The Risk of Autoimmune Disorders in Treated Celiac Disease Patients in Olmsted County, Minnesota
Background: Patients with autoimmune disorders (ADs) are at increased risk for celiac disease (CD), but data are conflicting on the risk of ADs in treated patients with CD. We aimed to assess the incidence of ADs in treated patients with CD. Methods: Using the Rochester Epidemiology Project, we retrospectively searched for the medical records at Mayo Clinic and Olmsted Medical Center from January 1997 to December 2015 for patients with CD who met accepted diagnostic criteria. For each patient with CD, we identified 2 age and sex-matched controls during the same study period. The incidence rate of AD diagnosis 5 years ...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 21, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Celiac Disease Source Type: research

Diagnostic Delays in Children With Coeliac Disease in the Central European Region
Objectives: Coeliac disease (CD) is a systemic autoimmune disorder affecting about 1% of the population. Many patients remain undiagnosed or are diagnosed with substantial delay. We assessed diagnostic delays in symptomatic CD children in Central Europe (CE). Methods: Paediatric gastroenterologists in 5 CE countries retrospectively reported data of their patients diagnosed in 2016. Age at first CD-related symptom(s), first visit to paediatric gastroenterologist and confirmed diagnosis were used to determine diagnostic delays. Results: Data from 393 children (65% girls, median age 7 years, range 7 months to 18.5 yea...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 21, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Celiac Disease Source Type: research

Should We Assess Vitamin D Status in Pediatric Patients With Celiac Disease?
Objectives: Screening for vitamin D status in celiac disease (CD) has been recommended but the literature provides varying support. We sought to assess the vitamin D status in newly diagnosed children with CD and in a non-CD control population and relate them to vitamin D intake. Methods: In a cross-sectional study, serum 25-hydroxyvitamin D (25-OHD) levels were drawn in children with newly diagnosed CD and compared with pediatric outpatients with functional abdominal complaints. Anthropometric data as well as vitamin D intake based on milk and multivitamin ingestion were collected. Results: Thirty-eight newly diag...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 21, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Celiac Disease Source Type: research

Modulation of in vitro digestibility and physical characteristics of protein enriched gluten free breads by defining hydration
Publication date: January 2020Source: LWT, Volume 117Author(s): Marta Sahagún, Yaiza Benavent-Gil, Cristina M. Rosell, Manuel GómezAbstractThe association of diabetes on celiac disease together with the high glycemic index of gluten-free breads makes necessary the pursuit of a solution to reduce this glycemic response. Protein enrichment and changes on hydration level may be tools to get it. Thus, the aim of this study was to analyze the effect of two proteins (pea and egg white) on the digestibility and physical characteristics of gluten-free breads, with either the same hydration or specific volume. Protein...
Source: LWT Food Science and Technology - September 20, 2019 Category: Food Science Source Type: research

A Cooking-Based Intervention Promotes Gluten-Free Diet Adherence and Quality of Life for Adults with Celiac Disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 20, 2019 Category: Gastroenterology Authors: Randi L. Wolf, Mary Morawetz, Anne R. Lee, Pamela Koch, Isobel R. Contento, Patricia Zybert, Peter HR. Green, Benjamin Lebwohl Source Type: research

Prevalence of anti-tissue transglutaminase antibodies in patients with irritable bowel syndrome in Duhok city
ConclusionThe prevalence of anti tTG antibodies in irritable bowel syndrome is high. Patients with D-IBS should be screened for celiac disease.ResumoIntroduçãoA síndrome do intestino irritável (SII) é um distúrbio gastrointestinal comum; a doença celíaca é uma enteropatia autoimune que pode imitar qualquer distúrbio gastrointestinal funcional. O objetivo deste estudo foi estimar a prevalência de anticorpos contra a doença celíaca (antitransglutaminase tecidual - tTG) em pacientes com SII.Pacientes e MétodosEste estudo transvers...
Source: Journal of Coloproctology - September 14, 2019 Category: Gastroenterology Source Type: research

Gut microbiome investigation in celiac disease: from methods to its pathogenetic role
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - September 10, 2019 Category: Laboratory Medicine Source Type: research

Intra-arterial infusion chemotherapy versus isolated upper abdominal perfusion for advanced pancreatic cancer: a retrospective cohort study on 454 patients
ConclusionsResponsiveness of pancreatic cancer to regional chemotherapy is drug exposure dependent. The isolated perfusion procedure is superior to intra-arterial infusion in survival times. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - September 10, 2019 Category: Cancer & Oncology Source Type: research

