant reduction of patient compliance. (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - August 29, 2018 Category: Nutrition Authors: Michele Di Stefano, Eugenia Vittoria Pesatori, Giulia Francesca Manfredi, Mara De Amici, Giacomo Grandi, Alessandro Gabriele, Davide Iozzi, Giuseppe Di Fede Tags: Original article Source Type: research

Celiac Disease Autoimmunity
AbstractCeliac disease is an autoimmune condition triggered by the ingestion of gluten, the protein fraction of wheat, barley and rye. It is not simply an intestinal disease; it is multifactorial caused by many different genetic factors acting together with non-genetic causes. Similar to other autoimmune diseases, celiac disease is a polygenic disorder for which the major histocompatibility complex locus is the most important genetic factor, and is the result of an immune response to self-antigens leading to tissue destruction and the autoantibodies production. Celiac disease exemplifies how an illness can have autoimmune-...
Source: Archivum Immunologiae et Therapiae Experimentalis - August 25, 2018 Category: Allergy & Immunology Source Type: research

Comparison of Clinical Methods With the Faecal Gluten Immunogenic Peptide to Assess Gluten Intake in Coeliac Disease
Objectives: Detection of faecal gluten immunogenic peptides (GIP) is a biomarker of recent gluten consumption. GIP levels can be used to monitor gluten intake and compliment clinical methods to evaluate compliance to gluten-free diet (GFD). In the present study, recent gluten intake was measured by GIP in children with coeliac disease (CD) and compared to routine clinical measures to evaluate GFD compliance. Methods: GIP was measured in 90 samples from 63 CD children (44 previously and 19 newly diagnosed with follow-up samples at 6 and 12 months on GFD). Compliance to GFD was evaluated based on clinical assessment, ti...
Source: Journal of Pediatric Gastroenterology and Nutrition - August 23, 2018 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Celiac Disease Source Type: research

Celiac Disease 30 Years After Diagnosis: Struggling With Gluten-free Adherence or Gaining Gluten Tolerance?
Conclusions: Although poor adherence to GFD is the major predictor of persistence of mucosal lesions at follow-up histology, a proportion of patients did not show a relapse of villous atrophy in spite chronic voluntary gluten ingestion, nor increase in mortality. Moreover, GFD knowledge and adherence could be partly lost during the transition between childhood and adulthood. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - August 23, 2018 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Celiac Disease Source Type: research

Birth Month as a Risk Factor for the Diagnosis of Celiac Disease Later in Life: A Population-based Study
In conclusion, children born in May and June are at increased risk for CD. This increased risk provides further evidence that perinatal environmental factors increase the risk of developing CD. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - August 23, 2018 Category: Gastroenterology Tags: Short Communication: Gastroenterology: Celiac Disease Source Type: research

Preparation distance to prevent gluten contamination
Rationale: Gluten contamination is a health risk for especially people who have the gluten allergy or celiac disease. The aim of this single-blind randomized study was to assess the optimum distance to prevent gluten contamination. (Source: Clinical Nutrition)
Source: Clinical Nutrition - August 22, 2018 Category: Nutrition Authors: L. Parlak, D. Dikmen Source Type: research

The effect of nutrition training on clinical findings and anthropometric measurements of children with celiac disease
Rationale: Adherence to the gluten-free diet is strongly associated with the health-related quality of life and clinical signs in celiac disease. Frequent monitoring of nutritional training improves the quality of life and adapts to the diet of individuals. The aim of this study was to investigate the reflection of nutrition training on clinical findings and anthropometric measurements of children with celiac disease. (Source: Clinical Nutrition)
Source: Clinical Nutrition - August 22, 2018 Category: Nutrition Authors: G. Kaner, N. İnanç, N. Seremet Kürklü, N. Atalay Source Type: research

Preferred gluten free cereals in children with celiac disease
Rationale: The only treatment for celiac disease (CD) is a lifelong gluten free diet. Despite these restrictions, patients with CD can eat a well-balanced diet with a variety of gluten-free foods, including rice, maize, potato, amaranth, quinoa, buckwheat or bean flour instead of gluten containing counterparts. The aim of this study was to evaluate preferred gluten free cereals by children with CD. (Source: Clinical Nutrition)
Source: Clinical Nutrition - August 22, 2018 Category: Nutrition Authors: D. Y ıldırım, M.A. Göktaş, H. Demir, I.N. Saltık Temizel, H. Özen, A. Yüce, H. Gökmen Özel Source Type: research

