P105 The growth in children with Celiac disease after the gluten free diet: a comparison between Italian and American children
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - October 5, 2018 Category: Gastroenterology Authors: N. Sansotta, M. Cipolli, S. Guandalini Source Type: research

P103 Longitudinal analysis of intestinal biopsies from children with potential Coeliac disease: immunohistochemical markers predicting evolution to villous atrophy
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - October 5, 2018 Category: Gastroenterology Authors: R. Mandile, M.A. Maglio, V. Discepolo, B. Buono, F. Imperato, L. Greco, R. Troncone, R. Auricchio Source Type: research

P099 Screening of Celiac disease: adherence to the ESPGHAN guidelines
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - October 5, 2018 Category: Gastroenterology Authors: E. Franceschini, M.E. Lionetti, S. Gatti, T. Galeazzi, C. Monachesi, A.K. Verma, M. Vallorani, A. Palpacelli, V. Albano, C. Catassi Source Type: research

P098 Personalized approach for the management of potential Celiac children
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - October 5, 2018 Category: Gastroenterology Authors: R. Auricchio, R. Mandile, M.R. Del Vecchio, S. Scapaticci, Maria Antonia Maglio, V. Discepolo, E. Miele, D. Cielo, R. Troncone, L. Greco Source Type: research

P097 Non-Celiac gluten sensitivity in pediatric age
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - October 5, 2018 Category: Gastroenterology Authors: M. Bavastrelli, L. Caivano, C. Maimone, M. Maimone, G. Midulla Source Type: research

P096 Children with “borderline” TTG values in a screening for Coeliac disease on school population: follow-up after two years
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - October 5, 2018 Category: Gastroenterology Authors: F. Anton, L. Balanzoni, M. Cinquetti, M.T. Trevisan, N. Scattolo, S. Gatti, E. Lionetti, R. Annibali, A. Palpacelli, E. Franceschini, T. Galeazzi, A. Verma, C. Monachesi, C. Catassi Source Type: research

P095 Influence of early environmental factors on the establishment of gut microbiome composition, function, and metabolomics profiles in infants at risk of Celiac disease
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - October 5, 2018 Category: Gastroenterology Authors: F. Valitutti, M. Leonard, M. Montuori, R. Francavilla, B. Malamisura, P. Piemontese, L. Elli, A. Calvi, M. Baldassarre, L. Norsa, C.M. Trovato, L. Raguseo, V. Kenyon, T. Passaro, P. Roggero, M. Crocco, M. Chieppa, J. Troisi, G. Scala, M.E. Lionetti, C. Ca Source Type: research

Anxiety after coeliac disease diagnosis predicts mucosal healing: a population ‐based study
Alimentary Pharmacology&Therapeutics, EarlyView. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - October 5, 2018 Category: Drugs & Pharmacology Authors: Jonas F. Ludvigsson, Benjamin Lebwohl, Qi Chen, Gabriella Br öms, Randi L. Wolf, Peter H. R. Green, Louise Emilsson Source Type: research

The Role of Human Leukocyte Antigen in Celiac Disease Diagnostics
Celiac disease is an autoimmune disease affecting the small intestine, triggered by gluten sensitization in genetically susceptible individuals worldwide. Celiac disease development is strongly linked to the presence of HLA-DQ2 and/or DQ8, which present the immunogenic gluten peptides and trigger the immune response leading to pathogenesis. Because of the variability of clinical symptoms, the disease is often underdiagnosed. Intestinal biopsy and the presence of antibodies to deamidated gliadin and tissue transglutaminase are recommended diagnostic tools. Genetic testing for HLA DQ2 and DQ8 can be used to rule out disease ...
Source: Clinics in Laboratory Medicine - October 5, 2018 Category: Laboratory Medicine Authors: Eszter L ázár-Molnár, Melissa Snyder Source Type: research

In situ Gluten ‐Chitosan Interlocked Self‐Assembled Supramolecular Architecture Reduces T‐Cell‐Mediated Immune Response to Gluten in Celiac Disease
Molecular Nutrition&Food Research,Volume 0, Issue ja, -Not available-. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 5, 2018 Category: Food Science Authors: Miguel Ribeiro, Stefania Picascia, Larbi Rhazi, Carmen Gianfrani, Jose Maria Carrillo, Marta Rodriguez ‐Quijano, Gérard Branlard, Fernando M. Nunes Source Type: research