The Skin in Celiac Disease Patients: The Other Side of the Coin.
e; SP Abstract Celiac disease (CD) is an autoimmune enteropathy that primarily affects the small intestine and is characterized by atrophy of intestinal villi. The manifestations of the disease improve following a gluten-free diet (GFD). CD is associated with various extra-intestinal diseases. Several skin manifestations are described in CD patients. The present paper reviews all CD-associated skin diseases reported in the literature and tries to analyze the pathogenic mechanisms possibly involved in these associations. Different hypotheses have been proposed to explain the possible mechanisms involved in every as...
Source: Medicina (Kaunas) - September 9, 2019 Category: Universities & Medical Training Authors: Abenavoli L, Dastoli S, Bennardo L, Boccuto L, Passante M, Silvestri M, Proietti I, Potenza C, Luzza F, Nisticò SP Tags: Medicina (Kaunas) Source Type: research

Effect of celiac disease on maternal and neonatal outcomes of pregnancy
. (Source: Journal of Maternal-Fetal and Neonatal Medicine)
Source: Journal of Maternal-Fetal and Neonatal Medicine - September 6, 2019 Category: Perinatology & Neonatology Authors: Brittney Elliott Nicholas Czuzoj-Shulman Andrea R. Spence Daniel S. Mishkin Haim Arie Abenhaim Source Type: research

Sucrase-Isomaltase Deficiency as a Potential Masquerader in Irritable Bowel Syndrome
ConclusionSID was found in 35% of patients with presumed IBS-D/M and should be considered in the differential diagnosis of patients presenting with abdominal pain, diarrhea, or bloating. Further studies should better characterize the clinical features of SID and investigate the effects of dietary modification in this group of patients. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - September 6, 2019 Category: Gastroenterology Source Type: research

Effect of celiac disease on maternal and neonatal outcomes of pregnancy
. (Source: Journal of Maternal-Fetal and Neonatal Medicine)
Source: Journal of Maternal-Fetal and Neonatal Medicine - September 6, 2019 Category: Perinatology & Neonatology Authors: Brittney Elliott Nicholas Czuzoj-Shulman Andrea R. Spence Daniel S. Mishkin Haim Arie Abenhaim Source Type: research

EFSUMB Gastrointestinal Ultrasound (GIUS) Task Force Group: Celiac sprue and other rare gastrointestinal diseases ultrasound features.
Authors: Dietrich CF, Hollerweger A, Dirks K, Higginson A, Serra C, Calabrese E, Dong Y, Hausken T, Maconi G, Mihmanli I, Nürnberg D, Nylund K, Pallotta N, Ripollés T, Romanini L, Săftoiu A, Sporea I, Wüstner M, Maaser C, Gilja OH Abstract Transabdominal gastrointestinal ultrasound (GIUS) is unique in its capacity to examine the bowel non-invasively and in its physiological condition, including extra-intestinal features such as the splanchnic vessels, mesentery, omentum and lymph nodes- even at the bedside. Despite this, and its extensive documentation for its usefulness, it has only been fully im...
Source: Medical Ultrasonography - September 4, 2019 Category: Radiology Tags: Med Ultrason Source Type: research

Cancer of the oesophagus and lymph nodes management in the neoadjuvant or definitive radiochemotherapy setting.
nat S Abstract Despite representing a 1% of diagnosed cancer cases in the USA and up to 5% in eastern Asia and Africa, oesophageal cancer still holds numerous questions concerning the best therapeutic management. For squamous cell carcinoma, while radiochemotherapy has proven itself to be the gold standard as part of the trimodality or alone as a definitive treatment, radiotherapy modalities are still debated especially regarding lymph node irradiation. Involved nodes irradiation was developed with the aim of maintaining clinical outcomes and enhancing quality of life but lacks grade 1 evidence. In this article, w...
Source: Cancer Radiotherapie - September 3, 2019 Category: Cancer & Oncology Authors: Bourbonné V, Pradier O, Schick U, Servagi-Vernat S Tags: Cancer Radiother Source Type: research