Invited commentary
The diagnosis of chronic intestinal ischemia can be problematic and is most often based on a combination of clinical symptoms and imaging studies demonstrating high-grade stenosis or occlusion of the celiac and superior mesenteric arteries. In general, functional tests demonstrating physiologic abnormalities correlating with intestinal malperfusion are not used as they are not widely known or available. For many years, investigators in The Netherlands have, however, advocated use of a combination of clinical symptoms, arterial imaging studies, and functional tests of mucosal perfusion to potentially improve diagnostic accu...
Source: Journal of Vascular Surgery - August 22, 2018 Category: Surgery Authors: Gregory L. Moneta Tags: Clinical research study Source Type: research

Anti-type 2 transglutaminase antibodies as modulators of type 2 transglutaminase functions: a possible pathological role in celiac disease.
Abstract Auto-antibodies to the ubiquitous enzyme type-2 transglutaminase (TG2) are a specific hallmark of celiac disease (CD), a widely diffused, multi-factorial disease, affecting genetically predisposed subjects. In CD an inflammatory response, at the intestinal level, is triggered by diet consumption of gluten-containing cereals. Intestinal mucosa displays various degrees of atrophy and hyperplasia, with consequent global intestinal dysfunction and other relevant extra-intestinal symptoms. Through deamidation of specific glutamines of gluten-derived gliadin peptides, TG2 strongly enhances gliadin immunogenicit...
Source: Cellular and Molecular Life Sciences : CMLS - August 22, 2018 Category: Cytology Authors: Martucciello S, Paolella G, Esposito C, Lepretti M, Caputo I Tags: Cell Mol Life Sci Source Type: research

Gluten and Neuroimmunology. Rare association with Myasthenia Gravis and Literature Review
SUMMARY As the celiac disease (CD), the non-celiac gluten sensitivity (NCGS) has also been associated with several autoimmune manifestations. It is rarely associated with myasthenia gravis (MG). This paper shall introduce the case of a young female patient, initially presenting a peripheral neuropathy framework. During clinical and neurological follow-up, she began to present symptoms of various immune-mediated morbidities. Diseases related to gluten represent a clinical spectrum of manifestations with a trigger in common, the ingestion of gluten. CD is the most well-known and serious disease of the spectrum, also called g...
Source: Revista da Associacao Medica Brasileira - August 21, 2018 Category: General Medicine Source Type: research

Exuberant keloid scar associated with skin neoplasia
SUMMARY As the celiac disease (CD), the non-celiac gluten sensitivity (NCGS) has also been associated with several autoimmune manifestations. It is rarely associated with myasthenia gravis (MG). This paper shall introduce the case of a young female patient, initially presenting a peripheral neuropathy framework. During clinical and neurological follow-up, she began to present symptoms of various immune-mediated morbidities. Diseases related to gluten represent a clinical spectrum of manifestations with a trigger in common, the ingestion of gluten. CD is the most well-known and serious disease of the spectrum, also called g...
Source: Revista da Associacao Medica Brasileira - August 21, 2018 Category: General Medicine Source Type: research

Central retinal vein occlusion revealing celiac disease: The first report of two cases from India
Ravinder Kaur Malhi, Abhinav Dhami, Nirmaljeet Singh Malhi, Amit Soni, Gobinder Singh DhamiIndian Journal of Ophthalmology 2018 66(9):1315-1317 (Source: Indian Journal of Ophthalmology)
Source: Indian Journal of Ophthalmology - August 20, 2018 Category: Opthalmology Authors: Ravinder Kaur Malhi Abhinav Dhami Nirmaljeet Singh Malhi Amit Soni Gobinder Singh Dhami Source Type: research