Gut and bone connection: celiac disease presented as hypertrophic osteoarthropathy
Endocrine Practice, Ahead of Print. (Source: Endocrine Practice)
Source: Endocrine Practice - October 5, 2018 Category: Endocrinology Authors: Darin Ruanpeng Tasma Harindhanavudhi Source Type: research

Efficient Extraction and Digestion of Gluten Proteins.
Abstract Coeliac disease (CD) is a T-cell mediated autoimmune disorder triggered by ingestion of cereal gluten found in wheat (gliadins and glutenins), barley (hordeins), and rye (secalins). As the only treatment for CD is a lifelong gluten-free diet, the measurement of gluten in raw ingredients and processed food products is critical to protecting people with CD or gluten intolerance. The most commonly employed method is the enzyme-linked immunosorbent assay (ELISA), but more recently mass spectrometry has been employed wherein the extracted gluten proteins are digested to peptides that are then directly measured...
Source: Mol Biol Cell - October 4, 2018 Category: Molecular Biology Authors: Li H, Byrne K, Howitt CA, Colgrave ML Tags: Methods Mol Biol Source Type: research

Risk Factors Associated with the Occurrence of Autoimmune Diseases in Adult Coeliac Patients.
Conclusions: CD patients with family history of AD, overweight at CD diagnosis, and a delay of CD diagnosis had an increased risk of having another AD. The benefit of CD screening in these specific subsets of patients with AD awaits further investigation. PMID: 30275824 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - October 4, 2018 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Food Sensitivities
Food allergies are on the rise, for reasons that are not fully understood. However, there is a tendency to overestimate their frequency, mostly based on parents ’ reports or on the assumption that a positive skin or blood IgE test implies the existence of clinically relevant allergy. It is imperative to base food allergy diagnosis on well-defined criteria, avoiding “alternative” tests that are available to the general public. Non-celiac gluten sensiti vity is a misnomer and should be abandoned in favor of non-celiac wheat intolerance, an entity suffering from lack of biomarkers and still not convincingly ...
Source: Gastroenterology Clinics of North America - October 4, 2018 Category: Gastroenterology Authors: Catherine DeGeeter, Stefano Guandalini Source Type: research

The daily practice of (suspected) coeliac disease management by general practitioners: A qualitative approach.
CONCLUSION: The different views of GPs on how to diagnose and monitor CD could be a basis for further research to improve CD detection rate and CD care. PMID: 30277085 [PubMed - in process] (Source: European Journal of General Practice)
Source: European Journal of General Practice - October 4, 2018 Category: Primary Care Tags: Eur J Gen Pract Source Type: research

Experiences of coeliac disease in a changing gluten ‐free landscape
Journal of Human Nutrition and Dietetics, EarlyView. (Source: Journal of Human Nutrition and Dietetics)
Source: Journal of Human Nutrition and Dietetics - October 3, 2018 Category: Nutrition Authors: J. A. King, G. G. Kaplan, J. Godley Source Type: research

Letter: identifying coeliac disease among patients with bloating —Authors' reply
Alimentary Pharmacology&Therapeutics,Volume 48, Issue 8, Page 883-883, October 2018. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - October 3, 2018 Category: Drugs & Pharmacology Authors: Isabel A. Hujoel, Alberto Rubio ‐Tapia Source Type: research

Letter: identifying coeliac disease among patients with bloating
Alimentary Pharmacology&Therapeutics,Volume 48, Issue 8, Page 882-883, October 2018. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - October 3, 2018 Category: Drugs & Pharmacology Authors: P. Ellul, C. Zammit Source Type: research

[Kelly-Paterson Syndrome and coeliac disease in adult].
PMID: 30292384 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - October 3, 2018 Category: General Medicine Authors: Jaziri H, Bouchereb A, Ksiaa M, Hammami A, Eleuch N, Brahem A, Salem A, Ben Slama A, Jmaa A Tags: Presse Med Source Type: research

Novel steps forward in the histopathology of non-celiac gluten sensitivity, authors ’ reply
(Source: Virchows Archiv)
Source: Virchows Archiv - October 1, 2018 Category: Pathology Source Type: research

Novel steps forward in the histopathology of non-celiac gluten sensitivity
(Source: Virchows Archiv)
Source: Virchows Archiv - October 1, 2018 Category: Pathology Source Type: research