Neuropsychiatric manifestations in celiac disease
Publication date: October 2019Source: Epilepsy & Behavior, Volume 99Author(s): Chiara Maria Trovato, Umberto Raucci, Francesco Valitutti, Monica Montuori, Maria Pia Villa, Salvatore Cucchiara, Pasquale ParisiAbstractCeliac disease (CD) is a systemic, chronic immune-mediated disorder elicited by gluten and related prolamines in genetically susceptible subjects. Main manifestations of CD involve the digestive tract; however, a growing body of evidence supports the theory that symptoms may occur in every part of the body. It is known that some patients with CD can be asymptomatic, and additionally, the incidence of &ldquo...
Source: Epilepsy and Behavior - September 1, 2019 Category: Neurology Source Type: research

Diagnosing Celiac Disease: Towards Wide-Scale Screening and Serology-Based Criteria?
Authors: Popp A, Kivelä L, Fuchs V, Kurppa K Abstract Celiac disease is one of the most common food-related chronic disorders in children. Unfortunately, this multifaceted disease is challenging to recognize and remains markedly underdiagnosed. Screening of either known at-risk groups or even the whole population could increase the suboptimal diagnostic yield substantially. Many recent guidelines recommend screening of at least selected risk groups, but more wide-scale screening remains controversial. The increasing prevalence of celiac disease and the development of autoantibody assays have also led to a grad...
Source: Gastroenterology Research and Practice - September 1, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

112 Substantially increased risk of dermatitis herpetiformis in children and adolescents with atopic dermatitis
Atopic dermatitis (AD) is an eczematous inflammatory skin disease being the most common skin disease in children. AD is associated with an increased risk for several atopic, somatic and psychiatric comorbidities. Recent epidemiological data suggests that AD patients are at risk for autoimmune diseases, but the risk of celiac disease (CD) in children and adolescents with AD has shown conflicting results. Dermatitis herpetiformis (DH) is a rare autoimmune bullous skin disease with worldwide highest prevalence in Finland. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - September 1, 2019 Category: Dermatology Authors: S. Kauppi, J. Jokelainen, M. Timonen, K. Tasanen, L. Huilaja Tags: Clinical Research and Epidemiology Source Type: research

089 Atopic Dermatitis Is Associated With an Increased Risk of Autoimmune Diseases: A Population-Based Cohort Study Using UK Primary Care Data
Atopic dermatitis (AD) is associated with a wide range of comorbidities, particularly allergies, but its association with nonatopic autoimmune disease is less well defined. Recent genome-wide association studies have reported shared genetic loci between AD and autoimmune diseases. In the UK, most patients with these conditions are managed in primary care, meaning general practice (GP) databases provide a rich data source for studying AD. A retrospective cohort study was undertaken to examine the association between AD and the following autoimmune diseases (rheumatoid arthritis [RA], ulcerative colitis [UC], Crohn ’s ...
Source: Journal of Investigative Dermatology - September 1, 2019 Category: Dermatology Authors: H. Alexander, S. de Lusignan, S. Mashayekhi, C. Feeney, C. Flohr Tags: Clinical Research and Epidemiology Source Type: research

Gastrointestinal findings in 26 adults with common variable immunodeficiency: The fickle nature of the disease manifests in gastrointestinal biopsies.
avşargil B Abstract BACKGROUND/AIMS: The aim of the present study was to demonstrate the histopathological findings in gastrointestinal (GI) biopsies in adults with common variable immunodeficiency (CVID). MATERIALS AND METHODS: A total of 172 GI biopsies of 26 patients with CVID obtained over a 16-year period were reevaluated. Findings were analyzed using descriptive analyzes and χ2 test. RESULTS: Female-to-male ratio was 1.36. The median age at diagnosis was 36±13.94 (16-72) years. Chronic esophagitis was noted in 3 patients. The absence of plasma cells in the stomach, duodenum, and colon w...
Source: The Turkish Journal of Gastroenterology - September 1, 2019 Category: Gastroenterology Authors: Pehlivanoğlu B, Ardeniz Ö, Hassoy H, Sezak M, Özdemir H, Ünal NG, Onay H, Doğanavşargil B Tags: Turk J Gastroenterol Source Type: research

Does celiac disease cause autoimmune sensorineural hearing loss?
CONCLUSION: In this study with a higher number of CD patients when compared with the previous studies, it has been shown that CD does not appear to cause autoimmune sensorineural hearing loss. In addition, the status of the patients regarding the activeness or the remission of CD did not display a differ between the CD patients in terms of hearing levels. PMID: 31530521 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - September 1, 2019 Category: Gastroenterology Authors: Yazıcı A, Yıldırım AE, Konduk BT Tags: Turk J Gastroenterol Source Type: research