Duodenal and Rectal Mucosa Inflammation in Patients With Non-celiac Wheat Sensitivity
Studies of non-celiac gluten or wheat sensitivity (NCGWS) have increased but there are no biomarkers of this disorder. We aimed to evaluate histologic features of colon and rectal tissues from patients with NCGWS. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 20, 2018 Category: Gastroenterology Authors: Antonio Carroccio, Giulio Giannone, Pasquale Mansueto, Maurizio Soresi, Francesco La Blasca, Francesca Fayer, Rosario Iacobucci, Rossana Porcasi, Tiziana Catalano, Girolamo Geraci, Andrea Arini, Alberto D ’Alcamo, Vincenzo Villanacci, Ada M. Florena Source Type: research

Quality of life in coeliac disease: item reduction, scale development and psychometric evaluation of the Coeliac Disease Assessment Questionnaire (CDAQ)
Alimentary Pharmacology&Therapeutics, EarlyView. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - August 20, 2018 Category: Drugs & Pharmacology Authors: Helen Crocker , Crispin Jenkinson , Michele Peters Source Type: research

Algorithms to define abnormal growth in children: external validation and head-to-head comparison.
ude B Abstract Background: Growth monitoring of apparently healthy children aims at early detection of serious conditions by use of both clinical expertise and algorithms that define abnormal growth. The seven existing algorithms provide contradictory definitions of growth abnormality and have a low level of validation. Objective: An external validation study with head-to-head comparison of the seven algorithms combined with study of the impact of use of the World Health Organization (WHO) versus national growth charts on algorithm performance. Study design: With a case-referent approach, we retrospectiv...
Source: The Journal of Clinical Endocrinology and Metabolism - August 20, 2018 Category: Endocrinology Authors: Scherdel P, Matczak S, Léger J, Martinez-Vinson C, Goulet O, Brauner R, Nicklaus S, Resche-Rigon M, Chalumeau M, Heude B Tags: J Clin Endocrinol Metab Source Type: research

Anti-Saccharomyces cerevisiae as Unusual Antibody in Autoimmune Polyglandular Syndrome Type III: A Case Report.
CONCLUSION: Based on the coexistence of these diseases, the patient was diagnosed with APS type III. Moreover, ASCA seropositivity was detected although she has no overt intestinal disease. PMID: 30117403 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 18, 2018 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Minimally Invasive Salvage Lymphadenectomy in Gynecological Cancer Patients: a Single Institution Series
ConclusionsIn our experience minimally invasive surgery is a valid therapeutic approach in very select patients with localized lymph-nodal recurrence of gynecological cancers, with benefits about peri and post-operative morbidities and without compromising their oncological outcome. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - August 18, 2018 Category: Surgery Source Type: research

Statement on Best Practices in the Use of Pathology as a Diagnostic Tool for Celiac Disease: A Guide for Clinicians and Pathologists
Small intestinal biopsy interpretation has been the cornerstone for the diagnosis of celiac disease for over 50 years. Despite the existence of sensitive and specific serological tests, duodenal mucosal biopsies continue to be obtained in the vast majority of patients in whom a diagnosis of celiac disease is being considered. The accurate evaluation of these biopsies requires coordination and information sharing between the gastroenterologist, laboratory, and pathologist in order to optimize tissue sampling, preparation and interpretation. This document, a collaboration between the Rodger C. Haggitt Gastrointestinal Pathol...
Source: The American Journal of Surgical Pathology - August 16, 2018 Category: Pathology Tags: Special Article Source Type: research

Restless leg syndrome in children with celiac disease.
In this study we did not determine an increased prevalence of RLS in children with CD. However, in CD group, the age at the onset of RLS symptoms was significantly younger and the disease was more severe in CD group compared with the control cases. PMID: 30102482 [PubMed - in process] (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - August 15, 2018 Category: Pediatrics Authors: Işıkay S, Işıkay N, Per H, Çarman KB, Kocamaz H Tags: Turk J Pediatr Source Type: research