Health-related quality of life in Spanish coeliac children using the generic KIDSCREEN-52 questionnaire
Conclusion: Overall, the KIDSCREEN-52 questionnaire revealed that CD had no substantial negative impacts on the children ’s QOL. However, some concerns from the children’s perspective were identified, such as issues regarding relationships with their peers. These issues will need to be addressed in order to improve QOL in children with CD.What is Known:•According to the Spanish version of the specific CDDUX, parents and children felt CD had no substantial negative impacts on their HRQOL.What is New:•According to the generic KIDSCREEN-52 questionnaire, QOL in Spanish coeliac children does not seem to b...
Source: European Journal of Pediatrics - October 1, 2018 Category: Pediatrics Source Type: research

The celiac seagull
(Source: Abdominal Imaging)
Source: Abdominal Imaging - October 1, 2018 Category: Radiology Source Type: research

Distal Pancreatectomy with Celiac Axis Resection (DP-CAR) for Pancreatic Cancer. How I do It
This article proposes a standardized approach to DP-CAR, including routine neoadjuvant (FOLFIRINOX) chemotherapy. This approach to selecting patients and performing DP-CAR has the potential to improve short-term outcomes and overall surviv al in selected patients, but it should be reserved for high-volume centers. (Source: Journal of Gastrointestinal Surgery)
Source: Journal of Gastrointestinal Surgery - October 1, 2018 Category: Surgery Source Type: research

Can High Titres of Anti Tissue Transglutaminase Antibodies Reduce the Need for Intestinal Biopsy for Diagnosis of Celiac Disease?
This study confirms that a small intestinal biopsy is not always necessary for the diagnosis of CD in symptomatic patients with high tTGA levels (>70  IU/ml). (Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - October 1, 2018 Category: Biochemistry Source Type: research

Positive IgA against transglutaminase 2 in patients with distal radius and ankle fractures compared to community-based controls.
CONCLUSIONS: There were no significantly increased odds of CD in adult patients with fractures compared to controls; however, results imply that positive IgA TG2 is more prevalent in fracture patients than in controls. This study indicates that universal screening for CD in fracture patients is not warranted, but supports current clinical practice in Norway to suspect and investigate for CD in patients with fracture, osteoporosis and other risk factors for CD. PMID: 30265163 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - September 30, 2018 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Evaluation of screening for celiac disease in children with juvenile idiopathic arthritis
Acta Paediatrica,Volume 0, Issue ja, -Not available-. (Source: Acta Paediatrica)
Source: Acta Paediatrica - September 28, 2018 Category: Pediatrics Authors: Anders Öman, Tony Hansson, Martin Carlsson, Lillemor Berntson Source Type: research

A single-tube, EuroClonality-inspired, TRG clonality multiplex PCR aids management of patients with enteropathic diseases, including from formaldehyde-fixed, paraffin-embedded tissues
Celiac disease is a chronic inflammation of the small intestine with villous atrophy that can become refractory to a gluten-free diet. Two categories of refractory celiac disease (I and II) can be distinguished by the phenotype of intra-epithelial lymphocytes and the status of TRG genes. Their distinction is important because 30% to 50% of type II, but only 0% to 14% of type I, evolve to an aggressive enteropathy-associated T-cell lymphoma and therefore require intensive treatment. Currently, differential diagnosis integrates immunohistochemistry, immunophenotyping, and TRG clonality analyses but each have limitations. (So...
Source: Journal of Molecular Diagnostics - September 27, 2018 Category: Pathology Authors: Coralie Derrieux, Am élie Trinquand, Julie Bruneau, Virginie Verkarre, Ludovic Lhermitte, Marion Alcantara, Patrick Villarese, Bertrand Meresse, David Sibon, Olivier Hermine, Nicole Brousse, Thierry Molina, Christophe Cellier, Nadine Cerf-Bensussan, Geor Tags: Regular Article Source Type: research

Low Sensitivity of Simtomax Point of Care Test in Detection of Celiac Disease in a Prospective Multicenter Study
Point of care tests (POCTs) might be used to identify patients with undiagnosed celiac disease who require further evaluation. We performed a large multicenter study to determine the performance of a POCT for celiac disease and assessed celiac disease prevalence in endoscopy centers. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 26, 2018 Category: Gastroenterology Authors: Paul Tangermann, Federica Branchi, Alice Itzlinger, Jens Aschenbeck, Stefan Schubert, Jochen Maul, Thomas Liceni, Andreas Schr öder, Frank Heller, Wolfgang Spitz, Ulrich Möhler, Ulrich Graefe, Michael Radke, Stefan Trenkel, Markus Schmitt, Christoph Lod Source Type: research