Red patches on the tongue with white borders • history of geographic tongue • incompletely treated celiac disease • Dx?
Red patches on the tongue with white borders • history of geographic tongue • incompletely treated celiac disease • Dx? J Fam Pract. 2019 Sep;68(7):E9-E11 Authors: Bray SC, Carek PJ PMID: 31532821 [PubMed - in process] (Source: The Journal of Family Practice)
Source: The Journal of Family Practice - September 1, 2019 Category: Practice Management Authors: Bray SC, Carek PJ Tags: J Fam Pract Source Type: research

An association between crypt apoptotic bodies and mucosal flattening in celiac disease patients exposed to dietary gluten
Celiac disease (CD) is characterized histologically by inflammation and villous atrophy. Villous atrophy is thought to result from a disruption of epithelial cellular proliferation and death. Epithelial cells ... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - August 31, 2019 Category: Pathology Authors: Michael Lee, Shane Betman, Alina Iuga, Hui-Min Yang, Jude Fleming, Peter H. R. Green, Benjamin Lebwohl and Stephen M. Lagana Tags: Research Source Type: research

Neuropsychiatric manifestations in celiac disease.
Abstract Celiac disease (CD) is a systemic, chronic immune-mediated disorder elicited by gluten and related prolamines in genetically susceptible subjects. Main manifestations of CD involve the digestive tract; however, a growing body of evidence supports the theory that symptoms may occur in every part of the body. It is known that some patients with CD can be asymptomatic, and additionally, the incidence of "nonclassical" CD with extraintestinal presentation is apparently increasing. We aimed to perform a thorough review of existing evidence for neurological manifestations of CD, providing an up-to-dat...
Source: Epilepsy and Behaviour - August 31, 2019 Category: Neurology Authors: Trovato CM, Raucci U, Valitutti F, Montuori M, Villa MP, Cucchiara S, Parisi P Tags: Epilepsy Behav Source Type: research

Antigen-specific tolerance to self-antigens in protein replacement therapy, gene therapy and autoimmunity.
Abstract Trials of antigen-specific tolerance have been undertaken in the clinic for over fifty years and the results of these antigen-specific clinical trials are described in this review. Antigen-specific tolerization of the immune system in protein replacement therapy for hemophilia A is an accepted treatment. Clinical trials are ongoing for autoimmune conditions such as type 1 diabetes, multiple sclerosis, neuromyelitis optica, and rheumatoid arthritis with various antigen-specific strategies. Trials for tolerization in celiac disease aim for antigen specific tolerance to gluten, an environmental trigger, whic...
Source: Current Opinion in Immunology - August 30, 2019 Category: Allergy & Immunology Authors: Steinman L, Ho PP, Robinson WH, Utz PJ, Villoslada P Tags: Curr Opin Immunol Source Type: research

Are Viruses and Parasites linked to Celiac Disease? A question that still has no definite answer.
Abstract Celiac disease is a complex autoimmune enteropathy of the small intestine that commonly occurs in genetically predisposed individuals due to intake of gluten and related proteins. Gluten consumption, duration of breast-feeding, various infections, especially frequent intestine infections, vaccinations and use of antibiotics can be linked to celiac disease. It is predicted that it affects 1% of the global population and its incidence rate is increasing. Celiac disease is closely related to Turner's syndrome, type I diabetes mellitus, Down's syndrome, and other autoimmune conditions and most people with the...
Source: Current Pharmaceutical Biotechnology - August 28, 2019 Category: Biotechnology Authors: Shariati A, Aslani HR, Shayesteh MRH, Taghipour A, Nasser A, Safari H, Alizade-Sani M, Dehghan A, Azimi T Tags: Curr Pharm Biotechnol Source Type: research

Common Problems Found in the Methodological Approach to Small Bowel Biopsies in the Diagnosis of Celiac Disease
Small bowel biopsy (SBB) is not always helpful to establish celiac disease diagnosis. Hence we have conducted a retrospective study to know the amount of SBB in our center that was not optimal for this purpose. Histological findings were not appropriate for diagnosis in 3.56% (34 out of 955). The main problem encountered was inadequate sample cutting, although this could be solved by a new recut in almost 30% of cases. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - August 23, 2019 Category: Gastroenterology Tags: Short Communication: Gastroenterology Celiac Disease Source Type: research