Coeliac disease.
Authors: Glissen Brown JR, Singh P Abstract Coeliac disease (CD) develops in genetically susceptible individuals who, in response to unclear environmental triggers, develop an immune response triggered by gluten ingestion. It is now recognised as a global disease affecting about 0.7% of the world's population. The clinical presentation ranges from malabsorption to asymptomatic individuals diagnosed by screening high-risk groups. Diagnosis requires the demonstration of small intestinal villous atrophy in the presence of circulating coeliac auto-antibodies and/or an unequivocal response to a gluten-free diet (GFD). R...
Source: Paediatrics and international child health - August 14, 2018 Category: Pediatrics Tags: Paediatr Int Child Health Source Type: research

Distal Pancreatectomy with Celiac Axis Resection (DP-CAR) for Pancreatic Cancer. How I do It
This article proposes a standardized approach to DP-CAR, including routine neoadjuvant (FOLFIRINOX) chemotherapy. This approach to selecting patients and performing DP-CAR has the potential to improve short-term outcomes and overall surviv al in selected patients, but it should be reserved for high-volume centers. (Source: Journal of Gastrointestinal Surgery)
Source: Journal of Gastrointestinal Surgery - August 13, 2018 Category: Surgery Source Type: research

Regional and National Variations in Reasons for Gluten Avoidance
Background: Although studies have assessed the prevalence of celiac disease (CD), less is known about the prevalence of gluten avoidance because of nonceliac gluten sensitivity (GS). The avoidance of foods other than gluten is also understudied in these 2 groups. Methods: Participants visiting a web site for information about a newly developed portable gluten detection device (Nima) were instructed to complete questions about food and gluten avoidance patterns. We assessed the relative proportion of CD and GS across world regions and United States (US) regions and determined the distribution of food avoidance patterns...
Source: Journal of Clinical Gastroenterology - August 11, 2018 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Celiac disease biomarkers identified by transcriptome analysis of small intestinal biopsies.
n J Abstract Establishing a celiac disease (CD) diagnosis can be difficult, such as when CD-specific antibody levels are just above cutoff or when small intestinal biopsies show low-grade injuries. To investigate the biological pathways involved in CD and select potential biomarkers to aid in CD diagnosis, RNA sequencing of duodenal biopsies from subjects with either confirmed Active CD (n = 20) or without any signs of CD (n = 20) was performed. Gene enrichment and pathway analysis highlighted contexts, such as immune response, microbial infection, phagocytosis, intestinal barrier funct...
Source: Cellular and Molecular Life Sciences : CMLS - August 10, 2018 Category: Cytology Authors: Bragde H, Jansson U, Fredrikson M, Grodzinsky E, Söderman J Tags: Cell Mol Life Sci Source Type: research

Sleep Disturbances Are Commonly Reported Among Patients Presenting to a Gastroenterology Clinic
ConclusionsPatients presenting to a tertiary care GI clinic report poorer sleep than healthy controls. In general, patients with IBS report the highest rates of sleep difficulties compared to patients with other diagnoses. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - August 9, 2018 Category: Gastroenterology Source Type: research

Discriminant value of IEL counts and distribution pattern through the spectrum of gluten sensitivity: a simple diagnostic approach
AbstractIntraepithelial lymphocytosis (IELosis) with or without villous abnormality is a characteristic feature of gluten sensitivity (GS) including celiac disease (CD) and non-celiac-GS, although various conditions may also be associated with IELosis. In order to distinguish GS from the other causes of IELosis, a threshold for IEL counts is necessary. We aimed to determine a cut-off value for IELs and monitor its value in the spectrum of GS in a large cohort. For this purpose, the duodenal biopsies from four groups of individuals including Types 1 (n = 88) and 3 (n = 92) CD, non-CD IELosis (n&t...
Source: Virchows Archiv - August 9, 2018 Category: Pathology Source Type: research

[Palliative therapy concepts for pancreatic carcinoma].
GF Abstract The majority of patients with ductal pancreatic adenocarcinoma are already in a locally advanced or metastatic stage at the time of diagnosis and require palliative therapy. Interventional and operative measures are available for the restoration of biliary outflow in bile duct obstruction and the continuity of the upper intestinal lumen in duodenal or gastric outlet obstruction. In the presence of tumor-related pain, pain therapy according to the World Health Organization (WHO) scheme or a truncus coeliacus blockade, in cachexia a nutritional therapy and in thromboembolic events an anti...
Source: Der Chirurg - August 9, 2018 Category: Surgery Authors: Brunner M, Grützmann R, Weber GF Tags: Chirurg Source Type: research