Q-X1-P-X2 motif search for potential celiac disease risk has poor selectivity.
Abstract The European Food Safety Authority (EFSA) recently published guidelines for assessment of potential celiac disease risk for newly expressed proteins in genetically modified (GM) crops. This novel step-wise approach prescribes, in part, how to conduct sequence identity searches between a newly expressed protein and known celiac disease peptides including a Q/E-X1-P-X2 amino acid motif. To evaluate the specificity of the recommended sequence identity searches in the context of risk assessment, protein sequences from celiac disease causing crops, as well as from crops not associated with celiac, were compare...
Source: Regulatory Toxicology and Pharmacology : RTP - September 25, 2018 Category: Toxicology Authors: Song P, Podevin N, Mirsky H, Anderson J, Delaney B, Mathesius C, Rowe L, Herman RA Tags: Regul Toxicol Pharmacol Source Type: research

Gluten-free baked muffins developed with Prosopis alba flour
Publication date: December 2018Source: LWT, Volume 98Author(s): L.P. Sciammaro, C. Ferrero, M.C. PuppoAbstractBaked flour products are basic in people's diet; the problem arises when celiac people tend to follow this kind of diet. In this work we exploit the benefit of American carob, Prosopis alba flour (PAF) in developing gluten-free muffins jointly with corn flour (CF) and rice flour (RF). All muffins obtained presented very good physical and sensory characteristics. The muffin with the highest amount of PAF presented low chewiness and was the most adhesive. Crumb structure of muffins with PAF presented alveoli of more ...
Source: LWT Food Science and Technology - September 22, 2018 Category: Food Science Source Type: research

Electronic Medical Records Enable Precision Medicine Approaches for Celiac Disease
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2018 Category: Gastroenterology Tags: Invited Commentaries Source Type: research

Comorbidities in Childhood Celiac Disease: A Phenome Wide Association Study Using the Electronic Health Record
Conclusions: An EHR-based PheWAS method is a powerful, efficient, and cost-effective method to screen for possible CD comorbidities and validate associations at the population level. Ours is the first PheWAS of CD to confirm a significant association of eosinophilic disorders of the esophagus with CD in a controlled study. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2018 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Celiac Disease Source Type: research

Will the Real Coeliac Disease Please Stand Up? Coeliac Disease Prevalence in the German LIFE Child Study
Objectives: Assessing the seroprevalence and the prevalence of definite coeliac disease (CD) in the German LIFE Child Health study cohort including immunoglobulin A (IgA) antibodies against tissue transglutaminase (IgA-TTG) in addition to IgG antibodies against deamidated gliadin peptides (IgG-DGP) and human leukocyte antigen (HLA)-DQ2/8 genotyping. Methods: Samples from children and adolescents were first screened for IgA-TTG and IgG-DGP. If IgA-TTG was above 0.5 times the upper limit of normal and/or IgG-DGP was positive, IgA antibodies against endomysium (IgA-EmA) were measured, and HLA was genotyped. In patients w...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2018 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Celiac Disease Source Type: research

Going gluten free in non-celiac autoimmune diseases: the missing ingredient.
Authors: Lerner A, Matthias T PMID: 30220227 [PubMed - as supplied by publisher] (Source: Expert Review of Clinical Immunology)
Source: Expert Review of Clinical Immunology - September 19, 2018 Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research

Systematic Literature Review of the Economic Burden of Celiac Disease
ConclusionsMost of the few available economic studies of CD assess testing and diagnosis costs, especially in Europe. Methods of testing generally are considered cost effective when they combine diagnostic modalities in symptomatic patients. Most costs to a payer of managing CD derive from outpatient care. Following GFD initiation, patients lose fewer days from work and school than pretreatment. (Source: PharmacoEconomics)
Source: PharmacoEconomics - September 17, 2018 Category: Health Management Source Type: research

Individual screening strategy for pediatric celiac disease
(Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - September 17, 2018 Category: Pediatrics Source Type: research