Online resources for celiac disease
No abstract available (Source: Nursing)
Source: Nursing - August 23, 2019 Category: Nursing Tags: Department: INFOBYTES Source Type: research

High Prevalence of Celiac Disease Among Screened First-Degree Relatives
To investigate the prevalence of first-degree relatives (FDRs) with celiac disease detected at screening and diagnostic significance of anti-tissue transglutaminase (anti-TTG). (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - August 22, 2019 Category: Internal Medicine Authors: Shilpa S. Nellikkal, Yamen Hafed, Joseph J. Larson, Joseph A. Murray, Imad Absah Tags: Original article Source Type: research

Mantle Cell Lymphoma and Ampullary Tubulovillous Adenoma in Celiac Disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 21, 2019 Category: Gastroenterology Authors: Hilary E. Pitner, David Y. Lo, Kofi Clarke Tags: Image of the Month Source Type: research

Bilateral vestibulopathy disclosing the diagnosis of celiac disease
(Source: Neurological Sciences)
Source: Neurological Sciences - August 19, 2019 Category: Neurology Source Type: research

Viruses, Vol. 11, Pages 762: Viruses and Autoimmunity: A Review on the Potential Interaction and Molecular Mechanisms
M. Yassine For a long time, viruses have been shown to modify the clinical picture of several autoimmune diseases, including type 1 diabetes (T1D), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren’s syndrome (SS), herpetic stromal keratitis (HSK), celiac disease (CD), and multiple sclerosis (MS). Best examples of viral infections that have been proposed to modulate the induction and development of autoimmune diseases are the infections with enteric viruses such as Coxsackie B virus (CVB) and rotavirus, as well as influenza A viruses (IAV), and herpesviruses. Other virus...
Source: Viruses - August 19, 2019 Category: Virology Authors: Maria K. Smatti Farhan S. Cyprian Gheyath K. Nasrallah Asmaa A. Al Thani Ruba O. Almishal Hadi M. Yassine Tags: Review Source Type: research

The evolution of celiac disease publications: a holistic approach with bibliometric analysis
AbstractBackgroundDespite the increasing number of publications on celiac disease, there is a lack of studies that made a holistic bibliometric evaluation of the studies on this topic.AimsThe purpose of this study is to analyze the publications about celiac disease by using bibliometric methods and this way to demonstrate the celiac disease –related trends, top effective articles, journals, and international collaborations between the countries and institutions.MethodsAll articles published between 1980 and 2018 on celiac disease were downloaded from Web of Science and analyzed with bibliometric methods. The correlat...
Source: Irish Journal of Medical Science - August 17, 2019 Category: General Medicine Source Type: research

Prevalence of celiac disease in primary care: the need for its own code
Celiac disease (CD) is an autoimmune chronic enteropathy of the small intestine caused by exposure to gluten in genetically predisposed individuals. CD is not easy to diagnose due to its unspecific symptomatol... (Source: BMC Health Services Research)
Source: BMC Health Services Research - August 16, 2019 Category: General Medicine Authors: Ricardo Fueyo-D íaz, Rosa Magallón-Botaya, Barbara Masluk, Guillermo Palacios-Navarro, Angela Asensio-Martínez, Santiago Gascón-Santos, Bárbara Olivan-Blázquez and Juan José Sebastián-Domingo Tags: Research article Source Type: research

Efficacy of Celiac Branch Preservation in Billroth- Ⅰ Reconstruction After Laparoscopy-Assisted Distal Gastrectomy
The goal of the present retrospective study was to elucidate the efficacy of conserving the celiac branch (CB), which can reduce the adverse reactions of Billroth- Ⅰ (B-Ⅰ) restoration after the laparoscopy-assisted distal gastrectomy (LADG). (Source: Journal of Surgical Research)
Source: Journal of Surgical Research - August 16, 2019 Category: Surgery Authors: Yaofu Liu, Xinye Cui, Yi Zhang, Liang Cao, Xiang Hu Tags: Gastrointestinal Source Type: research