IJERPH, Vol. 15, Pages 1679: Rebuilding the Gut Microbiota Ecosystem
la Serena Schippa A microbial ecosystem in which bacteria no longer live in a mutualistic association is called dysbiotic. Gut microbiota dysbiosis is a condition related with the pathogenesis of intestinal illnesses (irritable bowel syndrome, celiac disease, and inflammatory bowel disease) and extra-intestinal illnesses (obesity, metabolic disorder, cardiovascular syndrome, allergy, and asthma). Dysbiosis status has been related to various important pathologies, and many therapeutic strategies aimed at restoring the balance of the intestinal ecosystem have been implemented. These strategies include the administratio...
Source: International Journal of Environmental Research and Public Health - August 7, 2018 Category: Environmental Health Authors: Antonella Gagliardi Valentina Totino Fatima Cacciotti Valerio Iebba Bruna Neroni Giulia Bonfiglio Maria Trancassini Claudio Passariello Fabrizio Pantanella Serena Schippa Tags: Review Source Type: research

Gliadin intake induces oxidative-stress responses in Caenorhabditis elegans.
Abstract Clinical attention to gluten-related disorders, such as celiac disease and nonceliac gluten sensitivity, is on the rise. However, identifying the pathophysiological mechanisms of gluten-related disorders remains elusive. Gliadin, a component of gluten, is known to play a major role in gluten toxicity. Caenorhabditis elegans has been widely used as the predominant experimental animal model to study toxicity and stress response in biomedical research. We investigated the stress response induced by gliadin intake in C. elegans to evaluate its toxicity and found brood size, body bending, and pumping rate...
Source: Biochemical and Biophysical Research communications - August 7, 2018 Category: Biochemistry Authors: Lim SD, Min H, Youn E, Kawasaki I, Shim YH Tags: Biochem Biophys Res Commun Source Type: research

Celiac Autoimmunity is Associated with Lower Blood Pressure and Renal Risk in Type 1 Diabetes.
Conclusions: These findings show that strongly positive celiac autoimmunity status in individuals with childhood onset type 1 diabetes is associated with lower baseline blood pressure and cholesterol measurements as well as lower macroalbuminuria risk after 25 years of type 1 diabetes duration with no increase in the risk of microalbuminuria or ESRD. PMID: 30099548 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - August 6, 2018 Category: Endocrinology Authors: Williams KV, Cristaldi CL, Miller RG, Arena VC, Libman I, Huang Y, Becker DJ, Orchard TJ Tags: J Clin Endocrinol Metab Source Type: research

Breaking bread: examining the impact of policy changes in access to state-funded provisions of gluten-free foods in England
Coeliac disease affects approximately 1% of the population and is increasingly diagnosed in the United Kingdom. A nationwide consultation in England has recommend that state-funded provisions for gluten-free (... (Source: BMC Medicine)
Source: BMC Medicine - August 2, 2018 Category: Internal Medicine Authors: Myles-Jay Linton, Tim Jones, Amanda Owen-Smith, Rupert A. Payne, Joanna Coast, Joel Glynn and William Hollingworth Tags: Research article Source Type: research

[Overweight and obesity in celiac disease: expression of the interleukin profile Th17].
CONCLUSION: body weight excess in celiac patients is not influenced by the expression levels of Th17 interleukins. PMID: 30070888 [PubMed - in process] (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - August 2, 2018 Category: Nutrition Authors: Parada A, Aguirre C, Pérez-Bravo F Tags: Nutr Hosp Source Type: research

Clinical, Endoscopic and Histological Differentiation between Celiac Disease and Tropical Sprue: A Systematic review
Journal of Gastroenterology and Hepatology,Volume 0, Issue ja, -Not available-. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - August 2, 2018 Category: Gastroenterology Authors: PragyaSharma , VandanaBaloda , Gaurav P SGahlot , AlkaSingh , RituMehta , SreenivasVishnubathla , KulwantKapoor , VineetAhuja , SiddharthaDatta Gupta , Govind KMakharia , PrasenjitDas Source Type: research