Systematic Literature Review of the Economic Burden of Celiac Disease
ConclusionsMost of the few available economic studies of CD assess testing and diagnosis costs, especially in Europe. Methods of testing generally are considered cost effective when they combine diagnostic modalities in symptomatic patients. Most costs to a payer of managing CD derive from outpatient care. Following GFD initiation, patients lose fewer days from work and school than pretreatment. (Source: PharmacoEconomics)
Source: PharmacoEconomics - September 17, 2018 Category: Health Management Source Type: research

Occurrence of Hypothyroidism, Diabetes Mellitus, and Celiac Disease in Emirati Children with Down's Syndrome.
Conclusions: Celiac disease was the least prevalent autoimmune disease in patients with DS patients, while type 1 DM and hypothyroidism were both significantly associated with DS. PMID: 30210717 [PubMed] (Source: Oman Medical Journal)
Source: Oman Medical Journal - September 15, 2018 Category: Middle East Health Tags: Oman Med J Source Type: research

Coeliac disease and dermatitis herpetiformis – Authors' reply
Publication date: 15–21 September 2018Source: The Lancet, Volume 392, Issue 10151Author(s): Benjamin Lebwohl, David S Sanders, Peter HR Green (Source: The Lancet)
Source: The Lancet - September 14, 2018 Category: General Medicine Source Type: research

Coeliac disease and dermatitis herpetiformis
Publication date: 15–21 September 2018Source: The Lancet, Volume 392, Issue 10151Author(s): Giacomo Caio, Roberto De Giorgio, Umberto Volta (Source: The Lancet)
Source: The Lancet - September 14, 2018 Category: General Medicine Source Type: research

Coeliac disease and dermatitis herpetiformis
Publication date: 15–21 September 2018Source: The Lancet, Volume 392, Issue 10151Author(s): François Rodrigues, Claude Bachmeyer (Source: The Lancet)
Source: The Lancet - September 14, 2018 Category: General Medicine Source Type: research

Development and Validation of the Coeliac Disease Food Attitudes and Behaviours Scale.
Conclusions: The CD-FAB is a reliable and valid measure of food attitudes and behaviours in coeliac disease. As a new disease-specific instrument, it may be a useful tool for evaluating food concerns in individuals with coeliac disease in a clinical setting and for further exploring the development of disordered eating patterns in coeliac disease. Further research is required to assess the full potential of the CD-FAB. PMID: 30210536 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - September 14, 2018 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Dilemmas in diagnosis and early management of coeliac disease
This article deals with the challenges of using the new triple test in diagnosis as well as some of the commonly seen dilemmas associated with diagnosis and early management of coeliac disease. (Source: Paediatrics and Child Health)
Source: Paediatrics and Child Health - September 14, 2018 Category: Pediatrics Authors: Theodoric Wong, Lisa Whyte Tags: Symposium: gastroenterology Source Type: research

Gluten may be making you tired and depressed according to a new study
Gluten might not cause gut problems in people who don ’t have coeliac disease, but a study of 14 people suggests it may occasionally cause fatigue or depression (Source: New Scientist - Health)
Source: New Scientist - Health - September 13, 2018 Category: Consumer Health News Source Type: research

Incidence and Risk of Celiac Disease after Type 1 Diabetes: A Population ‐Based Cohort Study Using The Health Improvement Network Database
Pediatric Diabetes,Volume 0, Issue ja, -Not available-. (Source: Pediatric Diabetes)
Source: Pediatric Diabetes - September 13, 2018 Category: Endocrinology Authors: Mary Ellen Vajravelu , Ron Keren , David R. Weber , Ritu Verma , Diva D. De Le ón , Michelle R. Denburg Source Type: research

Food intolerance in patients with manifest autoimmunity. Observational study
Publication date: Available online 11 September 2018Source: Autoimmunity ReviewsAuthor(s): Francis CouckeAbstractIn the professional medical and scientific world, there is not many interest in the correlation of food intolerance and autoimmune diseases. However there is a lot of evidence that e.g. gluten or gliadine can induce autoimmmune diseases: example the interest in coeliac disease and autoimmunity. There is however a lot of informationavailable about leaky gut and autoimmunity.We performed an observational study in our data base;, where we selected 100 patients with manifest autoimmune disease with clear symptoms an...
Source: Autoimmunity Reviews - September 11, 2018 Category: Allergy & Immunology Source Type: research