MON-PO352: Clinical Efficacy of a Durum Wheat Variety-Based (Senatore Cappelli) Pasta in Patients with Non-Celiac Gluten Sensitivity: A Double-Blind Randomized Crossover Trial
(Source: Clinical Nutrition)
Source: Clinical Nutrition - August 15, 2019 Category: Nutrition Authors: M.C. Mele, E. Rinninella, M. Cintoni, L. Basso, G. Egidi, S. Leone, E. Persichetti, F. Grassi, G. Ianiro, G. Rizzati, M. Napoli, M.V. Matteo, V. Mora, C. Fanali, A. Leonetti, S. Benedettelli, G. Cammarota, A. Gasbarrini Tags: Liver and gastrointestinal tract II Source Type: research

SUN-PO174: The Nutritional Adequacy of a Gluten-Free Diet in Adults with Celiac Disease
(Source: Clinical Nutrition)
Source: Clinical Nutrition - August 15, 2019 Category: Nutrition Authors: K. G ładyś, M. Guzek, K. Adrych, S. Małgorzewicz, Z. Kochan Tags: Nutrition and chronic disease I Source Type: research

Gluten Intake in First 5 Years and Incidence of Celiac Disease and Autoimmunity in At-Risk Children
This cohort study investigates the association between gluten intake in the first 5 years of life and celiac disease autoimmunity and biopsy-confirmed celiac disease in genetically at-risk children over a median 9-year follow-up. (Source: JAMA)
Source: JAMA - August 13, 2019 Category: General Medicine Source Type: research

Gluten and Celiac Disease Risk
Celiac disease provides a unique model for autoimmune research because the following key elements are known: the specific genes involved in its pathogenesis and the environmental trigger. Substantial genetic research has uncovered the strong influence of the HLA antigen and its mechanistic role in presenting deamidated gluten to effector immune cells involved in the pathogenesis of celiac disease. Researchers also have identified more than 57 alleles in addition to HLA genes that confer risk. Although this information is crucial to understanding celiac disease, it cannot explain the substantial increase in the prevalence o...
Source: JAMA - August 13, 2019 Category: General Medicine Source Type: research

Robot-assisted radical prostatectomy due to a primary carcinoid prostatic tumour in a three-year-old child: a case report
We present an extremely rare case of a 3-year-old child with a primary carcinoid tumour of the prostate. A 3-year-old boy presented with failure to thrive, constipation, recurrent respiratory tract infections and pain in the genital area. His karyotype was normal and cystic fibrosis and coeliac disease were excluded prior to further investigation. An abdominopelvic CT scan revealed a prostatic mass. Transrectal ultrasound-guided prostate biopsy was therefore performed and pathological examination revealed a carcinoid tumour. (Source: Urology)
Source: Urology - August 12, 2019 Category: Urology & Nephrology Authors: Erika Llorens de Knecht, Santiago Guadarrama Vega, Gloria Donate, Joan Palou Redorta, Anna Bujons Tur Source Type: research

Robot-assisted Radical Prostatectomy Due to a Primary Carcinoid Prostatic Tumor in a Three-Year-Old Child: A Case Report
We present an extremely rare case of a 3-year-old child with a primary carcinoid tumor of the prostate. A 3-year-old boy presented with failure to thrive, constipation, recurrent respiratory tract infections, and pain in the genital area. His karyotype was normal and cystic fibrosis and coeliac disease were excluded prior to further investigation. An abdominopelvic computed tomography scan revealed a prostatic mass. Transrectal ultrasound-guided prostate biopsy was therefore performed and pathological examination revealed a carcinoid tumor. (Source: Urology)
Source: Urology - August 12, 2019 Category: Urology & Nephrology Authors: Erika Llorens de Knecht, Santiago Guadarrama Vega, Gloria Donate, Joan Palou Redorta, Anna Bujons Tur Tags: Pediatric Case Reports Source Type: research

Celiac Disease: Updates on Pathology and Differential Diagnosis
Celiac disease is a gluten-triggered immune-mediated disorder, characterized by inflammation of the enteric mucosa following lymphocytic infiltration and eventually resulting in villous blunting. There have been many developments in refining diagnostic laboratory tests for celiac disease in the last decade. Biopsy-sparing diagnostic guidelines have been proposed and validated in a few recent prospective studies. However, despite these developments, histologic evaluation of duodenal mucosa remains one of the most essential diagnostic tools as it helps in the diagnosis of celiac disease in individuals who do not fulfill the ...
Source: Advances in Anatomic Pathology - August 10, 2019 Category: Pathology Tags: Review Articles Source Type: research

Response to article: “Unusual anatomical variation: tetrafurcation of the coeliac trunk”
(Source: Surgical and Radiologic Anatomy)
Source: Surgical and Radiologic Anatomy - August 9, 2019 Category: Anatomy Source Type: research

Jejunoileal fold pattern reversal in celiac disease
(Source: Abdominal Imaging)
Source: Abdominal Imaging - August 9, 2019 Category: Radiology Source Type: research

Should we worry about the eyes of celiac patients?
CONCLUSION: In conclusion, in addition to other extraintestinal manifestations of celiac disease, diagnosis time longer than 60 months in pediatric celiac patients, nonadherence to the gluten-free diet, and antibody positivity should be focused on during ophthalmologic examination and choroid measurement. PMID: 31394930 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - August 9, 2019 Category: Opthalmology Authors: Doğan G, Şen S, Çavdar E, Mayalı H, Cengiz Özyurt B, Kurt E, Kasırga E Tags: Eur J Ophthalmol Source Type: research

18F-Fluciclovine Uptake in Celiac Ganglia: A Pitfall in Prostate Cancer PET Imaging
We present 4 cases of patients who underwent 18F-fluciclovine PET for prostate cancer demonstrating physiologic uptake in the celiac ganglia, which could be mistaken for metastatic lymphadenopathy if the celiac ganglia have a nodular configuration and uptake higher than bone marrow. Uptake in celiac, cervical, and sacral ganglia has been reported previously as an important pitfall in 68Ga-PSMA-HBED-CC PET for prostate cancer. In our patients, only celiac ganglion uptake was visualized. Advances in PET scanner technology may cause physiologic uptake of 18F-fluciclovine in celiac ganglia to become more visually distinguishab...
Source: Clinical Nuclear Medicine - August 8, 2019 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Celiac Disease on FDG PET/CT
An FDG PET with diagnostic CT was performed on a 52-year-old man for investigation of lymphocytosis and the clinical suspicion of lymphoma. The PET/CT demonstrated diffuse small bowel uptake, prominent mesenteric lymph nodes without significant FDG uptake, and other features suggestive of celiac disease. Subsequently, the patient was found to have markedly elevated celiac disease antibodies (deamidated gliadin IgG and tissue transglutaminase IgA) and to be HLA DQ2 and DQ8 allele positive on genotyping for celiac disease. Gastroscopy and duodenal biopsy also confirmed the diagnosed. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - August 8, 2019 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

No major reduction in bone mineral density after long-term treatment of patients with Celiac Disease.
augeberg G PMID: 31401019 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - August 7, 2019 Category: Internal Medicine Authors: Hære P, Høie O, Lundin KEA, Haugeberg G Tags: Eur J Intern Med Source Type: research

Fatigue, Sleep, and Autoimmune and Related Disorders
Profound and debilitating fatigue is the most common complaint reported among individuals with autoimmune disease, such as systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, celiac disease, chronic fatigue syndrome, and rheumatoid arthritis. Fatigue is multi-faceted and broadly defined, which makes understanding the cause of its manifestations especially difficult in conditions with diverse pathology including autoimmune diseases. In general, fatigue is defined by debilitating periods of exhaustion that interfere with normal activities. The severity and duration of fatigue episodes vary, but fatigue can cau...
Source: Frontiers in Immunology - August 6, 2019 Category: Allergy & Immunology Source Type: research

A case of checkpoint inhibitor-induced celiac disease
ConclusionsThere has been only one published case reporting ICI-induced celiac disease. Our case report highlights a rare irAE (celiac disease) associated with ICI treatment. It is unclear whether the patient had previously undiagnosed celiac disease or whether ICIs triggered her enteritis. Our patient was able to continue treatment with ICIs with dietary modifications, suggesting correct diagnosis is critical for optimal patient outcome. (Source: Journal for Immunotherapy of Cancer)
Source: Journal for Immunotherapy of Cancer - August 5, 2019 Category: Cancer & Oncology Source Type: research

Misuse of serological screening tests for celiac disease in children: A prospective study in Italy
Despite a well-established diagnostic algorithm for celiac disease, it remains unclear whether prescriptions for celiac serological tests comply with the current pediatric guidelines. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - August 3, 2019 Category: Gastroenterology Authors: Elisa Franceschini, Maria Elena Lionetti, Grazia D ’Adamo, Elisa D’Angelo, Simona Gatti, Giulia Naspi Catassi, Basilio Malamisura, Carlo Catassi Tags: Alimentary Tract Source Type: research